Genetic Polymorphisms in IGF-I and IGFBP-3 Are Associated with Prostate Cancer in the Chinese Population
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{"title"=>"Genetic polymorphisms in IGF-I and IGFBP-3 are associated with prostate cancer in the Chinese population", "type"=>"journal", "authors"=>[{"first_name"=>"Jian", "last_name"=>"Qian", "scopus_author_id"=>"55604952400"}, {"first_name"=>"Hai", "last_name"=>"Zhou", "scopus_author_id"=>"55589364600"}, {"first_name"=>"Jiawei", "last_name"=>"Chen", "scopus_author_id"=>"7501898135"}, {"first_name"=>"Qi", "last_name"=>"Ding", "scopus_author_id"=>"36157027900"}, {"first_name"=>"Qiang", "last_name"=>"Cao", "scopus_author_id"=>"36570112100"}, {"first_name"=>"Chao", "last_name"=>"Qin", "scopus_author_id"=>"7102688047"}, {"first_name"=>"Pengfei", "last_name"=>"Shao", "scopus_author_id"=>"36863062100"}, {"first_name"=>"Pu", "last_name"=>"Li", "scopus_author_id"=>"7404774183"}, {"first_name"=>"Hongzhou", "last_name"=>"Cai", "scopus_author_id"=>"55277516400"}, {"first_name"=>"Xiaoxin", "last_name"=>"Meng", "scopus_author_id"=>"36454786200"}, {"first_name"=>"Xiaobing", "last_name"=>"Ju", "scopus_author_id"=>"7006676609"}, {"first_name"=>"Meilin", "last_name"=>"Wang", "scopus_author_id"=>"56151035900"}, {"first_name"=>"Zhengdong", "last_name"=>"Zhang", "scopus_author_id"=>"55608623600"}, {"first_name"=>"Jie", "last_name"=>"Li", "scopus_author_id"=>"36067784800"}, {"first_name"=>"Lixin", "last_name"=>"Hua", "scopus_author_id"=>"7101969783"}, {"first_name"=>"Changjun", "last_name"=>"Yin", "scopus_author_id"=>"16481676000"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pmid"=>"24586243", "scopus"=>"2-s2.0-84896133566", "doi"=>"10.1371/journal.pone.0085609", "pui"=>"372608168", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84896133566"}, "id"=>"2003046a-f08e-30cb-af06-67befc29ade8", "abstract"=>"Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are members of the insulin-like growth factor (IGF) family that play important roles in carcinogenesis. We hypothesized that the functional polymorphisms in IGF-I and IGFBP-3 may be associated with the risk of prostate cancer (PCa) in the Chinese population. This hospital-based case-control study included 664 PCa patients and 702 cancer-free controls. Nine SNPs in IGF-I and IGFBP-3 were genotyped using the TaqMan assay. The genetic associations between the pathogenesis and progression of PCa were assessed by logistic regression. We found that the genotype and allele frequency distribution of rs6218, rs35767 and rs5742612 were significantly different when comparing PCa cases to controls (P = 0.005, 0.005 and 0.020, respectively). In the combined analysis, individuals with 2-6 risk alleles had an elevated risk of PCa compared to those with 0-1 risk alleles. We also found that the association between the combined risk alleles and the risk of PCa appeared stronger in the following subgroups: individuals older than 71 years of age (OR = 1.41, 95%CI = 1.05-1.91, P = 0.020), nonsmokers (OR = 1.68, 95%CI = 1.21-2.32, P = 0.002), nondrinkers (OR = 1.32, 95%CI = 1.02-1.61, P = 0.002), and those with a negative family history of PCa (OR = 1.28, 95%CI = 1.02-1.71, P = 0.022). Our results indicate that the three SNPs (rs6218, rs35767 and rs5742612) and the joint genotypes with 2-6 risk alleles, may contribute to the susceptibility to PCa, but not the progression, in the Chinese population.", "link"=>"http://www.mendeley.com/research/genetic-polymorphisms-igfi-igfbp3-associated-prostate-cancer-chinese-population", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>3, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>3, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>0}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1395559"], "description"=>"<p>*Two-sided χ<sup>2</sup> test for either genotype distributions or allele frequencies between the cases and controls.</p>†<p>Adjusted for age, smoking status, drinking status and family history of cancer in logistic regression model; 95% CI: 95% confidence interval.</p>‡<p>The 0–6 represents the numbers of risk alleles within the combined genotypes; the risk alleles used for the calculation were the rs6218C, rs35767T and rs5742612C alleles.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Population biology", "population genetics", "Genetic polymorphism", "epidemiology", "Cancer epidemiology", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "Cancer risk factors", "urology", "Prostate diseases", "genotypes", "pca", "cases"], "article_id"=>942156, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Jian Qian", "Hai Zhou", "Jiawei Chen", "Qi Ding", "Qiang Cao", "Chao Qin", "Pengfei Shao", "Pu Li", "Hongzhou Cai", "Xiaoxin Meng", "Xiaobing Ju", "Meilin Wang", "Zhengdong Zhang", "Jie Li", "Lixin Hua", "Changjun Yin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085609.t003", "stats"=>{"downloads"=>5, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Stratification_analyses_between_IGF_I_and_IGFBP_3_genotypes_and_risk_of_PCa_in_cases_and_controls_/942156", "title"=>"Stratification analyses between <i>IGF-I</i> and <i>IGFBP-3</i> genotypes and risk of PCa in cases and controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-21 04:05:24"}

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Behavior", "average_usage"=>[333]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[266]}]}
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