Modeling the Dynamics of a Non-Limited and a Self-Limited Gene Drive System in Structured Aedes aegypti Populations
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{"title"=>"Modeling the dynamics of a non-limited and a self-limited gene drive system in structured Aedes aegypti populations", "type"=>"journal", "authors"=>[{"first_name"=>"Mathieu", "last_name"=>"Legros", "scopus_author_id"=>"24479280100"}, {"first_name"=>"Chonggang", "last_name"=>"Xu", "scopus_author_id"=>"55846291300"}, {"first_name"=>"Amy", "last_name"=>"Morrison", "scopus_author_id"=>"7402258304"}, {"first_name"=>"Thomas W.", "last_name"=>"Scott", "scopus_author_id"=>"7402144111"}, {"first_name"=>"Alun L.", "last_name"=>"Lloyd", "scopus_author_id"=>"35555137200"}, {"first_name"=>"Fred", "last_name"=>"Gould", "scopus_author_id"=>"7101644663"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84892420898", "sgr"=>"84892420898", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0083354", "pmid"=>"24340097", "isbn"=>"10.1371/journal.pone.0083354", "pui"=>"372116545"}, "id"=>"c5aacfa9-c7ef-31e6-8d46-5ec2f390079c", "abstract"=>"Recently there have been significant advances in research on genetic strategies to control populations of disease-vectoring insects. Some of these strategies use the gene drive properties of selfish genetic elements to spread physically linked anti-pathogen genes into local vector populations. Because of the potential of these selfish elements to spread through populations, control approaches based on these strategies must be carefully evaluated to ensure a balance between the desirable spread of the refractoriness-conferring genetic cargo and the avoidance of potentially unwanted outcomes such as spread to non-target populations. There is also a need to develop better estimates of the economics of such releases. We present here an evaluation of two such strategies using a biologically realistic mathematical model that simulates the resident Aedes aegypti mosquito population of Iquitos, Peru. One strategy uses the selfish element Medea, a non-limited element that could permanently spread over a large geographic area; the other strategy relies on Killer-Rescue genetic constructs, and has been predicted to have limited spatial and temporal spread. We simulate various operational approaches for deploying these genetic strategies, and quantify the optimal number of released transgenic mosquitoes needed to achieve definitive spread of Medea-linked genes and/or high frequencies of Killer-Rescue-associated elements. We show that for both strategies the most efficient approach for achieving spread of anti-pathogen genes within three years is generally to release adults of both sexes in multiple releases over time. Even though females in these releases should not transmit disease, there could be public concern over such releases, making the less efficient male-only release more practical. This study provides guidelines for operational approaches to population replacement genetic strategies, as well as illustrates the use of detailed spatial models to assist in safe and efficient implementation of such novel genetic strategies.", "link"=>"http://www.mendeley.com/research/modeling-dynamics-nonlimited-selflimited-gene-drive-system-structured-aedes-aegypti-populations", "reader_count"=>45, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Master"=>3, "Other"=>5, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Master"=>3, "Other"=>5, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>3, "Environmental Science"=>3, "Biochemistry, Genetics and Molecular Biology"=>5, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>20, "Medicine and Dentistry"=>5, "Veterinary Science and Veterinary Medicine"=>1, "Social Sciences"=>4, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Social Sciences"=>{"Social Sciences"=>4}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>20}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>2, "United Kingdom"=>2, "Switzerland"=>1}, "group_count"=>12}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1309328"], "description"=>"<p>For each scenario the final frequency of each allele in the population after three years is plotted (20 replicates, average ± SD). Top: <i>c</i><sub>K</sub> = <i>c</i><sub>R</sub> = 0. Bottom: <i>c</i><sub>K</sub> = <i>c</i><sub>R</sub> = 0.1. Dark circles: final frequency of R allele. Light triangles: final frequency of K allele. </p>", "links"=>[], "tags"=>["alleles", "frequencies", "releases", "homozygous", "kr", "males"], "article_id"=>873141, "categories"=>["Biological Sciences"], "users"=>["Mathieu Legros", "Chonggang Xu", "Amy Morrison", "Thomas W. Scott", "Alun L. Lloyd", "Fred Gould"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083354.g007", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Final_R_and_K_alleles_frequencies_with_multiple_releases_of_homozygous_KR_adult_males_in_every_house_/873141", "title"=>"Final R and K alleles frequencies with multiple releases of homozygous KR adult males in every house.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-10 03:30:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/1309324"], "description"=>"<p>Proportion represents the fraction out of 20 simulations that reaches a given outcome 3 years after the first release. Outcomes are defined by the final allelic frequency <i>f</i> of the Medea construct in the population. Categories defined as in Figure 1. Both panels: <i>c</i><sub>F</sub>=0.1. Top panel: <i>c</i><sub>M</sub>=0; bottom panel: <i>c</i><sub>M</sub>=0.1.</p>", "links"=>[], "tags"=>["homozygous", "males", "females"], "article_id"=>873137, "categories"=>["Biological Sciences"], "users"=>["Mathieu Legros", "Chonggang Xu", "Amy Morrison", "Thomas W. Scott", "Alun L. Lloyd", "Fred Gould"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083354.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Single_release_of_homozygous_Medea_adult_males_and_females_in_every_house_/873137", "title"=>"Single release of homozygous <i>Medea</i> adult males and females in every house.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-10 03:30:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/1309322"], "description"=>"<p>Proportion represents the fraction out of 20 simulations that reaches a given outcome 3 years after the first release. Outcomes are defined by the final allelic frequency <i>f</i> of the Medea construct in the population as in Figure 1. Both panels: <i>c</i><sub>F</sub>=0.1. Top panel: <i>c</i><sub>M</sub>=0; bottom panel: <i>c</i><sub>M</sub>=0.1. The total number of adults produced from released eggs is estimated based on the average adult production of an egg cohort of corresponding size. </p>", "links"=>[], "tags"=>["homozygous", "eggs"], "article_id"=>873135, "categories"=>["Biological Sciences"], "users"=>["Mathieu Legros", "Chonggang Xu", "Amy Morrison", "Thomas W. Scott", "Alun L. Lloyd", "Fred Gould"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083354.g002", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Single_release_of_homozygous_Medea_eggs_in_10_of_houses_/873135", "title"=>"Single release of homozygous <i>Medea</i> eggs in 10% of houses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-10 03:30:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/1309323"], "description"=>"<p>Proportion represents the fraction out of 20 simulations that reaches a given outcome 3 years after the first release. Outcomes are defined by the final allelic frequency <i>f</i> of the Medea construct in the population as in Figure 1. All scenarios involve 10 weekly releases. All panels: <i>c</i><sub>F</sub>=0.1. Top panels: <i>c</i><sub>M</sub>=0; bottom panels: <i>c</i><sub>M</sub>=0.1. Left column: release of adults in every house. Right column: release of eggs in 10% of houses. </p>", "links"=>[], "tags"=>["releases", "homozygous", "adults"], "article_id"=>873136, "categories"=>["Biological Sciences"], "users"=>["Mathieu Legros", "Chonggang Xu", "Amy Morrison", "Thomas W. Scott", "Alun L. Lloyd", "Fred Gould"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083354.g003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multiple_releases_of_homozygous_Medea_adults_and_eggs_/873136", "title"=>"Multiple releases of homozygous <i>Medea</i> adults and eggs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-10 03:30:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/1309321"], "description"=>"<p>Proportion represents the fraction out of 20 simulations that reaches a given outcome 3 years after the first release. Outcomes are defined by the final allelic frequency <i>f</i> of the Medea construct in the population. ‘Spread’: <i>f</i>>0.8; ‘Spreading’: 0.2c<sub>F</sub>=0.1. Top panel: <i>c</i><sub>M</sub>=0; bottom panel: <i>c</i><sub>M</sub>=0.1.</p>", "links"=>[], "tags"=>["homozygous", "males"], "article_id"=>873134, "categories"=>["Biological Sciences"], "users"=>["Mathieu Legros", "Chonggang Xu", "Amy Morrison", "Thomas W. Scott", "Alun L. Lloyd", "Fred Gould"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083354.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Single_release_of_homozygous_Medea_adult_males_in_every_house_/873134", "title"=>"Single release of homozygous <i>Medea</i> adult males in every house.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-10 03:30:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/1309332", "https://ndownloader.figshare.com/files/1309333", "https://ndownloader.figshare.com/files/1309334"], "description"=>"<div><p>Recently there have been significant advances in research on genetic strategies to control populations of disease-vectoring insects. Some of these strategies use the gene drive properties of selfish genetic elements to spread physically linked anti-pathogen genes into local vector populations. Because of the potential of these selfish elements to spread through populations, control approaches based on these strategies must be carefully evaluated to ensure a balance between the desirable spread of the refractoriness-conferring genetic cargo and the avoidance of potentially unwanted outcomes such as spread to non-target populations. There is also a need to develop better estimates of the economics of such releases. We present here an evaluation of two such strategies using a biologically realistic mathematical model that simulates the resident <i>Aedes aegypti</i> mosquito population of Iquitos, Peru. One strategy uses the selfish element <i>Medea</i>, a non-limited element that could permanently spread over a large geographic area; the other strategy relies on Killer-Rescue genetic constructs, and has been predicted to have limited spatial and temporal spread. We simulate various operational approaches for deploying these genetic strategies, and quantify the optimal number of released transgenic mosquitoes needed to achieve definitive spread of <i>Medea</i>-linked genes and/or high frequencies of Killer-Rescue-associated elements. We show that for both strategies the most efficient approach for achieving spread of anti-pathogen genes within three years is generally to release adults of both sexes in multiple releases over time. Even though females in these releases should not transmit disease, there could be public concern over such releases, making the less efficient male-only release more practical. This study provides guidelines for operational approaches to population replacement genetic strategies, as well as illustrates the use of detailed spatial models to assist in safe and efficient implementation of such novel genetic strategies. </p> </div>", "links"=>[], "tags"=>["modeling", "non-limited", "self-limited", "structured", "populations"], "article_id"=>873145, "categories"=>["Biological Sciences"], "users"=>["Mathieu Legros", "Chonggang Xu", "Amy Morrison", "Thomas W. Scott", "Alun L. Lloyd", "Fred Gould"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0083354.s001", "https://dx.doi.org/10.1371/journal.pone.0083354.s002", "https://dx.doi.org/10.1371/journal.pone.0083354.s003"], "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Modeling_the_Dynamics_of_a_Non_Limited_and_a_Self_Limited_Gene_Drive_System_in_Structured_Aedes_aegypti_Populations/873145", "title"=>"Modeling the Dynamics of a Non-Limited and a Self-Limited Gene Drive System in Structured <i>Aedes aegypti</i> Populations", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-12-10 03:30:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/1309326"], "description"=>"<p>For each scenario the final frequency of the R allele in the population is plotted (20 replicates, average ± SD). Top: single release of adult males in every house. Bottom: single release of eggs in 10% of houses. Dark: <i>c</i><sub>K</sub> = <i>c</i><sub>R</sub> = 0. Light: <i>c</i><sub>K</sub> = <i>c</i><sub>R</sub> = 0.1. Note that the Y-axis is different in Figure 6 A and B.</p>", "links"=>[], "tags"=>["allele", "homozygous", "kr"], "article_id"=>873139, "categories"=>["Biological Sciences"], "users"=>["Mathieu Legros", "Chonggang Xu", "Amy Morrison", "Thomas W. Scott", "Alun L. Lloyd", "Fred Gould"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083354.g006", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Final_R_allele_frequency_with_single_release_of_homozygous_KR_individuals_/873139", "title"=>"Final R allele frequency with single release of homozygous KR individuals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-10 03:30:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/1309325"], "description"=>"<p>The trajectories represent the change in frequencies of K allele (red, dashed lines) and R allele (green, solid lines) in the population in one simulation of releases of KR males in every house. The model is run for one year without release to establish the resident population, releases then start on day 365. Dark lines: <i>c</i><sub>K</sub> = <i>c</i><sub>R</sub> = 0. Light lines: <i>c</i><sub>K</sub> = <i>c</i><sub>R</sub> = 0.1. Top: single release of 100 males per house. Bottom: 10 weekly releases of 10 males per house each. In both cases, the total number of males released is 61,200. </p>", "links"=>[], "tags"=>["allele", "frequencies", "releases", "homozygous", "kr", "males"], "article_id"=>873138, "categories"=>["Biological Sciences"], "users"=>["Mathieu Legros", "Chonggang Xu", "Amy Morrison", "Thomas W. Scott", "Alun L. Lloyd", "Fred Gould"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083354.g005", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Time_series_of_allele_frequencies_with_releases_of_homozygous_KR_adult_males_in_every_house_/873138", "title"=>"Time series of allele frequencies with releases of homozygous KR adult males in every house.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-10 03:30:05"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biotechnology", "average_usage"=>[259, 472, 622, 759, 885, 1009, 1123, 1232, 1335, 1437, 1533, 1627, 1698]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[281, 484, 611, 728, 835, 934, 1030, 1123, 1214, 1299, 1383, 1464]}, {"subject_area"=>"/Medicine and health sciences/Epidemiology", "average_usage"=>[263, 452, 568, 671, 758, 847, 921, 1023, 1101, 1187, 1264, 1340, 1394]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[265, 456, 578, 682, 782, 881, 965, 1053, 1133, 1223, 1310, 1391, 1457]}]}
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