EGFR, HER-2 and KRAS in Canine Gastric Epithelial Tumors: A Potential Human Model?
Publication Date
January 15, 2014
Journal
PLOS ONE
Authors
Rossella Terragni, Andrea Casadei Gardini, Silvia Sabattini, Giuliano Bettini, et al
Volume
9
Issue
1
Pages
e85388
DOI
https://dx.plos.org/10.1371/journal.pone.0085388
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0085388
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24454858
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893207
Europe PMC
http://europepmc.org/abstract/MED/24454858
Web of Science
000330235100079
Scopus
84898637547
Mendeley
http://www.mendeley.com/research/egfr-her2-kras-canine-gastric-epithelial-tumors-potential-human-model-2
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Mendeley | Further Information

{"title"=>"EGFR, HER-2 and KRAS in canine gastric epithelial tumors: A potential human model?", "type"=>"journal", "authors"=>[{"first_name"=>"Rossella", "last_name"=>"Terragni", "scopus_author_id"=>"6602549298"}, {"first_name"=>"Andrea", "last_name"=>"Casadei Gardini", "scopus_author_id"=>"55631575700"}, {"first_name"=>"Silvia", "last_name"=>"Sabattini", "scopus_author_id"=>"25923134700"}, {"first_name"=>"Giuliano", "last_name"=>"Bettini", "scopus_author_id"=>"6603769330"}, {"first_name"=>"Dino", "last_name"=>"Amadori", "scopus_author_id"=>"7005467871"}, {"first_name"=>"Chiara", "last_name"=>"Talamonti", "scopus_author_id"=>"56114767400"}, {"first_name"=>"Massimo", "last_name"=>"Vignoli", "scopus_author_id"=>"55929130700"}, {"first_name"=>"Laura", "last_name"=>"Capelli", "scopus_author_id"=>"55208430500"}, {"first_name"=>"Jimmy H.", "last_name"=>"Saunders", "scopus_author_id"=>"7402341345"}, {"first_name"=>"Marianna", "last_name"=>"Ricci", "scopus_author_id"=>"37011501700"}, {"first_name"=>"Paola", "last_name"=>"Ulivi", "scopus_author_id"=>"7801598771"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84898637547", "doi"=>"10.1371/journal.pone.0085388", "pui"=>"372838316", "issn"=>"19326203", "pmid"=>"24454858", "scopus"=>"2-s2.0-84898637547"}, "id"=>"890ec916-4b10-34df-9e3a-abec63f43e96", "abstract"=>"Epidermal growth factor receptor (EGFR or HER-1) and its analog c-erbB-2 (HER-2) are protein tyrosine kinases correlated with prognosis and response to therapy in a variety of human cancers. KRAS mediates the transduction of signals between EGFR and the nucleus, and its mutation has been identified as a predictor of resistance to anti-EGFR drugs. In human oncology, the importance of the EGFR/HER-2/KRAS signalling pathway in gastric cancer is well established, and HER-2 testing is required before initiating therapy. Conversely, this pathway has never been investigated in canine gastric tumours. A total of 19 canine gastric epithelial neoplasms (5 adenomas and 14 carcinomas) were retrospectively evaluated for EGFR/HER-2 immunohistochemical expression and KRAS mutational status. Five (35.7%) carcinomas were classified as intestinal-type and 9 (64.3%) as diffuse-type. EGFR was overexpressed (≥1+) in 8 (42.1%) cases and HER-2 (3+) in 11 (57.9%) cases, regardless of tumour location or biological behaviour. The percentage of EGFR-positive tumours was significantly higher in the intestinal-type (80%) than in the diffuse-type (11.1%, p = 0.023). KRAS gene was wild type in 18 cases, whereas one mucinous carcinoma harboured a point mutation at codon 12 (G12R). EGFR and HER-2 may be promising prognostic and therapeutic targets in canine gastric epithelial neoplasms. The potential presence of KRAS mutation should be taken into account as a possible mechanism of drug resistance. Further studies are necessary to evaluate the role of dog as a model for human gastric cancer.", "link"=>"http://www.mendeley.com/research/egfr-her2-kras-canine-gastric-epithelial-tumors-potential-human-model-2", "reader_count"=>31, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>5, "Student > Master"=>5, "Other"=>3, "Student > Bachelor"=>3, "Lecturer"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>5, "Student > Master"=>5, "Other"=>3, "Student > Bachelor"=>3, "Lecturer"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>10, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Veterinary Science and Veterinary Medicine"=>11}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>11}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1348219"], "description"=>"<p>(<b>A</b>). Dog, stomach. Signet ring cell carcinoma (case No. 15). EGFR immunohistochemistry. Faint and partial membrane labelling of the neoplastic cells (1+). Haematoxylin counterstain. 200x. (<b>B</b>) Dog, stomach. Papillary adenoma (case No. 2). EGFR immunohistochemistry. Strong and complete membrane labeling of the neoplastic cells (3+). Haematoxylin counterstain. 100x. (<b>C</b>) Dog, stomach. Tubulopapillary adenoma (case No. 4). HER-2 immunohistochemistry. Moderate basolateral membrane labeling of the neoplastic cells (2+). Haematoxylin counterstain. 200x. (<b>D</b>) Dog, stomach. In situ tubulopapillary carcinoma (case No. 6). HER-2 immunohistochemistry. Strong and complete membrane labeling of the neoplastic cells (3+). Haematoxylin counterstain. 200x. (<b>E</b>) Dog, stomach, fundus. EGFR immunohistochemistry. Negative labeling of the mucosal epithelium. Faint granular cytoplasmic positivity of the parietal cells. Haematoxylin counterstain. 200x. (<b>F</b>) Dog, stomach, pyloric antrum. HER-2 immunohistochemistry. Scattered foci of faint basolateral positivity. Haematoxylin counterstain. 200x.</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Model organisms", "Animal models", "Clinical research design", "Animal models of disease", "epidemiology", "Cancer epidemiology", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "Gastric cancer", "Animal types", "Small animals", "Veterinary diseases", "Veterinary epidemiology", "her-2", "immunohistochemistry", "canine"], "article_id"=>901784, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Rossella Terragni", "Andrea Casadei Gardini", "Silvia Sabattini", "Giuliano Bettini", "Dino Amadori", "Chiara Talamonti", "Massimo Vignoli", "Laura Capelli", "Jimmy H. Saunders", "Marianna Ricci", "Paola Ulivi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085388.g001", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_EGFR_and_HER_2_immunohistochemistry_of_canine_samples_/901784", "title"=>"EGFR and HER-2 immunohistochemistry of canine samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-15 03:30:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1348222"], "description"=>"<p>Association between EGFR/HER-2 status and clinical pathological parameters in 19 canine gastric epithelial neoplasms.</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Model organisms", "Animal models", "Clinical research design", "Animal models of disease", "epidemiology", "Cancer epidemiology", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "Gastric cancer", "Animal types", "Small animals", "Veterinary diseases", "Veterinary epidemiology", "pathological", "19", "canine", "gastric", "epithelial"], "article_id"=>901787, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Rossella Terragni", "Andrea Casadei Gardini", "Silvia Sabattini", "Giuliano Bettini", "Dino Amadori", "Chiara Talamonti", "Massimo Vignoli", "Laura Capelli", "Jimmy H. Saunders", "Marianna Ricci", "Paola Ulivi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085388.t002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_EGFR_HER_2_status_and_clinical_pathological_parameters_in_19_canine_gastric_epithelial_neoplasms_/901787", "title"=>"Association between EGFR/HER-2 status and clinical pathological parameters in 19 canine gastric epithelial neoplasms.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-15 03:30:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1348220"], "description"=>"<p>Mutation analysis performed by direct sequencing on wild type (<b>A</b>) and mutated (<b>B</b>) samples. Arrows indicate the point mutation.</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Model organisms", "Animal models", "Clinical research design", "Animal models of disease", "epidemiology", "Cancer epidemiology", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "Gastric cancer", "Animal types", "Small animals", "Veterinary diseases", "Veterinary epidemiology"], "article_id"=>901785, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Rossella Terragni", "Andrea Casadei Gardini", "Silvia Sabattini", "Giuliano Bettini", "Dino Amadori", "Chiara Talamonti", "Massimo Vignoli", "Laura Capelli", "Jimmy H. Saunders", "Marianna Ricci", "Paola Ulivi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085388.g002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_KRAS_analysis_/901785", "title"=>"KRAS analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-15 03:30:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1348221"], "description"=>"<p>N/A, not applicable;</p><p>TNM staging system for gastric carcinomas according to the classification of the American Joint Commission on Cancer<sup>11</sup>.</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Model organisms", "Animal models", "Clinical research design", "Animal models of disease", "epidemiology", "Cancer epidemiology", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "Gastric cancer", "Animal types", "Small animals", "Veterinary diseases", "Veterinary epidemiology", "details", "19", "cases", "canine", "gastric", "epithelial"], "article_id"=>901786, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Rossella Terragni", "Andrea Casadei Gardini", "Silvia Sabattini", "Giuliano Bettini", "Dino Amadori", "Chiara Talamonti", "Massimo Vignoli", "Laura Capelli", "Jimmy H. Saunders", "Marianna Ricci", "Paola Ulivi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085388.t001", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Animal_details_and_tumor_characteristics_in_19_cases_of_canine_gastric_epithelial_neoplasms_/901786", "title"=>"Animal details and tumor characteristics in 19 cases of canine gastric epithelial neoplasms.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-15 03:30:56"}

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[266]}]}
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