Epigenetic Regulation of αA-crystallin in High Myopia-Induced Dark Nuclear Cataract
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{"title"=>"Epigenetic regulation of αA-crystallin in high myopia-induced dark nuclear cataract", "type"=>"journal", "authors"=>[{"first_name"=>"Xiang Jia", "last_name"=>"Zhu", "scopus_author_id"=>"16744747800"}, {"first_name"=>"Peng", "last_name"=>"Zhou", "scopus_author_id"=>"56581027100"}, {"first_name"=>"Ke Ke", "last_name"=>"Zhang", "scopus_author_id"=>"55987625800"}, {"first_name"=>"Jin", "last_name"=>"Yang", "scopus_author_id"=>"37072836800"}, {"first_name"=>"Yi", "last_name"=>"Luo", "scopus_author_id"=>"55712621100"}, {"first_name"=>"Yi", "last_name"=>"Lu", "scopus_author_id"=>"56908096800"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0081900", "pui"=>"372056229", "issn"=>"19326203", "sgr"=>"84891719735", "scopus"=>"2-s2.0-84891719735"}, "id"=>"060693bf-d106-30dd-82b7-7e77047ed561", "abstract"=>"Purpose: To assess the etiology of early-onset dark nucleus in\\nhigh-myopic patients and its relationship with the epigenetic regulation\\nof alpha A-crystallin (CRYAA).\\nMethods: We reviewed clinical data from patients who underwent cataract\\nsurgery at our center in 2012. Lens epithelial samples were collected\\nduring capsulorhexis, whereas young lens epithelium was donated.\\nCataract type and severity were graded according to the Lens Opacity\\nClassification System III (LOCS III). DNA methylation was analyzed by\\npyrosequencing the CpG islands of the CRYAA promoter in the following\\ngroups: Age-Related Cataract (ARC) Nuclear Color (NC) 2-3; High-Myopic\\nCataract (HMC) NC2-3; ARC NC5-6; HMC NC5-6; and in young lenses graded\\nNC1. We analyzed CRYAA expression by real-time polymerase chain reaction\\n(PCR), reverse transcription PCR, and immunohistochemistry.\\nResults: The odds ratio of dark nucleus in high-myopic patients was 5.16\\n(95% confidence interval: 3.98-6.69; p<0.001). CpG islands in lens\\nepithelial CRYAA promoter in the HMC NC5-6 Group exhibited the highest\\nmethylation of all the groups, but no statistically significant\\ndifferences were evident between the HMC NC2-3 and ARC NC2-3 Groups.\\nLikewise, CRYAA mRNA and protein levels in the HMC NC5-6 Group were\\nsignificantly lower than the ARC NC5-6 Group and high-myopic controls.\\nConclusions: High myopia is a risk factor for dark nucleus.\\nDownregulation of CRYAA via the hypermethylation of CpG islands in its\\npromoter could underlie the earlier onset of dark nucleus in high-myopic\\npatients.", "link"=>"http://www.mendeley.com/research/epigenetic-regulation-%CE%B1acrystallin-high-myopiainduced-dark-nuclear-cataract", "reader_count"=>6, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Other"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Other"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>2, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1301335"], "description"=>"<p>(A) Representative pyrosequencing results of the Age-Related Cataract (ARC) Nuclear Color (NC) 5–6 and High-Myopic Cataract (HMC) NC5–6 Groups. (B) Anterior segment photos of patients in each group. (C) The six selected CpG islands in the HMC NC5–6 Group (57.6±2.6%) displayed hypermethylation compared with the ARC NC5–6 Group (48.1±3.4%). (D) Percentage of methylation at each individual CpG site in each group. (*Statistically significant differences were found between the ARC NC5–6 and HMC NC5–6 Groups; *all p<0.05).</p>", "links"=>[], "tags"=>["methylation", "promoter", "high-myopic", "cataracts", "age-related", "classified", "opacity", "classification", "iii"], "article_id"=>866906, "categories"=>["Biological Sciences"], "users"=>["Xiang-Jia Zhu", "Peng Zhou", "Ke-Ke Zhang", "Jin Yang", "Yi Luo", "Yi Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081900.g004", "stats"=>{"downloads"=>2, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CpG_island_methylation_in_the_945_A_crystallin_promoter_was_significantly_greater_in_high_myopic_cataracts_than_in_age_related_cataracts_classified_as_Lens_Opacity_Classification_System_III_Grade_Nuclear_Color_5_6_/866906", "title"=>"CpG island methylation in the <i>αA-crystallin</i> promoter was significantly greater in high-myopic cataracts than in age-related cataracts classified as Lens Opacity Classification System III Grade Nuclear Color 5–6.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 02:50:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301329"], "description"=>"<p>(A) Representative Pyrosequencing results of the Control, Age-Related Cataract (ARC) Nuclear Color (NC) 2–3 and High-Myopic Cataract (HMC) NC2–3 Groups. (B) Anterior segment photos of patients in each group. (C) The six selected CpG islands in the ARC NC2–3 (44±8.3%) and HMC NC2–3 (43.7±3.8%) Groups displayed higher methylation compared with the Control Group (34±6.1%). (D) Percentage of methylation at each individual CpG site in each group. (*Statistically significant differences were found between the Control and ARC NC2–3 Groups; <sup>&</sup>statistically significant differences were found between the Control and HMC NC2–3 Groups; *<sup>,&</sup>all p<0.05. However, no statistically significant differences were found between the two cataract groups.)</p>", "links"=>[], "tags"=>["methylation", "promoter", "age-related", "cataracts", "high-myopic", "classified", "opacity", "classification", "iii"], "article_id"=>866900, "categories"=>["Biological Sciences"], "users"=>["Xiang-Jia Zhu", "Peng Zhou", "Ke-Ke Zhang", "Jin Yang", "Yi Luo", "Yi Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081900.g002", "stats"=>{"downloads"=>4, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CpG_island_methylation_in_the_945_A_crystallin_promoter_was_similar_in_age_related_cataracts_and_high_myopic_cataracts_classified_as_Lens_Opacity_Classification_System_III_Grade_Nuclear_Color_2_3_/866900", "title"=>"CpG island methylation in the <i>αA-crystallin</i> promoter was similar in age-related cataracts and high-myopic cataracts classified as Lens Opacity Classification System III Grade Nuclear Color 2–3.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 02:50:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301326"], "description"=>"<p>Statistically significant differences were evident in the 40–55, 56–65, and 66–75 years age groups (Pearson’s chi-squared test; *all p<0.05).</p>", "links"=>[], "tags"=>["cataracts", "groups", "age-related", "cataract", "high-myopic"], "article_id"=>866897, "categories"=>["Biological Sciences"], "users"=>["Xiang-Jia Zhu", "Peng Zhou", "Ke-Ke Zhang", "Jin Yang", "Yi Luo", "Yi Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081900.g001", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prevalence_of_Grade_Nuclear_Color_5_8211_6_cataracts_in_different_age_groups_among_age_related_cataract_and_high_myopic_cataract_/866897", "title"=>"Prevalence of Grade Nuclear Color 5–6 cataracts in different age groups among age-related cataract and high-myopic cataract.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 02:50:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301345"], "description"=>"<p>Illustration for the possible mechanism of high-myopia-induced dark nuclear cataract.</p>", "links"=>[], "tags"=>["high-myopia-induced"], "article_id"=>866914, "categories"=>["Biological Sciences"], "users"=>["Xiang-Jia Zhu", "Peng Zhou", "Ke-Ke Zhang", "Jin Yang", "Yi Luo", "Yi Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081900.g006", "stats"=>{"downloads"=>3, "page_views"=>304, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Illustration_for_the_possible_mechanism_of_high_myopia_induced_dark_nuclear_cataract_/866914", "title"=>"Illustration for the possible mechanism of high-myopia-induced dark nuclear cataract.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 02:50:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301338"], "description"=>"<p>αA-crystallin expression in the lens epithelium of each group was detected by (A) real-time polymerase chain reaction (PCR; also showing levels of <i>αA-crystallin</i> relative to <i>β-actin</i>) and (B) reverse transcription PCR. (C, D) Representative immunohistochemistry images of the Age-Related Cataract Nuclear Color (NC) 5–6 and High-Myopic Cataract NC5–6 Groups. (E) Mean staining density in each group (*both p<0.05).</p>", "links"=>[], "tags"=>["epithelium", "high-myopic", "cataract", "age-related"], "article_id"=>866909, "categories"=>["Biological Sciences"], "users"=>["Xiang-Jia Zhu", "Peng Zhou", "Ke-Ke Zhang", "Jin Yang", "Yi Luo", "Yi Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081900.g005", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_945_913_crystallin_expression_in_the_lens_epithelium_was_significantly_lower_in_the_High_Myopic_Cataract_Nuclear_Color_5_8211_6_Group_than_in_the_Age_Related_Cataract_Nuclear_Color_5_8211_6_Group_/866909", "title"=>"αΑ-crystallin expression in the lens epithelium was significantly lower in the High-Myopic Cataract Nuclear Color 5–6 Group than in the Age-Related Cataract Nuclear Color 5–6 Group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 02:50:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301332"], "description"=>"<p>Alpha-crystallin expression in the lens epithelium of each group was detected by (A) real-time polymerase chain reaction (PCR; also showing levels of <i>αA-crystallin</i> relative to <i>β-actin</i>) and (B) reverse transcription PCR (C, D, E) Representative immunohistochemistry images of the Control, Age-Related Cataract Nuclear Color (NC) 2–3, and High-Myopic Cataract NC2–3 Groups. (F) Mean staining density in each group (*all p<0.05).</p>", "links"=>[], "tags"=>["age-related", "cataracts", "high-myopic", "classified", "opacity", "classification", "iii"], "article_id"=>866903, "categories"=>["Biological Sciences"], "users"=>["Xiang-Jia Zhu", "Peng Zhou", "Ke-Ke Zhang", "Jin Yang", "Yi Luo", "Yi Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081900.g003", "stats"=>{"downloads"=>0, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_945_A_crystallin_was_similar_in_age_related_cataracts_and_high_myopic_cataracts_classified_as_Lens_Opacity_Classification_System_III_Grade_Nuclear_Color_2_3_/866903", "title"=>"Expression of <i>αA-crystallin</i> was similar in age-related cataracts and high-myopic cataracts classified as Lens Opacity Classification System III Grade Nuclear Color 2–3.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 02:50:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301348"], "description"=>"†<p>age-related cataract.</p>‡<p>high-myopic cataract.</p>§<p>nuclear color.</p>", "links"=>[], "tags"=>["patients", "nucleus"], "article_id"=>866917, "categories"=>["Biological Sciences"], "users"=>["Xiang-Jia Zhu", "Peng Zhou", "Ke-Ke Zhang", "Jin Yang", "Yi Luo", "Yi Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081900.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_patients_with_a_dark_nucleus_Nuclear_Color_5_8211_6_in_each_group_/866917", "title"=>"Number of patients with a dark nucleus (Nuclear Color 5–6) in each group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-03 02:50:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301347"], "description"=>"†<p>age-related cataract.</p>‡<p>high-myopic cataract.</p>§<p>nuclear color.</p>", "links"=>[], "tags"=>[], "article_id"=>866916, "categories"=>["Biological Sciences"], "users"=>["Xiang-Jia Zhu", "Peng Zhou", "Ke-Ke Zhang", "Jin Yang", "Yi Luo", "Yi Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081900.t002", "stats"=>{"downloads"=>2, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_the_samples_/866916", "title"=>"Baseline characteristics of the samples.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-03 02:50:28"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"246", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
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  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
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  • {"unique-ip"=>"14", "full-text"=>"10", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
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  • {"unique-ip"=>"13", "full-text"=>"7", "pdf"=>"45", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"9", "pdf"=>"38", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"16", "pdf"=>"42", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"50", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"44", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"26", "full-text"=>"22", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
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  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"10", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[248, 440, 562, 666, 765, 856, 944, 1028, 1112, 1198, 1282, 1362, 1430]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[272, 472, 600, 713, 815, 911, 1004, 1094, 1185, 1273, 1358, 1441]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[284, 491, 620, 738, 843, 945, 1043, 1137, 1225, 1315, 1400, 1479, 1555]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[248, 441, 564, 668, 769, 859, 948, 1034, 1117, 1202, 1290, 1368, 1437]}, {"subject_area"=>"/Medicine and health sciences/Ophthalmology", "average_usage"=>[217, 391, 496, 595, 697, 781, 875, 952, 1050, 1136, 1210, 1272, 1332]}, {"subject_area"=>"/Medicine and health sciences/Surgical and invasive medical procedures", "average_usage"=>[223, 396, 511, 599, 690, 775, 859, 936, 1012, 1090, 1168, 1237, 1299]}]}
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