Phosphatase Complex Pph3/Psy2 Is Involved in Regulation of Efficient Non-Homologous End-Joining Pathway in the Yeast Saccharomyces cerevisiae
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{"title"=>"Phosphatase complex Pph3/Psy2 is involved in regulation of efficient non-homologous end-joining pathway in the yeast Saccharomyces cerevisiae", "type"=>"journal", "authors"=>[{"first_name"=>"Katayoun", "last_name"=>"Omidi", "scopus_author_id"=>"48561422600"}, {"first_name"=>"Mohsen", "last_name"=>"Hooshyar", "scopus_author_id"=>"36128584700"}, {"first_name"=>"Matthew", "last_name"=>"Jessulat", "scopus_author_id"=>"16241511300"}, {"first_name"=>"Bahram", "last_name"=>"Samanfar", "scopus_author_id"=>"48561859600"}, {"first_name"=>"Megan", "last_name"=>"Sanders", "scopus_author_id"=>"55419177600"}, {"first_name"=>"Daniel", "last_name"=>"Burnside", "scopus_author_id"=>"55699175800"}, {"first_name"=>"Sylvain", "last_name"=>"Pitre", "scopus_author_id"=>"14325705700"}, {"first_name"=>"Andrew", "last_name"=>"Schoenrock", "scopus_author_id"=>"38862978200"}, {"first_name"=>"Jianhua", "last_name"=>"Xu", "scopus_author_id"=>"54411591300"}, {"first_name"=>"Mohan", "last_name"=>"Babu", "scopus_author_id"=>"55959749500"}, {"first_name"=>"Ashkan", "last_name"=>"Golshani", "scopus_author_id"=>"7003669698"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24498054", "sgr"=>"84900301984", "doi"=>"10.1371/journal.pone.0087248", "scopus"=>"2-s2.0-84900301984", "pui"=>"373059501", "isbn"=>"1932-6203", "issn"=>"19326203"}, "id"=>"34558143-b078-34f3-ba0d-1d806e73e4f0", "abstract"=>"One of the main mechanisms for double stranded DNA break (DSB) repair is through the non-homologous end-joining (NHEJ) pathway. Using plasmid and chromosomal repair assays, we showed that deletion mutant strains for interacting proteins Pph3p and Psy2p had reduced efficiencies in NHEJ. We further observed that this activity of Pph3p and Psy2p appeared linked to cell cycle Rad53p and Chk1p checkpoint proteins. Pph3/Psy2 is a phosphatase complex, which regulates recovery from the Rad53p DNA damage checkpoint. Overexpression of Chk1p checkpoint protein in a parallel pathway to Rad53p compensated for the deletion of PPH3 or PSY2 in a chromosomal repair assay. Double mutant strains Δpph3/Δchk1 and Δpsy2/Δchk1 showed additional reductions in the efficiency of plasmid repair, compared to both single deletions which is in agreement with the activity of Pph3p and Psy2p in a parallel pathway to Chk1p. Genetic interaction analyses also supported a role for Pph3p and Psy2p in DNA damage repair, the NHEJ pathway, as well as cell cycle progression. Collectively, we report that the activity of Pph3p and Psy2p further connects NHEJ repair to cell cycle progression.", "link"=>"http://www.mendeley.com/research/phosphatase-complex-pph3psy2-involved-regulation-efficient-nonhomologous-endjoining-pathway-yeast-sa", "reader_count"=>13, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>5, "Student > Master"=>1, "Student > Bachelor"=>3, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>5, "Student > Master"=>1, "Student > Bachelor"=>3, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>9, "Computer Science"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1372025"], "description"=>"<p>Single deletion mutants for <i>PPH3</i> or <i>PSY2</i> showed increased sensitivity to DSB inducing agent bleomycin. Double deletion mutant strains <i>Δpph3Δchk1</i> and <i>Δpsy2Δchk1</i> had elevated sensitivity in comparison to single deletion mutants <i>Δpph3</i> and <i>Δpsy2.</i> In contrast double deletion mutant strains <i>Δpph3Δrad53</i> and <i>Δpsy2Δrad53</i> had reduced sensitivity in comparison to single deletion mutants <i>Δpsy2</i> and <i>Δpph3</i>.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Protein interactions", "genetics", "gene expression", "Gene function", "Gene networks", "Molecular genetics", "genomics", "Functional genomics", "microbiology", "Model organisms", "Yeast and fungal models", "Saccharomyces cerevisiae", "Molecular cell biology", "systems biology"], "article_id"=>922669, "categories"=>["Biological Sciences"], "users"=>["Katayoun Omidi", "Mohsen Hooshyar", "Matthew Jessulat", "Bahram Samanfar", "Megan Sanders", "Daniel Burnside", "Sylvain Pitre", "Andrew Schoenrock", "Jianhua Xu", "Mohan Babu", "Ashkan Golshani"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087248.g003", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Strain_sensitivity_analysis_to_bleomycin_/922669", "title"=>"Strain sensitivity analysis to bleomycin.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-31 04:04:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1372024"], "description"=>"<p>(A) Fraction of the colonies that grew after HO endonuclease induction. Deletion mutant for <i>PPH3</i> or <i>PSY2</i> had reduced survival and recovered when <i>CHK1</i> was overexpressed. Overexpression of <i>RAD53</i> reduced survival when <i>PPH3</i> or <i>PSY2</i> were deleted. (B) Fraction of the colonies that grew after HO endonuclease induction when cells were synchronized in G1, S or G2/M phases. (C) Illustration of conceptual basis for the observed activity of Pph3/Psy2 complex and Chk1p in parallel pathways. (D) Illustration of conceptual basis for the observed activity Pph3/Psy2 complex (enzyme) in relationship to Rad53p (substrate). Overexpression of the substrate in the absence of the enzyme can result in a very sick phenotype. [X]↑ refers to overexpression of gene X.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Protein interactions", "genetics", "gene expression", "Gene function", "Gene networks", "Molecular genetics", "genomics", "Functional genomics", "microbiology", "Model organisms", "Yeast and fungal models", "Saccharomyces cerevisiae", "Molecular cell biology", "systems biology", "jkm139-based"], "article_id"=>922668, "categories"=>["Biological Sciences"], "users"=>["Katayoun Omidi", "Mohsen Hooshyar", "Matthew Jessulat", "Bahram Samanfar", "Megan Sanders", "Daniel Burnside", "Sylvain Pitre", "Andrew Schoenrock", "Jianhua Xu", "Mohan Babu", "Ashkan Golshani"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087248.g002", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phenotypic_analysis_of_JKM139_based_strains_/922668", "title"=>"Phenotypic analysis of JKM139-based strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-31 04:04:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1372020"], "description"=>"<p>Each experiment was repeated at least five times. Error bars represent standard deviation. *indicates P value of <0.05. <i>Δyku70</i> was used as a positive control.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Protein interactions", "genetics", "gene expression", "Gene function", "Gene networks", "Molecular genetics", "genomics", "Functional genomics", "microbiology", "Model organisms", "Yeast and fungal models", "Saccharomyces cerevisiae", "Molecular cell biology", "systems biology", "yeast"], "article_id"=>922664, "categories"=>["Biological Sciences"], "users"=>["Katayoun Omidi", "Mohsen Hooshyar", "Matthew Jessulat", "Bahram Samanfar", "Megan Sanders", "Daniel Burnside", "Sylvain Pitre", "Andrew Schoenrock", "Jianhua Xu", "Mohan Babu", "Ashkan Golshani"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087248.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plasmid_repair_efficiency_for_different_yeast_strains_/922664", "title"=>"Plasmid repair efficiency for different yeast strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-31 04:04:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1372032"], "description"=>"<div><p>One of the main mechanisms for double stranded DNA break (DSB) repair is through the non-homologous end-joining (NHEJ) pathway. Using plasmid and chromosomal repair assays, we showed that deletion mutant strains for interacting proteins Pph3p and Psy2p had reduced efficiencies in NHEJ. We further observed that this activity of Pph3p and Psy2p appeared linked to cell cycle Rad53p and Chk1p checkpoint proteins. Pph3/Psy2 is a phosphatase complex, which regulates recovery from the Rad53p DNA damage checkpoint. Overexpression of Chk1p checkpoint protein in a parallel pathway to Rad53p compensated for the deletion of <i>PPH3</i> or <i>PSY2</i> in a chromosomal repair assay. Double mutant strains <i>Δpph3/Δchk1</i> and <i>Δpsy2/Δchk1</i> showed additional reductions in the efficiency of plasmid repair, compared to both single deletions which is in agreement with the activity of Pph3p and Psy2p in a parallel pathway to Chk1p. Genetic interaction analyses also supported a role for Pph3p and Psy2p in DNA damage repair, the NHEJ pathway, as well as cell cycle progression. Collectively, we report that the activity of Pph3p and Psy2p further connects NHEJ repair to cell cycle progression.</p></div>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Protein interactions", "genetics", "gene expression", "Gene function", "Gene networks", "Molecular genetics", "genomics", "Functional genomics", "microbiology", "Model organisms", "Yeast and fungal models", "Saccharomyces cerevisiae", "Molecular cell biology", "systems biology", "phosphatase", "non-homologous", "end-joining", "pathway", "yeast"], "article_id"=>922676, "categories"=>["Biological Sciences"], "users"=>["Katayoun Omidi", "Mohsen Hooshyar", "Matthew Jessulat", "Bahram Samanfar", "Megan Sanders", "Daniel Burnside", "Sylvain Pitre", "Andrew Schoenrock", "Jianhua Xu", "Mohan Babu", "Ashkan Golshani"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087248", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Phosphatase_Complex_Pph3_Psy2_Is_Involved_in_Regulation_of_Efficient_Non_Homologous_End_Joining_Pathway_in_the_Yeast_Saccharomyces_cerevisiae_/922676", "title"=>"Phosphatase Complex Pph3/Psy2 Is Involved in Regulation of Efficient Non-Homologous End-Joining Pathway in the Yeast <i>Saccharomyces cerevisiae</i>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-31 04:04:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1372029"], "description"=>"<p>Overexpression of <i>PPH3</i> and <i>PSY2</i> formed conditional SDL interactions with members of MRX complex, in addition to <i>CHK1</i>, <i>SAW1</i> and <i>NEJ1.</i> Solid and dashed lines represent interactions found in the presence of bleomycin (3 µg/ml) and HU (45 mM), respectively.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Protein interactions", "genetics", "gene expression", "Gene function", "Gene networks", "Molecular genetics", "genomics", "Functional genomics", "microbiology", "Model organisms", "Yeast and fungal models", "Saccharomyces cerevisiae", "Molecular cell biology", "systems biology", "dosage", "lethality"], "article_id"=>922673, "categories"=>["Biological Sciences"], "users"=>["Katayoun Omidi", "Mohsen Hooshyar", "Matthew Jessulat", "Bahram Samanfar", "Megan Sanders", "Daniel Burnside", "Sylvain Pitre", "Andrew Schoenrock", "Jianhua Xu", "Mohan Babu", "Ashkan Golshani"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087248.g005", "stats"=>{"downloads"=>0, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Synthetic_dosage_lethality_SDL_analysis_/922673", "title"=>"Synthetic dosage lethality (SDL) analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-31 04:04:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1372028"], "description"=>"<p>Most of the interactors are involved in DNA repair and/or cell cycle progression. Conditional interactions were identified in the presence of sub-inhibitory concentrations of HU (45 mM) or bleomycin (3 µg/ml).</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Protein interactions", "genetics", "gene expression", "Gene function", "Gene networks", "Molecular genetics", "genomics", "Functional genomics", "microbiology", "Model organisms", "Yeast and fungal models", "Saccharomyces cerevisiae", "Molecular cell biology", "systems biology", "synthetic", "interactions"], "article_id"=>922672, "categories"=>["Biological Sciences"], "users"=>["Katayoun Omidi", "Mohsen Hooshyar", "Matthew Jessulat", "Bahram Samanfar", "Megan Sanders", "Daniel Burnside", "Sylvain Pitre", "Andrew Schoenrock", "Jianhua Xu", "Mohan Babu", "Ashkan Golshani"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087248.g004", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analysis_of_the_synthetic_sick_interactions_for_PPH3_A_and_PSY2_B_/922672", "title"=>"Analysis of the synthetic sick interactions for <i>PPH3</i> (A) and <i>PSY2</i> (B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-31 04:04:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1372030"], "description"=>"<p>Of the 26 that interacted with Psy2p, 8 have a role in DNA repair, 7 in both DNA repair and regulation of cell cycle, and 11 in “other” cellular processes. * are proteins that interact with both Pph3p and Psy2p.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Protein interactions", "genetics", "gene expression", "Gene function", "Gene networks", "Molecular genetics", "genomics", "Functional genomics", "microbiology", "Model organisms", "Yeast and fungal models", "Saccharomyces cerevisiae", "Molecular cell biology", "systems biology", "pph3p", "24", "dna", "10", "cellular"], "article_id"=>922674, "categories"=>["Biological Sciences"], "users"=>["Katayoun Omidi", "Mohsen Hooshyar", "Matthew Jessulat", "Bahram Samanfar", "Megan Sanders", "Daniel Burnside", "Sylvain Pitre", "Andrew Schoenrock", "Jianhua Xu", "Mohan Babu", "Ashkan Golshani"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087248.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protein_Protein_interaction_prediction_for_Pph3p_and_Psy2p_Of_the_24_proteins_that_interact_with_Pph3p_6_have_a_role_in_DNA_repair_8_in_both_DNA_repair_and_regulation_of_cell_cycle_and_10_in_8220_other_8221_cellular_processes_/922674", "title"=>"Protein-Protein interaction prediction for Pph3p and Psy2p. Of the 24 proteins that interact with Pph3p, 6 have a role in DNA repair, 8 in both DNA repair and regulation of cell cycle, and 10 in “other” cellular processes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-01-31 04:04:37"}

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  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"38", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[282]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[286]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[306, 482]}]}
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