High-Resolution Echo-Planar Spectroscopic Imaging of the Human Calf
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{"title"=>"High-resolution echo-planar spectroscopic imaging of the human calf", "type"=>"journal", "authors"=>[{"first_name"=>"Jan", "last_name"=>"Weis", "scopus_author_id"=>"7202856469"}, {"first_name"=>"Morten", "last_name"=>"Bruvold", "scopus_author_id"=>"57195444342"}, {"first_name"=>"Francisco", "last_name"=>"Ortiz-Nieto", "scopus_author_id"=>"24402728500"}, {"first_name"=>"Håkan", "last_name"=>"Ahlström", "scopus_author_id"=>"18733834800"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84900455142", "scopus"=>"2-s2.0-84900455142", "doi"=>"10.1371/journal.pone.0087533", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"373070834", "issn"=>"19326203", "pmid"=>"24498129"}, "id"=>"30970595-aaf8-31c0-81f4-eb5b99f57cde", "abstract"=>"BACKGROUND: This study exploits the speed benefits of echo-planar spectroscopic imaging (EPSI) to acquire lipid spectra of skeletal muscle. The main purpose was to develop a high-resolution EPSI technique for clinical MR scanner, to visualise the bulk magnetic susceptibility (BMS) shifts of extra-myocellular lipid (EMCL) spectral lines, and to investigate the feasibility of this method for the assessment of intra-myocellular (IMCL) lipids.\\n\\nMETHODS: The study group consisted of six healthy volunteers. A two dimensional EPSI sequence with point-resolved spectroscopy (PRESS) spatial localization was implemented on a 3T clinical MR scanner. Measurements were performed by means of 64×64 spatial matrix and nominal voxel size 3×3×15 mm(3). The total net measurement time was 3 min 12 sec for non-water-suppressed (1 acquisition) and 12 min 48 sec for water-suppressed scans (4 acquisitions).\\n\\nRESULTS: Spectra of the human calf had a very good signal-to-noise ratio and linewidths sufficient to differentiate IMCL resonances from EMCL. The use of a large spatial matrix reduces inter-voxel signal contamination of the strong EMCL signals. Small voxels enabled visualisation of the methylene EMCL spectral line splitting and their BMS shifts up to 0.5 ppm relative to the correspondent IMCL line. The mean soleus muscle IMCL content of our six volunteers was 0.30±0.10 vol% (range 0.18-0.46) or 3.6±1.2 mmol/kg wet weight (range: 2.1-5.4).\\n\\nCONCLUSION: This study demonstrates that high-spatial resolution PRESS EPSI of the muscle lipids is feasible on standard clinical scanners.", "link"=>"http://www.mendeley.com/research/highresolution-echoplanar-spectroscopic-imaging-human-calf", "reader_count"=>12, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>3, "Student > Master"=>3, "Other"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>3, "Student > Master"=>3, "Other"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>1, "Physics and Astronomy"=>2, "Psychology"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Switzerland"=>1, "Germany"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1368059"], "description"=>"<p>G<sub>r</sub>, G<sub>p</sub>, and G<sub>s</sub> are gradients in read, phase-encoding, and slice selection directions, respectively. B<sub>1</sub> depicts excitation rf pulses.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "muscle", "Muscle biochemistry", "Biochemistry", "metabolism", "Lipid metabolism", "Bioengineering", "Medical devices", "Drugs and devices", "Metabolic disorders", "nutrition", "obesity", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "epsi"], "article_id"=>919333, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Jan Weis", "Morten Bruvold", "Francisco Ortiz-Nieto", "Håkan Ahlström"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087533.g001", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_2D_PRESS_EPSI_sequence_/919333", "title"=>"2D PRESS EPSI sequence.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 03:32:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368061"], "description"=>"<p>Large thin and thick rectangles show lipid (-CH<sub>2</sub>-)n and TMA PRESS boxes, respectively. Dashed rectangle depicts shimming volume.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "muscle", "Muscle biochemistry", "Biochemistry", "metabolism", "Lipid metabolism", "Bioengineering", "Medical devices", "Drugs and devices", "Metabolic disorders", "nutrition", "obesity", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "2d", "epsi", "spatial", "matrix", "transversal", "coronal"], "article_id"=>919335, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Jan Weis", "Morten Bruvold", "Francisco Ortiz-Nieto", "Håkan Ahlström"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087533.g002", "stats"=>{"downloads"=>4, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Planning_of_2D_PRESS_EPSI_experiment_with_a_spatial_matrix_64_64_on_the_background_of_T_1_weighted_transversal_and_coronal_spin_echo_images_/919335", "title"=>"Planning of 2D PRESS EPSI experiment with a spatial matrix 64×64 on the background of T<sub>1</sub>-weighted transversal and coronal spin echo images.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 03:32:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368063"], "description"=>"<p>(a) Profile of the usual k-space weighting functions: optimized Hanning (full line), standard Hanning (dashed line) and Hamming (dotted line). (b) Optimized 2D Hanning filter. (c) Standard 2D Hanning filter. (d) Fat image computed without application of k-space filter. (e) Fat image computed from filtered data set using an optimized 2D Hanning filter. (f) Fat image computed from filtered data set using a standard 2D Hanning filter.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "muscle", "Muscle biochemistry", "Biochemistry", "metabolism", "Lipid metabolism", "Bioengineering", "Medical devices", "Drugs and devices", "Metabolic disorders", "nutrition", "obesity", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "filters"], "article_id"=>919337, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Jan Weis", "Morten Bruvold", "Francisco Ortiz-Nieto", "Håkan Ahlström"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087533.g003", "stats"=>{"downloads"=>5, "page_views"=>49, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_K_space_filters_of_raw_data_and_correspondent_fat_images_/919337", "title"=>"K-space filters of raw data and correspondent fat images.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 03:32:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368065"], "description"=>"<p>Spectra represent, tibialis anterior (ta) muscle, bone marrow (mar), soleus (sol) and gastrocnemius medialis (gm) muscles. Spectra were corrected for shifts caused by magnetic field deviations. EMCL<sub>CH2</sub> sub-peaks in soleus can be seen between 0.4 and 0.5 ppm, from IMCL<sub>CH2</sub> line (arrows).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "muscle", "Muscle biochemistry", "Biochemistry", "metabolism", "Lipid metabolism", "Bioengineering", "Medical devices", "Drugs and devices", "Metabolic disorders", "nutrition", "obesity", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "spectra", "voxel", "depicted", "corresponding"], "article_id"=>919339, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Jan Weis", "Morten Bruvold", "Francisco Ortiz-Nieto", "Håkan Ahlström"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087533.g004", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Magnitude_spectra_vertical_columns_of_the_voxel_rows_depicted_by_gray_and_white_line_in_the_corresponding_fat_image_/919339", "title"=>"Magnitude spectra (vertical columns) of the voxel rows, depicted by gray and white line in the corresponding fat image.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 03:32:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368066"], "description"=>"<p>(a) Spectrum computed without application of k-space filter during data processing. (b) Spectrum computed from filtered data set, using an optimized 2D Hanning filter. (c) Spectrum computed from filtered data set, using a standard 2D Hanning filter.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "muscle", "Muscle biochemistry", "Biochemistry", "metabolism", "Lipid metabolism", "Bioengineering", "Medical devices", "Drugs and devices", "Metabolic disorders", "nutrition", "obesity", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "spectra", "soleus", "voi", "mrsi", "voxels"], "article_id"=>919340, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Jan Weis", "Morten Bruvold", "Francisco Ortiz-Nieto", "Håkan Ahlström"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087533.g005", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Magnitude_spectra_of_soleus_muscle_108_voxels_VOI_indicate_white_MRSI_voxels_in_T_1_weighted_image_/919340", "title"=>"Magnitude spectra of soleus muscle (108 voxels). VOI indicate white MRSI voxels in T<sub>1</sub>-weighted image.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 03:32:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368067"], "description"=>"<p>Spectrum of soleus muscle is completed by LCModel fits and residue. VOIs indicate white and gray MRSI voxels in T<sub>1</sub>-weighted image.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "muscle", "Muscle biochemistry", "Biochemistry", "metabolism", "Lipid metabolism", "Bioengineering", "Medical devices", "Drugs and devices", "Metabolic disorders", "nutrition", "obesity", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "spectra", "marrow", "tibialis", "anterior", "45", "posterior", "compartment", "36", "gastrocnemius", "medialis", "40", "soleus", "42"], "article_id"=>919341, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Jan Weis", "Morten Bruvold", "Francisco Ortiz-Nieto", "Håkan Ahlström"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087533.g006", "stats"=>{"downloads"=>2, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Magnitude_spectra_of_bone_marrow_mar_4_voxels_and_in_tibialis_anterior_ta_45_voxels_deep_posterior_compartment_dp_36_voxels_gastrocnemius_medialis_gm_40_voxels_and_soleus_sol_42_voxels_muscles_/919341", "title"=>"Magnitude spectra of bone marrow (mar, 4 voxels) and in tibialis anterior (ta, 45 voxels), deep posterior compartment (dp, 36 voxels), gastrocnemius medialis (gm, 40 voxels), and soleus (sol, 42 voxels) muscles.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 03:32:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368069"], "description"=>"<p>VOIs V1–V5 contains four MRSI voxels (white squares).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "muscle", "Muscle biochemistry", "Biochemistry", "metabolism", "Lipid metabolism", "Bioengineering", "Medical devices", "Drugs and devices", "Metabolic disorders", "nutrition", "obesity", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "employed", "computing", "spectra"], "article_id"=>919343, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Jan Weis", "Morten Bruvold", "Francisco Ortiz-Nieto", "Håkan Ahlström"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087533.g007", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Volumes_of_interest_employed_for_computing_the_spectra_shown_in_figures_8_and_9_/919343", "title"=>"Volumes of interest employed for computing the spectra shown in figures 8 and 9.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 03:32:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368071"], "description"=>"<p>Left panel represents spectra computed without application of k-space filter during data processing. Middle and right panel depict spectra computed from filtered data set using an optimized and standard 2D Hanning k-space filter, respectively. <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087533#pone-0087533-g006\" target=\"_blank\">Figure 6</a> shows VOIs.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "muscle", "Muscle biochemistry", "Biochemistry", "metabolism", "Lipid metabolism", "Bioengineering", "Medical devices", "Drugs and devices", "Metabolic disorders", "nutrition", "obesity", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "spectra", "computed", "vois"], "article_id"=>919345, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Jan Weis", "Morten Bruvold", "Francisco Ortiz-Nieto", "Håkan Ahlström"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087533.g008", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Magnitude_spectra_computed_from_the_VOIs_V1_8211_V5_four_voxels_/919345", "title"=>"Magnitude spectra computed from the VOIs V1–V5 (four voxels).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 03:32:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1368072"], "description"=>"<p>Left panel represents spectra computed without application of k-space filter during data processing. Middle and right panel depict spectra computed from filtered data set using an optimized and standard 2D Hanning k-space filter, respectively.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "muscle", "Muscle biochemistry", "Biochemistry", "metabolism", "Lipid metabolism", "Bioengineering", "Medical devices", "Drugs and devices", "Metabolic disorders", "nutrition", "obesity", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "spectra", "computed", "v3", "voxels", "voxel", "v3a", "v3b", "v3c", "v3d"], "article_id"=>919346, "categories"=>["Physics", "Biological Sciences", "Medicine", "Engineering"], "users"=>["Jan Weis", "Morten Bruvold", "Francisco Ortiz-Nieto", "Håkan Ahlström"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087533.g009", "stats"=>{"downloads"=>0, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Magnitude_spectra_computed_from_the_volume_of_interest_V3_four_white_voxels_in_Fig_7_and_its_individual_voxel_spectra_V3a_left_up_V3b_right_up_V3c_left_bottom_and_V3d_right_bottom_/919346", "title"=>"Magnitude spectra computed from the volume of interest V3 (four white voxels in Fig. 7) and its individual voxel spectra V3a (left up), V3b (right up), V3c (left bottom), and V3d (right bottom).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-30 03:32:24"}

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  • {"unique-ip"=>"3", "full-text"=>"0", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[267]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[293]}, {"subject_area"=>"/Computer and information sciences/Information technology", "average_usage"=>[314, 484]}, {"subject_area"=>"/Engineering and technology/Signal processing", "average_usage"=>[276]}]}
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