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{"title"=>"Gated F-18 FDG PET for Assessment of Left Ventricular Volumes and Ejection Fraction Using QGS and 4D-MSPECT in Patients with Heart Failure: A Comparison with Cardiac MRI", "type"=>"journal", "authors"=>[{"first_name"=>"Yan", "last_name"=>"Li"}, {"first_name"=>"Li", "last_name"=>"Wang"}, {"first_name"=>"Shi-Hua", "last_name"=>"Zhao"}, {"first_name"=>"Zuo-Xiang", "last_name"=>"He"}, {"first_name"=>"Dao-Yu", "last_name"=>"Wang"}, {"first_name"=>"Feng", "last_name"=>"Guo"}, {"first_name"=>"Wei", "last_name"=>"Fang"}, {"first_name"=>"Min-Fu", "last_name"=>"Yang"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0080227", "pmid"=>"24404123", "issn"=>"1932-6203"}, "id"=>"59812bdd-1473-34ee-a881-d9296351d453", "abstract"=>"PURPOSE: Ventricular function is a powerful predictor of survival in patients with heart failure (HF). However, studies characterizing gated F-18 FDG PET for the assessment of the cardiac function are rare. The aim of this study was to prospectively compare gated F-18 FDG PET and cardiac MRI for the assessment of ventricular volume and ejection fraction (EF) in patients with HF.\\n\\nMETHODS: Eighty-nine patients with diagnosed HF who underwent both gated F-18 FDG PET/CT and cardiac MRI within 3 days were included in the analysis. Left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), and EF were obtained from gated F-18 FDG PET/CT using the Quantitative Gated SPECT (QGS) and 4D-MSPECT software.\\n\\nRESULTS: LV EDV and LV ESV measured by QGS were significantly lower than those measured by cardiac MRI (both P<0.0001). In contrast, the corresponding values for LV EDV for 4D-MSPECT were comparable, and LV ESV was underestimated with borderline significance compared with cardiac MRI (P = 0.047). LV EF measured by QGS and cardiac MRI showed no significant differences, whereas the corresponding values for 4D-MSPECT were lower than for cardiac MRI (P<0.0001). The correlations of LV EDV, LV ESV, and LV EF between gated F-18 FDG PET/CT and cardiac MRI were excellent for both QGS (r = 0.92, 0.92, and 0.76, respectively) and 4D-MSPECT (r = 0.93, 0.94, and 0.75, respectively). However, Bland-Altman analysis revealed a significant systemic error, where LV EDV (-27.9±37.0 mL) and ESV (-18.6±33.8 mL) were underestimated by QGS.\\n\\nCONCLUSION: Despite the observation that gated F-18 FDG PET/CT were well correlated with cardiac MRI for assessing LV function, variation was observed between the two imaging modalities, and so these imaging techniques should not be used interchangeably.", "link"=>"http://www.mendeley.com/research/gated-f18-fdg-pet-assessment-left-ventricular-volumes-ejection-fraction-using-qgs-4dmspect-patients-2", "reader_count"=>15, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>1, "Physics and Astronomy"=>1, "Chemical Engineering"=>1, "Computer Science"=>3}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>2}

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• http://doi.org/10.1007/s40336-014-0070-2
• http://doi.org/10.1007/s12350-019-01709-9
• http://doi.org/10.1007/s12350-020-02476-8
• http://doi.org/10.1007/s12350-015-0331-0
• http://doi.org/10.1007/s12350-020-02391-y

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Relative Metric

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F1000Prime