Atheroprotective Effect of Oleoylethanolamide (OEA) Targeting Oxidized LDL
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{"title"=>"Atheroprotective effect of Oleoylethanolamide (OEA) targeting oxidized LDL", "type"=>"journal", "authors"=>[{"first_name"=>"Angran", "last_name"=>"Fan", "scopus_author_id"=>"56503174300"}, {"first_name"=>"Xiaofeng", "last_name"=>"Wu", "scopus_author_id"=>"56687839600"}, {"first_name"=>"Huijuan", "last_name"=>"Wu", "scopus_author_id"=>"56687850900"}, {"first_name"=>"Long", "last_name"=>"Li", "scopus_author_id"=>"55836057900"}, {"first_name"=>"Rui", "last_name"=>"Huang", "scopus_author_id"=>"56687990800"}, {"first_name"=>"Yueyong", "last_name"=>"Zhu", "scopus_author_id"=>"7406072660"}, {"first_name"=>"Yan", "last_name"=>"Qiu", "scopus_author_id"=>"56658954700"}, {"first_name"=>"Jin", "last_name"=>"Fu", "scopus_author_id"=>"35229214200"}, {"first_name"=>"Jie", "last_name"=>"Ren", "scopus_author_id"=>"56658933500"}, {"first_name"=>"Chenggang", "last_name"=>"Zhu", "scopus_author_id"=>"56328324600"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24465540", "sgr"=>"84921417873", "doi"=>"10.1371/journal.pone.0085337", "scopus"=>"2-s2.0-84921417873", "pui"=>"372853010", "issn"=>"19326203"}, "id"=>"e58f940c-483e-3398-a347-08af15227c63", "abstract"=>"Dietary fat-derived lipid oleoylethanolamide (OEA) has shown to modulate lipid metabolism through a peroxisome proliferator-activated receptor-alpha (PPAR-α)-mediated mechanism. In our study, we further demonstrated that OEA, as an atheroprotective agent, modulated the atherosclerotic plaques development. In vitro studies showed that OEA antagonized oxidized LDL (ox-LDL)-induced vascular endothelial cell proliferation and vascular smooth muscle cell migration, and suppressed lipopolysaccharide (LPS)-induced LDL modification and inflammation. In vivo studies, atherosclerosis animals were established using balloon-aortic denudation (BAD) rats and ApoE(-/-) mice fed with high-caloric diet (HCD) for 17 or 14 weeks respectively, and atherosclerotic plaques were evaluated by oil red staining. The administration of OEA (5 mg/kg/day, intraperitoneal injection, i.p.) prevented or attenuated the formation of atherosclerotic plaques in HCD-BAD rats or HCD-ApoE(-/-) mice. Gene expression analysis of vessel tissues from these animals showed that OEA induced the mRNA expressions of PPAR-α and downregulated the expression of M-CFS, an atherosclerotic marker, and genes involved in oxidation and inflammation, including iNOS, COX-2, TNF-α and IL-6. Collectively, our results suggested that OEA exerted a pharmacological effect on modulating atherosclerotic plaque formation through the inhibition of LDL modification in vascular system and therefore be a potential candidate for anti-atherosclerosis drug.", "link"=>"http://www.mendeley.com/research/atheroprotective-effect-oleoylethanolamide-oea-targeting-oxidized-ldl", "reader_count"=>14, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Master"=>2, "Other"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Master"=>2, "Other"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>5, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1351508"], "description"=>"<p>The effect of OEA combined with or without MK886 on mRNA expression levels of PPAR-α (A), iNOS (B) and COX-2 (C), assessed by real-time quantitative PCR, on RAW246.7 cells treated with LPS, LDL or LPS/LDL. Vehicle, saline; LPS, 0.5 μg/ml; LDL, 50 μg/ml; OEA, 50 μM; MK886, 10 μM. * p<0.05, *** p<0.001, one-way ANOVA, n = 6.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "neutral lipids", "metabolism", "proteins", "lipoproteins", "Lipoprotein metabolism", "Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "suppressed", "lps-induced", "inflammation", "mediated"], "article_id"=>904240, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Angran Fan", "Xiaofeng Wu", "Huijuan Wu", "Long Li", "Rui Huang", "Yueyong Zhu", "Yan Qiu", "Jin Fu", "Jie Ren", "Chenggang Zhu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085337.g004", "stats"=>{"downloads"=>6, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_OEA_suppressed_LPS_induced_inflammation_mediated_through_PPAR_945_signaling_/904240", "title"=>"OEA suppressed LPS-induced inflammation mediated through PPAR-α signaling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-20 03:16:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1351513"], "description"=>"<p>(A–D), The effect of vehicle (A–C) or OEA (D) on atherosclerotic plaque formation in BAD rats fed with normal diet (BAD-ND, A), sham-operated rats fed with high-caloric diet (sham-HCD, B), and BAD rats fed with HCD (BAD-HACD, C-D). Scale bar, 50 μm. (E–J), The effect of vehicle (−) or OEA (+) on mRNA expression levels of PPAR-α (E), M-CSF (F), iNOS (G), CRP (H), TNF-α (I) and IL-6 (J) in aorta tissues of BAD-ND rats, sham-HCD rats and BAD-HCD rats. Vehicle, 5% PEG/5% Tween-80 in saline; OEA, 5 mg/kg/day, i.p.; * p<0.05, ** p<0.01, *** p<0.001, one-way ANOVA, n = 7–9 rats/group.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "neutral lipids", "metabolism", "proteins", "lipoproteins", "Lipoprotein metabolism", "Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "prevented", "atherosclerotic", "plaque"], "article_id"=>904242, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Angran Fan", "Xiaofeng Wu", "Huijuan Wu", "Long Li", "Rui Huang", "Yueyong Zhu", "Yan Qiu", "Jin Fu", "Jie Ren", "Chenggang Zhu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085337.g005", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_OEA_prevented_atherosclerotic_plaque_formation_in_BAD_rats_/904242", "title"=>"OEA prevented atherosclerotic plaque formation in BAD rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-20 03:16:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1351538", "https://ndownloader.figshare.com/files/1351539", "https://ndownloader.figshare.com/files/1351540", "https://ndownloader.figshare.com/files/1351542", "https://ndownloader.figshare.com/files/1351543", "https://ndownloader.figshare.com/files/1351544", "https://ndownloader.figshare.com/files/1351545", "https://ndownloader.figshare.com/files/1351546", "https://ndownloader.figshare.com/files/1351547"], "description"=>"<div><p>Dietary fat-derived lipid oleoylethanolamide (OEA) has shown to modulate lipid metabolism through a peroxisome proliferator-activated receptor-alpha (PPAR-α)-mediated mechanism. In our study, we further demonstrated that OEA, as an atheroprotective agent, modulated the atherosclerotic plaques development. <i>In vitro</i> studies showed that OEA antagonized oxidized LDL (ox-LDL)-induced vascular endothelial cell proliferation and vascular smooth muscle cell migration, and suppressed lipopolysaccharide (LPS)-induced LDL modification and inflammation. <i>In vivo</i> studies, atherosclerosis animals were established using balloon-aortic denudation (BAD) rats and ApoE<sup>-/-</sup> mice fed with high-caloric diet (HCD) for 17 or 14 weeks respectively, and atherosclerotic plaques were evaluated by oil red staining. The administration of OEA (5 mg/kg/day, intraperitoneal injection, i.p.) prevented or attenuated the formation of atherosclerotic plaques in HCD-BAD rats or HCD-ApoE<sup>−/−</sup> mice. Gene expression analysis of vessel tissues from these animals showed that OEA induced the mRNA expressions of PPAR-α and downregulated the expression of M-CFS, an atherosclerotic marker, and genes involved in oxidation and inflammation, including iNOS, COX-2, TNF-α and IL-6. Collectively, our results suggested that OEA exerted a pharmacological effect on modulating atherosclerotic plaque formation through the inhibition of LDL modification in vascular system and therefore be a potential candidate for anti-atherosclerosis drug.</p></div>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "neutral lipids", "metabolism", "proteins", "lipoproteins", "Lipoprotein metabolism", "Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "oleoylethanolamide", "targeting", "oxidized"], "article_id"=>904261, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Angran Fan", "Xiaofeng Wu", "Huijuan Wu", "Long Li", "Rui Huang", "Yueyong Zhu", "Yan Qiu", "Jin Fu", "Jie Ren", "Chenggang Zhu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0085337.s001", "https://dx.doi.org/10.1371/journal.pone.0085337.s002", "https://dx.doi.org/10.1371/journal.pone.0085337.s003", "https://dx.doi.org/10.1371/journal.pone.0085337.s004", "https://dx.doi.org/10.1371/journal.pone.0085337.s005", "https://dx.doi.org/10.1371/journal.pone.0085337.s006", "https://dx.doi.org/10.1371/journal.pone.0085337.s007", "https://dx.doi.org/10.1371/journal.pone.0085337.s008", "https://dx.doi.org/10.1371/journal.pone.0085337.s009"], "stats"=>{"downloads"=>56, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Atheroprotective_Effect_of_Oleoylethanolamide_OEA_Targeting_Oxidized_LDL_/904261", "title"=>"Atheroprotective Effect of Oleoylethanolamide (OEA) Targeting Oxidized LDL", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-01-20 03:16:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1351500"], "description"=>"<p>(A) OEA dose-dependently reduced ox-LDL-induced cell proliferation as evaluated by CCK-8 assay. (B) The effect of OEA with or without MK886 on cell apoptosis, assessed by flow cytometer, in HUVEC cells treated with LDL or ox-LDL; Vehicle, 0.1% DMSO; LDL, 50 μg/ml; ox-LDL, 50 μg/ml; OEA 50 μM or concentration in μM; MK886, 10 μM. <sup>#</sup> p<0.05, <sup>###</sup> p<0.001 vs vehicle group; * p<0.05, *** p<0.001 vs ox-LDL group; one-way ANOVA, n = 6–8.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "neutral lipids", "metabolism", "proteins", "lipoproteins", "Lipoprotein metabolism", "Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "reversed", "vascular", "endothelial", "proliferation", "apoptosis", "induced"], "article_id"=>904232, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Angran Fan", "Xiaofeng Wu", "Huijuan Wu", "Long Li", "Rui Huang", "Yueyong Zhu", "Yan Qiu", "Jin Fu", "Jie Ren", "Chenggang Zhu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085337.g001", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_OEA_reversed_vascular_endothelial_cell_proliferation_and_apoptosis_induced_by_ox_LDL_/904232", "title"=>"OEA reversed vascular endothelial cell proliferation and apoptosis induced by ox-LDL.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-20 03:16:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1351521"], "description"=>"<p>Oil red O staining (A) and H & E staining (B–E) showed aortic atherosclerotic formation in wild-type C57mice fed with HCD (A<sub>1</sub>, B), ApoE<b><sup>−</sup></b><sup>/<b>−</b></sup> mice fed with normal diet (A<sub>2</sub>, C), ApoE<b><sup>−</sup></b><sup>/<b>−</b></sup> mice fed with HCD (A<sub>3</sub>, D), and ApoE<b><sup>−</sup></b><sup>/<b>−</b></sup>-HCD mice with OEA administration (5 mg/kg, i.p.) (A<sub>4</sub>, E). Scale bar, 2 mm or 0.5 mm. (F–K), The effect of OEA on mRNA expression levels of PPAR-α (F), M-CSF (G), COX-2 (H), CRP (I), TNF-α (J) and IL-6 (K) in aorta tissues of wt-HCD mice, ApoE<b><sup>−</sup></b><sup>/<b>−</b></sup>-ND mice and ApoE<b><sup>−</sup></b><sup>/<b>−</b></sup>-HCD mice. Vehicle, 5% PEG/5% Tween-80 in saline; OEA, 5 mg/kg/day, i.p.; * p<0.05, ** p<0.01, *** p<0.001, one-way ANOVA, n = 6–8 mice/group.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "neutral lipids", "metabolism", "proteins", "lipoproteins", "Lipoprotein metabolism", "Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "reduced", "atherosclerotic", "plaque"], "article_id"=>904250, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Angran Fan", "Xiaofeng Wu", "Huijuan Wu", "Long Li", "Rui Huang", "Yueyong Zhu", "Yan Qiu", "Jin Fu", "Jie Ren", "Chenggang Zhu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085337.g006", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_OEA_reduced_atherosclerotic_plaque_formation_in_ApoE_8722_8722_mice_/904250", "title"=>"OEA reduced atherosclerotic plaque formation in ApoE<sup>−/−</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-20 03:16:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1351504"], "description"=>"<p>(A–H), The effect of vehicle (A), LDL (B), ox-LDL (C) ,OEA (D) and MK886 (E–H) on VSMC migration, assessed by transwell assay; (I) Quantitation of chemotaxis of A–H. Vehicle, 0.1% DMSO; LDL, 50 μg/ml; ox-LDL, 50 μg/ml; OEA, 50 μM; MK886, 10 μM. *** p<0.001, one-way ANOVA, n = 6.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "neutral lipids", "metabolism", "proteins", "lipoproteins", "Lipoprotein metabolism", "Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "reduced", "ox-ldl-induced", "vsmc"], "article_id"=>904236, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Angran Fan", "Xiaofeng Wu", "Huijuan Wu", "Long Li", "Rui Huang", "Yueyong Zhu", "Yan Qiu", "Jin Fu", "Jie Ren", "Chenggang Zhu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085337.g002", "stats"=>{"downloads"=>1, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_OEA_reduced_ox_LDL_induced_VSMC_migration_via_PPAR_945_signaling_/904236", "title"=>"OEA reduced ox-LDL-induced VSMC migration via PPAR-α signaling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-20 03:16:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1351506"], "description"=>"<p>The effect of vehicle (0.1% DMSO), LDL (50 μg/ml), ox-LDL (50 μg/ml), OEA (50 μM) or MK886 (10 μM) on mRNA expression levels of PPAR-α (A, D), iNOS (B, E) and COX-2 (C, F) in mouse primary macrophages (A–C) or mouse macrophage RAW246.7 cells (D–F). N.S., not significant; * p<0.05, ** p<0.01, *** p<0.001, one-way ANOVA, n = 4–8.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "neutral lipids", "metabolism", "proteins", "lipoproteins", "Lipoprotein metabolism", "Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "ox-ldl-induced", "inflammation", "oea", "mediated"], "article_id"=>904238, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Angran Fan", "Xiaofeng Wu", "Huijuan Wu", "Long Li", "Rui Huang", "Yueyong Zhu", "Yan Qiu", "Jin Fu", "Jie Ren", "Chenggang Zhu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085337.g003", "stats"=>{"downloads"=>0, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inhibition_of_ox_LDL_induced_inflammation_by_OEA_was_mediated_by_PPAR_945_signaling_/904238", "title"=>"Inhibition of ox-LDL-induced inflammation by OEA was mediated by PPAR-α signaling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-20 03:16:08"}

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