Insights into the Motif Preference of APOBEC3 Enzymes
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{"title"=>"Insights into the motif preference of APOBEC3 enzymes", "type"=>"journal", "authors"=>[{"first_name"=>"Diako", "last_name"=>"Ebrahimi", "scopus_author_id"=>"14322990600"}, {"first_name"=>"Hamid", "last_name"=>"Alinejad-Rokny", "scopus_author_id"=>"53871090400"}, {"first_name"=>"Miles P.", "last_name"=>"Davenport", "scopus_author_id"=>"7101990885"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84900311128", "sgr"=>"84900311128", "pui"=>"373059569", "isbn"=>"1932-6203", "pmid"=>"24498164", "doi"=>"10.1371/journal.pone.0087679"}, "id"=>"73c7daa9-bd1e-38ca-bc00-aa1c347c62ef", "abstract"=>"We used a multivariate data analysis approach to identify motifs associated with HIV hypermutation by different APOBEC3 enzymes. The analysis showed that APOBEC3G targets G mainly within GG, TG, TGG, GGG, TGGG and also GGGT. The G nucleotides flanked by a C at the 3' end (in +1 and +2 positions) were indicated as disfavoured targets by APOBEC3G. The G nucleotides within GGGG were found to be targeted at a frequency much less than what is expected. We found that the infrequent G-to-A mutation within GGGG is not limited to the inaccessibility, to APOBEC3, of poly Gs in the central and 3'polypurine tracts (PPTs) which remain double stranded during the HIV reverse transcription. GGGG motifs outside the PPTs were also disfavoured. The motifs GGAG and GAGG were also found to be disfavoured targets for APOBEC3. The motif-dependent mutation of G within the HIV genome by members of the APOBEC3 family other than APOBEC3G was limited to GA→AA changes. The results did not show evidence of other types of context dependent G-to-A changes in the HIV genome.", "link"=>"http://www.mendeley.com/research/insights-motif-preference-apobec3-enzymes", "reader_count"=>22, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>3, "Computer Science"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1372723"], "description"=>"<p>Each line is a full genome hypermutated sequence within which the positions of GGGG motifs are shown by small triangles.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "dna", "DNA modification", "biophysics", "Computational biology", "genomics", "genetics", "epigenetics", "gene expression", "microbiology", "immunity", "Innate immunity", "Molecular cell biology", "Infectious diseases", "Viral diseases", "hiv", "DNA metabolism", "polypurine", "tracts", "alignment", "54", "hypermutated", "hiv-1", "sequences"], "article_id"=>923250, "categories"=>["Physics", "Biological Sciences", "Medicine"], "users"=>["Diako Ebrahimi", "Hamid Alinejad-Rokny", "Miles P. Davenport"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087679.g005", "stats"=>{"downloads"=>2, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Conserved_polypurine_tracts_shown_in_a_representative_alignment_of_54_hypermutated_HIV_1_sequences_used_in_this_study_/923250", "title"=>"Conserved polypurine tracts shown in a representative alignment of 54 hypermutated HIV-1 sequences used in this study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-31 04:34:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1372725"], "description"=>"<p>The number of available GGs (i.e. mutability) has been used to normalize the results. a) Analysis of whole HIV genome; b) Analysis of the HIV genome without polypurine tracts. Hypermutated sequences (see reference <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087679#pone.0087679-Armitage1\" target=\"_blank\">[5]</a> for details) are shown on the horizontal axes.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "dna", "DNA modification", "biophysics", "Computational biology", "genomics", "genetics", "epigenetics", "gene expression", "microbiology", "immunity", "Innate immunity", "Molecular cell biology", "Infectious diseases", "Viral diseases", "hiv", "DNA metabolism", "motifs", "g-to-a"], "article_id"=>923252, "categories"=>["Physics", "Biological Sciences", "Medicine"], "users"=>["Diako Ebrahimi", "Hamid Alinejad-Rokny", "Miles P. Davenport"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087679.g006", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percentage_change_of_motifs_within_which_G_to_A_change_s_in_the_context_of_G_G_has_occurred_/923252", "title"=>"Percentage change of motifs within which G-to-A change(s) in the context of GG has occurred.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-31 04:34:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1372702"], "description"=>"<p>a) Scores plot (PC1 <i>vs</i>. PC2). Each point is a full genome HIV-1 sequence. PC1 differentiates between subtype B and other groups whereas PC2 discriminates among C, A1 and 01_AE. b) Loadings plot (PC1 <i>vs</i>. PC2). Each point is a motif. The broad distribution of motifs (identities of some of which are shown as examples) indicates that the difference among HIV groups is not due to a subset of motifs.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "dna", "DNA modification", "biophysics", "Computational biology", "genomics", "genetics", "epigenetics", "gene expression", "microbiology", "immunity", "Innate immunity", "Molecular cell biology", "Infectious diseases", "Viral diseases", "hiv", "DNA metabolism", "motif", "hiv-1", "sequences", "a1"], "article_id"=>923237, "categories"=>["Physics", "Biological Sciences", "Medicine"], "users"=>["Diako Ebrahimi", "Hamid Alinejad-Rokny", "Miles P. Davenport"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087679.g002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Principal_component_analysis_of_the_motif_representation_data_of_HIV_1_sequences_from_subtypes_recombinant_B_C_A1_and_01_AE_/923237", "title"=>"Principal component analysis of the motif representation data of HIV-1 sequences from subtypes/recombinant B, C, A1 and 01_AE.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-31 04:34:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1372709"], "description"=>"<p>a) Scores plot (PC3 <i>vs</i>. PC4). Each point is an HIV-1 full genome sequence. Hypermutated sequences identified by the LANL database are indicated by “H” <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087679#pone.0087679-Ebrahimi2\" target=\"_blank\">[11]</a>. b) Loadings plot (PC3 <i>vs</i>. PC4). Each point is a motif. The motifs associated with hypermutation by APOBEC3G appear as outliers. Note that only two sequences (indicated by arrows) contain GA→AA footprints that is a hallmark of mutation by APOBEC3F and/or other similar APOBEC3 enzymes <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087679#pone.0087679-Ebrahimi2\" target=\"_blank\">[11]</a>.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "dna", "DNA modification", "biophysics", "Computational biology", "genomics", "genetics", "epigenetics", "gene expression", "microbiology", "immunity", "Innate immunity", "Molecular cell biology", "Infectious diseases", "Viral diseases", "hiv", "DNA metabolism", "motif", "hiv-1", "sequences", "a1"], "article_id"=>923240, "categories"=>["Physics", "Biological Sciences", "Medicine"], "users"=>["Diako Ebrahimi", "Hamid Alinejad-Rokny", "Miles P. Davenport"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087679.g003", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Principal_component_analysis_of_the_motif_representation_data_of_HIV_1_sequences_from_subtypes_recombinant_B_C_A1_and_01_AE_/923240", "title"=>"Principal component analysis of the motif representation data of HIV-1 sequences from subtypes/recombinant B, C, A1 and 01_AE.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-31 04:34:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1372692"], "description"=>"<p>A schematic of principal component analysis applied to the motif representation data of HIV sequences.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "dna", "DNA modification", "biophysics", "Computational biology", "genomics", "genetics", "epigenetics", "gene expression", "microbiology", "immunity", "Innate immunity", "Molecular cell biology", "Infectious diseases", "Viral diseases", "hiv", "DNA metabolism", "schematic", "applied", "motif"], "article_id"=>923227, "categories"=>["Physics", "Biological Sciences", "Medicine"], "users"=>["Diako Ebrahimi", "Hamid Alinejad-Rokny", "Miles P. Davenport"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087679.g001", "stats"=>{"downloads"=>2, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_schematic_of_principal_component_analysis_applied_to_the_motif_representation_data_of_HIV_sequences_/923227", "title"=>"A schematic of principal component analysis applied to the motif representation data of HIV sequences.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-31 04:34:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1372714"], "description"=>"<p>a) Scores plot (PC11 vs. PC13). Each point is an HIV-1 full genome sequence. The accession numbers of the two sequences that extend in the direction of mutation by APOBEC3F and/or other similar APOBEC3 members are shown near their points. b) Loadings plot (PC11 vs. PC13). Each point is a motif. The arrow shows the direction of GA→AA mutation by APOBEC3F and/or other similar APOBEC3 enzymes.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "dna", "DNA modification", "biophysics", "Computational biology", "genomics", "genetics", "epigenetics", "gene expression", "microbiology", "immunity", "Innate immunity", "Molecular cell biology", "Infectious diseases", "Viral diseases", "hiv", "DNA metabolism", "motif", "hiv-1", "sequences", "a1"], "article_id"=>923245, "categories"=>["Physics", "Biological Sciences", "Medicine"], "users"=>["Diako Ebrahimi", "Hamid Alinejad-Rokny", "Miles P. Davenport"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087679.g004", "stats"=>{"downloads"=>3, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Principal_component_analysis_of_the_motif_representation_data_of_HIV_1_sequences_from_subtypes_recombinant_B_C_A1_and_01_AE_/923245", "title"=>"Principal component analysis of the motif representation data of HIV-1 sequences from subtypes/recombinant B, C, A1 and 01_AE.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-01-31 04:34:04"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"18", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[341, 529]}, {"subject_area"=>"/Biology and life sciences/Microbiology", "average_usage"=>[317]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[292, 461]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[310]}]}
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