Immunohistochemistry for Myc Predicts Survival in Colorectal Cancer
Publication Date
February 04, 2014
Journal
PLOS ONE
Authors
Christopher W. Toon, Angela Chou, Adele Clarkson, Keshani De Silva, et al
Volume
9
Issue
2
Pages
e87456
DOI
https://dx.plos.org/10.1371/journal.pone.0087456
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0087456
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24503701
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913591
Europe PMC
http://europepmc.org/abstract/MED/24503701
Web of Science
000330631800039
Scopus
84895137216
Mendeley
http://www.mendeley.com/research/immunohistochemistry-myc-predicts-survival-colorectal-cancer-1
Events
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Mendeley | Further Information

{"title"=>"Immunohistochemistry for Myc predicts survival in colorectal cancer", "type"=>"journal", "authors"=>[{"first_name"=>"Christopher W.", "last_name"=>"Toon", "scopus_author_id"=>"14014480900"}, {"first_name"=>"Angela", "last_name"=>"Chou", "scopus_author_id"=>"35331732300"}, {"first_name"=>"Adele", "last_name"=>"Clarkson", "scopus_author_id"=>"7006789792"}, {"first_name"=>"Keshani", "last_name"=>"DeSilva", "scopus_author_id"=>"6602479523"}, {"first_name"=>"Michelle", "last_name"=>"Houang", "scopus_author_id"=>"37026103900"}, {"first_name"=>"Joseph C Y", "last_name"=>"Chan", "scopus_author_id"=>"55894194500"}, {"first_name"=>"Loretta L.", "last_name"=>"Sioson", "scopus_author_id"=>"36009362800"}, {"first_name"=>"Lucy", "last_name"=>"Jankova", "scopus_author_id"=>"56054337400"}, {"first_name"=>"Anthony J.", "last_name"=>"Gill", "scopus_author_id"=>"8717215600"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24503701", "doi"=>"10.1371/journal.pone.0087456", "sgr"=>"84895137216", "scopus"=>"2-s2.0-84895137216", "issn"=>"19326203", "pui"=>"372510332"}, "id"=>"111a900f-0037-314d-a72d-ad286e34a86d", "abstract"=>"MYC over-expression as determined by molecular means has been reported as a favorable prognostic biomarker in colorectal carcinoma (CRC). However MYC expression analysis is not available in the routine clinical setting. We investigated whether immunohistochemistry (IHC) for the myc protein using a novel commercially available rabbit monoclonal antibody [clone Y69] which is currently in widespread clinical use for lymphoma diagnosis could be used to predict outcome in resected CRC. Myc IHC was performed on a tissue microarray (TMA) comprising a retrospective cohort of 1421 CRC patients and scored blinded as to all clinical and pathological data. IHC was also performed on a subcohort of whole section CRCs to assess staining characteristics and concordance with TMA expression. MYC over-expression was found in 980 (69%) of CRCs and was associated with tumor stage and DNA mismatch repair/BRAF status. There was substantial agreement between TMA and whole section myc IHC (kappa = 0.742, p<0.01). CRCs with MYC over-expression demonstrated improved 5-year survival (93.2% vs. 57.3%), with the effect significantly modulated by the dominant effect of tumor stage, age at diagnosis and lymphovascular space invasion status on survival. We conclude that myc status as determined by IHC alone can be used to predict overall survival in patients with CRC undergoing surgical resection.", "link"=>"http://www.mendeley.com/research/immunohistochemistry-myc-predicts-survival-colorectal-cancer-1", "reader_count"=>13, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>2, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1375684"], "description"=>"<p>Panel A: Myc positive IHC staining; Panel B: Myc negative IHC staining; Panel C: Kaplan Meier analysis (Log Rank test p = 0.01); Panel D: Univariable Cox regression.</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Diagnostic medicine", "pathology", "anatomical pathology", "histopathology", "Surgical pathology", "General pathology", "biomarkers", "Biomarker epidemiology", "Cancer epidemiology", "Clinical epidemiology", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "Colon adenocarcinoma", "Rectal cancer", "myc", "ihc", "kaplan", "meier", "univariable", "cox"], "article_id"=>925755, "categories"=>["Medicine"], "users"=>["Christopher W. Toon", "Angela Chou", "Adele Clarkson", "Keshani DeSilva", "Michelle Houang", "Joseph C. Y. Chan", "Loretta L. Sioson", "Lucy Jankova", "Anthony J. Gill"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087456.g001", "stats"=>{"downloads"=>1, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Panel_A_Myc_positive_IHC_staining_Panel_B_Myc_negative_IHC_staining_Panel_C_Kaplan_Meier_analysis_Log_Rank_test_p_8202_8202_0_01_Panel_D_Univariable_Cox_regression_/925755", "title"=>"Panel A: Myc positive IHC staining; Panel B: Myc negative IHC staining; Panel C: Kaplan Meier analysis (Log Rank test p = 0.01); Panel D: Univariable Cox regression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-04 03:49:04"}
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  • {"files"=>["https://ndownloader.figshare.com/files/1375686"], "description"=>"<p>Panel A: Kaplan Meier curves showing superior overall survival of CRCs with MYC over-expression compared to myc negative CRCs (Log Rank test p<0.01); Panel B: Univariable Cox regression analysis showing MYC over-expression significantly correlated with improved overall survival [hazard ratio = 0.30 (95%CI = 0.15–0.60), p<0.01].</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Diagnostic medicine", "pathology", "anatomical pathology", "histopathology", "Surgical pathology", "General pathology", "biomarkers", "Biomarker epidemiology", "Cancer epidemiology", "Clinical epidemiology", "oncology", "Cancers and neoplasms", "Gastrointestinal tumors", "Colon adenocarcinoma", "Rectal cancer", "ihc", "crcs", "confirming", "tma"], "article_id"=>925757, "categories"=>["Medicine"], "users"=>["Christopher W. Toon", "Angela Chou", "Adele Clarkson", "Keshani DeSilva", "Michelle Houang", "Joseph C. Y. Chan", "Loretta L. Sioson", "Lucy Jankova", "Anthony J. Gill"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087456.g002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Myc_IHC_on_whole_section_CRCs_from_2004_confirming_TMA_findings_/925757", "title"=>"Myc IHC on whole section CRCs from 2004, confirming TMA findings.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-04 03:49:04"}
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Relative Metric

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