Systematic Review of the Use of Dried Blood Spots for Monitoring HIV Viral Load and for Early Infant Diagnosis
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Systematic review of the use of dried blood spots for monitoring HIV viral load and for early infant diagnosis", "type"=>"journal", "authors"=>[{"first_name"=>"Pieter W.", "last_name"=>"Smit", "scopus_author_id"=>"55603945300"}, {"first_name"=>"Kimberly A.", "last_name"=>"Sollis", "scopus_author_id"=>"55329477100"}, {"first_name"=>"Susan", "last_name"=>"Fiscus", "scopus_author_id"=>"7005239232"}, {"first_name"=>"Nathan", "last_name"=>"Ford", "scopus_author_id"=>"7102556235"}, {"first_name"=>"Marco", "last_name"=>"Vitoria", "scopus_author_id"=>"35735282900"}, {"first_name"=>"Shaffiq", "last_name"=>"Essajee", "scopus_author_id"=>"6507711189"}, {"first_name"=>"David", "last_name"=>"Barnett", "scopus_author_id"=>"7201605954"}, {"first_name"=>"Ben", "last_name"=>"Cheng", "scopus_author_id"=>"56652966800"}, {"first_name"=>"Suzanne M.", "last_name"=>"Crowe", "scopus_author_id"=>"35415007300"}, {"first_name"=>"Thomas", "last_name"=>"Denny", "scopus_author_id"=>"7005696879"}, {"first_name"=>"Alan", "last_name"=>"Landay", "scopus_author_id"=>"14325119400"}, {"first_name"=>"Wendy", "last_name"=>"Stevens", "scopus_author_id"=>"55513764500"}, {"first_name"=>"Vincent", "last_name"=>"Habiyambere", "scopus_author_id"=>"6507936792"}, {"first_name"=>"Joseph H.", "last_name"=>"Perriens", "scopus_author_id"=>"56498891700"}, {"first_name"=>"Rosanna W.", "last_name"=>"Peeling", "scopus_author_id"=>"7005844347"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203", "pmid"=>"24603442", "scopus"=>"2-s2.0-84897469181", "doi"=>"10.1371/journal.pone.0086461", "sgr"=>"84897469181", "pui"=>"372731633"}, "id"=>"a1b66a1f-4d8d-355d-85d6-241bb025c2d2", "abstract"=>"BACKGROUND: Dried blood spots (DBS) have been used as alternative specimens to plasma to increase access to HIV viral load (VL) monitoring and early infant diagnosis (EID) in remote settings. We systematically reviewed evidence on the performance of DBS compared to plasma for VL monitoring and EID.\\n\\nMETHODS AND FINDINGS: Thirteen peer reviewed HIV VL publications and five HIV EID papers were included. Depending on the technology and the viral load distribution in the study population, the percentage of DBS samples that are within 0.5 log of VL in plasma ranged from 52-100%. Because the input sample volume is much smaller in a blood spot, there is a risk of false negatives with DBS. Sensitivity of DBS VL was found to be 78-100% compared to plasma at VL below 1000 copies/ml, but this increased to 100% at a threshold of 5000 copies/ml. Unlike a plasma VL test which measures only cell free HIV RNA, a DBS VL also measures proviral DNA as well as cell-associated RNA, potentially leading to false positive results when using DBS. The systematic review showed that specificity was close to 100% at DBS VL above 5000 copies/ml, and this threshold would be the most reliable for predicting true virologic failure using DBS. For early infant diagnosis, DBS has a sensitivity of 100% compared to fresh whole blood or plasma in all studies.\\n\\nCONCLUSIONS: Although limited data are available for EID, DBS offer a highly sensitive and specific sampling strategy to make viral load monitoring and early infant diagnosis more accessible in remote settings. A standardized approach for sampling, storing, and processing DBS samples would be essential to allow successful implementation.\\n\\nTRIAL REGISTRATION: PROSPERO Registration #: CRD42013003621.", "link"=>"http://www.mendeley.com/research/systematic-review-dried-blood-spots-monitoring-hiv-viral-load-early-infant-diagnosis-2", "reader_count"=>99, "reader_count_by_academic_status"=>{"Unspecified"=>7, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>27, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>10, "Student > Master"=>12, "Other"=>8, "Student > Bachelor"=>11, "Lecturer"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>7, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>27, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>10, "Student > Master"=>12, "Other"=>8, "Student > Bachelor"=>11, "Lecturer"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>11, "Agricultural and Biological Sciences"=>20, "Chemistry"=>2, "Engineering"=>4, "Nursing and Health Professions"=>6, "Biochemistry, Genetics and Molecular Biology"=>3, "Materials Science"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>38, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Social Sciences"=>6, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>38}, "Social Sciences"=>{"Social Sciences"=>6}, "Psychology"=>{"Psychology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>11}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Engineering"=>{"Engineering"=>4}, "Chemistry"=>{"Chemistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>20}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "reader_count_by_country"=>{"Belgium"=>1, "Tanzania"=>1, "Brazil"=>1, "South Africa"=>1, "France"=>1, "Kenya"=>1, "Switzerland"=>1}, "group_count"=>9}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84897469181"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84897469181?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897469181&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84897469181&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84897469181", "dc:identifier"=>"SCOPUS_ID:84897469181", "eid"=>"2-s2.0-84897469181", "dc:title"=>"Systematic review of the use of dried blood spots for monitoring HIV viral load and for early infant diagnosis", "dc:creator"=>"Smit P.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-03-06", "prism:coverDisplayDate"=>"6 March 2014", "prism:doi"=>"10.1371/journal.pone.0086461", "citedby-count"=>"74", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"London School of Hygiene & Tropical Medicine", "affiliation-city"=>"London", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"24603442", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e86461", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0086461", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"73", "xml_views"=>"6", "html_views"=>"320"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"73", "xml_views"=>"3", "html_views"=>"225"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"69", "xml_views"=>"0", "html_views"=>"283"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"234"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"52", "xml_views"=>"3", "html_views"=>"269"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"37", "xml_views"=>"2", "html_views"=>"153"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"32", "xml_views"=>"2", "html_views"=>"207"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"198"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"157"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"34", "xml_views"=>"2", "html_views"=>"111"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"73"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"100"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"136"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"132"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"111"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"155"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"117"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"141"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"141"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"165"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"157"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"126"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"103"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"146"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"142"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"111"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"59", "xml_views"=>"0", "html_views"=>"205"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"131"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"108"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"49", "xml_views"=>"0", "html_views"=>"127"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"56", "xml_views"=>"0", "html_views"=>"113"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"110"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"69", "xml_views"=>"2", "html_views"=>"128"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"37", "xml_views"=>"2", "html_views"=>"152"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"40", "xml_views"=>"4", "html_views"=>"175"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"41", "xml_views"=>"1", "html_views"=>"244"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"30", "xml_views"=>"2", "html_views"=>"185"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"159"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"32", "xml_views"=>"2", "html_views"=>"163"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"183"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"196"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"177"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"251"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"240"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"156"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"119"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"70"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"68"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"29", "xml_views"=>"3", "html_views"=>"50"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"73"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"47", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"46", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"63", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"14"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1409175"], "description"=>"<p>Number of publications matching a selection (18 out of 24) of quality criteria drawn from the STARD guidelines.</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Systematic reviews", "Diagnostic medicine", "Test evaluation", "Clinical epidemiology", "Infectious disease epidemiology", "Pediatric epidemiology", "Infectious diseases", "Viral diseases", "hiv", "HIV diagnosis and management", "Non-clinical medicine", "Health services research", "Public health", "Child health", "Health screening", "publications", "matching", "drawn", "stard"], "article_id"=>953306, "categories"=>["Medicine"], "users"=>["Pieter W. Smit", "Kimberly A. Sollis", "Susan Fiscus", "Nathan Ford", "Marco Vitoria", "Shaffiq Essajee", "David Barnett", "Ben Cheng", "Suzanne M. Crowe", "Thomas Denny", "Alan Landay", "Wendy Stevens", "Vincent Habiyambere", "Joseph H. Perriens", "Rosanna W. Peeling"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086461.g004", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_publications_matching_a_selection_18_out_of_24_of_quality_criteria_drawn_from_the_STARD_guidelines_/953306", "title"=>"Number of publications matching a selection (18 out of 24) of quality criteria drawn from the STARD guidelines.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1409170"], "description"=>"<p>Search algorithm.</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Systematic reviews", "Diagnostic medicine", "Test evaluation", "Clinical epidemiology", "Infectious disease epidemiology", "Pediatric epidemiology", "Infectious diseases", "Viral diseases", "hiv", "HIV diagnosis and management", "Non-clinical medicine", "Health services research", "Public health", "Child health", "Health screening"], "article_id"=>953301, "categories"=>["Medicine"], "users"=>["Pieter W. Smit", "Kimberly A. Sollis", "Susan Fiscus", "Nathan Ford", "Marco Vitoria", "Shaffiq Essajee", "David Barnett", "Ben Cheng", "Suzanne M. Crowe", "Thomas Denny", "Alan Landay", "Wendy Stevens", "Vincent Habiyambere", "Joseph H. Perriens", "Rosanna W. Peeling"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086461.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Search_algorithm_/953301", "title"=>"Search algorithm.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1409178"], "description"=>"<p>*sensitivity and specificity given against plasma.</p><p>** infants (median 6 months, none on ART).</p>‡<p>adults (median 34 years, all on ART).</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Systematic reviews", "Diagnostic medicine", "Test evaluation", "Clinical epidemiology", "Infectious disease epidemiology", "Pediatric epidemiology", "Infectious diseases", "Viral diseases", "hiv", "HIV diagnosis and management", "Non-clinical medicine", "Health services research", "Public health", "Child health", "Health screening", "specificity", "dbs", "vl", "compared"], "article_id"=>953309, "categories"=>["Medicine"], "users"=>["Pieter W. Smit", "Kimberly A. Sollis", "Susan Fiscus", "Nathan Ford", "Marco Vitoria", "Shaffiq Essajee", "David Barnett", "Ben Cheng", "Suzanne M. Crowe", "Thomas Denny", "Alan Landay", "Wendy Stevens", "Vincent Habiyambere", "Joseph H. Perriens", "Rosanna W. Peeling"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086461.t001", "stats"=>{"downloads"=>1, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sensitivity_and_Specificity_of_DBS_for_HIV_VL_compared_to_plasma_/953309", "title"=>"Sensitivity and Specificity of DBS for HIV VL compared to plasma.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-06 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1409177"], "description"=>"<p>*sensitivity and specificity given against whole blood or plasma.</p>‡<p>version number unknown.</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Systematic reviews", "Diagnostic medicine", "Test evaluation", "Clinical epidemiology", "Infectious disease epidemiology", "Pediatric epidemiology", "Infectious diseases", "Viral diseases", "hiv", "HIV diagnosis and management", "Non-clinical medicine", "Health services research", "Public health", "Child health", "Health screening", "specificity", "dbs", "compared"], "article_id"=>953308, "categories"=>["Medicine"], "users"=>["Pieter W. Smit", "Kimberly A. Sollis", "Susan Fiscus", "Nathan Ford", "Marco Vitoria", "Shaffiq Essajee", "David Barnett", "Ben Cheng", "Suzanne M. Crowe", "Thomas Denny", "Alan Landay", "Wendy Stevens", "Vincent Habiyambere", "Joseph H. Perriens", "Rosanna W. Peeling"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086461.t002", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sensitivity_and_Specificity_of_DBS_for_HIV_early_infant_diagnosis_compared_to_plasma_/953308", "title"=>"Sensitivity and Specificity of DBS for HIV early infant diagnosis compared to plasma.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-06 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1409174"], "description"=>"<p>Sensitivity per viral load range of DBS compared to matching plasma samples.</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Systematic reviews", "Diagnostic medicine", "Test evaluation", "Clinical epidemiology", "Infectious disease epidemiology", "Pediatric epidemiology", "Infectious diseases", "Viral diseases", "hiv", "HIV diagnosis and management", "Non-clinical medicine", "Health services research", "Public health", "Child health", "Health screening", "viral", "dbs", "compared", "matching", "plasma"], "article_id"=>953305, "categories"=>["Medicine"], "users"=>["Pieter W. Smit", "Kimberly A. Sollis", "Susan Fiscus", "Nathan Ford", "Marco Vitoria", "Shaffiq Essajee", "David Barnett", "Ben Cheng", "Suzanne M. Crowe", "Thomas Denny", "Alan Landay", "Wendy Stevens", "Vincent Habiyambere", "Joseph H. Perriens", "Rosanna W. Peeling"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086461.g003", "stats"=>{"downloads"=>7, "page_views"=>105, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sensitivity_per_viral_load_range_of_DBS_compared_to_matching_plasma_samples_/953305", "title"=>"Sensitivity per viral load range of DBS compared to matching plasma samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1409173"], "description"=>"<p>a haematocrit corrected. b viral load adjusted for smaller input volume. c standard haematocrit value used to correct. * data obtained from Bland-Altman figures. *Bias (DBS-plasma) was plotted as the mean with 1 standard deviation (SD). A negative value represents an HIV VL underestimation compared to plasma while a positive HIV VL bias represents an overestimation of the HIV VL compared to plasma. SD was recalculated to 1 SD when presented as 1.96 or 2SD. In case of bias discrepancy between the text and Bland Altman figure, the bias noted in the text was used (15).</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Systematic reviews", "Diagnostic medicine", "Test evaluation", "Clinical epidemiology", "Infectious disease epidemiology", "Pediatric epidemiology", "Infectious diseases", "Viral diseases", "hiv", "HIV diagnosis and management", "Non-clinical medicine", "Health services research", "Public health", "Child health", "Health screening", "viral"], "article_id"=>953304, "categories"=>["Medicine"], "users"=>["Pieter W. Smit", "Kimberly A. Sollis", "Susan Fiscus", "Nathan Ford", "Marco Vitoria", "Shaffiq Essajee", "David Barnett", "Ben Cheng", "Suzanne M. Crowe", "Thomas Denny", "Alan Landay", "Wendy Stevens", "Vincent Habiyambere", "Joseph H. Perriens", "Rosanna W. Peeling"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086461.g002", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bias_per_HIV_viral_load_range_given_for_each_assay_/953304", "title"=>"Bias* per HIV viral load range, given for each assay.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1409180", "https://ndownloader.figshare.com/files/1409181", "https://ndownloader.figshare.com/files/1409182", "https://ndownloader.figshare.com/files/1409183"], "description"=>"<div><p>Background</p><p>Dried blood spots (DBS) have been used as alternative specimens to plasma to increase access to HIV viral load (VL) monitoring and early infant diagnosis (EID) in remote settings. We systematically reviewed evidence on the performance of DBS compared to plasma for VL monitoring and EID.</p><p>Methods and Findings</p><p>Thirteen peer reviewed HIV VL publications and five HIV EID papers were included. Depending on the technology and the viral load distribution in the study population, the percentage of DBS samples that are within 0.5 log of VL in plasma ranged from 52–100%. Because the input sample volume is much smaller in a blood spot, there is a risk of false negatives with DBS. Sensitivity of DBS VL was found to be 78–100% compared to plasma at VL below 1000 copies/ml, but this increased to 100% at a threshold of 5000 copies/ml. Unlike a plasma VL test which measures only cell free HIV RNA, a DBS VL also measures proviral DNA as well as cell-associated RNA, potentially leading to false positive results when using DBS. The systematic review showed that specificity was close to 100% at DBS VL above 5000 copies/ml, and this threshold would be the most reliable for predicting true virologic failure using DBS. For early infant diagnosis, DBS has a sensitivity of 100% compared to fresh whole blood or plasma in all studies.</p><p>Conclusions</p><p>Although limited data are available for EID, DBS offer a highly sensitive and specific sampling strategy to make viral load monitoring and early infant diagnosis more accessible in remote settings. A standardized approach for sampling, storing, and processing DBS samples would be essential to allow successful implementation.</p><p>Trial Registration</p><p>PROSPERO Registration #: CRD42013003621.</p></div>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Systematic reviews", "Diagnostic medicine", "Test evaluation", "Clinical epidemiology", "Infectious disease epidemiology", "Pediatric epidemiology", "Infectious diseases", "Viral diseases", "hiv", "HIV diagnosis and management", "Non-clinical medicine", "Health services research", "Public health", "Child health", "Health screening", "spots", "monitoring", "viral"], "article_id"=>953311, "categories"=>["Medicine"], "users"=>["Pieter W. Smit", "Kimberly A. Sollis", "Susan Fiscus", "Nathan Ford", "Marco Vitoria", "Shaffiq Essajee", "David Barnett", "Ben Cheng", "Suzanne M. Crowe", "Thomas Denny", "Alan Landay", "Wendy Stevens", "Vincent Habiyambere", "Joseph H. Perriens", "Rosanna W. Peeling"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0086461.s001", "https://dx.doi.org/10.1371/journal.pone.0086461.s002", "https://dx.doi.org/10.1371/journal.pone.0086461.s003", "https://dx.doi.org/10.1371/journal.pone.0086461.s004"], "stats"=>{"downloads"=>5, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Systematic_Review_of_the_Use_of_Dried_Blood_Spots_for_Monitoring_HIV_Viral_Load_and_for_Early_Infant_Diagnosis_/953311", "title"=>"Systematic Review of the Use of Dried Blood Spots for Monitoring HIV Viral Load and for Early Infant Diagnosis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-03-06 02:48:53"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"51", "full-text"=>"50", "pdf"=>"33", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"33", "full-text"=>"35", "pdf"=>"29", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"29", "full-text"=>"38", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"39", "full-text"=>"40", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"42", "full-text"=>"50", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"47", "full-text"=>"55", "pdf"=>"34", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"44", "full-text"=>"47", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"50", "full-text"=>"56", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"60", "full-text"=>"61", "pdf"=>"43", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"2", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"40", "full-text"=>"44", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"51", "full-text"=>"54", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"62", "full-text"=>"67", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"54", "full-text"=>"75", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"26", "full-text"=>"31", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"26", "full-text"=>"32", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"26", "full-text"=>"31", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"26", "full-text"=>"29", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"48", "full-text"=>"54", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"28", "full-text"=>"29", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"68", "full-text"=>"66", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"52", "full-text"=>"61", "pdf"=>"56", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"44", "full-text"=>"46", "pdf"=>"38", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"74", "full-text"=>"75", "pdf"=>"31", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"44", "full-text"=>"50", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"42", "full-text"=>"45", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"43", "full-text"=>"47", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"33", "full-text"=>"36", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"37", "full-text"=>"37", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"38", "full-text"=>"44", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"37", "full-text"=>"45", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"72", "full-text"=>"53", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"7", "cited-by"=>"1", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"30", "full-text"=>"34", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"35", "full-text"=>"34", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"27", "full-text"=>"33", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"36", "full-text"=>"38", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"27", "full-text"=>"29", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"32", "full-text"=>"37", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"33", "full-text"=>"39", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"50", "full-text"=>"61", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"30", "full-text"=>"34", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"29", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"29", "full-text"=>"29", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"39", "full-text"=>"45", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"28", "full-text"=>"30", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"37", "full-text"=>"36", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"43", "full-text"=>"46", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"38", "full-text"=>"35", "pdf"=>"18", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"31", "full-text"=>"42", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"42", "full-text"=>"43", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"49", "full-text"=>"49", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"34", "full-text"=>"40", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"37", "full-text"=>"46", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"43", "full-text"=>"53", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"26", "full-text"=>"33", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"33", "full-text"=>"32", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"33", "full-text"=>"41", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"36", "full-text"=>"42", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"32", "full-text"=>"43", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"17", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[280]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[266]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[256]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[300]}]}
Loading … Spinner
There are currently no alerts