Genome-Wide Methylation and Gene Expression Changes in Newborn Rats following Maternal Protein Restriction and Reversal by Folic Acid
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Genome-wide methylation and gene expression changes in newborn rats following maternal protein restriction and reversal by folic acid.", "type"=>"journal", "authors"=>[{"first_name"=>"Gioia", "last_name"=>"Altobelli"}, {"first_name"=>"Irina G", "last_name"=>"Bogdarina"}, {"first_name"=>"Elia", "last_name"=>"Stupka"}, {"first_name"=>"Adrian J L", "last_name"=>"Clark"}, {"first_name"=>"Simon", "last_name"=>"Langley-Evans"}], "year"=>2013, "source"=>"PloS one", "identifiers"=>{"issn"=>"1932-6203", "sgr"=>"84894225384", "pui"=>"372425346", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"24391732", "doi"=>"10.1371/journal.pone.0082989"}, "keywords"=>["Animals", "Animals, Newborn", "DNA Methylation", "DNA Methylation: drug effects", "Diet, Protein-Restricted", "Diet, Protein-Restricted: adverse effects", "Epigenesis, Genetic", "Epigenesis, Genetic: drug effects", "Female", "Folic Acid", "Folic Acid: administration & dosage", "Gene Expression", "Gene Expression: drug effects", "Genome", "Genome-Wide Association Study", "Humans", "Male", "Maternal Nutritional Physiological Phenomena", "Pregnancy", "Prenatal Exposure Delayed Effects", "Prenatal Exposure Delayed Effects: genetics", "Rats", "Rats, Wistar"], "id"=>"818e4bbf-072f-3fc8-88e2-1da939de752a", "abstract"=>"A large body of evidence from human and animal studies demonstrates that the maternal diet during pregnancy can programme physiological and metabolic functions in the developing fetus, effectively determining susceptibility to later disease. The mechanistic basis of such programming is unclear but may involve resetting of epigenetic marks and fetal gene expression. The aim of this study was to evaluate genome-wide DNA methylation and gene expression in the livers of newborn rats exposed to maternal protein restriction. On day one postnatally, there were 618 differentially expressed genes and 1183 differentially methylated regions (FDR 5%). The functional analysis of differentially expressed genes indicated a significant effect on DNA repair/cycle/maintenance functions and of lipid, amino acid metabolism and circadian functions. Enrichment for known biological functions was found to be associated with differentially methylated regions. Moreover, these epigenetically altered regions overlapped genetic loci associated with metabolic and cardiovascular diseases. Both expression changes and DNA methylation changes were largely reversed by supplementing the protein restricted diet with folic acid. Although the epigenetic and gene expression signatures appeared to underpin largely different biological processes, the gene expression profile of DNA methyl transferases was altered, providing a potential link between the two molecular signatures. The data showed that maternal protein restriction is associated with widespread differential gene expression and DNA methylation across the genome, and that folic acid is able to reset both molecular signatures.", "link"=>"http://www.mendeley.com/research/genomewide-methylation-gene-expression-changes-newborn-rats-following-maternal-protein-restriction-r-2", "reader_count"=>31, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Student > Master"=>10, "Student > Bachelor"=>6, "Lecturer > Senior Lecturer"=>2}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Student > Master"=>10, "Student > Bachelor"=>6, "Lecturer > Senior Lecturer"=>2}, "reader_count_by_subject_area"=>{"Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>14, "Chemistry"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Environmental Science"=>{"Environmental Science"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>2, "Luxembourg"=>1, "Portugal"=>1}, "group_count"=>6}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84894225384"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84894225384?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84894225384&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84894225384&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84894225384", "dc:identifier"=>"SCOPUS_ID:84894225384", "eid"=>"2-s2.0-84894225384", "dc:title"=>"Genome-wide methylation and gene expression changes in newborn rats following maternal protein restriction and reversal by folic acid", "dc:creator"=>"Altobelli G.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"12", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-12-31", "prism:coverDisplayDate"=>"31 December 2013", "prism:doi"=>"10.1371/journal.pone.0082989", "citedby-count"=>"41", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University College London", "affiliation-city"=>"London", "affiliation-country"=>"United Kingdom"}, {"@_fa"=>"true", "affilname"=>"Barts and The London School of Medicine and Dentistry", "affiliation-city"=>"London", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"24391732", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e82989", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0082989", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Twitter

Counter

  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"107", "xml_views"=>"15", "html_views"=>"703"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"227"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"208"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"140"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"186"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"409"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"231"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"81"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"79"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"65"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"36"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"94"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"11"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"6", "html_views"=>"6"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1333844"], "description"=>"<p>(A) Venn's diagrams showing the number of differentially expressed gene probes in comparisons MLP vs. C (P-C), MLP-F vs. C (F-C) and MLP vs. MLP-F (P-F) at FDR 5% (top) and FDR 1% (bottom). Number of gene probes whose expression was unaltered is indicated in black (right). Numbers of altered gene probes in MLP-C contrast at different FDR are indicated in green (left). (B) qRT-PCR mRNA analysis for 8 genes: <i>Dnmt1</i>, <i>Dnmt3a</i>, <i>Dnmt3b</i>, <i>Aurkb</i>, <i>Mcm6</i>, <i>Hat1</i>, <i>Gnmt</i> and <i>Gmnn</i>. Results are given in relative units, as ratio of number of copies in assessed gene and housekeeping gene GAPDH. <sup>×</sup> P<0.05; <sup>××</sup> P<0.01; <sup>×××</sup> P<0.001. ns P>0.05.</p>", "links"=>[], "tags"=>["developmental biology", "genetics", "genomics", "Computer applications", "Computing methods", "Ontology and logics", "Anatomy and physiology", "Endocrinology", "Metabolic disorders", "Non-clinical medicine", "genes", "maternal", "undernutrition"], "article_id"=>890400, "categories"=>["Information And Computing Sciences", "Biological Sciences", "Medicine"], "users"=>["Gioia Altobelli", "Irina G. Bogdarina", "Elia Stupka", "Adrian J. L. Clark", "Simon Langley-Evans"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0082989.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differentially_expressed_genes_in_maternal_undernutrition_model_/890400", "title"=>"Differentially expressed genes in maternal undernutrition model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-31 03:43:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1333847"], "description"=>"<p>The overlap between the total number of GWAS loci investigated and DMR containing loci is significant (p = 0.0025).</p>", "links"=>[], "tags"=>["developmental biology", "genetics", "genomics", "Computer applications", "Computing methods", "Ontology and logics", "Anatomy and physiology", "Endocrinology", "Metabolic disorders", "Non-clinical medicine", "loci", "GWAS", "studies", "pertaining", "metabolic", "cardiovascular", "phenotypes", "differentially", "methylated", "regions", "orthologous"], "article_id"=>890403, "categories"=>["Information And Computing Sciences", "Biological Sciences", "Medicine"], "users"=>["Gioia Altobelli", "Irina G. Bogdarina", "Elia Stupka", "Adrian J. L. Clark", "Simon Langley-Evans"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0082989.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_List_of_loci_from_selected_GWAS_studies_pertaining_to_metabolic_and_cardiovascular_phenotypes_associated_to_Low_Protein_diet_that_contain_differentially_methylated_regions_in_their_orthologous_rat_locus_/890403", "title"=>"List of loci from selected GWAS studies pertaining to metabolic and cardiovascular phenotypes associated to Low Protein diet that contain differentially methylated regions in their orthologous rat locus.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-31 03:43:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1333848", "https://ndownloader.figshare.com/files/1333849", "https://ndownloader.figshare.com/files/1333851", "https://ndownloader.figshare.com/files/1333853", "https://ndownloader.figshare.com/files/1333855", "https://ndownloader.figshare.com/files/1333858", "https://ndownloader.figshare.com/files/1333859", "https://ndownloader.figshare.com/files/1333861", "https://ndownloader.figshare.com/files/1333862", "https://ndownloader.figshare.com/files/1333864", "https://ndownloader.figshare.com/files/1333866", "https://ndownloader.figshare.com/files/1333868", "https://ndownloader.figshare.com/files/1333870", "https://ndownloader.figshare.com/files/1333872", "https://ndownloader.figshare.com/files/1333874", "https://ndownloader.figshare.com/files/1333876", "https://ndownloader.figshare.com/files/1333879", "https://ndownloader.figshare.com/files/1333881"], "description"=>"<div><p>A large body of evidence from human and animal studies demonstrates that the maternal diet during pregnancy can programme physiological and metabolic functions in the developing fetus, effectively determining susceptibility to later disease. The mechanistic basis of such programming is unclear but may involve resetting of epigenetic marks and fetal gene expression. The aim of this study was to evaluate genome-wide DNA methylation and gene expression in the livers of newborn rats exposed to maternal protein restriction. On day one postnatally, there were 618 differentially expressed genes and 1183 differentially methylated regions (FDR 5%). The functional analysis of differentially expressed genes indicated a significant effect on DNA repair/cycle/maintenance functions and of lipid, amino acid metabolism and circadian functions. Enrichment for known biological functions was found to be associated with differentially methylated regions. Moreover, these epigenetically altered regions overlapped genetic loci associated with metabolic and cardiovascular diseases. Both expression changes and DNA methylation changes were largely reversed by supplementing the protein restricted diet with folic acid. Although the epigenetic and gene expression signatures appeared to underpin largely different biological processes, the gene expression profile of DNA methyl transferases was altered, providing a potential link between the two molecular signatures. The data showed that maternal protein restriction is associated with widespread differential gene expression and DNA methylation across the genome, and that folic acid is able to reset both molecular signatures.</p></div>", "links"=>[], "tags"=>["developmental biology", "genetics", "genomics", "Computer applications", "Computing methods", "Ontology and logics", "Anatomy and physiology", "Endocrinology", "Metabolic disorders", "Non-clinical medicine", "methylation", "newborn", "rats", "maternal", "reversal", "folic"], "article_id"=>890404, "categories"=>["Information And Computing Sciences", "Biological Sciences", "Medicine"], "users"=>["Gioia Altobelli", "Irina G. Bogdarina", "Elia Stupka", "Adrian J. L. Clark", "Simon Langley-Evans"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0082989.s001", "https://dx.doi.org/10.1371/journal.pone.0082989.s002", "https://dx.doi.org/10.1371/journal.pone.0082989.s003", "https://dx.doi.org/10.1371/journal.pone.0082989.s004", "https://dx.doi.org/10.1371/journal.pone.0082989.s005", "https://dx.doi.org/10.1371/journal.pone.0082989.s006", "https://dx.doi.org/10.1371/journal.pone.0082989.s007", "https://dx.doi.org/10.1371/journal.pone.0082989.s008", "https://dx.doi.org/10.1371/journal.pone.0082989.s009", "https://dx.doi.org/10.1371/journal.pone.0082989.s010", "https://dx.doi.org/10.1371/journal.pone.0082989.s011", "https://dx.doi.org/10.1371/journal.pone.0082989.s012", "https://dx.doi.org/10.1371/journal.pone.0082989.s013", "https://dx.doi.org/10.1371/journal.pone.0082989.s014", "https://dx.doi.org/10.1371/journal.pone.0082989.s015", "https://dx.doi.org/10.1371/journal.pone.0082989.s016", "https://dx.doi.org/10.1371/journal.pone.0082989.s017", "https://dx.doi.org/10.1371/journal.pone.0082989.s018"], "stats"=>{"downloads"=>4, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genome_Wide_Methylation_and_Gene_Expression_Changes_in_Newborn_Rats_following_Maternal_Protein_Restriction_and_Reversal_by_Folic_Acid_/890404", "title"=>"Genome-Wide Methylation and Gene Expression Changes in Newborn Rats following Maternal Protein Restriction and Reversal by Folic Acid", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-12-31 03:43:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1333845"], "description"=>"<p>For each locus, Panel A shows the validation data obtained from bisulfite conversion followed by cloning and sequencing, which provides methylation status at single CpG site resolution for different livers and different clones (black circles represent methylated CpG, white circles unmethylated CpG). All loci except for <i>Sfmbt1</i> validated significant difference in DNA Methylation (<i>Agtrap</i> P<0.01, <i>Fgf5</i> P<0.01; Dnmt1 P<0.05; <i>Mcm6</i> P<0.01, Mann-Whitney U test), in line with that indicated by genome-wide MBD-Seq data. Panel B provides an overview of the genomic locus, the gene structure, the location of the DMR validated, and the level of methylation across the locus for each of the animal groups analyzed (Control = “cmbd”, Low Protein = “pmbd”, and Low Protein with Folic Acid Supplementation = “fmbd”). Panel C summarises the percent methylation in control and low protein for each locus assessed by bisulphite sequencing.</p>", "links"=>[], "tags"=>["developmental biology", "genetics", "genomics", "Computer applications", "Computing methods", "Ontology and logics", "Anatomy and physiology", "Endocrinology", "Metabolic disorders", "Non-clinical medicine", "genomic", "loci", "containing", "differentially", "methylated", "regions", "livers", "newborns", "mothers", "fed"], "article_id"=>890401, "categories"=>["Information And Computing Sciences", "Biological Sciences", "Medicine"], "users"=>["Gioia Altobelli", "Irina G. Bogdarina", "Elia Stupka", "Adrian J. L. Clark", "Simon Langley-Evans"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0082989.g002", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Figure_panel_representing_five_genomic_loci_Agtrap_Fgf5_Dnmt1_Mcm6_S_fmbt_1_containing_differentially_methylated_regions_DMRs_between_livers_obtained_from_newborns_whose_mothers_were_fed_a_control_diet_18_protein_and_livers_obtained_from_newborns_whose_m/890401", "title"=>"Figure panel representing five genomic loci (<i>Agtrap, Fgf5, Dnmt1, Mcm6</i>, S<i>fmbt</i>1) containing differentially methylated regions (DMRs) between livers obtained from newborns whose mothers were fed a control diet (18% protein) and livers obtained from newborns whose mothers were fed a low protein (9% protein) diet.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-31 03:43:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1333846"], "description"=>"<p>At FDR 5% only 15 genes (hypergeometric probability = 0.69) are found in both lists, of which 6 were down-regulated (<i>Dym</i>, <i>Glrx2</i>, <i>Mlph</i>, <i>Myh10</i>, <i>Pftk1</i>, And <i>Prep</i>) and 9 up-regulated (<i>Abcc8</i>, <i>Abhd6</i>, <i>Cep350</i>, <i>Ctsa</i>, <i>Eif2b3</i>, <i>Pdk1</i>, <i>Serpina11</i>, <i>Tpcn2</i>, And <i>Tyw3</i>). The total number of mapped genes is 555 in MBD and 577 in GEX.</p>", "links"=>[], "tags"=>["developmental biology", "genetics", "genomics", "Computer applications", "Computing methods", "Ontology and logics", "Anatomy and physiology", "Endocrinology", "Metabolic disorders", "Non-clinical medicine", "differentially", "separated", "up-regulated", "down-regulated", "dmrs-neighboring"], "article_id"=>890402, "categories"=>["Information And Computing Sciences", "Biological Sciences", "Medicine"], "users"=>["Gioia Altobelli", "Irina G. Bogdarina", "Elia Stupka", "Adrian J. L. Clark", "Simon Langley-Evans"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0082989.g003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Intersection_of_differentially_expressed_GEX_separated_in_up_regulated_UP_and_down_regulated_DW_and_DMRs_neighboring_MBD_genes_/890402", "title"=>"Intersection of differentially expressed (GEX), separated in up-regulated (UP) and down-regulated (DW), and DMRs-neighboring (MBD) genes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-31 03:43:11"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"77", "full-text"=>"90", "pdf"=>"45", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"51", "full-text"=>"46", "pdf"=>"23", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"35", "full-text"=>"34", "pdf"=>"32", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"34", "full-text"=>"47", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"1", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"30", "full-text"=>"27", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"13", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"32", "full-text"=>"32", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"31", "full-text"=>"20", "pdf"=>"12", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"28", "full-text"=>"29", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"24", "full-text"=>"16", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"45", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"34", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"121", "supp-data"=>"435", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"9", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"26", "full-text"=>"30", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"26", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"18", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[272, 472, 600, 713, 815, 911, 1004, 1094, 1185, 1273, 1358, 1441]}, {"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[295, 511, 651, 775, 882, 992, 1100, 1201, 1304, 1400, 1486, 1570, 1650]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[284, 491, 620, 738, 843, 945, 1043, 1137, 1225, 1315, 1400, 1479, 1555]}, {"subject_area"=>"/Medicine and health sciences/Nutrition", "average_usage"=>[273, 476, 611, 714, 821, 911, 1005, 1103, 1201, 1287, 1388, 1478, 1557]}]}
Loading … Spinner
There are currently no alerts