PLGA-Carbon Nanotube Conjugates for Intercellular Delivery of Caspase-3 into Osteosarcoma Cells
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{"title"=>"PLGA-carbon nanotube conjugates for intercellular delivery of caspase-3 into osteosarcoma cells", "type"=>"journal", "authors"=>[{"first_name"=>"Qingsu", "last_name"=>"Cheng", "scopus_author_id"=>"55540105600"}, {"first_name"=>"Marc Olivier", "last_name"=>"Blais", "scopus_author_id"=>"55987349500"}, {"first_name"=>"Greg", "last_name"=>"Harris", "scopus_author_id"=>"55924575200"}, {"first_name"=>"Ehsan", "last_name"=>"Jabbarzadeh", "scopus_author_id"=>"8725306300"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84891696537", "doi"=>"10.1371/journal.pone.0081947", "pui"=>"372056239", "pmid"=>"24312611", "scopus"=>"2-s2.0-84891696537", "issn"=>"19326203", "isbn"=>"10.1371/journal.pone.0081947"}, "id"=>"cfe58d49-b931-36fd-9cb0-628add14bd79", "abstract"=>"Cancer has arisen to be of the most prominent health care issues across the world in recent years. Doctors have used physiological intervention as well as chemical and radioactive therapeutics to treat cancer thus far. As an alternative to current methods, gene delivery systems with high efficiency, specificity, and safety that can reduce side effects such as necrosis of tissue are under development. Although viral vectors are highly efficient, concerns have arisen from the fact that viral vectors are sourced from lethal diseases. With this in mind, rod shaped nano-materials such as carbon nanotubes (CNTs) have become an attractive option for drug delivery due to the enhanced permeability and retention effect in tumors as well as the ability to penetrate the cell membrane. Here, we successfully engineered poly (lactic-co-glycolic) (PLGA) functionalized CNTs to reduce toxicity concerns, provide attachment sites for pro-apoptotic protein caspase-3 (CP3), and tune the temporal release profile of CP3 within bone cancer cells. Our results showed that CP3 was able to attach to functionalized CNTs, forming CNT-PLGA-CP3 conjugates. We show this conjugate can efficiently transduce cells at dosages as low as 0.05 μg/ml and suppress cell proliferation up to a week with no further treatments. These results are essential to showing the capabilities of PLGA functionalized CNTs as a non-viral vector gene delivery technique to tune cell fate.", "link"=>"http://www.mendeley.com/research/plgacarbon-nanotube-conjugates-intercellular-delivery-caspase3-osteosarcoma-cells", "reader_count"=>23, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>4, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Materials Science"=>2, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Chemical Engineering"=>1, "Chemistry"=>9, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>4}, "Materials Science"=>{"Materials Science"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>9}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"India"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1301697"], "description"=>"<div><p>Cancer has arisen to be of the most prominent health care issues across the world in recent years. Doctors have used physiological intervention as well as chemical and radioactive therapeutics to treat cancer thus far. As an alternative to current methods, gene delivery systems with high efficiency, specificity, and safety that can reduce side effects such as necrosis of tissue are under development. Although viral vectors are highly efficient, concerns have arisen from the fact that viral vectors are sourced from lethal diseases. With this in mind, rod shaped nano-materials such as carbon nanotubes (CNTs) have become an attractive option for drug delivery due to the enhanced permeability and retention effect in tumors as well as the ability to penetrate the cell membrane. Here, we successfully engineered poly (lactic-co-glycolic) (PLGA) functionalized CNTs to reduce toxicity concerns, provide attachment sites for pro-apoptotic protein caspase-3 (CP3), and tune the temporal release profile of CP3 within bone cancer cells. Our results showed that CP3 was able to attach to functionalized CNTs, forming CNT-PLGA-CP3 conjugates. We show this conjugate can efficiently transduce cells at dosages as low as 0.05 μg/ml and suppress cell proliferation up to a week with no further treatments. These results are essential to showing the capabilities of PLGA functionalized CNTs as a non-viral vector gene delivery technique to tune cell fate.</p> </div>", "links"=>[], "tags"=>["nanotube", "conjugates", "intercellular", "caspase-3", "osteosarcoma"], "article_id"=>867180, "categories"=>["Biological Sciences"], "users"=>["Qingsu Cheng", "Marc-Olivier Blais", "Greg Harris", "Ehsan Jabbarzadeh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081947", "stats"=>{"downloads"=>21, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PLGA_Carbon_Nanotube_Conjugates_for_Intercellular_Delivery_of_Caspase_3_into_Osteosarcoma_Cells_/867180", "title"=>"PLGA-Carbon Nanotube Conjugates for Intercellular Delivery of Caspase-3 into Osteosarcoma Cells", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-03 03:14:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301692"], "description"=>"<p>The dosages with osteosarcoma cells were 0.05 μg/ml, 0.1 μg/ml, 0.5 μg/ml, and 1 μg/ml and 3 μg/ml, respectively. The results showed that CNT-PLGA-fBSA could easily penetrate into cells and transduce osteosarcoma cells. All images are 20x magnification.</p>", "links"=>[], "tags"=>["fluorescent", "images", "cnt-plga-fbsa", "mg-63", "osteosarcoma"], "article_id"=>867175, "categories"=>["Biological Sciences"], "users"=>["Qingsu Cheng", "Marc-Olivier Blais", "Greg Harris", "Ehsan Jabbarzadeh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081947.g005", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Optic_and_fluorescent_combined_images_of_CNT_PLGA_fBSA_delivery_into_MG_63_osteosarcoma_cells_/867175", "title"=>"Optic and fluorescent combined images of CNT-PLGA-fBSA delivery into MG-63 osteosarcoma cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 03:14:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301691"], "description"=>"<p>(A) Infra-red spectrum (B) light microscopy of CNT-PLGA-BSA (C) fluorescent images of CNT-PLGA-fBSA. Results show that protein has been successfully attached to CNT-PLGA complex, forming CNT-PLGA-BSA conjugates.</p>", "links"=>[], "tags"=>["linkage", "cnt-plga"], "article_id"=>867174, "categories"=>["Biological Sciences"], "users"=>["Qingsu Cheng", "Marc-Olivier Blais", "Greg Harris", "Ehsan Jabbarzadeh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081947.g004", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protein_linkage_to_CNT_PLGA_conjugates_/867174", "title"=>"Protein linkage to CNT-PLGA conjugates.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 03:14:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301683"], "description"=>"<p>TEM image of CNTs. The results show that CNTs have no outer coating prior to PLGA and protein conjugation.</p>", "links"=>[], "tags"=>["carbon", "nanotubes"], "article_id"=>867171, "categories"=>["Biological Sciences"], "users"=>["Qingsu Cheng", "Marc-Olivier Blais", "Greg Harris", "Ehsan Jabbarzadeh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081947.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pristine_carbon_nanotubes_prior_to_conjugation_/867171", "title"=>"Pristine carbon nanotubes prior to conjugation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 03:14:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301675"], "description"=>"<p>CNTs are carboxylated, coated with PLGA, and functionalized with caspase-3. The conjugates are able to penetrate into MG-63 cells and release caspase-3 through the degradation of PLGA.</p>", "links"=>[], "tags"=>["cnt-plga", "conjugate", "fabrication", "intercellular"], "article_id"=>867170, "categories"=>["Biological Sciences"], "users"=>["Qingsu Cheng", "Marc-Olivier Blais", "Greg Harris", "Ehsan Jabbarzadeh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081947.g001", "stats"=>{"downloads"=>0, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_representation_of_CNT_PLGA_conjugate_fabrication_and_intercellular_delivery_/867170", "title"=>"Schematic representation of CNT-PLGA conjugate fabrication and intercellular delivery.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 03:14:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301696"], "description"=>"<p>Cell viability on day 1 (A) and day 3 (B) of MG-63 cells under exposure to differing dosages of CNTs, CNT-PLGA, CNT-PLGA-BSA, caspase-3, Pro-Ject and CNT-PLGA-CP3 treatment. * means significant difference of cell viability under CNT-PLGA-CP3 cojugate exposure and other groups of same dosage. </p>", "links"=>[], "tags"=>["nanotubes", "penetrate", "cells"], "article_id"=>867179, "categories"=>["Biological Sciences"], "users"=>["Qingsu Cheng", "Marc-Olivier Blais", "Greg Harris", "Ehsan Jabbarzadeh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081947.g007", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Carbon_nanotubes_have_the_ability_to_penetrate_cells_and_release_caspase_3_/867179", "title"=>"Carbon nanotubes have the ability to penetrate cells and release caspase-3.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 03:14:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301695"], "description"=>"<p>Determination of CNTs delivered into osteosarcoma cells. Dosage is 3 μg/ml. (A) Osteosarcoma cells cultured with CNT-PLGA-fBSA (B) Image of fluorescent signal within osteosarcoma cells (C) Optic and fluorescent combined image of CNT-PLGA-fBSA image (D) TEM image of a single CNT-PLGA-BSA penetrating the cell body. </p>", "links"=>[], "tags"=>["cnt-plga-proteins"], "article_id"=>867178, "categories"=>["Biological Sciences"], "users"=>["Qingsu Cheng", "Marc-Olivier Blais", "Greg Harris", "Ehsan Jabbarzadeh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081947.g006", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Penetration_of_CNT_PLGA_proteins_into_the_cells_/867178", "title"=>"Penetration of CNT-PLGA-proteins into the cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 03:14:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1301690"], "description"=>"<p>(A) XRD pattern (B) XRD pattern (C) UV-Vis spectrum (D) TEM image. Results were able to show that PLGA is successfully conjugated to CNTs.</p>", "links"=>[], "tags"=>["cnt-plga"], "article_id"=>867173, "categories"=>["Biological Sciences"], "users"=>["Qingsu Cheng", "Marc-Olivier Blais", "Greg Harris", "Ehsan Jabbarzadeh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0081947.g003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterization_of_CNT_PLGA_complex_/867173", "title"=>"Characterization of CNT-PLGA complex.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-03 03:14:41"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"9", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Engineering and technology", "average_usage"=>[254, 440, 558, 675, 785, 883, 972, 1061, 1154, 1248, 1336, 1414, 1489]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[267, 466, 592, 709, 806, 901, 989, 1075, 1162, 1254, 1342, 1424, 1486]}]}
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