Cerebrospinal Fluid Neopterin Analysis in Neuropediatric Patients: Establishment of a New Cut Off-Value for the Identification of Inflammatory-Immune Mediated Processes
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{"title"=>"Cerebrospinal fluid neopterin analysis in neuropediatric patients: Establishment of a new cut off-value for the identification of inflammatory-immune mediated processes", "type"=>"journal", "authors"=>[{"first_name"=>"Marta", "last_name"=>"Molero-Luis", "scopus_author_id"=>"26432761900"}, {"first_name"=>"Sergio", "last_name"=>"Fernández-Ureña", "scopus_author_id"=>"37033876400"}, {"first_name"=>"Iolanda", "last_name"=>"Jordán", "scopus_author_id"=>"23100404700"}, {"first_name"=>"Mercedes", "last_name"=>"Serrano", "scopus_author_id"=>"7201394033"}, {"first_name"=>"Aida", "last_name"=>"Ormazábal", "scopus_author_id"=>"8347663100"}, {"first_name"=>"Àngels", "last_name"=>"Garcia-Cazorla", "scopus_author_id"=>"35512818300"}, {"first_name"=>"Rafael", "last_name"=>"Artuch", "scopus_author_id"=>"7004114130"}, {"first_name"=>"B.", "last_name"=>"Pérez-Dueñas", "scopus_author_id"=>"6602545967"}, {"first_name"=>"J.", "last_name"=>"Campistol", "scopus_author_id"=>"7103042466"}, {"first_name"=>"M.", "last_name"=>"O'Callagan", "scopus_author_id"=>"56024526500"}, {"first_name"=>"M.", "last_name"=>"Pineda", "scopus_author_id"=>"35473639700"}, {"first_name"=>"C.", "last_name"=>"Sierra", "scopus_author_id"=>"7006398295"}, {"first_name"=>"M.", "last_name"=>"Casado", "scopus_author_id"=>"35078139000"}, {"first_name"=>"C.", "last_name"=>"Muñoz-Almagro", "scopus_author_id"=>"6603569864"}, {"first_name"=>"M.", "last_name"=>"Monsonís", "scopus_author_id"=>"55503129300"}, {"first_name"=>"J.", "last_name"=>"Velasco", "scopus_author_id"=>"56937958200"}, {"first_name"=>"A.", "last_name"=>"Valls", "scopus_author_id"=>"26434043700"}, {"first_name"=>"F. J.", "last_name"=>"Cambra", "scopus_author_id"=>"57189089966"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84893416315", "issn"=>"19326203", "scopus"=>"2-s2.0-84893416315", "pmid"=>"24367586", "pui"=>"372252741", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0083237"}, "id"=>"fe414e86-ab74-3ae8-8481-45d69db637d7", "abstract"=>"OBJECTIVE: A high level of cerebrospinal fluid (CSF) neopterin is a marker of central nervous system inflammatory-immune mediated processes. We aimed to assess data from 606 neuropediatric patients, describing the clinical and biochemical features of those neurological disorders presenting CSF neopterin values above a new cut-off value that was defined in our laboratory.\\n\\nMETHODS: To establish the new CSF neopterin cut-off value, we studied two groups of patients: Group 1 comprised 68 patients with meningoencephalitis, and Group 2 comprised 52 children with a confirmed peripheral infection and no central nervous system involvement. We studied 606 CSF samples from neuropediatric patients who were classified into 3 groups: genetic diagnosis (A), acquired/unknown etiologic neurologic diseases (B) and inflammatory-immune mediated processes (C).\\n\\nRESULTS: The CSF neopterin cut-off value was 61 nmol/L. Out of 606 cases, 56 presented a CSF neopterin level above this value. Group C had significantly higher CSF neopterin, protein and leukocyte values than the other groups. Sixteen of twenty-three patients in this group had a CSF neopterin level above the cut-off, whereas three and seven patients presented increased leukocyte and protein values, respectively. A significant association was found among CSF neopterin, proteins and leukocytes in the 606 patients. White matter disturbances were associated with high CSF neopterin concentrations.\\n\\nCONCLUSIONS: Although children with inflammatory-immune mediated processes presented higher CSF neopterin values, patients with other neurological disorders also showed increased CSF neopterin concentrations. These results stress the importance of CSF neopterin analysis for the identification of inflammatory-immune mediated processes.", "link"=>"http://www.mendeley.com/research/cerebrospinal-fluid-neopterin-analysis-neuropediatric-patients-establishment-new-cut-offvalue-identi", "reader_count"=>17, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>7, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>7, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>10, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1321219"], "description"=>"<p>Each group shows the percentage of patients with high CSF WBC, high CSF proteins and high CSF neopterin. The inflammatory/immune-mediated group had a significantly elevated percentage of high CSF WBC (<sup>*</sup>X<sup>2</sup> = 27.91, p<0.001), high CSF proteins (<sup>Ψ</sup>X<sup>2</sup> = 17.51, p<0.001) and high CSF NP (<sup>Φ</sup>X<sup>2</sup> = 103.73, p<0.001) compared with the other groups.</p>", "links"=>[], "tags"=>["606", "neurological", "patients"], "article_id"=>881176, "categories"=>["Biological Sciences"], "users"=>["Marta Molero-Luis", "Sergio Fernández-Ureña", "Iolanda Jordán", "Mercedes Serrano", "Aida Ormazábal", "Angels García-Cazorla", "Rafael Artuch"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083237.g002", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representation_of_the_606_neurological_patients_in_the_clinical_groups_/881176", "title"=>"Representation of the 606 neurological patients in the clinical groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-18 03:27:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/1321220"], "description"=>"<p>Out of 550 patients with CSF neopterin levels below 61 nmol/l, 68 patients had altered CSF proteins, and nine had altered CSF leucocytes. CSF NP: cerebrospinal fluid neopterin. The results are shown as the median and interval in brackets.</p>", "links"=>[], "tags"=>["csf", "neopterin"], "article_id"=>881177, "categories"=>["Biological Sciences"], "users"=>["Marta Molero-Luis", "Sergio Fernández-Ureña", "Iolanda Jordán", "Mercedes Serrano", "Aida Ormazábal", "Angels García-Cazorla", "Rafael Artuch"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083237.t003", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patients_with_CSF_neopterin_levels_below_61_l_n_8202_8202_550_/881177", "title"=>"Patients with CSF neopterin levels below 61/l (n = 550).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-18 03:27:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/1321221"], "description"=>"<p>*Inflammatory/immune-mediated group had significantly elevated CSF neopterin (X<sup>2</sup> = 35.01, p<0.001), CSF proteins (X<sup>2</sup> = 12.71, p = 0.002) and CSF leukocytes (X<sup>2</sup> = 6.23, p = 0.044) compared with the other groups. Moreover, up to 69.6% of the patients more frequently had CSF NP>61 nmol/L. Out of 56 patients with a CSF neopterin level above 61 nmol/l, 13 patients had altered CSF proteins and four had altered CSF leucocytes.</p><p>AGS: Aicardi-Goutières syndrome; ARCI: arthrogryposis, renal tubular dysfunction, cholestasis, ichthyosis syndrome; anti-NMDA encephalitis: anti-(N-methyl D-aspartate) receptor encephalitis; CINCA: chronic infantile neurological, cutaneous and articular syndrome; VLCAD: very long-chain acyl-CoA dehydrogenase; CSF NP: cerebrospinal fluid neopterin; WBC: white blood cells. Dist: disturbances. The results are shown as the median and interval in brackets.</p>", "links"=>[], "tags"=>["csf", "neopterin"], "article_id"=>881178, "categories"=>["Biological Sciences"], "users"=>["Marta Molero-Luis", "Sergio Fernández-Ureña", "Iolanda Jordán", "Mercedes Serrano", "Aida Ormazábal", "Angels García-Cazorla", "Rafael Artuch"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083237.t002", "stats"=>{"downloads"=>4, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patients_with_CSF_neopterin_levels_above_61_l_n_8202_8202_56_/881178", "title"=>"Patients with CSF neopterin levels above 61/l (n = 56).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-18 03:27:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/1321222"], "description"=>"<p>*Significant values were observed in Total Group 1 vs Total Group 2 (U-Mann Whitney test). The data for the CSF variables are shown as median and range in brackets. CSF: cerebrospinal fluid, WBC: white blood cells.</p>", "links"=>[], "tags"=>["biochemical", "subjects", "cns", "infections", "peripheral"], "article_id"=>881179, "categories"=>["Biological Sciences"], "users"=>["Marta Molero-Luis", "Sergio Fernández-Ureña", "Iolanda Jordán", "Mercedes Serrano", "Aida Ormazábal", "Angels García-Cazorla", "Rafael Artuch"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083237.t001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CSF_biochemical_values_from_subjects_with_CNS_infections_and_peripheral_infections_/881179", "title"=>"CSF biochemical values from subjects with CNS infections and peripheral infections.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-18 03:27:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/1321218"], "description"=>"<p>The samples were classified into two groups according to the condition that they presented either bacterial/viral central infection (n = 68) or peripheral infection (n = 52). The area under the curve was 0.934 (range: 0.883–0.985) with 61 nmol/l as the new cut-off. The sensitivity was 91.3%, and the specificity was 88.5%.</p>", "links"=>[], "tags"=>["csf", "neopterin"], "article_id"=>881175, "categories"=>["Biological Sciences"], "users"=>["Marta Molero-Luis", "Sergio Fernández-Ureña", "Iolanda Jordán", "Mercedes Serrano", "Aida Ormazábal", "Angels García-Cazorla", "Rafael Artuch"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083237.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ROC_curve_to_determine_the_new_CSF_neopterin_cut_off_/881175", "title"=>"ROC curve to determine the new CSF neopterin cut-off.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-18 03:27:26"}

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Relative Metric

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