Increased Amygdala Response to Shame in Remitted Major Depressive Disorder
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{"title"=>"Increased amygdala response to shame in remitted major depressive disorder", "type"=>"journal", "authors"=>[{"first_name"=>"Erdem", "last_name"=>"Pulcu", "scopus_author_id"=>"55760159400"}, {"first_name"=>"Karen", "last_name"=>"Lythe", "scopus_author_id"=>"8635195300"}, {"first_name"=>"Rebecca", "last_name"=>"Elliott", "scopus_author_id"=>"7402638581"}, {"first_name"=>"Sophie", "last_name"=>"Green", "scopus_author_id"=>"56324955400"}, {"first_name"=>"Jorge", "last_name"=>"Moll", "scopus_author_id"=>"7102497419"}, {"first_name"=>"John F.W.", "last_name"=>"Deakin", "scopus_author_id"=>"7004839680"}, {"first_name"=>"Roland", "last_name"=>"Zahn", "scopus_author_id"=>"7102439467"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84899547848", "sgr"=>"84899547848", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0086900", "pmid"=>"24497992", "isbn"=>"1932-6203", "pui"=>"373070781"}, "id"=>"c5030589-e756-39e2-826c-630abcb8e092", "abstract"=>"Proneness to self-blaming moral emotions such as shame and guilt is increased in major depressive disorder (MDD), and may play an important role in vulnerability even after symptoms have subsided. Social psychologists have argued that shame-proneness is relevant for depression vulnerability and is distinct from guilt. Shame depends on the imagined critical perception of others, whereas guilt results from one's own judgement. The neuroanatomy of shame in MDD is unknown. Using fMRI, we compared 21 participants with MDD remitted from symptoms with no current co-morbid axis-I disorders, and 18 control participants with no personal or family history of MDD. The MDD group exhibited higher activation of the right amygdala and posterior insula for shame relative to guilt (SPM8). This neural difference was observed despite equal levels of rated negative emotional valence and frequencies of induced shame and guilt experience across groups. These same results were found in the medication-free MDD subgroup (N = 15). Increased amygdala and posterior insula activations, known to be related to sensory perception of emotional stimuli, distinguish shame from guilt responses in remitted MDD. People with MDD thus exhibit changes in the neural response to shame after symptoms have subsided. This supports the hypothesis that shame and guilt play at least partly distinct roles in vulnerability to MDD. Shame-induction may be a more sensitive probe of residual amygdala hypersensitivity in MDD compared with facial emotion-evoked responses previously found to normalize on remission.", "link"=>"http://www.mendeley.com/research/increased-amygdala-response-shame-remitted-major-depressive-disorder", "reader_count"=>66, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>3, "Student > Doctoral Student"=>9, "Researcher"=>13, "Student > Ph. D. Student"=>11, "Student > Master"=>10, "Student > Bachelor"=>7, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>3, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>3, "Student > Doctoral Student"=>9, "Researcher"=>13, "Student > Ph. D. Student"=>11, "Student > Master"=>10, "Student > Bachelor"=>7, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>3, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>8, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>12, "Neuroscience"=>4, "Arts and Humanities"=>1, "Psychology"=>33, "Social Sciences"=>3, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Neuroscience"=>{"Neuroscience"=>4}, "Social Sciences"=>{"Social Sciences"=>3}, "Psychology"=>{"Psychology"=>33}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Unspecified"=>{"Unspecified"=>8}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Uruguay"=>1, "United States"=>1, "South Africa"=>1, "United Kingdom"=>1}, "group_count"=>6}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1368746"], "description"=>"*<p>All co-morbid disorders were fully remitted at time of study. None of the co-morbid disorders was a likely primary cause of the depressive episodes. SSRI = selective serotonin reuptake inhibitor, SNRI = serotonin norepinephrine reuptake inhibitor. MDD subtype classification was based on adapting the SCID-I for DSMIV-TR to allow lifetime assessment of the subtypes. All medication-free participants had stopped medication well before the required washout phase.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "neuroanatomy", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions", "neurology", "remitted", "mdd"], "article_id"=>919800, "categories"=>["Biological Sciences", "Medicine", "Sociology"], "users"=>["Erdem Pulcu", "Karen Lythe", "Rebecca Elliott", "Sophie Green", "Jorge Moll", "John F. W. Deakin", "Roland Zahn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086900.t001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_characteristics_of_remitted_MDD_group_N_8202_8202_21_/919800", "title"=>"Clinical characteristics of remitted MDD group (N = 21).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-30 04:19:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368749"], "description"=>"<p>Only regions are reported that survived voxel- or cluster-based FWE-corrected p = .05 over the whole brain or our <i>a priori</i> ROIs. c = cluster-based FWE-correction. 1 = ROI with strong a priori predictions. 2 = Control ROI with weak a priori predictions. Control group: N = 18, remitted MDD group: N = 21.</p>*<p>Additional analyses for each group separately showed that the amygdala and posterior insula were activated for shame vs. guilt in the MDD group, but not for guilt vs. shame in the control group (at FWE-corrected p = .10 over ROIs).</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "neuroanatomy", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions", "neurology"], "article_id"=>919803, "categories"=>["Biological Sciences", "Medicine", "Sociology"], "users"=>["Erdem Pulcu", "Karen Lythe", "Rebecca Elliott", "Sophie Green", "Jorge Moll", "John F. W. Deakin", "Roland Zahn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086900.t004", "stats"=>{"downloads"=>1, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BOLD_fMRI_results_/919803", "title"=>"BOLD fMRI results.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-30 04:19:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368747"], "description"=>"<p>Summaries of between-group differences at p = .05, two-sided (MDD group: N = 21, control group: N = 18). Unpleasantness ratings were obtained on a 7-step visual analogue Likert scales (range 1 to 7). Ratings for guilt trials were reported previously <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Green3\" target=\"_blank\">[31]</a>.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "neuroanatomy", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions", "neurology", "ratings"], "article_id"=>919801, "categories"=>["Biological Sciences", "Medicine", "Sociology"], "users"=>["Erdem Pulcu", "Karen Lythe", "Rebecca Elliott", "Sophie Green", "Jorge Moll", "John F. W. Deakin", "Roland Zahn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086900.t003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summaries_of_moral_emotion_ratings_and_response_times_/919801", "title"=>"Summaries of moral emotion ratings and response times.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-30 04:19:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368748"], "description"=>"<p>CC = contingency coefficient, * = significant at p = .05 threshold, 2-tailed, control: N = 18, remitted MDD: N = 21, U = Mann-Whitney-U. A similar table has been reported in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Green3\" target=\"_blank\">[31]</a>.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "neuroanatomy", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions", "neurology"], "article_id"=>919802, "categories"=>["Biological Sciences", "Medicine", "Sociology"], "users"=>["Erdem Pulcu", "Karen Lythe", "Rebecca Elliott", "Sophie Green", "Jorge Moll", "John F. W. Deakin", "Roland Zahn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086900.t002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Group_comparison_on_demographic_and_basic_clinical_variables_/919802", "title"=>"Group comparison on demographic and basic clinical variables.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-30 04:19:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368745"], "description"=>"<p>This was confirmed by a supporting data analysis using the mean regression coefficients of the activated clusters in the amygdala (24, −4, −18) and posterior insula (40, −16, 0). For both regions, there was a moral emotion by group interaction (amygdala: F<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Freud1\" target=\"_blank\">[1]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Pessoa1\" target=\"_blank\">[37]</a> = 10.5, p = .003; posterior insula: F<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Freud1\" target=\"_blank\">[1]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Pessoa1\" target=\"_blank\">[37]</a> = 16.9, p<.0001) and no main effect of moral emotion (amygdala: F<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Freud1\" target=\"_blank\">[1]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Pessoa1\" target=\"_blank\">[37]</a> = .126, p  = .725; posterior insula: F<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Freud1\" target=\"_blank\">[1]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Pessoa1\" target=\"_blank\">[37]</a> = .11, p = .75) or group (amygdala: F <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Freud1\" target=\"_blank\">[1]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Pessoa1\" target=\"_blank\">[37]</a> = .30, p = .59; posterior insula: F <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Freud1\" target=\"_blank\">[1]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Pessoa1\" target=\"_blank\">[37]</a> = .79, p = .38). The increased shame-response relative to guilt compared with the control group was also found in the remitted MDD subgroup not currently taking medication (amygdala: p = .01, t<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Green3\" target=\"_blank\">[31]</a> = 2.6; posterior insula: p<.0001, t<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086900#pone.0086900-Green3\" target=\"_blank\">[31]</a> = 4.1).</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "neuroanatomy", "Mental health", "psychiatry", "Mood disorders", "psychology", "behavior", "emotions", "neurology", "mdd", "showed", "higher", "activation", "amygdala", "posterior", "insula", "compared", "maps", "voxel-level", "uncorrected"], "article_id"=>919799, "categories"=>["Biological Sciences", "Medicine", "Sociology"], "users"=>["Erdem Pulcu", "Karen Lythe", "Rebecca Elliott", "Sophie Green", "Jorge Moll", "John F. W. Deakin", "Roland Zahn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0086900.g001", "stats"=>{"downloads"=>5, "page_views"=>111, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_MDD_group_showed_higher_activation_in_the_right_amygdala_panel_a_and_right_posterior_insula_panel_b_for_shame_versus_guilt_compared_with_the_control_group_displayed_are_whole_brain_maps_at_voxel_level_p_8202_8202_005_uncorrected_and_cluster_size_of_4/919799", "title"=>"The MDD group showed higher activation in the right amygdala (panel a) and right posterior insula (panel b) for shame versus guilt compared with the control group (displayed are whole brain maps at voxel-level p = .005 uncorrected and cluster size of 4 voxels).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 04:19:53"}

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Relative Metric

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