Clinical Features of Patients with Dysthymia in a Large Cohort of Han Chinese Women with Recurrent Major Depression
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{"title"=>"Clinical features of patients with dysthymia in a large cohort of han chinese women with recurrent major depression", "type"=>"journal", "authors"=>[{"first_name"=>"Wenqing", "last_name"=>"Wu", "scopus_author_id"=>"56028205300"}, {"first_name"=>"Zhoubing", "last_name"=>"Wang", "scopus_author_id"=>"53880609500"}, {"first_name"=>"Yan", "last_name"=>"Wei", "scopus_author_id"=>"54396685500"}, {"first_name"=>"Guanghua", "last_name"=>"Zhang", "scopus_author_id"=>"45662313600"}, {"first_name"=>"Shenxun", "last_name"=>"Shi", "scopus_author_id"=>"35435924200"}, {"first_name"=>"Jingfang", "last_name"=>"Gao", "scopus_author_id"=>"8595715500"}, {"first_name"=>"Youhui", "last_name"=>"Li", "scopus_author_id"=>"54395898100"}, {"first_name"=>"Ming", "last_name"=>"Tao", "scopus_author_id"=>"36109147700"}, {"first_name"=>"Kerang", "last_name"=>"Zhang", "scopus_author_id"=>"56027986100"}, {"first_name"=>"Xumei", "last_name"=>"Wang", "scopus_author_id"=>"36144568100"}, {"first_name"=>"Chengge", "last_name"=>"Gao", "scopus_author_id"=>"7402617437"}, {"first_name"=>"Lijun", "last_name"=>"Yang", "scopus_author_id"=>"54396620100"}, {"first_name"=>"Kan", "last_name"=>"Li", "scopus_author_id"=>"55447454300"}, {"first_name"=>"Jianguo", "last_name"=>"Shi", "scopus_author_id"=>"55261438500"}, {"first_name"=>"Gang", "last_name"=>"Wang", "scopus_author_id"=>"56399525100"}, {"first_name"=>"Lanfen", "last_name"=>"Liu", "scopus_author_id"=>"7405255414"}, {"first_name"=>"Jinbei", "last_name"=>"Zhang", "scopus_author_id"=>"37099161700"}, {"first_name"=>"Bo", "last_name"=>"Du", "scopus_author_id"=>"26665898700"}, {"first_name"=>"Guoqing", "last_name"=>"Jiang", "scopus_author_id"=>"56086277000"}, {"first_name"=>"Jianhua", "last_name"=>"Shen", "scopus_author_id"=>"55488324900"}, {"first_name"=>"Ying", "last_name"=>"Liu", "scopus_author_id"=>"56029064500"}, {"first_name"=>"Wei", "last_name"=>"Liang", "scopus_author_id"=>"56027340200"}, {"first_name"=>"Jing", "last_name"=>"Sun", "scopus_author_id"=>"56402024000"}, {"first_name"=>"Jian", "last_name"=>"Hu", "scopus_author_id"=>"57191291322"}, {"first_name"=>"Tiebang", "last_name"=>"Liu", "scopus_author_id"=>"12041688600"}, {"first_name"=>"Xueyi", "last_name"=>"Wang", "scopus_author_id"=>"36615962600"}, {"first_name"=>"Guodong", "last_name"=>"Miao", "scopus_author_id"=>"48662732100"}, {"first_name"=>"Huaqing", "last_name"=>"Meng", "scopus_author_id"=>"9133658800"}, {"first_name"=>"Yi", "last_name"=>"Li", "scopus_author_id"=>"56029053400"}, {"first_name"=>"Chunmei", "last_name"=>"Hu", "scopus_author_id"=>"56086231600"}, {"first_name"=>"Guoping", "last_name"=>"Huang", "scopus_author_id"=>"56085400900"}, {"first_name"=>"Gongying", "last_name"=>"Li", "scopus_author_id"=>"56028184500"}, {"first_name"=>"Baowei", "last_name"=>"Ha", "scopus_author_id"=>"56028849900"}, {"first_name"=>"Hong", "last_name"=>"Deng", "scopus_author_id"=>"35204671600"}, {"first_name"=>"Qiyi", "last_name"=>"Mei", "scopus_author_id"=>"56027759400"}, {"first_name"=>"Hui", "last_name"=>"Zhong", "scopus_author_id"=>"56027496500"}, {"first_name"=>"Shugui", "last_name"=>"Gao", "scopus_author_id"=>"55447178600"}, {"first_name"=>"Hong", "last_name"=>"Sang", "scopus_author_id"=>"56028557100"}, {"first_name"=>"Yutang", "last_name"=>"Zhang", "scopus_author_id"=>"14068164700"}, {"first_name"=>"Xiang", "last_name"=>"Fang", "scopus_author_id"=>"56085678900"}, {"first_name"=>"Fengyu", "last_name"=>"Yu", "scopus_author_id"=>"56031317200"}, {"first_name"=>"Donglin", "last_name"=>"Yang", "scopus_author_id"=>"56031508400"}, {"first_name"=>"Tieqiao", "last_name"=>"Liu", "scopus_author_id"=>"7405913770"}, {"first_name"=>"Yunchun", "last_name"=>"Chen", "scopus_author_id"=>"22833345400"}, {"first_name"=>"Xiaohong", "last_name"=>"Hong", "scopus_author_id"=>"24398670400"}, {"first_name"=>"Wenyuan", "last_name"=>"Wu", "scopus_author_id"=>"55707497300"}, {"first_name"=>"Guibing", "last_name"=>"Chen", "scopus_author_id"=>"56027742400"}, {"first_name"=>"Min", "last_name"=>"Cai", "scopus_author_id"=>"36930041900"}, {"first_name"=>"Yan", "last_name"=>"Song", "scopus_author_id"=>"56027630100"}, {"first_name"=>"Jiyang", "last_name"=>"Pan", "scopus_author_id"=>"12139028000"}, {"first_name"=>"Jicheng", "last_name"=>"Dong", "scopus_author_id"=>"56085225300"}, {"first_name"=>"Runde", "last_name"=>"Pan", "scopus_author_id"=>"56028238300"}, {"first_name"=>"Wei", "last_name"=>"Zhang", "scopus_author_id"=>"56155363000"}, {"first_name"=>"Zhenming", "last_name"=>"Shen", "scopus_author_id"=>"56085543100"}, {"first_name"=>"Zhengrong", "last_name"=>"Liu", "scopus_author_id"=>"56028166400"}, {"first_name"=>"Danhua", "last_name"=>"Gu", "scopus_author_id"=>"56027543800"}, {"first_name"=>"Xiaoping", "last_name"=>"Wang", "scopus_author_id"=>"55089285800"}, {"first_name"=>"Xiaojuan", "last_name"=>"Liu", "scopus_author_id"=>"56028560000"}, {"first_name"=>"Qiwen", "last_name"=>"Zhang", "scopus_author_id"=>"56027872200"}, {"first_name"=>"Yihan", "last_name"=>"Li", "scopus_author_id"=>"43061162200"}, {"first_name"=>"Yiping", "last_name"=>"Chen", "scopus_author_id"=>"55914728800"}, {"first_name"=>"Kenneth S.", "last_name"=>"Kendler", "scopus_author_id"=>"35396760800"}, {"first_name"=>"Jonathan", "last_name"=>"Flint", "scopus_author_id"=>"7102999294"}, {"first_name"=>"Zhen", "last_name"=>"Zhang", "scopus_author_id"=>"56080510300"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84893534833", "pui"=>"372309742", "doi"=>"10.1371/journal.pone.0083490", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84893534833", "pmid"=>"24386213"}, "id"=>"2027e68f-2193-3b89-bbbd-bab6e84f5d40", "abstract"=>"BackgroundDysthymia is a form of chronic mild depression that has a complex relationship with major depressive disorder (MDD). Here we investigate the role of environmental risk factors, including stressful life events and parenting style, in patients with both MDD and dysthymia. We ask whether these risk factors act in the same way in MDD with and without dysthymia.ResultsWe examined the clinical features in 5,950 Han Chinese women with MDD between 30–60 years of age across China. We confirmed earlier results by replicating prior analyses in 3,950 new MDD cases. There were no significant differences between the two data sets. We identified sixteen stressful life events that significantly increase the risk of dysthymia, given the presence of MDD. Low parental warmth, from either mother or father, increases the risk of dysthymia. Highly threatening but short-lived threats (such as rape) are more specific for MDD than dysthymia. While for MDD more severe life events show the largest odds ratio versus controls, this was not seen for cases of MDD with or without dysthymia.ConclusionsThere are increased rates of stressful life events in MDD with dysthymia, but the impact of life events on susceptibility to dysthymia with MDD differs from that seen for MDD alone. The pattern does not fit a simple dose-response relationship, suggesting that there are moderating factors involved in the relationship between environmental precipitants and the onset of dysthymia. It is possible that severe life events in childhood events index a general susceptibility to chronic depression, rather than acting specifically as risk factors for dysthymia.", "link"=>"http://www.mendeley.com/research/clinical-features-patients-dysthymia-large-cohort-han-chinese-women-recurrent-major-depression-2", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Librarian"=>1, "Student > Doctoral Student"=>3, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>3, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Librarian"=>1, "Student > Doctoral Student"=>3, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>3, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>3, "Neuroscience"=>1, "Psychology"=>6}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1329863"], "description"=>"<p>The table shows the P-value, odds ratio and 95% confidence intervals (95% CI) for the relationship between dysthymia and three facets of perceived parenting. Results are reported for both maternal and paternal perceived parenting values.</p>", "links"=>[], "tags"=>["Clinical research design", "Cohort studies", "Mental health", "psychiatry", "Anxiety disorders", "Mood disorders", "Neuroses", "psychology", "behavior", "Psychological stress", "parenting", "susceptibility"], "article_id"=>887515, "categories"=>["Medicine", "Sociology"], "users"=>["Wenqing Wu", "Zhoubing Wang", "Yan Wei", "Guanghua Zhang", "Shenxun Shi", "Jingfang Gao", "Youhui Li", "Ming Tao", "Kerang Zhang", "Xumei Wang", "Chengge Gao", "Lijun Yang", "Kan Li", "Jianguo Shi", "Gang Wang", "Lanfen Liu", "Jinbei Zhang", "Bo Du", "Guoqing Jiang", "Jianhua Shen", "Ying Liu", "Wei Liang", "Jing Sun", "Jian Hu", "Tiebang Liu", "Xueyi Wang", "Guodong Miao", "Huaqing Meng", "Yi Li", "Chunmei Hu", "Guoping Huang", "Gongying Li", "Baowei Ha", "Hong Deng", "Qiyi Mei", "Hui Zhong", "Shugui Gao", "Hong Sang", "Yutang Zhang", "Xiang Fang", "Fengyu Yu", "Donglin Yang", "Tieqiao Liu", "Yunchun Chen", "Xiaohong Hong", "Wenyuan Wu", "Guibing Chen", "Min Cai", "Yan Song", "Jiyang Pan", "Jicheng Dong", "Runde Pan", "Wei Zhang", "Zhenming Shen", "Zhengrong Liu", "Danhua Gu", "Xiaoping Wang", "Xiaojuan Liu", "Qiwen Zhang", "Yihan Li", "Yiping Chen", "Kenneth S. Kendler", "Jonathan Flint", "Zhen Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083490.t003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Contribution_of_perceived_parenting_to_the_susceptibility_to_dysthymia_/887515", "title"=>"Contribution of perceived parenting to the susceptibility to dysthymia.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-27 02:50:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1329864"], "description"=>"<p>The table shows results from two cohorts as well as the combined dataset. Cohort 1 was collected from the beginning of 2008 to the middle of 2010 and cohort 2 from mid 2010 to the end of 2012. The last two columns show the means, or where appropriate the percentages (%), of each clinical feature for the combined data set. ‘Dysthymia’ refers to MDD cases with dysthymia and ‘No dysthymia’ refers to MDD without dysthymia. Abbreviations used: MDD, major depressive disorer; OR: odds ratio. 95% CI: 95% confidence intervals. *<i>p</i><0.05 **<i>p</i><0.01 ***<i>p</i><0.001</p>", "links"=>[], "tags"=>["Clinical research design", "Cohort studies", "Mental health", "psychiatry", "Anxiety disorders", "Mood disorders", "Neuroses", "psychology", "behavior", "Psychological stress", "dysthymia", "replication"], "article_id"=>887516, "categories"=>["Medicine", "Sociology"], "users"=>["Wenqing Wu", "Zhoubing Wang", "Yan Wei", "Guanghua Zhang", "Shenxun Shi", "Jingfang Gao", "Youhui Li", "Ming Tao", "Kerang Zhang", "Xumei Wang", "Chengge Gao", "Lijun Yang", "Kan Li", "Jianguo Shi", "Gang Wang", "Lanfen Liu", "Jinbei Zhang", "Bo Du", "Guoqing Jiang", "Jianhua Shen", "Ying Liu", "Wei Liang", "Jing Sun", "Jian Hu", "Tiebang Liu", "Xueyi Wang", "Guodong Miao", "Huaqing Meng", "Yi Li", "Chunmei Hu", "Guoping Huang", "Gongying Li", "Baowei Ha", "Hong Deng", "Qiyi Mei", "Hui Zhong", "Shugui Gao", "Hong Sang", "Yutang Zhang", "Xiang Fang", "Fengyu Yu", "Donglin Yang", "Tieqiao Liu", "Yunchun Chen", "Xiaohong Hong", "Wenyuan Wu", "Guibing Chen", "Min Cai", "Yan Song", "Jiyang Pan", "Jicheng Dong", "Runde Pan", "Wei Zhang", "Zhenming Shen", "Zhengrong Liu", "Danhua Gu", "Xiaoping Wang", "Xiaojuan Liu", "Qiwen Zhang", "Yihan Li", "Yiping Chen", "Kenneth S. Kendler", "Jonathan Flint", "Zhen Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083490.t001", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relation_between_dysthymia_and_clinical_features_replication_and_analysis_of_complete_data_set_/887516", "title"=>"Relation between dysthymia and clinical features: replication and analysis of complete data set.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-27 02:50:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1329861"], "description"=>"<p>The vertical axis shows the odds ratios, the horizontal axis the sixteen stressful life events that precede the onset of MDD alone (shown as a red box plot) and dysthymia with MDD (blue boxes). Box plots show the distribution of comparisons with 100 simulated ages of onset. Note that the result for the rape event on MDD alone is not shown because the OR is 40.</p>", "links"=>[], "tags"=>["Clinical research design", "Cohort studies", "Mental health", "psychiatry", "Anxiety disorders", "Mood disorders", "Neuroses", "psychology", "behavior", "Psychological stress", "ratios", "preceding", "onset", "dysthymia", "depressive"], "article_id"=>887513, "categories"=>["Medicine", "Sociology"], "users"=>["Wenqing Wu", "Zhoubing Wang", "Yan Wei", "Guanghua Zhang", "Shenxun Shi", "Jingfang Gao", "Youhui Li", "Ming Tao", "Kerang Zhang", "Xumei Wang", "Chengge Gao", "Lijun Yang", "Kan Li", "Jianguo Shi", "Gang Wang", "Lanfen Liu", "Jinbei Zhang", "Bo Du", "Guoqing Jiang", "Jianhua Shen", "Ying Liu", "Wei Liang", "Jing Sun", "Jian Hu", "Tiebang Liu", "Xueyi Wang", "Guodong Miao", "Huaqing Meng", "Yi Li", "Chunmei Hu", "Guoping Huang", "Gongying Li", "Baowei Ha", "Hong Deng", "Qiyi Mei", "Hui Zhong", "Shugui Gao", "Hong Sang", "Yutang Zhang", "Xiang Fang", "Fengyu Yu", "Donglin Yang", "Tieqiao Liu", "Yunchun Chen", "Xiaohong Hong", "Wenyuan Wu", "Guibing Chen", "Min Cai", "Yan Song", "Jiyang Pan", "Jicheng Dong", "Runde Pan", "Wei Zhang", "Zhenming Shen", "Zhengrong Liu", "Danhua Gu", "Xiaoping Wang", "Xiaojuan Liu", "Qiwen Zhang", "Yihan Li", "Yiping Chen", "Kenneth S. Kendler", "Jonathan Flint", "Zhen Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083490.g001", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_odds_ratios_for_events_preceding_the_onset_of_dysthymia_and_major_depressive_disorder_/887513", "title"=>"Distribution of odds ratios for events preceding the onset of dysthymia and major depressive disorder.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-27 02:50:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1329862"], "description"=>"<p>The table shows the result of assessing the relationship between dysthymia and life events that were reported to precede the first onset of dysthymia, within cases of major depression. The table gives the P-value, odds ratio and 95% confidence intervals (95% CI) for logistic regression and sixteen stressful life events, and childhood sexual abuse (reported as either non genital, genital or intercourse). The last two columns show the percentage of cases reporting each event, regardless of the age of onset. ‘Dysthymia’ refers to MDD cases with dysthymia and ‘No dysthymia’ refers to MDD without dysthymia. The thresholds for P-values corrected for multiple testing are shown as *<i>p</i><0.05 **<i>p</i><0.01 ***<i>p</i><0.001.</p>", "links"=>[], "tags"=>["Clinical research design", "Cohort studies", "Mental health", "psychiatry", "Anxiety disorders", "Mood disorders", "Neuroses", "psychology", "behavior", "Psychological stress", "dysthymia", "mdd", "stressful"], "article_id"=>887514, "categories"=>["Medicine", "Sociology"], "users"=>["Wenqing Wu", "Zhoubing Wang", "Yan Wei", "Guanghua Zhang", "Shenxun Shi", "Jingfang Gao", "Youhui Li", "Ming Tao", "Kerang Zhang", "Xumei Wang", "Chengge Gao", "Lijun Yang", "Kan Li", "Jianguo Shi", "Gang Wang", "Lanfen Liu", "Jinbei Zhang", "Bo Du", "Guoqing Jiang", "Jianhua Shen", "Ying Liu", "Wei Liang", "Jing Sun", "Jian Hu", "Tiebang Liu", "Xueyi Wang", "Guodong Miao", "Huaqing Meng", "Yi Li", "Chunmei Hu", "Guoping Huang", "Gongying Li", "Baowei Ha", "Hong Deng", "Qiyi Mei", "Hui Zhong", "Shugui Gao", "Hong Sang", "Yutang Zhang", "Xiang Fang", "Fengyu Yu", "Donglin Yang", "Tieqiao Liu", "Yunchun Chen", "Xiaohong Hong", "Wenyuan Wu", "Guibing Chen", "Min Cai", "Yan Song", "Jiyang Pan", "Jicheng Dong", "Runde Pan", "Wei Zhang", "Zhenming Shen", "Zhengrong Liu", "Danhua Gu", "Xiaoping Wang", "Xiaojuan Liu", "Qiwen Zhang", "Yihan Li", "Yiping Chen", "Kenneth S. Kendler", "Jonathan Flint", "Zhen Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0083490.t002", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relation_between_dysthymia_with_MDD_and_stressful_life_events_/887514", "title"=>"Relation between dysthymia with MDD and stressful life events.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-27 02:50:28"}

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Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Medicine and health sciences/Pediatrics", "average_usage"=>[248, 430, 563, 680, 778, 859, 949, 1017, 1115, 1199, 1281, 1364, 1431]}, {"subject_area"=>"/People and places", "average_usage"=>[270, 456, 573, 676, 773, 867, 955, 1037, 1120, 1205, 1286, 1363, 1436]}, {"subject_area"=>"/Social sciences", "average_usage"=>[289, 475, 593, 703, 805, 902, 990, 1078, 1158, 1250, 1336, 1417, 1482]}, {"subject_area"=>"/Social sciences/Sociology", "average_usage"=>[310, 523, 656, 780, 900, 1024, 1120, 1219, 1308, 1395, 1468, 1570, 1642]}]}
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