Renal Function Can Improve at Any Stage of Chronic Kidney Disease
Publication Date
December 13, 2013
Journal
PLOS ONE
Authors
Lise Weis, Marie Metzger, Jean Philippe Haymann, Eric Thervet, et al
Volume
8
Issue
12
Pages
e81835
DOI
https://dx.plos.org/10.1371/journal.pone.0081835
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0081835
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24349134
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862566
Europe PMC
http://europepmc.org/abstract/MED/24349134
Web of Science
000328734200015
Scopus
84892634992
Mendeley
http://www.mendeley.com/research/renal-function-improve-stage-chronic-kidney-disease-2
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Mendeley | Further Information

{"title"=>"Renal function can improve at any stage of chronic kidney disease", "type"=>"journal", "authors"=>[{"first_name"=>"Lise", "last_name"=>"Weis", "scopus_author_id"=>"55604199100"}, {"first_name"=>"Marie", "last_name"=>"Metzger", "scopus_author_id"=>"16319402900"}, {"first_name"=>"Jean Philippe", "last_name"=>"Haymann", "scopus_author_id"=>"35578400300"}, {"first_name"=>"Eric", "last_name"=>"Thervet", "scopus_author_id"=>"7006163539"}, {"first_name"=>"Martin", "last_name"=>"Flamant", "scopus_author_id"=>"6603557811"}, {"first_name"=>"François", "last_name"=>"Vrtovsnik", "scopus_author_id"=>"7004298131"}, {"first_name"=>"Cédric", "last_name"=>"Gauci", "scopus_author_id"=>"24576489900"}, {"first_name"=>"Pascal", "last_name"=>"Houillier", "scopus_author_id"=>"7006573659"}, {"first_name"=>"Marc", "last_name"=>"Froissart", "scopus_author_id"=>"7006065052"}, {"first_name"=>"Emmanuel", "last_name"=>"Letavernier", "scopus_author_id"=>"9736388600"}, {"first_name"=>"Bénédicte", "last_name"=>"Stengel", "scopus_author_id"=>"7003513100"}, {"first_name"=>"Jean Jacques", "last_name"=>"Boffa", "scopus_author_id"=>"55154528500"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84892634992", "pui"=>"372154224", "doi"=>"10.1371/journal.pone.0081835", "sgr"=>"84892634992", "pmid"=>"24349134"}, "id"=>"35104627-9c20-3415-803f-025c05994f4f", "abstract"=>"INTRODUCTION: Even though renal function decline is considered relentless in chronic kidney disease (CKD), improvement has been shown in patients with hypertensive nephropathy. Whether this can occur in any type of nephropathy and at any stage is unknown as are the features of patients who improve.\\n\\nMETHODS: We identified 406 patients in the NephroTest cohort with glomerular filtration rates (mGFR) measured by (51)Cr-EDTA clearance at least 3 times during at least 2 years of follow-up. Individual examination of mGFR trajectories by 4 independent nephrologists classified patients as improvers, defined as those showing a sustained mGFR increase, or nonimprovers. Twelve patients with erratic trajectories were excluded. Baseline data were compared between improvers and nonimprovers, as was the number of recommended therapeutic targets achieved over time (specifically, for systolic and diastolic blood pressure, proteinuria, and use of renin angiotensin system blockers).\\n\\nRESULTS: Measured GFR improved over time in 62 patients (15.3%). Their median mGFR slope was +1.88[IQR 1.38, 3.55] ml/min/year; it was -2.23[-3.9, -0.91] for the 332 nonimprovers. Improvers had various nephropathies, but not diabetic glomerulopathy or polycystic kidney disease. They did not differ from nonimprovers for age, sex, cardiovascular history, or CKD stage, but their urinary albumin excretion rate was lower. Improvers achieved significantly more recommended therapeutic targets (2.74±0.87) than nonimprovers (2.44±0.80, p<0.01). They also had fewer CKD-related metabolic complications and a lower prevalence of 25OH-vitamin-D deficiency.\\n\\nCONCLUSION: GFR improvement is possible in CKD patients at any CKD stage through stage 4-5. It is noteworthy that this GFR improvement is associated with a decrease in the number of metabolic complications over time.", "link"=>"http://www.mendeley.com/research/renal-function-improve-stage-chronic-kidney-disease-2", "reader_count"=>2, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1314310"], "description"=>"<p>Metabolic complications include hyperparathyroidism (≥60 ng/mL), anemia (Hb <11 g/dL), hyperphosphatemia (phosphate>1.38 mmol/L), acidosis (venous tCO<sub>2</sub> <22 mmol/L), hyperkalemia (potassium >5 mmol/L).</p>", "links"=>[], "tags"=>["patients", "metabolic", "complications", "ckd", "progression"], "article_id"=>877164, "categories"=>["Biological Sciences"], "users"=>["Lise Weis", "Marie Metzger", "Jean-Philippe Haymann", "Eric Thervet", "Martin Flamant", "François Vrtovsnik", "Cédric Gauci", "Pascal Houillier", "Marc Froissart", "Emmanuel Letavernier", "Benedicte Stengel", "Jean-Jacques Boffa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081835.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percentage_of_patients_with_one_two_or_three_or_more_metabolic_complications_at_first_and_last_visit_according_to_CKD_progression_status_/877164", "title"=>"Percentage of patients with one, two, or three or more metabolic complications at first and last visit according to CKD progression status.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-13 02:45:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1314322"], "description"=>"<p>Mean ± SD, median ± IQR, % (n).</p><p>Anemia according to WHO definition Hb <13 g/dL in men and <12 g/dL in women, KDOQI definition Hb <11 g/dL. PTH: parathyroid hormone, 25(OH)D and 1,25(OH)<sub>2</sub>D 1,25∶25-hydroxy- and 1,25-dihydroxy-vitamin D, Hb: hemoglobin, EPO: Erythropoietin.</p>", "links"=>[], "tags"=>["metabolism", "disorders", "ckd", "progression"], "article_id"=>877169, "categories"=>["Biological Sciences"], "users"=>["Lise Weis", "Marie Metzger", "Jean-Philippe Haymann", "Eric Thervet", "Martin Flamant", "François Vrtovsnik", "Cédric Gauci", "Pascal Houillier", "Marc Froissart", "Emmanuel Letavernier", "Benedicte Stengel", "Jean-Jacques Boffa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081835.t005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Biomarkers_of_metabolism_disorders_and_treatment_use_according_to_CKD_progression_status_/877169", "title"=>"Biomarkers of metabolism disorders and treatment use according to CKD progression status.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-13 02:45:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1314320"], "description"=>"<p>BP: blood pressure, UPCR: urinary protein-creatinine ratio, UACR: urinary albumin-creatinine ratio.</p>", "links"=>[], "tags"=>["cardiovascular", "renal", "ckd", "progression"], "article_id"=>877167, "categories"=>["Biological Sciences"], "users"=>["Lise Weis", "Marie Metzger", "Jean-Philippe Haymann", "Eric Thervet", "Martin Flamant", "François Vrtovsnik", "Cédric Gauci", "Pascal Houillier", "Marc Froissart", "Emmanuel Letavernier", "Benedicte Stengel", "Jean-Jacques Boffa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081835.t003", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_cardiovascular_and_renal_risk_factors_according_to_CKD_progression_status_/877167", "title"=>"Baseline cardiovascular and renal risk factors according to CKD progression status.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-13 02:45:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1314321"], "description"=>"<p>Abbreviations: mGFR, measured glomerular filtration rate; eGFR MDRD, estimated GFR using Modification of the Diet in Renal Disease equation; eGFR CKD-EPI, estimated GFR using Chronic Kidney Disease Epidemiology Collaboration equation.</p>", "links"=>[], "tags"=>["kidney", "ckd", "progression"], "article_id"=>877168, "categories"=>["Biological Sciences"], "users"=>["Lise Weis", "Marie Metzger", "Jean-Philippe Haymann", "Eric Thervet", "Martin Flamant", "François Vrtovsnik", "Cédric Gauci", "Pascal Houillier", "Marc Froissart", "Emmanuel Letavernier", "Benedicte Stengel", "Jean-Jacques Boffa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081835.t002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_patient_characteristics_and_kidney_function_according_to_CKD_progression_status_/877168", "title"=>"Baseline patient characteristics and kidney function according to CKD progression status.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-13 02:45:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1314315"], "description"=>"<p>Median slopes of measured and estimated GFR for improvers and non-improvers.</p>", "links"=>[], "tags"=>["slopes", "gfr", "improvers"], "article_id"=>877166, "categories"=>["Biological Sciences"], "users"=>["Lise Weis", "Marie Metzger", "Jean-Philippe Haymann", "Eric Thervet", "Martin Flamant", "François Vrtovsnik", "Cédric Gauci", "Pascal Houillier", "Marc Froissart", "Emmanuel Letavernier", "Benedicte Stengel", "Jean-Jacques Boffa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081835.t001", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Median_slopes_of_measured_and_estimated_GFR_for_improvers_and_non_improvers_/877166", "title"=>"Median slopes of measured and estimated GFR for improvers and non-improvers.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-13 02:45:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1314309"], "description"=>"<p>Study flow chart.</p>", "links"=>[], "tags"=>[], "article_id"=>877163, "categories"=>["Biological Sciences"], "users"=>["Lise Weis", "Marie Metzger", "Jean-Philippe Haymann", "Eric Thervet", "Martin Flamant", "François Vrtovsnik", "Cédric Gauci", "Pascal Houillier", "Marc Froissart", "Emmanuel Letavernier", "Benedicte Stengel", "Jean-Jacques Boffa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081835.g001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_flow_chart_/877163", "title"=>"Study flow chart.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-13 02:45:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1314324"], "description"=>"<div><p>Introduction</p><p>Even though renal function decline is considered relentless in chronic kidney disease (CKD), improvement has been shown in patients with hypertensive nephropathy. Whether this can occur in any type of nephropathy and at any stage is unknown as are the features of patients who improve.</p><p>Methods</p><p>We identified 406 patients in the NephroTest cohort with glomerular filtration rates (mGFR) measured by <sup>51</sup>Cr-EDTA clearance at least 3 times during at least 2 years of follow-up. Individual examination of mGFR trajectories by 4 independent nephrologists classified patients as improvers, defined as those showing a sustained mGFR increase, or nonimprovers. Twelve patients with erratic trajectories were excluded. Baseline data were compared between improvers and nonimprovers, as was the number of recommended therapeutic targets achieved over time (specifically, for systolic and diastolic blood pressure, proteinuria, and use of renin angiotensin system blockers).</p><p>Results</p><p>Measured GFR improved over time in 62 patients (15.3%). Their median mGFR slope was +1.88[IQR 1.38, 3.55] ml/min/year; it was −2.23[−3.9, −0.91] for the 332 nonimprovers. Improvers had various nephropathies, but not diabetic glomerulopathy or polycystic kidney disease. They did not differ from nonimprovers for age, sex, cardiovascular history, or CKD stage, but their urinary albumin excretion rate was lower. Improvers achieved significantly more recommended therapeutic targets (2.74±0.87) than nonimprovers (2.44±0.80, p<0.01). They also had fewer CKD-related metabolic complications and a lower prevalence of 25OH-vitamin-D deficiency.</p><p>Conclusion</p><p>GFR improvement is possible in CKD patients at any CKD stage through stage 4–5. It is noteworthy that this GFR improvement is associated with a decrease in the number of metabolic complications over time.</p></div>", "links"=>[], "tags"=>["kidney"], "article_id"=>877171, "categories"=>["Biological Sciences"], "users"=>["Lise Weis", "Marie Metzger", "Jean-Philippe Haymann", "Eric Thervet", "Martin Flamant", "François Vrtovsnik", "Cédric Gauci", "Pascal Houillier", "Marc Froissart", "Emmanuel Letavernier", "Benedicte Stengel", "Jean-Jacques Boffa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081835", "stats"=>{"downloads"=>5, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Renal_Function_Can_Improve_at_Any_Stage_of_Chronic_Kidney_Disease_/877171", "title"=>"Renal Function Can Improve at Any Stage of Chronic Kidney Disease", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-13 02:45:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1314323"], "description"=>"<p>Mean (±sd) number of achieved thepareutic targets at first and last visit, and mean across visits, according to CKD progression status.</p>", "links"=>[], "tags"=>["achieved", "thepareutic", "targets", "ckd", "progression"], "article_id"=>877170, "categories"=>["Biological Sciences"], "users"=>["Lise Weis", "Marie Metzger", "Jean-Philippe Haymann", "Eric Thervet", "Martin Flamant", "François Vrtovsnik", "Cédric Gauci", "Pascal Houillier", "Marc Froissart", "Emmanuel Letavernier", "Benedicte Stengel", "Jean-Jacques Boffa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081835.t004", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_177_sd_number_of_achieved_thepareutic_targets_at_first_and_last_visit_and_mean_across_visits_according_to_CKD_progression_status_/877170", "title"=>"Mean (±sd) number of achieved thepareutic targets at first and last visit, and mean across visits, according to CKD progression status.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-13 02:45:13"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"3366", "full-text"=>"3800", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"7", "cited-by"=>"1", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"5115", "full-text"=>"5732", "pdf"=>"19", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"3077", "full-text"=>"3415", "pdf"=>"19", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Medicine and health sciences/Nephrology", "average_usage"=>[231, 409, 512, 630, 712, 787, 885, 972, 1054, 1115, 1204, 1271, 1340]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[258, 449, 572, 679, 775, 866, 956, 1041, 1124, 1211, 1291, 1371, 1437]}, {"subject_area"=>"/Medicine and health sciences/Vascular medicine", "average_usage"=>[222, 394, 496, 593, 683, 762, 835, 910, 980, 1047, 1116, 1184, 1244]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[254, 431, 547, 651, 748, 842, 932, 1017, 1098, 1178, 1259, 1336, 1404]}]}
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