Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966
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{"title"=>"Long-term unemployment is associated with short telomeres in 31-year-old men: An observational study in the Northern Finland Birth Cohort 1966", "type"=>"journal", "authors"=>[{"first_name"=>"Leena", "last_name"=>"Ala-Mursula", "scopus_author_id"=>"6507437696"}, {"first_name"=>"Jessica L.", "last_name"=>"Buxton", "scopus_author_id"=>"7006242763"}, {"first_name"=>"Ellen", "last_name"=>"Ek", "scopus_author_id"=>"6602520455"}, {"first_name"=>"Markku", "last_name"=>"Koiranen", "scopus_author_id"=>"6603446758"}, {"first_name"=>"Anja", "last_name"=>"Taanila", "scopus_author_id"=>"6701780093"}, {"first_name"=>"Alexandra I.F.", "last_name"=>"Blakemore", "scopus_author_id"=>"7004341371"}, {"first_name"=>"Marjo Riitta", "last_name"=>"Järvelin", "scopus_author_id"=>"18535933700"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pmid"=>"24278245", "scopus"=>"2-s2.0-84894365038", "doi"=>"10.1371/journal.pone.0080094", "pui"=>"372435544", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84894365038"}, "id"=>"7bc07bbe-bb28-382c-8636-36734ff05309", "abstract"=>"OBJECTIVE: Life stress resulting from early-life experiences and domestic stress is linked with shorter leukocyte telomere length (LTL), but evidence on employment-related stress is scarce. We explored whether unemployment in early adulthood is associated with shorter LTL, a potential biomarker of premature aging. METHODS: We used data from 5620 men and women belonging to the Northern Finland Birth Cohort 1966. Individually registered unemployment days in 1995-97 were compared with data on biological, behavioral and socioeconomic health predictors and existing medical conditions obtained by surveys and clinical examinations at follow-up in 1997-98. Mean LTL at follow-up was measured by multiplex quantitative real-time PCR. We calculated odds ratios and their 95% confidence intervals (CI) of belonging to the sex-stratified shortest decile of standardized relative mean LTL according to the categories of: 0, <260, <500 and over 500 unemployment days, representing 0, <1, <2 and over 2 calendar years. RESULTS: Among men, unemployment exceeding 500 days during three years was associated with having shorter LTL at follow-up, compared to being continuously employed. The corresponding odds ratio was 2.61 (95% CI 1.16 to 5.85) in the fully adjusted model. Such an association was not found among women in this study. CONCLUSIONS: Long-term unemployment in early adulthood is associated with shorter LTL among men.", "link"=>"http://www.mendeley.com/research/longterm-unemployment-associated-short-telomeres-31yearold-men-observational-study-northern-finland", "reader_count"=>25, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>1, "Mathematics"=>2, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>8, "Business, Management and Accounting"=>1, "Psychology"=>3, "Social Sciences"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Social Sciences"=>{"Social Sciences"=>4}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Mathematics"=>{"Mathematics"=>2}}, "reader_count_by_country"=>{"United States"=>1, "France"=>1}, "group_count"=>0}

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Relative Metric

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