Characteristics of Networks of Interventions: A Description of a Database of 186 Published Networks
Publication Date
January 22, 2014
Journal
PLOS ONE
Authors
Adriani Nikolakopoulou, Anna Chaimani, Areti Angeliki Veroniki, Haris S. Vasiliadis, et al
Volume
9
Issue
1
Pages
e86754
DOI
https://dx.plos.org/10.1371/journal.pone.0086754
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0086754
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24466222
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899297
Europe PMC
http://europepmc.org/abstract/MED/24466222
Web of Science
000330283100206
Scopus
84899557077
Mendeley
http://www.mendeley.com/research/characteristics-networks-interventions-description-database-186-published-networks
Events
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Mendeley | Further Information

{"title"=>"Characteristics of networks of interventions: A description of a database of 186 published networks", "type"=>"generic", "authors"=>[{"first_name"=>"Adriani", "last_name"=>"Nikolakopoulou", "scopus_author_id"=>"56089187000"}, {"first_name"=>"Anna", "last_name"=>"Chaimani", "scopus_author_id"=>"55867072000"}, {"first_name"=>"Areti Angeliki", "last_name"=>"Veroniki", "scopus_author_id"=>"55636135500"}, {"first_name"=>"Haris S.", "last_name"=>"Vasiliadis", "scopus_author_id"=>"9733030900"}, {"first_name"=>"Christopher H.", "last_name"=>"Schmid", "scopus_author_id"=>"7201732815"}, {"first_name"=>"Georgia", "last_name"=>"Salanti", "scopus_author_id"=>"55927919500"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84899557077", "doi"=>"10.1371/journal.pone.0086754", "pui"=>"372974067", "pmid"=>"24466222", "scopus"=>"2-s2.0-84899557077", "issn"=>"19326203", "isbn"=>"1932-6203"}, "id"=>"d20956b0-0df8-3d91-9eff-95a224407d0b", "abstract"=>"Systematic reviews that employ network meta-analysis are undertaken and published with increasing frequency while related statistical methodology is evolving. Future statistical developments and evaluation of the existing methodologies could be motivated by the characteristics of the networks of interventions published so far in order to tackle real rather than theoretical problems. Based on the recently formed network meta-analysis literature we aim to provide an insight into the characteristics of networks in healthcare research. We searched PubMed until end of 2012 for meta-analyses that used any form of indirect comparison. We collected data from networks that compared at least four treatments regarding their structural characteristics as well as characteristics of their analysis. We then conducted a descriptive analysis of the various network characteristics. We included 186 networks of which 35 (19%) were star-shaped (treatments were compared to a common comparator but not between themselves). The median number of studies per network was 21 and the median number of treatments compared was 6. The majority (85%) of the non-star shaped networks included at least one multi-arm study. Synthesis of data was primarily done via network meta-analysis fitted within a Bayesian framework (113 (61%) networks). We were unable to identify the exact method used to perform indirect comparison in a sizeable number of networks (18 (9%)). In 32% of the networks the investigators employed appropriate statistical methods to evaluate the consistency assumption; this percentage is larger among recently published articles. Our descriptive analysis provides useful information about the characteristics of networks of interventions published the last 16 years and the methods for their analysis. Although the validity of network meta-analysis results highly depends on some basic assumptions, most authors did not report and evaluate them adequately. Reviewers and editors need to be aware of these assumptions and insist on their reporting and accuracy.", "link"=>"http://www.mendeley.com/research/characteristics-networks-interventions-description-database-186-published-networks", "reader_count"=>31, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>4, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>4, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>4, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>4, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Nursing and Health Professions"=>1, "Mathematics"=>5, "Medicine and Dentistry"=>14, "Agricultural and Biological Sciences"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>1, "Computer Science"=>2, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Social Sciences"=>{"Social Sciences"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Mathematics"=>{"Mathematics"=>5}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "Bulgaria"=>1, "France"=>1}, "group_count"=>1}

CrossRef

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1356578"], "description"=>"<p>Flow chart of identified networks.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Clinical research design", "epidemiology", "meta-analyses", "Systematic reviews", "Epidemiological methods", "Non-clinical medicine", "Health services research", "Research assessment", "Research monitoring", "Research reporting guidelines"], "article_id"=>909022, "categories"=>["Mathematics", "Medicine", "Science Policy"], "users"=>["Adriani Nikolakopoulou", "Anna Chaimani", "Areti Angeliki Veroniki", "Haris S. Vasiliadis", "Christopher H. Schmid", "Georgia Salanti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086754.g001", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_chart_of_identified_networks_/909022", "title"=>"Flow chart of identified networks.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 04:09:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1356592"], "description"=>"<p>The table shows the number of networks and the respective percentage in parenthesis.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Clinical research design", "epidemiology", "meta-analyses", "Systematic reviews", "Epidemiological methods", "Non-clinical medicine", "Health services research", "Research assessment", "Research monitoring", "Research reporting guidelines", "comparisons", "networks", "published"], "article_id"=>909036, "categories"=>["Mathematics", "Medicine", "Science Policy"], "users"=>["Adriani Nikolakopoulou", "Anna Chaimani", "Areti Angeliki Veroniki", "Haris S. Vasiliadis", "Christopher H. Schmid", "Georgia Salanti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086754.t005", "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_treatment_comparisons_in_full_and_star_networks_published_until_12_2012_/909036", "title"=>"Characteristics of the treatment comparisons in full and star networks published until 12/2012.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-22 04:09:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1356589"], "description"=>"<p>For a description of the network meta-analysis methods see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086754#pone-0086754-t001\" target=\"_blank\">Table 1</a>. The table shows the number of networks and the respective percentage in parenthesis.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Clinical research design", "epidemiology", "meta-analyses", "Systematic reviews", "Epidemiological methods", "Non-clinical medicine", "Health services research", "Research assessment", "Research monitoring", "Research reporting guidelines", "employed", "synthesise", "networks", "published"], "article_id"=>909033, "categories"=>["Mathematics", "Medicine", "Science Policy"], "users"=>["Adriani Nikolakopoulou", "Anna Chaimani", "Areti Angeliki Veroniki", "Haris S. Vasiliadis", "Christopher H. Schmid", "Georgia Salanti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086754.t006", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Methods_employed_to_synthesise_data_in_full_and_star_networks_published_until_12_2012_/909033", "title"=>"Methods employed to synthesise data in full and star networks published until 12/2012.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-22 04:09:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1356587"], "description"=>"<p>Description of methods to derive indirect and mixed estimates.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Clinical research design", "epidemiology", "meta-analyses", "Systematic reviews", "Epidemiological methods", "Non-clinical medicine", "Health services research", "Research assessment", "Research monitoring", "Research reporting guidelines", "methods", "indirect"], "article_id"=>909031, "categories"=>["Mathematics", "Medicine", "Science Policy"], "users"=>["Adriani Nikolakopoulou", "Anna Chaimani", "Areti Angeliki Veroniki", "Haris S. Vasiliadis", "Christopher H. Schmid", "Georgia Salanti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086754.t001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Description_of_methods_to_derive_indirect_and_mixed_estimates_/909031", "title"=>"Description of methods to derive indirect and mixed estimates.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-22 04:09:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1356586"], "description"=>"<p>Some characteristics could be estimated for all networks (186, published until 12/2012) whereas some other characteristics require outcome data and were estimated from 88 networks published until 3/2011 or their subsets. The exact number of networks evaluated in each case is given in square brackets. In parenthesis we present the interquartile range.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Clinical research design", "epidemiology", "meta-analyses", "Systematic reviews", "Epidemiological methods", "Non-clinical medicine", "Health services research", "Research assessment", "Research monitoring", "Research reporting guidelines"], "article_id"=>909030, "categories"=>["Mathematics", "Medicine", "Science Policy"], "users"=>["Adriani Nikolakopoulou", "Anna Chaimani", "Areti Angeliki Veroniki", "Haris S. Vasiliadis", "Christopher H. Schmid", "Georgia Salanti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086754.t003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Structural_characteristics_of_full_and_star_networks_/909030", "title"=>"Structural characteristics of full and star networks.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-22 04:09:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1356583"], "description"=>"<p>Networks that used more than one method are included in all relevant categories.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Clinical research design", "epidemiology", "meta-analyses", "Systematic reviews", "Epidemiological methods", "Non-clinical medicine", "Health services research", "Research assessment", "Research monitoring", "Research reporting guidelines", "published", "networks", "meta-analysis"], "article_id"=>909027, "categories"=>["Mathematics", "Medicine", "Science Policy"], "users"=>["Adriani Nikolakopoulou", "Anna Chaimani", "Areti Angeliki Veroniki", "Haris S. Vasiliadis", "Christopher H. Schmid", "Georgia Salanti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086754.g004", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_published_networks_by_year_1997_8211_2012_and_the_Network_Meta_Analysis_method_/909027", "title"=>"Number of published networks by year (1997–2012) and the Network Meta-Analysis method.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 04:09:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1356591"], "description"=>"<p>The table shows the number of networks and the respective percentage in parenthesis.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Clinical research design", "epidemiology", "meta-analyses", "Systematic reviews", "Epidemiological methods", "Non-clinical medicine", "Health services research", "Research assessment", "Research monitoring", "Research reporting guidelines", "outcomes", "measures", "networks", "published"], "article_id"=>909035, "categories"=>["Mathematics", "Medicine", "Science Policy"], "users"=>["Adriani Nikolakopoulou", "Anna Chaimani", "Areti Angeliki Veroniki", "Haris S. Vasiliadis", "Christopher H. Schmid", "Georgia Salanti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086754.t004", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_primary_outcomes_and_their_measures_in_full_and_star_networks_published_until_12_2012_/909035", "title"=>"Characteristics of the primary outcomes and their measures in full and star networks published until 12/2012.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-22 04:09:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1356590"], "description"=>"<p>For a description of the methods to evaluate inconsistency see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086754#pone-0086754-t002\" target=\"_blank\">Table 2</a>. The table shows the number of networks and the respective percentage in parenthesis.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Clinical research design", "epidemiology", "meta-analyses", "Systematic reviews", "Epidemiological methods", "Non-clinical medicine", "Health services research", "Research assessment", "Research monitoring", "Research reporting guidelines", "methods", "consistency", "151", "networks", "published"], "article_id"=>909034, "categories"=>["Mathematics", "Medicine", "Science Policy"], "users"=>["Adriani Nikolakopoulou", "Anna Chaimani", "Areti Angeliki Veroniki", "Haris S. Vasiliadis", "Christopher H. Schmid", "Georgia Salanti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086754.t007", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Statistical_methods_used_to_evaluate_consistency_in_151_full_networks_published_until_12_2012_/909034", "title"=>"Statistical methods used to evaluate consistency in 151 full networks published until 12/2012.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-22 04:09:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1356585"], "description"=>"<p>Description of statistical methods used to evaluate the consistency assumption.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Clinical research design", "epidemiology", "meta-analyses", "Systematic reviews", "Epidemiological methods", "Non-clinical medicine", "Health services research", "Research assessment", "Research monitoring", "Research reporting guidelines", "methods", "consistency"], "article_id"=>909029, "categories"=>["Mathematics", "Medicine", "Science Policy"], "users"=>["Adriani Nikolakopoulou", "Anna Chaimani", "Areti Angeliki Veroniki", "Haris S. Vasiliadis", "Christopher H. Schmid", "Georgia Salanti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086754.t002", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Description_of_statistical_methods_used_to_evaluate_the_consistency_assumption_/909029", "title"=>"Description of statistical methods used to evaluate the consistency assumption.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-22 04:09:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1356584"], "description"=>"<p>Appropriate statistical methods are presented in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086754#pone-0086754-t002\" target=\"_blank\">Table 2</a>. Networks that used more than one method are included in all relevant categories.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Clinical research design", "epidemiology", "meta-analyses", "Systematic reviews", "Epidemiological methods", "Non-clinical medicine", "Health services research", "Research assessment", "Research monitoring", "Research reporting guidelines", "published", "networks", "employed"], "article_id"=>909028, "categories"=>["Mathematics", "Medicine", "Science Policy"], "users"=>["Adriani Nikolakopoulou", "Anna Chaimani", "Areti Angeliki Veroniki", "Haris S. Vasiliadis", "Christopher H. Schmid", "Georgia Salanti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086754.g005", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_published_full_networks_by_year_1997_8211_2012_and_the_method_employed_to_examine_inconsistency_/909028", "title"=>"Number of published full networks by year (1997–2012) and the method employed to examine inconsistency.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 04:09:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1356581"], "description"=>"<p>BMC: BioMed Central BMJ: British Medical Journal CDSR: Cochrane Database of Systematic Reviews CMRO: Current Medical Research & Opinion HTA: Health Technology Assessment JCE: Journal of Clinical Epidemiology.</p>", "links"=>[], "tags"=>["statistics", "Biostatistics", "Clinical research design", "epidemiology", "meta-analyses", "Systematic reviews", "Epidemiological methods", "Non-clinical medicine", "Health services research", "Research assessment", "Research monitoring", "Research reporting guidelines", "meta-analysis", "articles", "networks", "published"], "article_id"=>909025, "categories"=>["Mathematics", "Medicine", "Science Policy"], "users"=>["Adriani Nikolakopoulou", "Anna Chaimani", "Areti Angeliki Veroniki", "Haris S. Vasiliadis", "Christopher H. Schmid", "Georgia Salanti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086754.g003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_meta_analysis_articles_with_full_and_star_networks_published_by_journal_/909025", "title"=>"Number of meta-analysis articles with full and star networks published by journal.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-22 04:09:25"}

PMC Usage Stats | Further Information

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Relative Metric

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