Curcuma longa Extract Associated with White Pepper Lessens High Fat Diet-Induced Inflammation in Subcutaneous Adipose Tissue
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{"title"=>"Curcuma longa extract associated with white pepper lessens high fat diet-induced inflammation in subcutaneous adipose tissue", "type"=>"journal", "authors"=>[{"first_name"=>"Audrey M.", "last_name"=>"Neyrinck", "scopus_author_id"=>"6508062522"}, {"first_name"=>"Maud", "last_name"=>"Alligier", "scopus_author_id"=>"37074118700"}, {"first_name"=>"Patrick B.", "last_name"=>"Memvanga", "scopus_author_id"=>"55250010100"}, {"first_name"=>"Elodie", "last_name"=>"Névraumont", "scopus_author_id"=>"56038958800"}, {"first_name"=>"Yvan", "last_name"=>"Larondelle", "scopus_author_id"=>"56251016600"}, {"first_name"=>"Véronique", "last_name"=>"Préat", "scopus_author_id"=>"7006587685"}, {"first_name"=>"Patrice D.", "last_name"=>"Cani", "scopus_author_id"=>"6507917827"}, {"first_name"=>"Nathalie M.", "last_name"=>"Delzenne", "scopus_author_id"=>"7003523433"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84894224317", "pui"=>"372407398", "doi"=>"10.1371/journal.pone.0081252", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84894224317", "pmid"=>"24260564"}, "id"=>"6c9b380c-f600-3831-afbc-1802b671f136", "abstract"=>"BACKGROUND: Supra-nutritional doses of curcumin, derived from the spice Curcuma longa, have been proposed as a potential treatment of inflammation and metabolic disorders related to obesity. The aim of the present study was to test whether Curcuma longa extract rich in curcumin and associated with white pepper (Curcuma-P®), at doses compatible with human use, could modulate systemic inflammation in diet-induced obese mice. We questioned the potential relevance of changes in adiposity and gut microbiota in the effect of Curcuma-P® in obesity.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Mice were fed either a control diet (CT), a high fat (HF) diet or a HF diet containing Curcuma longa extract (0.1 % of curcumin in the HF diet) associated with white pepper (0.01 %) for four weeks. Curcumin has been usually combined with white pepper, which contain piperine, in order to improve its bioavailability. This combination did not significantly modify body weight gain, glycemia, insulinemia, serum lipids and intestinal inflammatory markers. Tetrahydrocurcumin, but not curcumin accumulated in the subcutaneous adipose tissue. Importantly, the co-supplementation in curcuma extract and white pepper decreased HF-induced pro-inflammatory cytokines expression in the subcutaneous adipose tissue, an effect independent of adiposity, immune cells recruitment, angiogenesis, or modulation of gut bacteria controlling inflammation.\\n\\nCONCLUSIONS/SIGNIFICANCE: These findings support that nutritional doses of Curcuma longa, associated with white pepper, is able to decrease inflammatory cytokines expression in the adipose tissue and this effect could be rather linked to a direct effect of bioactive metabolites reaching the adipose tissue, than from changes in the gut microbiota composition.", "link"=>"http://www.mendeley.com/research/curcuma-longa-extract-associated-white-pepper-lessens-high-fat-dietinduced-inflammation-subcutaneous", "reader_count"=>50, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>2, "Student > Master"=>12, "Other"=>2, "Student > Bachelor"=>11, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>2, "Student > Master"=>12, "Other"=>2, "Student > Bachelor"=>11, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>6, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>20, "Medicine and Dentistry"=>11, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>3, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>20}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Lebanon"=>1, "Egypt"=>1}, "group_count"=>1}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1288052"], "description"=>"<p>Mice were fed a high fat diet (HF) or a high fat diet supplemented with Curcuma-P® (HF-CC) for 4 weeks. Values are expressed relative to controls (set at 1). Data with different superscript letters are significantly different at p<0.05, according to the post hoc ANOVA statistical analysis.</p>", "links"=>[], "tags"=>["markers", "subcutaneous", "adipose"], "article_id"=>856495, "categories"=>["Biological Sciences"], "users"=>["Audrey M. Neyrinck", "Maud Alligier", "Patrick B. Memvanga", "Elodie Névraumont", "Yvan Larondelle", "Véronique Préat", "Patrice D. Cani", "Nathalie M. Delzenne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0081252.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_mRNA_levels_of_key_markers_in_subcutaneous_adipose_tissue_/856495", "title"=>"mRNA levels of key markers in subcutaneous adipose tissue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-19 03:46:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1288054"], "description"=>"<p>Caecal bacterial content of total bacteria (A), <i>Bacteroides</i>-<i>Prevotella</i> spp. (B), <i>Bifidobacterium</i> spp. (C), <i>Lactobacillus</i> spp. (D). Bacterial quantities are expressed as Log<sub>10</sub> (bacterial cells/caecal content wet weight). Mice were fed a high fat diet (HF) or a high fat diet supplemented with Curcuma-P® (HF-CC) for 4 weeks. ANOVA test, p>0.05.</p>", "links"=>[], "tags"=>["quantification", "caecal"], "article_id"=>856497, "categories"=>["Biological Sciences"], "users"=>["Audrey M. Neyrinck", "Maud Alligier", "Patrick B. Memvanga", "Elodie Névraumont", "Yvan Larondelle", "Véronique Préat", "Patrice D. Cani", "Nathalie M. Delzenne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0081252.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bacterial_quantification_per_total_caecal_content_/856497", "title"=>"Bacterial quantification per total caecal content.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-19 03:46:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1288055"], "description"=>"<div><p>Background</p><p>Supra-nutritional doses of curcumin, derived from the spice <i>Curcuma longa</i>, have been proposed as a potential treatment of inflammation and metabolic disorders related to obesity. The aim of the present study was to test whether <i>Curcuma longa</i> extract rich in curcumin and associated with white pepper (Curcuma-P®), at doses compatible with human use, could modulate systemic inflammation in diet-induced obese mice. We questioned the potential relevance of changes in adiposity and gut microbiota in the effect of Curcuma-P® in obesity.</p> <p>Methodology/Principal Findings</p><p>Mice were fed either a control diet (CT), a high fat (HF) diet or a HF diet containing <i>Curcuma longa</i> extract (0.1 % of curcumin in the HF diet) associated with white pepper (0.01 %) for four weeks. Curcumin has been usually combined with white pepper, which contain piperine, in order to improve its bioavailability. This combination did not significantly modify body weight gain, glycemia, insulinemia, serum lipids and intestinal inflammatory markers. Tetrahydrocurcumin, but not curcumin accumulated in the subcutaneous adipose tissue. Importantly, the co-supplementation in curcuma extract and white pepper decreased HF-induced pro-inflammatory cytokines expression in the subcutaneous adipose tissue, an effect independent of adiposity, immune cells recruitment, angiogenesis, or modulation of gut bacteria controlling inflammation.</p> <p>Conclusions/Significance</p><p>These findings support that nutritional doses of <i>Curcuma longa</i>, associated with white pepper, is able to decrease inflammatory cytokines expression in the adipose tissue and this effect could be rather linked to a direct effect of bioactive metabolites reaching the adipose tissue, than from changes in the gut microbiota composition. </p> </div>", "links"=>[], "tags"=>["extract", "lessens", "diet-induced", "inflammation", "subcutaneous", "adipose"], "article_id"=>856498, "categories"=>["Biological Sciences"], "users"=>["Audrey M. Neyrinck", "Maud Alligier", "Patrick B. Memvanga", "Elodie Névraumont", "Yvan Larondelle", "Véronique Préat", "Patrice D. Cani", "Nathalie M. Delzenne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0081252"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Curcuma_longa_Extract_Associated_with_White_Pepper_Lessens_High_Fat_Diet_Induced_Inflammation_in_Subcutaneous_Adipose_Tissue_/856498", "title"=>"<i>Curcuma longa</i> Extract Associated with White Pepper Lessens High Fat Diet-Induced Inflammation in Subcutaneous Adipose Tissue", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-19 03:46:15"}

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Relative Metric

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