The Association of Pioglitazone and Urinary Tract Disease in Type 2 Diabetic Taiwanese: Bladder Cancer and Chronic Kidney Disease
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Mendeley | Further Information

{"title"=>"The association of pioglitazone and urinary tract disease in type 2 diabetic Taiwanese: bladder cancer and chronic kidney disease.", "type"=>"journal", "authors"=>[{"first_name"=>"Mei-Yueh", "last_name"=>"Lee"}, {"first_name"=>"Pi-Jung", "last_name"=>"Hsiao"}, {"first_name"=>"Yi-Hsin", "last_name"=>"Yang"}, {"first_name"=>"Kun-Der", "last_name"=>"Lin"}, {"first_name"=>"Shyi-Jang", "last_name"=>"Shin"}], "year"=>2014, "source"=>"PloS one", "identifiers"=>{"pmid"=>"24427312", "doi"=>"10.1371/journal.pone.0085479", "issn"=>"1932-6203"}, "keywords"=>["Biostatistics", "Bladder and ureteric disorders", "Bladder cancer", "Bladder cancer and urothelial neoplasias of the ur", "Cancers and neoplasms", "Chronic kidney disease", "Diabetes mellitus type 2", "Diabetic endocrinology", "Drugs and devices", "Endocrinology", "Genitourinary infections", "Genitourinary tract tumors", "Health care policy", "Health risk analysis", "Mathematics", "Medicine", "Metabolic disorders", "Nephrology", "Non-clinical medicine", "Oncology", "Research Article", "Statistical methods", "Statistics", "Urology"], "id"=>"c331f8b6-8bfa-3e7c-bb82-4c6e801dc946", "abstract"=>"OBJECTIVE: Although studies have shown an association between pioglitazone and bladder cancer, the associated factors have not been identified. The aim of this study was to investigate the factors that may link pioglitazone to bladder cancer.\\n\\nMATERIALS AND METHODS: In total, 34,970 study subjects were identified from the National Health Insurance Research Database in 2003 with follow-up from 2005 to 2009. The demographic characteristics of patients who had used and had never used pioglitazone, including age, sex, diabetes duration, urinary tract disease, nephropathy, bladder cancer, and cumulative dose and duration of pioglitazone therapy, were analyzed using the χ2 test. Cox proportional hazard regression models were used to determine the independent effects of pioglitazone on bladder cancer and newly developed chronic kidney disease.\\n\\nRESULTS: Among 3,497 ever users and 31,473 never users of pioglitazone, the respective incident cases of bladder cancer were 12 (0.4%) and 72 (0.2%), and for newly developed chronic kidney disease 245 (8.1%) and 663 (2.3%), respectively. Ever use of pioglitazone [1.59(1.32-1.91)], cumulative dose of pioglitazone <10,500 mg [1.69 (1.37-2.01)] and >10,500 mg [1.34 (1.04-1.73)], and duration of therapy <12 months [1.68 (1.36-2.08)] and >12 months [1.39 (1.09-1.76)] were associated with the development of chronic kidney disease.\\n\\nCONCLUSIONS: There was no association of pioglitazone use with bladder cancer development, however, there was an association with an increased risk of newly developed chronic kidney disease.", "link"=>"http://www.mendeley.com/research/association-pioglitazone-urinary-tract-disease-type-2-diabetic-taiwanese-bladder-cancer-chronic-kidn", "reader_count"=>8, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>5, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1345444"], "description"=>"<p>(A).never use and ever use of pioglitazone. (B).never use, cumulative dose <10500 mg and >10500 mg of pioglitazone. (C).never use, duration of therapy <12 months and >12 months of pioglitazone.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Statistical methods", "Drugs and devices", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "Metabolic disorders", "Nephrology", "Bladder and ureteric disorders", "Chronic kidney disease", "Non-clinical medicine", "Health care policy", "Health risk analysis", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "Genitourinary infections", "bladder"], "article_id"=>899553, "categories"=>["Mathematics", "Medicine"], "users"=>["Mei-Yueh Lee", "Pi-Jung Hsiao", "Yi-Hsin Yang", "Kun-Der Lin", "Shyi-Jang Shin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085479.g001", "stats"=>{"downloads"=>2, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Disease_free_survival_of_bladder_cancer_/899553", "title"=>"Disease free survival of bladder cancer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-10 03:06:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1345446"], "description"=>"<p>(A).never use and ever use of pioglitazone. (B). never use, cumulative dose <10500 mg and >10500 mg of pioglitazone. (C). never use, duration of therapy <12 months and >12 months of pioglitazone.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Statistical methods", "Drugs and devices", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "Metabolic disorders", "Nephrology", "Bladder and ureteric disorders", "Chronic kidney disease", "Non-clinical medicine", "Health care policy", "Health risk analysis", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "Genitourinary infections", "developed", "kidney"], "article_id"=>899555, "categories"=>["Mathematics", "Medicine"], "users"=>["Mei-Yueh Lee", "Pi-Jung Hsiao", "Yi-Hsin Yang", "Kun-Der Lin", "Shyi-Jang Shin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085479.g002", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Disease_free_survival_of_newly_developed_chronic_kidney_disease_after_use_of_pioglitazone_/899555", "title"=>"Disease free survival of newly developed chronic kidney disease after use of pioglitazone.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-10 03:06:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1345447"], "description"=>"<p>Demographics of the study cohort according to ever use of pioglitazone.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Statistical methods", "Drugs and devices", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "Metabolic disorders", "Nephrology", "Bladder and ureteric disorders", "Chronic kidney disease", "Non-clinical medicine", "Health care policy", "Health risk analysis", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "Genitourinary infections", "cohort"], "article_id"=>899556, "categories"=>["Mathematics", "Medicine"], "users"=>["Mei-Yueh Lee", "Pi-Jung Hsiao", "Yi-Hsin Yang", "Kun-Der Lin", "Shyi-Jang Shin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085479.t001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographics_of_the_study_cohort_according_to_ever_use_of_pioglitazone_/899556", "title"=>"Demographics of the study cohort according to ever use of pioglitazone.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-10 03:06:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1345448"], "description"=>"<p>Adjusted by age, sex, diabetes duration, income (monthly income NT$20,000) residential area, nephritis, chronic kidney disease, kidney infections, hydronephrosis, calculus of the lower urinary tract, calculus of the kidney and ureter, cystitis, other disorders of the urethra and urinary tract, other diabetes medication including sulfonylureas, metformin, acarbose, rosiglitazone and insulin. The adjusted HR of hypertension, hyperlipidemia and other diabetes medication were computed with the indicated variable of pioglitazone use.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Statistical methods", "Drugs and devices", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "Metabolic disorders", "Nephrology", "Bladder and ureteric disorders", "Chronic kidney disease", "Non-clinical medicine", "Health care policy", "Health risk analysis", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "Genitourinary infections", "ratios", "developed", "kidney"], "article_id"=>899557, "categories"=>["Mathematics", "Medicine"], "users"=>["Mei-Yueh Lee", "Pi-Jung Hsiao", "Yi-Hsin Yang", "Kun-Der Lin", "Shyi-Jang Shin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085479.t003", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hazard_ratios_of_newly_developed_chronic_kidney_disease_/899557", "title"=>"Hazard ratios of newly developed chronic kidney disease.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-10 03:06:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1345449"], "description"=>"<p>Adjusted by sex, age, duration of diabetes, other diabetes medications, income (monthly income NT$20,000), residential area, nephritis, chronic kidney disease, kidney infections, hydronephrosis, calculus of the lower urinary tract, cystitis, other disorders of the urethra and urinary tract, hypertension and hyperlipidemia. The adjusted HR of newly developed chronic kidney disease and calculus of the kidney and ureter were computed with the indicated variable of pioglitazone use.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Statistical methods", "Drugs and devices", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 2", "Metabolic disorders", "Nephrology", "Bladder and ureteric disorders", "Chronic kidney disease", "Non-clinical medicine", "Health care policy", "Health risk analysis", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "Genitourinary infections", "bladder"], "article_id"=>899558, "categories"=>["Mathematics", "Medicine"], "users"=>["Mei-Yueh Lee", "Pi-Jung Hsiao", "Yi-Hsin Yang", "Kun-Der Lin", "Shyi-Jang Shin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085479.t002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hazard_ratio_of_bladder_cancer_/899558", "title"=>"Hazard ratio of bladder cancer.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-10 03:06:58"}

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Relative Metric

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