Comprehensive Evaluation of the Anti-Angiogenic and Anti-Neoplastic Effects of Endostar on Liver Cancer through Optical Molecular Imaging
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{"title"=>"Comprehensive evaluation of the anti-angiogenic and anti-neoplastic effects of endostar on liver cancer through optical molecular imaging", "type"=>"journal", "authors"=>[{"first_name"=>"Qian", "last_name"=>"Zhang", "scopus_author_id"=>"55149916600"}, {"first_name"=>"Yang", "last_name"=>"Du", "scopus_author_id"=>"56086011600"}, {"first_name"=>"Zhenwen", "last_name"=>"Xue", "scopus_author_id"=>"38562471000"}, {"first_name"=>"Chongwei", "last_name"=>"Chi", "scopus_author_id"=>"56007905700"}, {"first_name"=>"Xiaohua", "last_name"=>"Jia", "scopus_author_id"=>"56086275000"}, {"first_name"=>"Jie", "last_name"=>"Tian", "scopus_author_id"=>"7401636162"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84896913037", "pmid"=>"24416426", "doi"=>"10.1371/journal.pone.0085559", "pui"=>"372704101", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203", "scopus"=>"2-s2.0-84896913037"}, "id"=>"9dcc5194-0fca-30da-bdb6-092adc7c79c7", "abstract"=>"Molecular imaging enables non-invasive monitoring of tumor growth, progression, and drug treatment response, and it has become an important tool to promote biological studies in recent years. In this study, we comprehensively evaluated the in vivo anti-angiogenic and anti-neoplastic effects of Endostar on liver cancer based on the optical molecular imaging systems including micro-computer tomography (Micro-CT), bioluminescence molecular imaging (BLI) and fluorescence molecular tomography (FMT). Firefly luciferase (fLuc) and green fluorescent protein (GFP) dual labeled human hepatocellular carcinoma cells (HCC-LM3-fLuc-GFP cells) were used to establish the subcutaneous and orthotopic liver tumor model. After the tumor cells were implanted 14∼18 days, Endostar (5 mg/kg/day) was administered through an intravenous tail vein injection for continuous 14 days. The computer tomography angiography (CTA) and BLI were carried out for the subcutaneous tumor model. FMT was executed for the orthotopic tumor model. The CTA data showed that tumor vessel formation and the peritumoral vasculature of subcutaneous tumor in the Endostar treatment group was significantly inhibited compared to the control group. The BLI data exhibited the obvious tumor inhibition day 8 post-treatment. The FMT detected the tumor suppression effects of Endostar as early as day 4 post-treatment and measured the tumor location. The above data confirmed the effects of Endostar on anti-angiogenesis and tumor suppression on liver cancer. Our system combined CTA, BLI, and FMT to offer more comprehensive information about the effects of Endostar on the suppression of vessel and tumor formation. Optical molecular imaging system enabled the non-invasive and reliable assessment of anti-tumor drug efficacy on liver cancer.", "link"=>"http://www.mendeley.com/research/comprehensive-evaluation-antiangiogenic-antineoplastic-effects-endostar-liver-cancer-through-optical", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>1, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>1, "Sports and Recreations"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1341820"], "description"=>"<p>The BLI of subcutaneous tumor model. Continuous BLI light intensity observation of the subcutaneous tumor model from day 0 to day 12.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Medical devices", "Drugs and devices", "Drug research and development", "Gastroenterology and hepatology", "Liver diseases", "oncology", "Cancer detection and diagnosis", "Cancer treatment", "radiology", "Diagnostic radiology", "Computed tomography", "bli", "subcutaneous"], "article_id"=>896717, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Qian Zhang", "Yang Du", "Zhenwen Xue", "Chongwei Chi", "Xiaohua Jia", "Jie Tian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085559.g004", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_BLI_of_subcutaneous_tumor_model_Continuous_BLI_light_intensity_observation_of_the_subcutaneous_tumor_model_from_day_0_to_day_12_/896717", "title"=>"The BLI of subcutaneous tumor model. Continuous BLI light intensity observation of the subcutaneous tumor model from day 0 to day 12.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 03:40:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1341814"], "description"=>"<p>A. The schematic of the multi-modality system. The red dashed line represents the BLI/FMT system; the blue dashed line represents the Micro-CT system. B. The figure of the multi-modality system, which is located in the black lead housing. C. The planar fluorescent imaging of mouse orthotopic tumor model at 0°degree, 90°degree, 180°degree and 270°degree.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Medical devices", "Drugs and devices", "Drug research and development", "Gastroenterology and hepatology", "Liver diseases", "oncology", "Cancer detection and diagnosis", "Cancer treatment", "radiology", "Diagnostic radiology", "Computed tomography", "fmt"], "article_id"=>896711, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Qian Zhang", "Yang Du", "Zhenwen Xue", "Chongwei Chi", "Xiaohua Jia", "Jie Tian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085559.g001", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Micro_CT_BLI_FMT_system_and_the_process_of_FMT_imaging_/896711", "title"=>"The Micro-CT/BLI/FMT system and the process of FMT imaging.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 03:40:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1341828"], "description"=>"<p>The quantitative FMT light intensity of the orthotopic tumor.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Medical devices", "Drugs and devices", "Drug research and development", "Gastroenterology and hepatology", "Liver diseases", "oncology", "Cancer detection and diagnosis", "Cancer treatment", "radiology", "Diagnostic radiology", "Computed tomography", "quantitative", "fmt", "orthotopic"], "article_id"=>896725, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Qian Zhang", "Yang Du", "Zhenwen Xue", "Chongwei Chi", "Xiaohua Jia", "Jie Tian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085559.g008", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_quantitative_FMT_light_intensity_of_the_orthotopic_tumor_/896725", "title"=>"The quantitative FMT light intensity of the orthotopic tumor.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 03:40:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1341827"], "description"=>"<p>The coronal degree view of the orthotopic tumor progression and drug response was monitored by the FMT system.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Medical devices", "Drugs and devices", "Drug research and development", "Gastroenterology and hepatology", "Liver diseases", "oncology", "Cancer detection and diagnosis", "Cancer treatment", "radiology", "Diagnostic radiology", "Computed tomography", "fmt", "orthotopic"], "article_id"=>896724, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Qian Zhang", "Yang Du", "Zhenwen Xue", "Chongwei Chi", "Xiaohua Jia", "Jie Tian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085559.g007", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_FMT_of_the_orthotopic_tumor_model_/896724", "title"=>"The FMT of the orthotopic tumor model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 03:40:15"}
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  • {"files"=>["https://ndownloader.figshare.com/files/1341818"], "description"=>"<p>A. The mouse body weight of the subcutaneous tumor model. B. The mouse tumor volume of the subcutaneous tumor model.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Medical devices", "Drugs and devices", "Drug research and development", "Gastroenterology and hepatology", "Liver diseases", "oncology", "Cancer detection and diagnosis", "Cancer treatment", "radiology", "Diagnostic radiology", "Computed tomography"], "article_id"=>896715, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Qian Zhang", "Yang Du", "Zhenwen Xue", "Chongwei Chi", "Xiaohua Jia", "Jie Tian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085559.g003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_mouse_body_weight_and_tumor_volume_/896715", "title"=>"The mouse body weight and tumor volume.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 03:40:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1341817"], "description"=>"<p>A and B show the 3D segmentation images by CTA The white arrows show the microvessel sprouting, the blood vessel near the tumor was marked in red, and the blood vessel away from the tumor was marked in blue. C and D show CD31 immunohistochemistry of the tumor vessels. The black arrow indicates the microvascular areas.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Medical devices", "Drugs and devices", "Drug research and development", "Gastroenterology and hepatology", "Liver diseases", "oncology", "Cancer detection and diagnosis", "Cancer treatment", "radiology", "Diagnostic radiology", "Computed tomography", "3d", "segmentation", "images", "cd31", "immunohistochemistry"], "article_id"=>896714, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Qian Zhang", "Yang Du", "Zhenwen Xue", "Chongwei Chi", "Xiaohua Jia", "Jie Tian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085559.g002", "stats"=>{"downloads"=>0, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_3D_segmentation_images_and_CD31_immunohistochemistry_of_the_tumor_vessels_/896714", "title"=>"The 3D segmentation images and CD31 immunohistochemistry of the tumor vessels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 03:40:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1341829"], "description"=>"<p>A and B. The FMT reconstruction of the orthotopic tumor model and the partial enlarged view.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Medical devices", "Drugs and devices", "Drug research and development", "Gastroenterology and hepatology", "Liver diseases", "oncology", "Cancer detection and diagnosis", "Cancer treatment", "radiology", "Diagnostic radiology", "Computed tomography", "3d", "fmt", "reconstruction", "orthotopic"], "article_id"=>896726, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Qian Zhang", "Yang Du", "Zhenwen Xue", "Chongwei Chi", "Xiaohua Jia", "Jie Tian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085559.g009", "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_3D_FMT_reconstruction_of_the_orthotopic_tumor_model_/896726", "title"=>"The 3D FMT reconstruction of the orthotopic tumor model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 03:40:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1341826"], "description"=>"<p>Laparotomy was performed on the mouse with the liver exposed in the field of view A, and then the liver was dissected. BLI was carried out again and the optical signal was distributed in the hepatic lobular margins in B. C. The H&E stain revealed that there were tumor nodes in the liver tissue.</p>", "links"=>[], "tags"=>["biotechnology", "Bioengineering", "Medical devices", "Drugs and devices", "Drug research and development", "Gastroenterology and hepatology", "Liver diseases", "oncology", "Cancer detection and diagnosis", "Cancer treatment", "radiology", "Diagnostic radiology", "Computed tomography", "orthotopic"], "article_id"=>896723, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Qian Zhang", "Yang Du", "Zhenwen Xue", "Chongwei Chi", "Xiaohua Jia", "Jie Tian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085559.g006", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Verifying_the_validity_of_the_orthotopic_tumor_model_/896723", "title"=>"Verifying the validity of the orthotopic tumor model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-08 03:40:15"}

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Relative Metric

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