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{"title"=>"Morphological differences between circulating tumor cells from prostate cancer patients and cultured prostate cancer cells", "type"=>"journal", "authors"=>[{"first_name"=>"Sunyoung", "last_name"=>"Park", "scopus_author_id"=>"57197524661"}, {"first_name"=>"Richard R.", "last_name"=>"Ang", "scopus_author_id"=>"56084737400"}, {"first_name"=>"Simon P.", "last_name"=>"Duffy", "scopus_author_id"=>"56350389600"}, {"first_name"=>"Jenny", "last_name"=>"Bazov", "scopus_author_id"=>"55704564800"}, {"first_name"=>"Kim N.", "last_name"=>"Chi", "scopus_author_id"=>"7102221563"}, {"first_name"=>"Peter C.", "last_name"=>"Black", "scopus_author_id"=>"7401834843"}, {"first_name"=>"Hongshen", "last_name"=>"Ma", "scopus_author_id"=>"56368152800"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84896944109", "sgr"=>"84896944109", "issn"=>"19326203", "isbn"=>"1932-6203", "pmid"=>"24416373", "doi"=>"10.1371/journal.pone.0085264", "pui"=>"372704125"}, "id"=>"8e7b2e15-3034-3599-bb7f-c2a3b5608879", "abstract"=>"Circulating tumor cell (CTC) enumeration promises to be an important predictor of clinical outcome for a range of cancers. Established CTC enumeration methods primarily rely on affinity capture of cell surface antigens, and have been criticized for underestimation of CTC numbers due to antigenic bias. Emerging CTC capture strategies typically distinguish these cells based on their assumed biomechanical characteristics, which are often validated using cultured cancer cells. In this study, we developed a software tool to investigate the morphological properties of CTCs from patients with castrate resistant prostate cancer and cultured prostate cancer cells in order to establish whether the latter is an appropriate model for the former. We isolated both CTCs and cultured cancer cells from whole blood using the CellSearch® system and examined various cytomorphological characteristics. In contrast with cultured cancer cells, CTCs enriched by CellSearch® system were found to have significantly smaller size, larger nuclear-cytoplasmic ratio, and more elongated shape. These CTCs were also found to exhibit significantly more variability than cultured cancer cells in nuclear-cytoplasmic ratio and shape profile.", "link"=>"http://www.mendeley.com/research/morphological-differences-between-circulating-tumor-cells-prostate-cancer-patients-cultured-prostate", "reader_count"=>77, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>4, "Researcher"=>16, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>26, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>11, "Student > Bachelor"=>9, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>4, "Researcher"=>16, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>26, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>11, "Student > Bachelor"=>9, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>17, "Biochemistry, Genetics and Molecular Biology"=>7, "Materials Science"=>2, "Mathematics"=>1, "Agricultural and Biological Sciences"=>18, "Medicine and Dentistry"=>14, "Veterinary Science and Veterinary Medicine"=>1, "Physics and Astronomy"=>9, "Chemistry"=>5}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>17}, "Materials Science"=>{"Materials Science"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Chemistry"=>{"Chemistry"=>5}, "Physics and Astronomy"=>{"Physics and Astronomy"=>9}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>18}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>1, "France"=>1, "Portugal"=>1, "India"=>1}, "group_count"=>1}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/1342442"], "description"=>"<p>Labview software performs the series of operations on large varying mages datasets provided by the CellSearch® system. Two parallel filtering and measurements, such as calculating area in pixels (A) and estimating the best-fit ellipse (B) are performed for optimal performance and results.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Cellular structures", "Cell nucleus", "Bioengineering", "Biomedical Engineering", "Anatomy and physiology", "Cell physiology", "oncology", "Basic cancer research", "urology", "Prostate diseases", "Prostate cancer", "labview"], "article_id"=>897227, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Sunyoung Park", "Richard R. Ang", "Simon P. Duffy", "Jenny Bazov", "Kim N. Chi", "Peter C. Black", "Hongshen Ma"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0085264.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Image_data_processing_using_LabView_software_/897227", "title"=>"Image data processing using LabView software.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 04:20:08"}
• {"files"=>["https://ndownloader.figshare.com/files/1342443"], "description"=>"<p>The average diameter of CTCs (7.97 µm) was significantly smaller than cultured cancer cells (13.38 µm) (p<0.001).</p>", "links"=>[], "tags"=>["Molecular cell biology", "Cellular structures", "Cell nucleus", "Bioengineering", "Biomedical Engineering", "Anatomy and physiology", "Cell physiology", "oncology", "Basic cancer research", "urology", "Prostate diseases", "Prostate cancer", "ctcs", "prostate", "cancer", "patients", "cultured"], "article_id"=>897228, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Sunyoung Park", "Richard R. Ang", "Simon P. Duffy", "Jenny Bazov", "Kim N. Chi", "Peter C. Black", "Hongshen Ma"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0085264.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Diameters_of_CTCs_from_prostate_cancer_patients_pre_treatment_and_cultured_prostate_cancer_cells_/897228", "title"=>"Diameters of CTCs from prostate cancer patients (pre-treatment) and cultured prostate cancer cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 04:20:08"}
• {"files"=>["https://ndownloader.figshare.com/files/1342452"], "description"=>"<p>CTCs were noticeably smaller than cultured cancer cells (A–D). Cultured cancer cells were mostly round with regular cell and nuclear shapes. The nucleus was typically centered and surrounded by cytokeratin (E–L). CTCs exhibited highly variable shapes, including round (E), oval (F), elongated (G–J), and clusters (L). Non-round and multi-nucleate cells were sometimes observed (G–K). The yellow scale bar is 5 µm in length.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Cellular structures", "Cell nucleus", "Bioengineering", "Biomedical Engineering", "Anatomy and physiology", "Cell physiology", "oncology", "Basic cancer research", "urology", "Prostate diseases", "Prostate cancer", "images", "cultured", "prostate", "cancer", "ctcs", "patients", "captured"], "article_id"=>897230, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Sunyoung Park", "Richard R. Ang", "Simon P. Duffy", "Jenny Bazov", "Kim N. Chi", "Peter C. Black", "Hongshen Ma"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0085264.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Example_images_of_cultured_prostate_cancer_cell_A_8211_D_and_CTCs_from_prostate_cancer_patients_E_8211_L_captured_using_the_CellSearch_174_system_/897230", "title"=>"Example images of cultured prostate cancer cell (A–D) and CTCs from prostate cancer patients (E–L) captured using the CellSearch® system.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 04:20:08"}
• {"files"=>["https://ndownloader.figshare.com/files/1342453"], "description"=>"<p>A: Elongation factor (EF) of CTCs from prostate cancer patients compared with cultured prostate cancer cells. The median EF of CTCs was generally greater with significant inter- and intra-patient variability. B: Nuclear cytoplasmic (N/C) ratios of CTCs from prostate cancer patients compared with cultured prostate cancer cells. Median with upper and lower quartiles is shown for each sample. The median N/C ratio for CTCs was generally greater with significant inter- and intra-patient variability.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Cellular structures", "Cell nucleus", "Bioengineering", "Biomedical Engineering", "Anatomy and physiology", "Cell physiology", "oncology", "Basic cancer research", "urology", "Prostate diseases", "Prostate cancer", "cytoplasmic"], "article_id"=>897231, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Sunyoung Park", "Richard R. Ang", "Simon P. Duffy", "Jenny Bazov", "Kim N. Chi", "Peter C. Black", "Hongshen Ma"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0085264.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Elongation_Factor_and_Nuclear_Cytoplasmic_Ratios_/897231", "title"=>"Elongation Factor and Nuclear Cytoplasmic Ratios.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 04:20:08"}
• {"files"=>["https://ndownloader.figshare.com/files/1342454"], "description"=>"<p>A: The diameter of cultured prostate cancer cells decreased ∼6% on average. B: The nuclear diameter of cultured prostate cancer cells decreased ∼10% on average.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Cellular structures", "Cell nucleus", "Bioengineering", "Biomedical Engineering", "Anatomy and physiology", "Cell physiology", "oncology", "Basic cancer research", "urology", "Prostate diseases", "Prostate cancer", "nucleus", "days", "cellsave"], "article_id"=>897232, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Sunyoung Park", "Richard R. Ang", "Simon P. Duffy", "Jenny Bazov", "Kim N. Chi", "Peter C. Black", "Hongshen Ma"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0085264.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_cell_and_nucleus_after_two_days_of_storage_in_the_CellSave_tubes_/897232", "title"=>"Changes in cell and nucleus after two days of storage in the CellSave tubes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 04:20:08"}
• {"files"=>["https://ndownloader.figshare.com/files/1342455", "https://ndownloader.figshare.com/files/1342456", "https://ndownloader.figshare.com/files/1342457", "https://ndownloader.figshare.com/files/1342458"], "description"=>"<div><p>Circulating tumor cell (CTC) enumeration promises to be an important predictor of clinical outcome for a range of cancers. Established CTC enumeration methods primarily rely on affinity capture of cell surface antigens, and have been criticized for underestimation of CTC numbers due to antigenic bias. Emerging CTC capture strategies typically distinguish these cells based on their assumed biomechanical characteristics, which are often validated using cultured cancer cells. In this study, we developed a software tool to investigate the morphological properties of CTCs from patients with castrate resistant prostate cancer and cultured prostate cancer cells in order to establish whether the latter is an appropriate model for the former. We isolated both CTCs and cultured cancer cells from whole blood using the CellSearch® system and examined various cytomorphological characteristics. In contrast with cultured cancer cells, CTCs enriched by CellSearch® system were found to have significantly smaller size, larger nuclear-cytoplasmic ratio, and more elongated shape. These CTCs were also found to exhibit significantly more variability than cultured cancer cells in nuclear-cytoplasmic ratio and shape profile.</p></div>", "links"=>[], "tags"=>["Molecular cell biology", "Cellular structures", "Cell nucleus", "Bioengineering", "Biomedical Engineering", "Anatomy and physiology", "Cell physiology", "oncology", "Basic cancer research", "urology", "Prostate diseases", "Prostate cancer", "differences", "circulating", "cells", "prostate", "cancer", "patients", "cultured"], "article_id"=>897233, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Sunyoung Park", "Richard R. Ang", "Simon P. Duffy", "Jenny Bazov", "Kim N. Chi", "Peter C. Black", "Hongshen Ma"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0085264.s001", "https://dx.doi.org/10.1371/journal.pone.0085264.s002", "https://dx.doi.org/10.1371/journal.pone.0085264.s003", "https://dx.doi.org/10.1371/journal.pone.0085264.s004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Morphological_Differences_between_Circulating_Tumor_Cells_from_Prostate_Cancer_Patients_and_Cultured_Prostate_Cancer_Cells_/897233", "title"=>"Morphological Differences between Circulating Tumor Cells from Prostate Cancer Patients and Cultured Prostate Cancer Cells", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-01-08 04:20:08"}

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Relative Metric

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F1000Prime