Familial Young-Onset Diabetes, Pre-Diabetes and Cardiovascular Disease Are Associated with Genetic Variants of DACH1 in Chinese
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese", "type"=>"journal", "authors"=>[{"first_name"=>"Ronald Ching Wan", "last_name"=>"Ma", "scopus_author_id"=>"8151571700"}, {"first_name"=>"Heung Man", "last_name"=>"Lee", "scopus_author_id"=>"8961768400"}, {"first_name"=>"Vincent Kwok Lim", "last_name"=>"Lam", "scopus_author_id"=>"25655156200"}, {"first_name"=>"Claudia Ha Ting", "last_name"=>"Tam", "scopus_author_id"=>"24765688600"}, {"first_name"=>"Janice Siu Ka", "last_name"=>"Ho", "scopus_author_id"=>"56804258400"}, {"first_name"=>"Hai Lu", "last_name"=>"Zhao", "scopus_author_id"=>"56988020200"}, {"first_name"=>"Jing", "last_name"=>"Guan", "scopus_author_id"=>"37001522700"}, {"first_name"=>"Alice Pik Shan", "last_name"=>"Kong", "scopus_author_id"=>"34869982000"}, {"first_name"=>"Eric", "last_name"=>"Lau", "scopus_author_id"=>"54792557300"}, {"first_name"=>"Guozhi", "last_name"=>"Zhang", "scopus_author_id"=>"56804009300"}, {"first_name"=>"Andrea", "last_name"=>"Luk", "scopus_author_id"=>"25521975400"}, {"first_name"=>"Ying", "last_name"=>"Wang", "scopus_author_id"=>"56011629400"}, {"first_name"=>"Stephen Kwok Wing", "last_name"=>"Tsui", "scopus_author_id"=>"7004961364"}, {"first_name"=>"Ting Fung", "last_name"=>"Chan", "scopus_author_id"=>"36795660300"}, {"first_name"=>"Cheng", "last_name"=>"Hu", "scopus_author_id"=>"14121598300"}, {"first_name"=>"Wei Ping", "last_name"=>"Jia", "scopus_author_id"=>"34768292900"}, {"first_name"=>"Kyong Soo", "last_name"=>"Park", "scopus_author_id"=>"35243240300"}, {"first_name"=>"Hong Kyu", "last_name"=>"Lee", "scopus_author_id"=>"35285918800"}, {"first_name"=>"Hiroto", "last_name"=>"Furuta", "scopus_author_id"=>"7101983360"}, {"first_name"=>"Kishio", "last_name"=>"Nanjo", "scopus_author_id"=>"7006374555"}, {"first_name"=>"E.", "last_name"=>"Shyong Tai", "scopus_author_id"=>"7005660980"}, {"first_name"=>"Daniel Peng Keat", "last_name"=>"Ng", "scopus_author_id"=>"7201646516"}, {"first_name"=>"Nelson Leung Sang", "last_name"=>"Tang", "scopus_author_id"=>"56329175600"}, {"first_name"=>"Jean", "last_name"=>"Woo", "scopus_author_id"=>"36040369400"}, {"first_name"=>"Ping Chung", "last_name"=>"Leung", "scopus_author_id"=>"55085136200"}, {"first_name"=>"Hong", "last_name"=>"Xue", "scopus_author_id"=>"35235981600"}, {"first_name"=>"Jeffrey", "last_name"=>"Wong", "scopus_author_id"=>"24443138800"}, {"first_name"=>"Po Sing", "last_name"=>"Leung", "scopus_author_id"=>"7401748938"}, {"first_name"=>"Terrence C.K.", "last_name"=>"Lau", "scopus_author_id"=>"36981810500"}, {"first_name"=>"Peter Chun Yip", "last_name"=>"Tong", "scopus_author_id"=>"7102333153"}, {"first_name"=>"Gang", "last_name"=>"Xu", "scopus_author_id"=>"57069303900"}, {"first_name"=>"Maggie Chor Yin", "last_name"=>"Ng", "scopus_author_id"=>"35286019700"}, {"first_name"=>"Wing Yee", "last_name"=>"So", "scopus_author_id"=>"7004974019"}, {"first_name"=>"Juliana Chung Ngor", "last_name"=>"Chan", "scopus_author_id"=>"7403287000"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84907973860", "sgr"=>"84907973860", "pui"=>"372852989", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"24465431", "doi"=>"10.1371/journal.pone.0084770"}, "id"=>"1e7a2fc1-6636-34ef-ac5b-280ce439a0d6", "abstract"=>"In Asia, young-onset type 2 diabetes (YOD) is characterized by obesity and increased risk for cardiovascular disease (CVD). In a genome-wide association study (GWAS) of 99 Chinese obese subjects with familial YOD diagnosed before 40-year-old and 101 controls, the T allele of rs1408888 in intron 1 of DACH1(Dachshund homolog 1) was associated with an odds ratio (OR) of 2.49(95% confidence intervals:1.57-3.96, P = 8.4 × 10(-5)). Amongst these subjects, we found reduced expression of DACH1 in peripheral blood mononuclear cells (PBMC) from 63 cases compared to 65 controls (P = 0.02). In a random cohort of 1468 cases and 1485 controls, amongst top 19 SNPs from GWAS, rs1408888 was associated with type 2 diabetes with a global P value of 0.0176 and confirmation in a multiethnic Asian case-control cohort (7370/7802) with an OR of 1.07(1.02-1.12, P(meta)  = 0.012). In 599 Chinese non-diabetic subjects, rs1408888 was linearly associated with systolic blood pressure and insulin resistance. In a case-control cohort (n = 953/953), rs1408888 was associated with an OR of 1.54(1.07-2.22, P = 0.019) for CVD in type 2 diabetes. In an autopsy series of 173 non-diabetic cases, TT genotype of rs1408888 was associated with an OR of 3.31(1.19-9.19, P = 0.0214) and 3.27(1.25-11.07, P = 0.0184) for coronary heart disease (CHD) and coronary arteriosclerosis. Bioinformatics analysis revealed that rs1408888 lies within regulatory elements of DACH1 implicated in islet development and insulin secretion. The T allele of rs1408888 of DACH1 was associated with YOD, prediabetes and CVD in Chinese.", "link"=>"http://www.mendeley.com/research/familial-youngonset-diabetes-prediabetes-cardiovascular-disease-associated-genetic-variants-dach1-ch", "reader_count"=>26, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>2, "Researcher"=>3, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>2, "Researcher"=>3, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>6, "Computer Science"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Hong Kong"=>1, "Nigeria"=>1, "Portugal"=>1}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84907973860"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84907973860?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84907973860&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84907973860&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84907973860", "dc:identifier"=>"SCOPUS_ID:84907973860", "eid"=>"2-s2.0-84907973860", "dc:title"=>"Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese", "dc:creator"=>"Ma R.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"1", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-01-20", "prism:coverDisplayDate"=>"20 January 2014", "prism:doi"=>"10.1371/journal.pone.0084770", "citedby-count"=>"11", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Prince of Wales Hospital Hong Kong", "affiliation-city"=>nil, "affiliation-country"=>"Hong Kong"}, {"@_fa"=>"true", "affilname"=>"Chinese University of Hong Kong", "affiliation-city"=>"Shatin", "affiliation-country"=>"Hong Kong"}], "pubmed-id"=>"24465431", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e84770", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0084770", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"42", "xml_views"=>"6", "html_views"=>"100"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"117"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"131"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"3", "html_views"=>"112"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"124"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"63"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"64"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"65"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"39"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"47"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"65"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"7"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"10"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"10"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"4"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1352204"], "description"=>"<p>Regional plot showing significant association of rs1408888 in the <i>DACH1</i> locus. The –log<sub>10 </sub><i>P</i> values for the allelic test from stage 1 (genome scan) were plotted as a function of genomic position (NCBI build 36). Rs1408888 which showed the strongest signal and neighboring genotyped SNPs in the joint analysis were denoted by purple diamond. LD information (based on HapMap) was shown by color-coded points. Two neighboring SNPs rs9572813 and rs17791181, which showed nominal significance and moderate linkage disequilibrium (0.4 < r<sup>2</sup> < 0.6) with rs1408888 were indicated. Estimated recombination rate (the blue line) based on the Japanese and Chinese HapMap population was plotted to reflect the local LD structure around the significant SNPs. Gene annotations were taken from NCBI. <b>Lower panel:</b> Bioinformatics analysis of genomic region surrounding rs1408888. The region harboring rs1408888 lies in close vicinity of 2 highly conserved non-coding elements, CNE803 and OREG0002711. The two blue arrowheads at the end indicate the positions of rs1408888 (right blue dot) and rs9572813 (left blue dot). The three internal red arrows indicate the positions of the three SNPs (rs17252745, rs17252752 and rs57143718, red dots from left to right) genotyped by sequencing. The allele frequencies of the SNPs are shown in pie chart at the bottom. The alignment of the highly conserved fugu CNE803, the human sequence corresponding to the fugu CNE and the eye prepared EST BY797940 are also shown.</p>", "links"=>[], "tags"=>["Computational biology", "genomics", "Genome analysis tools", "Genome-wide association studies", "genetics", "Human genetics", "Genetic association studies", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "nutrition", "obesity"], "article_id"=>904808, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Ronald Ching Wan Ma", "Heung Man Lee", "Vincent Kwok Lim Lam", "Claudia Ha Ting Tam", "Janice Siu Ka Ho", "Hai-Lu Zhao", "Jing Guan", "Alice Pik Shan Kong", "Eric Lau", "Guozhi Zhang", "Andrea Luk", "Ying Wang", "Stephen Kwok Wing Tsui", "Ting Fung Chan", "Cheng Hu", "Wei Ping Jia", "Kyong Soo Park", "Hong Kyu Lee", "Hiroto Furuta", "Kishio Nanjo", "E. Shyong Tai", "Daniel Peng-Keat Ng", "Nelson Leung Sang Tang", "Jean Woo", "Ping Chung Leung", "Hong Xue", "Jeffrey Wong", "Po Sing Leung", "Terrence C. K. Lau", "Peter Chun Yip Tong", "Gang Xu", "Maggie Chor Yin Ng", "Wing Yee So", "Juliana Chung Ngor Chan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0084770.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Upper_panel_/904808", "title"=>"Upper panel:", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-20 03:59:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1352205"], "description"=>"<p>Expression level was normalized to the expression of β actin using the ΔΔCt method. The results are represented as mean ± standard error of the mean (SEM) with age and sex adjustment.</p>", "links"=>[], "tags"=>["Computational biology", "genomics", "Genome analysis tools", "Genome-wide association studies", "genetics", "Human genetics", "Genetic association studies", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "nutrition", "obesity", "quantitative", "Real-time", "peripheral", "mononuclear", "cells", "extracted", "65", "subjects", "63", "young-onset", "diabetic", "patients"], "article_id"=>904809, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Ronald Ching Wan Ma", "Heung Man Lee", "Vincent Kwok Lim Lam", "Claudia Ha Ting Tam", "Janice Siu Ka Ho", "Hai-Lu Zhao", "Jing Guan", "Alice Pik Shan Kong", "Eric Lau", "Guozhi Zhang", "Andrea Luk", "Ying Wang", "Stephen Kwok Wing Tsui", "Ting Fung Chan", "Cheng Hu", "Wei Ping Jia", "Kyong Soo Park", "Hong Kyu Lee", "Hiroto Furuta", "Kishio Nanjo", "E. Shyong Tai", "Daniel Peng-Keat Ng", "Nelson Leung Sang Tang", "Jean Woo", "Ping Chung Leung", "Hong Xue", "Jeffrey Wong", "Po Sing Leung", "Terrence C. K. Lau", "Peter Chun Yip Tong", "Gang Xu", "Maggie Chor Yin Ng", "Wing Yee So", "Juliana Chung Ngor Chan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0084770.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_DACH1_detected_by_quantitative_real_time_PCR_in_peripheral_blood_mononuclear_cells_PBMC_extracted_from_65_control_subjects_and_63_young_onset_type_2_diabetic_patients_DM_/904809", "title"=>"Expression of <i>DACH1</i> detected by quantitative real-time PCR, in peripheral blood mononuclear cells (PBMC) extracted from 65 control subjects and 63 young-onset type 2 diabetic patients (DM).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-20 03:59:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1352206"], "description"=>"<p>Flow chart summarizing the study design, subject recruitment, experiments and data analysis.</p>", "links"=>[], "tags"=>["Computational biology", "genomics", "Genome analysis tools", "Genome-wide association studies", "genetics", "Human genetics", "Genetic association studies", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "nutrition", "obesity", "summarizing", "experiments"], "article_id"=>904810, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Ronald Ching Wan Ma", "Heung Man Lee", "Vincent Kwok Lim Lam", "Claudia Ha Ting Tam", "Janice Siu Ka Ho", "Hai-Lu Zhao", "Jing Guan", "Alice Pik Shan Kong", "Eric Lau", "Guozhi Zhang", "Andrea Luk", "Ying Wang", "Stephen Kwok Wing Tsui", "Ting Fung Chan", "Cheng Hu", "Wei Ping Jia", "Kyong Soo Park", "Hong Kyu Lee", "Hiroto Furuta", "Kishio Nanjo", "E. Shyong Tai", "Daniel Peng-Keat Ng", "Nelson Leung Sang Tang", "Jean Woo", "Ping Chung Leung", "Hong Xue", "Jeffrey Wong", "Po Sing Leung", "Terrence C. K. Lau", "Peter Chun Yip Tong", "Gang Xu", "Maggie Chor Yin Ng", "Wing Yee So", "Juliana Chung Ngor Chan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0084770.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_chart_summarizing_the_study_design_subject_recruitment_experiments_and_data_analysis_/904810", "title"=>"Flow chart summarizing the study design, subject recruitment, experiments and data analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-20 03:59:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1352207"], "description"=>"<p>Meta-analysis of risk association of <i>DACH1</i> rs1408888 with Type 2 diabetes in independent multi-ethnic Asian case-control cohorts.</p>", "links"=>[], "tags"=>["Computational biology", "genomics", "Genome analysis tools", "Genome-wide association studies", "genetics", "Human genetics", "Genetic association studies", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "nutrition", "obesity", "rs1408888", "multi-ethnic", "asian", "case-control"], "article_id"=>904811, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Ronald Ching Wan Ma", "Heung Man Lee", "Vincent Kwok Lim Lam", "Claudia Ha Ting Tam", "Janice Siu Ka Ho", "Hai-Lu Zhao", "Jing Guan", "Alice Pik Shan Kong", "Eric Lau", "Guozhi Zhang", "Andrea Luk", "Ying Wang", "Stephen Kwok Wing Tsui", "Ting Fung Chan", "Cheng Hu", "Wei Ping Jia", "Kyong Soo Park", "Hong Kyu Lee", "Hiroto Furuta", "Kishio Nanjo", "E. Shyong Tai", "Daniel Peng-Keat Ng", "Nelson Leung Sang Tang", "Jean Woo", "Ping Chung Leung", "Hong Xue", "Jeffrey Wong", "Po Sing Leung", "Terrence C. K. Lau", "Peter Chun Yip Tong", "Gang Xu", "Maggie Chor Yin Ng", "Wing Yee So", "Juliana Chung Ngor Chan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0084770.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Meta_analysis_of_risk_association_of_DACH1_rs1408888_with_Type_2_diabetes_in_independent_multi_ethnic_Asian_case_control_cohorts_/904811", "title"=>"Meta-analysis of risk association of <i>DACH1</i> rs1408888 with Type 2 diabetes in independent multi-ethnic Asian case-control cohorts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-20 03:59:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1352208"], "description"=>"<p>Data are expressed as <i>n</i>, mean±SD or median (interquartile range). <i>P</i> values were calculated from linear regression adjusted for sex and age assuming an additive model. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as (FPI ×FPG)÷22.5, and homeostasis model assessment of beta-cell function (HOMA-β) was calculated as FPI×20÷(FPG–3.5) where FPI = fasting plasma insulin and FPG = fasting plasma glucose. Beta cell function (×10<sup>−6</sup>) was determined by the formula: [insulin AUC<sub>30min</sub> (min.pmol/l)÷glucose AUC<sub>30min</sub> (min.mmol/l)] where AUC = area under curve. Insulinogenic index was calculated as (FPI during OGTT for 30 min – 0 min) ÷(FPG during OGTT for 30 min – 0 min) where OGTT = 75 gram oral glucose tolerance test.</p>", "links"=>[], "tags"=>["Computational biology", "genomics", "Genome analysis tools", "Genome-wide association studies", "genetics", "Human genetics", "Genetic association studies", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "nutrition", "obesity", "metabolic", "hong", "kong", "chinese", "adults", "stratified", "genotypes"], "article_id"=>904812, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Ronald Ching Wan Ma", "Heung Man Lee", "Vincent Kwok Lim Lam", "Claudia Ha Ting Tam", "Janice Siu Ka Ho", "Hai-Lu Zhao", "Jing Guan", "Alice Pik Shan Kong", "Eric Lau", "Guozhi Zhang", "Andrea Luk", "Ying Wang", "Stephen Kwok Wing Tsui", "Ting Fung Chan", "Cheng Hu", "Wei Ping Jia", "Kyong Soo Park", "Hong Kyu Lee", "Hiroto Furuta", "Kishio Nanjo", "E. Shyong Tai", "Daniel Peng-Keat Ng", "Nelson Leung Sang Tang", "Jean Woo", "Ping Chung Leung", "Hong Xue", "Jeffrey Wong", "Po Sing Leung", "Terrence C. K. Lau", "Peter Chun Yip Tong", "Gang Xu", "Maggie Chor Yin Ng", "Wing Yee So", "Juliana Chung Ngor Chan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0084770.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_and_metabolic_characteristics_of_Hong_Kong_Chinese_healthy_adults_stratified_according_to_the_genotypes_of_DACH1_rs1408888_/904812", "title"=>"Clinical and metabolic characteristics of Hong Kong Chinese healthy adults stratified according to the genotypes of <i>DACH1</i> rs1408888.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-20 03:59:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1352209"], "description"=>"*<p><b>Nearest Entrez genes within 250 Kb.</b></p><p>Stage 1 (genome scan) included 99 young-onset familial T2D patients and 101 controls. Stage 2 (replication stage) included 1468 T2D patients and 1485 controls. <i>P</i><sub>Allelic</sub> and <i>P</i><sub>permutation</sub> represent <i>P</i> values of allelic test and after permutation of 10,000 times based on 19 SNPs in stage 2, respectively.</p><p>Risk allele refers to the allele with a higher frequency in T2D patients than in controls in stage 1.</p><p>RAF (T2D) and RAF (Controls), risk allele frequencies in T2D patients and controls, respectively.</p><p>OR, odds ratio are reported with respect to the risk allele.</p>", "links"=>[], "tags"=>["Computational biology", "genomics", "Genome analysis tools", "Genome-wide association studies", "genetics", "Human genetics", "Genetic association studies", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "nutrition", "obesity", "snps", "familial", "young-onset", "hong", "kong", "chinese", "genome-wide", "illumina", "humanhap550"], "article_id"=>904813, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Ronald Ching Wan Ma", "Heung Man Lee", "Vincent Kwok Lim Lam", "Claudia Ha Ting Tam", "Janice Siu Ka Ho", "Hai-Lu Zhao", "Jing Guan", "Alice Pik Shan Kong", "Eric Lau", "Guozhi Zhang", "Andrea Luk", "Ying Wang", "Stephen Kwok Wing Tsui", "Ting Fung Chan", "Cheng Hu", "Wei Ping Jia", "Kyong Soo Park", "Hong Kyu Lee", "Hiroto Furuta", "Kishio Nanjo", "E. Shyong Tai", "Daniel Peng-Keat Ng", "Nelson Leung Sang Tang", "Jean Woo", "Ping Chung Leung", "Hong Xue", "Jeffrey Wong", "Po Sing Leung", "Terrence C. K. Lau", "Peter Chun Yip Tong", "Gang Xu", "Maggie Chor Yin Ng", "Wing Yee So", "Juliana Chung Ngor Chan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0084770.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_SNPs_with_familial_young_onset_Type_2_diabetes_and_obesity_in_Hong_Kong_Chinese_in_a_genome_wide_association_study_using_Illumina_HumanHap550_chip_with_P_values_less_than_10_8722_4_/904813", "title"=>"Association of SNPs with familial young-onset Type 2 diabetes and obesity in Hong Kong Chinese in a genome-wide association study using Illumina HumanHap550 chip with <i>P</i> values less than 10<sup>−4</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-20 03:59:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1352210"], "description"=>"<p>Data are expressed in mean±SD or median(interquatile range) or n, %). <sup>*</sup><i>P</i> values and ORs were estimated by the logistic regression with adjustment for logarithm of eGFR.</p><p>Cardiovascular diseases was diagnosed based on clinical history and assessment at enrolment to the Hong Kong Diabetes Registry and/or subsequent events defined by the International Classification of Diseases, Ninth Revision (ICD-9), retrieved from the Hong Kong Death Registry and Hong Kong Hospital Authority (HA) Central Computer System. Coronary heart disease (CHD) was defined as myocardial infarction (ICD-9 code 410), ischemic heart disease (ICD-9 code 411-414) or death due to CHD (ICD-9 code 410-414). Stroke was defined as non-fatal (ICD-9 code 432-434, 436) or fatal ischemic stroke (ICD-9 code 432-438), or, hemorrhagic stroke as defined by fatal and non-fatal subarachnoid hemorrhage (ICD-9 code 430), intracerebral hemorrhage (ICD-9 code 431) or other/unspecified intracranial hemorrhage (ICD-9 code 432). Peripheral vascular disease (PVD) was defined as ankle-brachial ratio<0.9 using Doppler ultrasound scan, diabetes with peripheral circulatory disorders (ICD-9 code 250.7), gangrene (ICD-9 code 785.4), angiopathy in diseases classified elsewhere (ICD-9 code 443.81), peripheral vascular disease unspecified (ICD-9 code 443.9), other peripheral vascular shunt or bypass (procedure code 39.29), insertion of non-drug-eluting peripheral vessel stents (procedure code 39.90) or amputation of lower limb (procedure code 84.1) without a traumatic amputation diagnosis code (ICD-9 code 895-897).</p>", "links"=>[], "tags"=>["Computational biology", "genomics", "Genome analysis tools", "Genome-wide association studies", "genetics", "Human genetics", "Genetic association studies", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "nutrition", "obesity", "metabolic", "case-control", "cohort", "hong", "kong", "chinese", "diabetic", "patients", "cardiovascular", "matched"], "article_id"=>904814, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Ronald Ching Wan Ma", "Heung Man Lee", "Vincent Kwok Lim Lam", "Claudia Ha Ting Tam", "Janice Siu Ka Ho", "Hai-Lu Zhao", "Jing Guan", "Alice Pik Shan Kong", "Eric Lau", "Guozhi Zhang", "Andrea Luk", "Ying Wang", "Stephen Kwok Wing Tsui", "Ting Fung Chan", "Cheng Hu", "Wei Ping Jia", "Kyong Soo Park", "Hong Kyu Lee", "Hiroto Furuta", "Kishio Nanjo", "E. Shyong Tai", "Daniel Peng-Keat Ng", "Nelson Leung Sang Tang", "Jean Woo", "Ping Chung Leung", "Hong Xue", "Jeffrey Wong", "Po Sing Leung", "Terrence C. K. Lau", "Peter Chun Yip Tong", "Gang Xu", "Maggie Chor Yin Ng", "Wing Yee So", "Juliana Chung Ngor Chan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0084770.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_and_metabolic_characteristics_of_a_case_control_cohort_of_Hong_Kong_Chinese_Type_2_diabetic_patients_with_or_without_cardiovascular_disease_CVD_matched_for_age_sex_and_disease_duration_/904814", "title"=>"Clinical and metabolic characteristics of a case-control cohort of Hong Kong Chinese Type 2 diabetic patients with or without cardiovascular disease (CVD) matched for age, sex and disease duration.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-20 03:59:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1352211"], "description"=>"<p>Clinical profiles of discovery, replication and validation cohorts in a 3-stage genome wide association study in Asian populations.</p>", "links"=>[], "tags"=>["Computational biology", "genomics", "Genome analysis tools", "Genome-wide association studies", "genetics", "Human genetics", "Genetic association studies", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "nutrition", "obesity", "profiles", "replication", "validation", "cohorts", "3-stage", "genome", "asian"], "article_id"=>904815, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Ronald Ching Wan Ma", "Heung Man Lee", "Vincent Kwok Lim Lam", "Claudia Ha Ting Tam", "Janice Siu Ka Ho", "Hai-Lu Zhao", "Jing Guan", "Alice Pik Shan Kong", "Eric Lau", "Guozhi Zhang", "Andrea Luk", "Ying Wang", "Stephen Kwok Wing Tsui", "Ting Fung Chan", "Cheng Hu", "Wei Ping Jia", "Kyong Soo Park", "Hong Kyu Lee", "Hiroto Furuta", "Kishio Nanjo", "E. Shyong Tai", "Daniel Peng-Keat Ng", "Nelson Leung Sang Tang", "Jean Woo", "Ping Chung Leung", "Hong Xue", "Jeffrey Wong", "Po Sing Leung", "Terrence C. K. Lau", "Peter Chun Yip Tong", "Gang Xu", "Maggie Chor Yin Ng", "Wing Yee So", "Juliana Chung Ngor Chan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0084770.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_profiles_of_discovery_replication_and_validation_cohorts_in_a_3_stage_genome_wide_association_study_in_Asian_populations_/904815", "title"=>"Clinical profiles of discovery, replication and validation cohorts in a 3-stage genome wide association study in Asian populations.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-20 03:59:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1352212"], "description"=>"<div><p>In Asia, young-onset type 2 diabetes (YOD) is characterized by obesity and increased risk for cardiovascular disease (CVD). In a genome-wide association study (GWAS) of 99 Chinese obese subjects with familial YOD diagnosed before 40-year-old and 101 controls, the T allele of rs1408888 in intron 1 of <i>DACH1</i>(Dachshund homolog 1) was associated with an odds ratio (OR) of 2.49(95% confidence intervals:1.57–3.96, <i>P</i> = 8.4×10<sup>−5</sup>). Amongst these subjects, we found reduced expression of <i>DACH1</i> in peripheral blood mononuclear cells (PBMC) from 63 cases compared to 65 controls (<i>P</i> = 0.02). In a random cohort of 1468 cases and 1485 controls, amongst top 19 SNPs from GWAS, rs1408888 was associated with type 2 diabetes with a global <i>P</i> value of 0.0176 and confirmation in a multiethnic Asian case-control cohort (7370/7802) with an OR of 1.07(1.02–1.12, <i>P<sub>meta</sub></i> = 0.012). In 599 Chinese non-diabetic subjects, rs1408888 was linearly associated with systolic blood pressure and insulin resistance. In a case-control cohort (n = 953/953), rs1408888 was associated with an OR of 1.54(1.07–2.22, <i>P</i> = 0.019) for CVD in type 2 diabetes. In an autopsy series of 173 non-diabetic cases, TT genotype of rs1408888 was associated with an OR of 3.31(1.19–9.19, <i>P</i> = 0.0214) and 3.27(1.25–11.07, <i>P</i> = 0.0184) for coronary heart disease (CHD) and coronary arteriosclerosis. Bioinformatics analysis revealed that rs1408888 lies within regulatory elements of <i>DACH1</i> implicated in islet development and insulin secretion. The T allele of rs1408888 of <i>DACH1</i> was associated with YOD, prediabetes and CVD in Chinese.</p></div>", "links"=>[], "tags"=>["Computational biology", "genomics", "Genome analysis tools", "Genome-wide association studies", "genetics", "Human genetics", "Genetic association studies", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "nutrition", "obesity", "familial", "young-onset", "pre-diabetes", "cardiovascular", "variants", "chinese"], "article_id"=>904816, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Ronald Ching Wan Ma", "Heung Man Lee", "Vincent Kwok Lim Lam", "Claudia Ha Ting Tam", "Janice Siu Ka Ho", "Hai-Lu Zhao", "Jing Guan", "Alice Pik Shan Kong", "Eric Lau", "Guozhi Zhang", "Andrea Luk", "Ying Wang", "Stephen Kwok Wing Tsui", "Ting Fung Chan", "Cheng Hu", "Wei Ping Jia", "Kyong Soo Park", "Hong Kyu Lee", "Hiroto Furuta", "Kishio Nanjo", "E. Shyong Tai", "Daniel Peng-Keat Ng", "Nelson Leung Sang Tang", "Jean Woo", "Ping Chung Leung", "Hong Xue", "Jeffrey Wong", "Po Sing Leung", "Terrence C. K. Lau", "Peter Chun Yip Tong", "Gang Xu", "Maggie Chor Yin Ng", "Wing Yee So", "Juliana Chung Ngor Chan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0084770"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Familial_Young_Onset_Diabetes_Pre_Diabetes_and_Cardiovascular_Disease_Are_Associated_with_Genetic_Variants_of_DACH1_in_Chinese/904816", "title"=>"Familial Young-Onset Diabetes, Pre-Diabetes and Cardiovascular Disease Are Associated with Genetic Variants of <i>DACH1</i> in Chinese", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-20 03:59:37"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"53", "full-text"=>"51", "pdf"=>"21", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"40", "full-text"=>"41", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"39", "full-text"=>"47", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"25", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"35", "full-text"=>"30", "pdf"=>"21", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"24", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"29", "full-text"=>"29", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"37", "full-text"=>"33", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"25", "full-text"=>"34", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"33", "full-text"=>"30", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"54", "full-text"=>"41", "pdf"=>"12", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"2", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"28", "full-text"=>"29", "pdf"=>"19", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"30", "full-text"=>"31", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"27", "full-text"=>"28", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"35", "full-text"=>"35", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"24", "full-text"=>"20", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"23", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"19", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"16", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[282]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[280]}, {"subject_area"=>"/Medicine and health sciences/Cardiology", "average_usage"=>[246]}, {"subject_area"=>"/Medicine and health sciences/Endocrinology", "average_usage"=>[282, 453]}, {"subject_area"=>"/Medicine and health sciences/Metabolic disorders", "average_usage"=>[252, 402]}, {"subject_area"=>"/People and places/Geographical locations", "average_usage"=>[298]}]}
Loading … Spinner
There are currently no alerts