Pch2 Prevents Mec1/Tel1-Mediated Hop1 Phosphorylation Occurring Independently of Red1 in Budding Yeast Meiosis
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{"title"=>"Pch2 prevents Mec1/Tel1-mediated Hop1 phosphorylation occurring independently of Red1 in budding yeast meiosis", "type"=>"journal", "authors"=>[{"first_name"=>"Yu Hui", "last_name"=>"Lo", "scopus_author_id"=>"36808366100"}, {"first_name"=>"Chi Ning", "last_name"=>"Chuang", "scopus_author_id"=>"55531739600"}, {"first_name"=>"Ting Fang", "last_name"=>"Wang", "scopus_author_id"=>"8340203100"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"24465650", "doi"=>"10.1371/journal.pone.0085687", "pui"=>"372868732", "issn"=>"19326203", "sgr"=>"84898877837", "scopus"=>"2-s2.0-84898877837"}, "id"=>"07250474-ac32-3b80-8140-bce1c3cf2bfe", "abstract"=>"A prominent feature of meiosis in most sexually reproducing organisms is interhomolog recombination whereby a significant fraction of the programmed meiotic double-strand breaks are repaired using intact homologous non-sister chromatids rather than sister chromatids. Budding yeast DNA damage checkpoint kinases Mec1 and Tel1 act together with the axial element protein Red1 to promote interhomolog recombination by phosphorylating another axial element protein Hop1. Mec1 and Tel1 also phosphorylate γH2A and the synaptonemal complex protein Zip1 independently of Red1 to facilitate premeiotic DNA replication and to destabilize homology-independent centromere pairing, respectively. It has been unclear why Hop1 phosphorylation is Red1-dependent. Here, we report that the pachytene checkpoint protein 2 (Pch2) specifically prevents Red1-independent Hop1 phosphorylation. Our findings reveal a new function for Pch2 in linking two axial element proteins Red1 and Hop1 thus coordinating their effects in meiotic recombination and the checkpoint network.", "link"=>"http://www.mendeley.com/research/pch2-prevents-mec1tel1mediated-hop1-phosphorylation-occurring-independently-red1-budding-yeast-meios-1", "reader_count"=>19, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>2, "Researcher"=>4, "Student > Ph. D. Student"=>9, "Student > Master"=>1, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>2, "Researcher"=>4, "Student > Ph. D. Student"=>9, "Student > Master"=>1, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>15}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}}, "reader_count_by_country"=>{"United States"=>1, "United Kingdom"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1354824"], "description"=>"<p>(A) Western blot time-course analyses of phosphorylated Hop1-T318, Zip1-S75, H2A-S129 and Rad54-T132 in sporulating cells were performed as recently described <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0085687#pone.0085687-Cheng1\" target=\"_blank\">[20]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0085687#pone.0085687-Chuang1\" target=\"_blank\">[22]</a>. Hsp104 was used as a loading control. All experiments were repeated twice, and the results of representative sporulation time courses are shown. Hyperphosphorylated Hop1 and hypophosphorylated Hop1 are indicated with black and white arrows, respectively. (B) Quantification of phosphorylated protein in (A) (see Materials & Methods). Relative levels of phosphorylated proteins were determined by setting the level of WT “5 hr” as 1.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "DNA-binding proteins", "enzymes", "genetics", "microbiology", "Mycology", "yeast", "Model organisms", "Molecular cell biology", "cell division", "meiosis", "Chromosome biology", "prevents", "hop1", "hypophosphorylation", "wt"], "article_id"=>907104, "categories"=>["Biological Sciences"], "users"=>["Yu-Hui Lo", "Chi-Ning Chuang", "Ting-Fang Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085687.g001", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PCH2_specifically_prevents_Mec1_Tel1_mediated_Hop1_hypophosphorylation_in_WT_and_red1_/907104", "title"=>"<i>PCH2</i> specifically prevents Mec1/Tel1-mediated Hop1 hypophosphorylation in WT and <i>red1</i>Δ.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-21 05:01:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/1354827"], "description"=>"<p>Spore viabilities were determined following sporulation in liquid medium at 30°C.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "DNA-binding proteins", "enzymes", "genetics", "microbiology", "Mycology", "yeast", "Model organisms", "Molecular cell biology", "cell division", "meiosis", "Chromosome biology", "viability", "four-spore"], "article_id"=>907107, "categories"=>["Biological Sciences"], "users"=>["Yu-Hui Lo", "Chi-Ning Chuang", "Ting-Fang Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085687.t001", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spore_Viability_of_Four_Spore_Tetrads_/907107", "title"=>"Spore Viability of Four-Spore Tetrads.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-21 05:01:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/1354825"], "description"=>"<p>(A) Western blot time-course analyses were performed as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0085687#pone-0085687-g001\" target=\"_blank\">Figure 1</a>. To validate the specificity of antisera against phosphorylated Hop1-T318, total meitoic cell lysates from strains carrying the wild-type (WT) <i>HOP1</i> allele (at 5 hr) and the <i>hop1<sup>T318A</sup></i> mutant allele (at 5 hr) were used as positive and negative controls, respectively. The <i>hop1<sup>T318A</sup></i> variant encodes a mutant protein in which the T318 residue of Hop1 has been mutated to alanine. (B) Quantification of phosphorylated protein in (A). Relative levels of phosphorylated proteins were determined by setting the level of WT “5 hr” as 1.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "DNA-binding proteins", "enzymes", "genetics", "microbiology", "Mycology", "yeast", "Model organisms", "Molecular cell biology", "cell division", "meiosis", "Chromosome biology", "catalytic", "subunit", "red1-independent", "hop1"], "article_id"=>907105, "categories"=>["Biological Sciences"], "users"=>["Yu-Hui Lo", "Chi-Ning Chuang", "Ting-Fang Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085687.g002", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rec8_and_the_catalytic_subunit_of_PP4_Pph3_do_not_affect_Red1_independent_Hop1_phosphorylation_/907105", "title"=>"Rec8 and the catalytic subunit of PP4, Pph3, do not affect Red1-independent Hop1 phosphorylation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-21 05:01:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/1354826"], "description"=>"<p>(A) Western blot time-course analyses were performed as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0085687#pone-0085687-g001\" target=\"_blank\">Figure 1</a>. (B) Quantification of phosphorylated protein in (A). Relative levels of phosphorylated proteins were determined by setting the level of <i>red1</i>Δ <i>pch2</i>Δ “5 hr” as 1.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "DNA-binding proteins", "enzymes", "genetics", "microbiology", "Mycology", "yeast", "Model organisms", "Molecular cell biology", "cell division", "meiosis", "Chromosome biology", "recapitulate", "preventing", "red1-independent", "hop1-t318"], "article_id"=>907106, "categories"=>["Biological Sciences"], "users"=>["Yu-Hui Lo", "Chi-Ning Chuang", "Ting-Fang Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0085687.g003", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Neither_dot1_nor_xrs2_N_can_recapitulate_the_effects_of_pch2_on_preventing_Red1_independent_Hop1_T318_phosphorylation_/907106", "title"=>"Neither <i>dot1</i>Δ nor <i>xrs2</i>Δ<i>N</i> can recapitulate the effects of <i>pch2</i>Δ on preventing Red1-independent Hop1-T318 phosphorylation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-21 05:01:51"}

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Relative Metric

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