Effects of Growth Hormone (GH) Therapy Withdrawal on Glucose Metabolism in Not Confirmed GH Deficient Adolescents at Final Height
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{"title"=>"Effects of Growth Hormone (GH) therapy withdrawal on glucose metabolism in not confirmed GH deficient adolescents at final height", "type"=>"journal", "authors"=>[{"first_name"=>"Flavia", "last_name"=>"Prodam", "scopus_author_id"=>"6602838716"}, {"first_name"=>"Silvia", "last_name"=>"Savastio", "scopus_author_id"=>"13205593000"}, {"first_name"=>"Giulia", "last_name"=>"Genoni", "scopus_author_id"=>"54410430600"}, {"first_name"=>"Deepak", "last_name"=>"Babu", "scopus_author_id"=>"55513163100"}, {"first_name"=>"Mara", "last_name"=>"Giordano", "scopus_author_id"=>"7201827409"}, {"first_name"=>"Roberta", "last_name"=>"Ricotti", "scopus_author_id"=>"6603163959"}, {"first_name"=>"Gianluca", "last_name"=>"Aimaretti", "scopus_author_id"=>"7003308152"}, {"first_name"=>"Gianni", "last_name"=>"Bona", "scopus_author_id"=>"7102986345"}, {"first_name"=>"Simonetta", "last_name"=>"Bellone", "scopus_author_id"=>"7004445067"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"373070799", "doi"=>"10.1371/journal.pone.0087157", "sgr"=>"84900428393", "scopus"=>"2-s2.0-84900428393", "isbn"=>"1932-6203", "pmid"=>"24498035"}, "id"=>"cdd1275b-f435-3d4b-a73b-ed41dec56b53", "abstract"=>"CONTEXT OBJECTIVE: Growth hormone deficiency (GHD) is associated with insulin resistance and diabetes, in particular after treatment in children and adults with pre-existing metabolic risk factors. Our aims were. i) to evaluate the effect on glucose metabolism of rhGH treatment and withdrawal in not confirmed GHD adolescents at the achievement of adult height; ii) to investigate the impact of GH receptor gene genomic deletion of exon 3 (d3GHR). DESIGN SETTING: We performed a longitudinal study (1 year) in a tertiary care center. METHODS: 23 GHD adolescent were followed in the last year of rhGH treatment (T0), 6 (T6) and 12 (T12) months after rhGH withdrawal with fasting and post-OGTT evaluations. 40 healthy adolescents were used as controls. HOMA-IR, HOMA%beta, insulinogenic (INS) and disposition (DI) indexes were calculated. GHR genotypes were determined by multiplex PCR. RESULTS: In the group as a whole, fasting insulin (p<0.05), HOMA-IR (p<0.05), insulin and glucose levels during OGTT (p<0.01) progressively decreased from T0 to T12 becoming similar to controls. During rhGH, a compensatory insulin secretion with a stable DI was recorded, and, then, HOMAbeta and INS decreased at T6 and T12 (p<0.05). By evaluating the GHR genotype, nDel GHD showed a decrease from T0 to T12 in HOMA-IR, HOMAbeta, INS (p<0.05) and DI. Del GHD showed a gradual increase in DI (p<0.05) and INS with a stable HOMA-IR and higher HDL-cholesterol (p<0.01). CONCLUSIONS: In not confirmed GHD adolescents the fasting deterioration in glucose homeostasis during rhGH is efficaciously coupled with a compensatory insulin secretion and activity at OGTT. The presence of at least one d3GHR allele is associated with lower glucose levels and higher HOMA-beta and DI after rhGH withdrawal. Screening for the d3GHR in the pediatric age may help physicians to follow and phenotype GHD patients also by a metabolic point of view.", "link"=>"http://www.mendeley.com/research/effects-growth-hormone-gh-therapy-withdrawal-glucose-metabolism-not-confirmed-gh-deficient-adolescen", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>5, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>6, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>5, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>6, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>12, "Sports and Recreations"=>1, "Psychology"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Brazil"=>1, "Italy"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1367348"], "description"=>"<div><p>Context, objective</p><p>Growth hormone deficiency (GHD) is associated with insulin resistance and diabetes, in particular after treatment in children and adults with pre-existing metabolic risk factors. Our aims were. i) to evaluate the effect on glucose metabolism of rhGH treatment and withdrawal in not confirmed GHD adolescents at the achievement of adult height; ii) to investigate the impact of GH receptor gene genomic deletion of exon 3 (d3GHR).</p><p>Design, setting</p><p>We performed a longitudinal study (1 year) in a tertiary care center.</p><p>Methods</p><p>23 GHD adolescent were followed in the last year of rhGH treatment (T0), 6 (T6) and 12 (T12) months after rhGH withdrawal with fasting and post-OGTT evaluations. 40 healthy adolescents were used as controls. HOMA-IR, HOMA%β, insulinogenic (INS) and disposition (DI) indexes were calculated. GHR genotypes were determined by multiplex PCR.</p><p>Results</p><p>In the group as a whole, fasting insulin (p<0.05), HOMA-IR (p<0.05), insulin and glucose levels during OGTT (p<0.01) progressively decreased from T0 to T12 becoming similar to controls. During rhGH, a compensatory insulin secretion with a stable DI was recorded, and, then, HOMAβ and INS decreased at T6 and T12 (p<0.05). By evaluating the GHR genotype, nDel GHD showed a decrease from T0 to T12 in HOMA-IR, HOMAβ, INS (p<0.05) and DI. Del GHD showed a gradual increase in DI (p<0.05) and INS with a stable HOMA-IR and higher HDL-cholesterol (p<0.01).</p><p>Conclusions</p><p>In not confirmed GHD adolescents the fasting deterioration in glucose homeostasis during rhGH is efficaciously coupled with a compensatory insulin secretion and activity at OGTT. The presence of at least one d3GHR allele is associated with lower glucose levels and higher HOMA-β and DI after rhGH withdrawal. Screening for the d3GHR in the pediatric age may help physicians to follow and phenotype GHD patients also by a metabolic point of view.</p></div>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "hormones", "insulin", "Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Hormone receptor signaling", "Endocrinology", "Diabetic endocrinology", "Metabolic disorders", "pediatrics", "glucose", "metabolism", "confirmed", "gh", "deficient", "adolescents"], "article_id"=>918749, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Flavia Prodam", "Silvia Savastio", "Giulia Genoni", "Deepak Babu", "Mara Giordano", "Roberta Ricotti", "Gianluca Aimaretti", "Gianni Bona", "Simonetta Bellone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087157", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_Growth_Hormone_GH_Therapy_Withdrawal_on_Glucose_Metabolism_in_Not_Confirmed_GH_Deficient_Adolescents_at_Final_Height_/918749", "title"=>"Effects of Growth Hormone (GH) Therapy Withdrawal on Glucose Metabolism in Not Confirmed GH Deficient Adolescents at Final Height", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 02:46:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1367346"], "description"=>"<p>Abbreviations. BMI, body mass index; HV, height velocity; IFG, impaired fasting glucose; IGT, impaired glucose tolerance; SBP: systolic blood pressure; DBP: diastolic blood pressure, SDS: standard deviation score.</p><p>Data are expressed as mean±SEM. a: p<0.0001 GHD T0 vs CS; b: p<0.05 GHD T0 vs CS; c: p<0.0001 GHD T12 vs CS.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "hormones", "insulin", "Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Hormone receptor signaling", "Endocrinology", "Diabetic endocrinology", "Metabolic disorders", "pediatrics", "deficient", "children", "rhgh", "12", "months", "subjects"], "article_id"=>918747, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Flavia Prodam", "Silvia Savastio", "Giulia Genoni", "Deepak Babu", "Mara Giordano", "Roberta Ricotti", "Gianluca Aimaretti", "Gianni Bona", "Simonetta Bellone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087157.t001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_parameters_of_growth_hormone_deficient_GHD_group_1_children_at_the_end_T0_of_rhGH_therapy_T0_after_12_months_rhGH_withdrawal_T12_and_of_control_subjects_CS_group_2_/918747", "title"=>"Clinical parameters of growth hormone deficient (GHD, group 1) children at the end (T0) of rhGH therapy (T0), after 12 months rhGH withdrawal (T12) and of control subjects (CS, group 2).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-30 02:46:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1367347"], "description"=>"<p>Abbreviations. DI, disposition index; INS, insulinogenic index; AUC, area under the curve; ΔG0-30: delta glucose;; ΔI0-30: delta insulin; HDL-c, HDL-cholesterol; LDL-c, LDL-cholesterol; T-c, total-cholesterol; TG, triglycerides. Data are expressed as mean±SEM. The significance among the three measures (T0, T6 and T12) was calculated by Friedman test.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "hormones", "insulin", "Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Hormone receptor signaling", "Endocrinology", "Diabetic endocrinology", "Metabolic disorders", "pediatrics", "deficient", "children", "rhgh", "12", "months"], "article_id"=>918748, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Flavia Prodam", "Silvia Savastio", "Giulia Genoni", "Deepak Babu", "Mara Giordano", "Roberta Ricotti", "Gianluca Aimaretti", "Gianni Bona", "Simonetta Bellone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087157.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Glucometabolic_parameters_of_growth_hormone_deficient_GHD_group_1_children_at_the_end_of_rhGH_therapy_T0_and_6_T6_and_12_T12_months_after_rhGH_withdrawal_/918748", "title"=>"Glucometabolic parameters of growth hormone deficient (GHD, group 1) children at the end of rhGH therapy (T0) and 6 (T6) and 12 (T12) months after rhGH withdrawal.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-30 02:46:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1367345"], "description"=>"<p>GHD adolescents are evaluated in the last year of therapy (T0) and after six (T6) and twelve (T12) rhGH withdrawal. Data are expressed as mean±SEM. The significance among the three measures (T0, T6 and T12) was calculated by Friedman test. The significance between GHD and CS was calculated by Mann-Whitney U test. *p<0.05.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "hormones", "insulin", "Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Hormone receptor signaling", "Endocrinology", "Diabetic endocrinology", "Metabolic disorders", "pediatrics", "insulinogenic", "disposition", "gh", "deficient", "adolescents", "27", "31", "receptor", "exon", "deletion"], "article_id"=>918746, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Flavia Prodam", "Silvia Savastio", "Giulia Genoni", "Deepak Babu", "Mara Giordano", "Roberta Ricotti", "Gianluca Aimaretti", "Gianni Bona", "Simonetta Bellone"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087157.g001", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HOMA_IR_Insulinogenic_INS_and_disposition_DI_index_in_GH_deficient_GHD_group_1_and_healthy_CS_group_2_adolescents_with_Del_27_subjects_and_without_nDel_31_subjects_the_GH_receptor_GHR_exon_3_deletion_d3GHR_/918746", "title"=>"HOMA-IR, Insulinogenic (INS) and disposition (DI) index in GH deficient (GHD, group 1) and healthy (CS, group 2) adolescents with (Del, 27 subjects) and without (nDel, 31 subjects) the GH receptor (GHR) exon 3 deletion (d3GHR).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 02:46:58"}

PMC Usage Stats | Further Information

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Relative Metric

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