A Novel Cellular Senescence Gene, SENEX, Is Involved in Peripheral Regulatory T Cells Accumulation in Aged Urinary Bladder Cancer
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{"title"=>"A novel cellular senescence gene, SENEX, is involved in peripheral regulatory T cells accumulation in aged urinary bladder cancer", "type"=>"journal", "authors"=>[{"first_name"=>"Tianping", "last_name"=>"Chen", "scopus_author_id"=>"55803917100"}, {"first_name"=>"Huiping", "last_name"=>"Wang", "scopus_author_id"=>"41461940200"}, {"first_name"=>"Zhiqiang", "last_name"=>"Zhang", "scopus_author_id"=>"55776418200"}, {"first_name"=>"Qing", "last_name"=>"Li", "scopus_author_id"=>"55703546700"}, {"first_name"=>"Kaili", "last_name"=>"Yan", "scopus_author_id"=>"55803722500"}, {"first_name"=>"Qianshan", "last_name"=>"Tao", "scopus_author_id"=>"55804003800"}, {"first_name"=>"Qianling", "last_name"=>"Ye", "scopus_author_id"=>"55314854800"}, {"first_name"=>"Shudao", "last_name"=>"Xiong", "scopus_author_id"=>"36021740200"}, {"first_name"=>"Yiping", "last_name"=>"Wang", "scopus_author_id"=>"55992347400"}, {"first_name"=>"Zhimin", "last_name"=>"Zhai", "scopus_author_id"=>"14022122100"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"372535230", "sgr"=>"84895541028", "issn"=>"19326203", "pmid"=>"24505313", "scopus"=>"2-s2.0-84895541028", "doi"=>"10.1371/journal.pone.0087774"}, "id"=>"7bc72cd3-4592-3b8c-aa90-8ed3cabc0d59", "abstract"=>"Regulatory T cells (Tregs) play an essential role in sustaining self-tolerance and immune homeostasis. Despite many studies on the correlation between Tregs accumulation and age, or malignancies, the related mechanism hasn't been well explored. To find out the mechanism of Tregs accumulation in aged urinary bladder cancer, we examined the novel cellular senesence gene SENEX and relevant apoptosis gene mRNA expression in sorted CD4+CD25(hi) Tregs from aged UBC donors, evaluated serum cytokine profiles related to tumor immunopathology, and further explored the relationship between SENEX expression, apoptosis gene expression and cytokine secretion. After having silenced down SENEX gene expression with RNA interference, we also evaluated the cellular apoptosis of Tregs sorted from aged UBC patients in response to H₂O₂-mediated stress. Our data indicated that upregulated SENEX mRNA expression in Tregs of aged UBC patients was correlated with pro-apoptotic gene expression and cytokine concentration. Silencing SENEX gene expression increased cellular apoptosis and pro-apoptotic gene expression of Tregs, in response to H₂O₂-mediated stress. Upregulated SENEX mRNA expression together with decreased pro-apoptotic gene expression and disturbances in cytokines synthesis may contribute to the Tregs proliferation and promote tumorigenesis and metastasis. Overall, upregulation of cellular senescence gene SENEX, was associated to regulatory T cells accumulation in aged urinary bladder cancer. Our study provides a new insight into understanding of peripheral Tregs accumulation in aged malignancies.", "link"=>"http://www.mendeley.com/research/novel-cellular-senescence-gene-senex-involved-peripheral-regulatory-t-cells-accumulation-aged-urinar", "reader_count"=>7, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>3, "Chemistry"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1378251"], "description"=>"<p>Sorted CD4+CD25<sup>high</sup> Tregs were stained with Annexin V-FITC before Flow cytometric analysis. Cell apoptosis were detected as Annexin V+ apoptotic cells. 100 µM H<sub>2</sub>O<sub>2</sub> treatment for 2 hours increased apoptotic cells in both Tregs (11.2±2.6%) and Teffs (13.1±4.3%), with no significant difference observed in H<sub>2</sub>O<sub>2</sub> induced apoptosis between Tregs and Teffs. Silencing down <i>SENEX</i> gene with RNA interference (RNAi) for 24h, follwed by H<sub>2</sub>O<sub>2</sub> treatment for 2 hours, increased apoptotic cells in Tregs (21.5±3.4%), but undergoing the same procedures, apoptotic cells wasn’t found to increase in Teffs (13.9±3.1%). No difference was observed in cellular apoptosis between Tregs and Teffs when cells were treated with SiRNA transfection alone.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "immunology", "Immune cells", "t cells", "Molecular cell biology", "Clinical immunology", "Immune system", "cytokines", "immunomodulation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "tregs", "apoptosis"], "article_id"=>927840, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tianping Chen", "Huiping Wang", "ZhiQiang Zhang", "Qing Li", "Kaili Yan", "Qianshan Tao", "Qianling Ye", "Shudao Xiong", "YiPing Wang", "Zhimin Zhai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087774.g007", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Silencing_down_SENEX_gene_expression_increased_Tregs_apoptosis_in_response_to_H_2_O_2_mediated_stress_in_vitro_/927840", "title"=>"Silencing down <i>SENEX</i> gene expression increased Tregs apoptosis in response to H<sub>2</sub>O<sub>2</sub>-mediated stress in vitro.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:11:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378252"], "description"=>"<p>Gene mRNA levels were detected by real-time quantitative PCR. After <i>SENEX</i> gene was silenced down for 24 hours, followed by H<sub>2</sub>O<sub>2</sub> treatment for 2 hours, apoptosis regulatory genes <i>Caspase-3</i>, <i>P53</i>, <i>P1</i>6 and <i>P21</i> mRNA expression (2<sup>−△△CT</sup> = 6705.73±1124.07, 253.08±16.01, 154.58±35.12 and 5135.79±985.47, respectively) upregulated in CD4+CD25<sup>hi</sup> Tregs (<i>p</i><0.05 for each Mann-Whitney U Test). Data are expressed as the mean ± SD. ▴ vs. H<sub>2</sub>O<sub>2</sub>-treated cells, P<0.05.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "immunology", "Immune cells", "t cells", "Molecular cell biology", "Clinical immunology", "Immune system", "cytokines", "immunomodulation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "tregs", "led", "upregulation", "mrna"], "article_id"=>927841, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tianping Chen", "Huiping Wang", "ZhiQiang Zhang", "Qing Li", "Kaili Yan", "Qianshan Tao", "Qianling Ye", "Shudao Xiong", "YiPing Wang", "Zhimin Zhai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087774.g008", "stats"=>{"downloads"=>6, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Silencing_down_Tregs_SENEX_gene_led_to_upregulation_of_P53_P16_P21_and_Caspase_3_mRNA_expression_in_response_to_stress_/927841", "title"=>"Silencing down Tregs <i>SENEX</i> gene led to upregulation of <i>P53</i>, <i>P16</i>, <i>P21</i> and <i>Caspase-3</i> mRNA expression in response to stress.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:11:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378253"], "description"=>"<p>Sequences used for Real-time quantitative PCR primers and SiRNA transfection.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "immunology", "Immune cells", "t cells", "Molecular cell biology", "Clinical immunology", "Immune system", "cytokines", "immunomodulation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "Real-time", "quantitative", "pcr", "primers", "sirna"], "article_id"=>927842, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tianping Chen", "Huiping Wang", "ZhiQiang Zhang", "Qing Li", "Kaili Yan", "Qianshan Tao", "Qianling Ye", "Shudao Xiong", "YiPing Wang", "Zhimin Zhai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087774.t001", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sequences_used_for_Real_time_quantitative_PCR_primers_and_SiRNA_transfection_/927842", "title"=>"Sequences used for Real-time quantitative PCR primers and SiRNA transfection.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-05 04:11:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378256", "https://ndownloader.figshare.com/files/1378257"], "description"=>"<div><p>Regulatory T cells (Tregs) play an essential role in sustaining self-tolerance and immune homeostasis. Despite many studies on the correlation between Tregs accumulation and age, or malignancies, the related mechanism hasn’t been well explored. To find out the mechanism of Tregs accumulation in aged urinary bladder cancer, we examined the novel cellular senesence gene <i>SENEX</i> and relevant apoptosis gene mRNA expression in sorted CD4+CD25<sup>hi</sup> Tregs from aged UBC donors, evaluated serum cytokine profiles related to tumor immunopathology, and further explored the relationship between <i>SENEX</i> expression, apoptosis gene expression and cytokine secretion. After having silenced down SENEX gene expression with RNA interference, we also evaluated the cellular apoptosis of Tregs sorted from aged UBC patients in response to H<sub>2</sub>O<sub>2</sub>-mediated stress. Our data indicated that upregulated <i>SENEX</i> mRNA expression in Tregs of aged UBC patients was correlated with pro-apoptotic gene expression and cytokine concentration. Silencing <i>SENEX</i> gene expression increased cellular apoptosis and pro-apoptotic gene expression of Tregs, in response to H<sub>2</sub>O<sub>2</sub>-mediated stress. Upregulated <i>SENEX</i> mRNA expression together with decreased pro-apoptotic gene expression and disturbances in cytokines synthesis may contribute to the Tregs proliferation and promote tumorigenesis and metastasis. Overall, upregulation of cellular senescence gene <i>SENEX</i>, was associated to regulatory T cells accumulation in aged urinary bladder cancer. Our study provides a new insight into understanding of peripheral Tregs accumulation in aged malignancies.</p></div>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "immunology", "Immune cells", "t cells", "Molecular cell biology", "Clinical immunology", "Immune system", "cytokines", "immunomodulation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "cellular", "senescence", "peripheral", "cells", "accumulation", "aged", "urinary", "bladder", "cancer"], "article_id"=>927845, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tianping Chen", "Huiping Wang", "ZhiQiang Zhang", "Qing Li", "Kaili Yan", "Qianshan Tao", "Qianling Ye", "Shudao Xiong", "YiPing Wang", "Zhimin Zhai"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0087774.s001", "https://dx.doi.org/10.1371/journal.pone.0087774.s002"], "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Novel_Cellular_Senescence_Gene_SENEX_Is_Involved_in_Peripheral_Regulatory_T_Cells_Accumulation_in_Aged_Urinary_Bladder_Cancer/927845", "title"=>"A Novel Cellular Senescence Gene, <i>SENEX</i>, Is Involved in Peripheral Regulatory T Cells Accumulation in Aged Urinary Bladder Cancer", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-02-05 04:11:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378238"], "description"=>"<p>Treg frequency was detected using Flow cytometry. An increased CD4+CD25+127<sup>low</sup> Tregs frequency (10.67±0.58%) was observed in Aged UBC Patients as compared to Aged Healthy Controls (7.14±0.41%) and Young Healthy Controls (5.09±0.37%). Expressed as the mean ± SD, data were analyzed with the parametric Student’s t test. ▴ vs. Young Healthy Controls, P<0.05; △vs. Aged Healthy Controls, P<0.05.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "immunology", "Immune cells", "t cells", "Molecular cell biology", "Clinical immunology", "Immune system", "cytokines", "immunomodulation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "treg", "aged", "ubc"], "article_id"=>927827, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tianping Chen", "Huiping Wang", "ZhiQiang Zhang", "Qing Li", "Kaili Yan", "Qianshan Tao", "Qianling Ye", "Shudao Xiong", "YiPing Wang", "Zhimin Zhai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087774.g001", "stats"=>{"downloads"=>5, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CD4_CD25_CD127_low_Treg_frequency_significantly_increased_in_aged_UBC_patients_/927827", "title"=>"CD4+CD25+CD127<sup>low</sup> Treg frequency significantly increased in aged UBC patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:11:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378242"], "description"=>"<p>Tregs were sorted by FACS, FoxP3 mRNA level was detected by real-time quantitative PCR. FoxP3 mRNA expression was increased in Tregs of both Aged UBC patients (2<sup>−△△CT</sup> = 0.0272±0.0081) and Aged Healthy Controls (0.0184±0.0059) as compared to Young Healthy Controls (0.0097±0.0039) (p = 0.035, 0.021 respectively). No difference was detected in Tregs FoxP3 mRNA expression between Aged UBC Patients and Aged Healthy controls. Expressed as the mean ± SD, the date were analyzed with the Mann-Whitney <i>U</i>-test. ▴ vs. Tregs sorted from Young Healthy Controls, P<0.05.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "immunology", "Immune cells", "t cells", "Molecular cell biology", "Clinical immunology", "Immune system", "cytokines", "immunomodulation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "mrna", "tregs", "sorted", "aged", "ubc"], "article_id"=>927831, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tianping Chen", "Huiping Wang", "ZhiQiang Zhang", "Qing Li", "Kaili Yan", "Qianshan Tao", "Qianling Ye", "Shudao Xiong", "YiPing Wang", "Zhimin Zhai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087774.g002", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FoxP3_mRNA_expression_significantly_increased_in_Tregs_sorted_from_aged_UBC_patients_/927831", "title"=>"FoxP3 mRNA expression significantly increased in Tregs sorted from aged UBC patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:11:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378245"], "description"=>"<p>Tregs were sorted by FACS, <i>SENEX</i> mRNA level was detected by real-time quantitative PCR. An significant increase in <i>SENEX</i> mRNA expression was detected in CD4+CD25<sup>hi</sup> Tregs (2<sup>−△△CT</sup> = 0.8532±0.1078) as compared to CD4+CD25- Teffs (0.1564±0.0731) in Aged UBC patients (<i>p</i> = 0.027), and this increase was not observed in other groups. Tregs <i>SENEX</i> mRNA expression in Aged UBC patients was signicantly higher than those in Aged Healthy Controls (0.0923±0.0519) and Young Healthy Controls (0.1455±0.0792) (p<0.05 for each Mann-Whitney <i>U</i>-test). Data were expressed as the mean ± SD. ▴ vs. Teffs sorted from Aged UBC patients, P<0.05; △vs. Tregs in Aged Healthy Controls and Young Healthy Controls, P<0.05.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "immunology", "Immune cells", "t cells", "Molecular cell biology", "Clinical immunology", "Immune system", "cytokines", "immunomodulation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "mrna", "tregs", "sorted", "aged", "ubc"], "article_id"=>927834, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tianping Chen", "Huiping Wang", "ZhiQiang Zhang", "Qing Li", "Kaili Yan", "Qianshan Tao", "Qianling Ye", "Shudao Xiong", "YiPing Wang", "Zhimin Zhai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087774.g003", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Upregulated_SENEX_mRNA_expression_in_CD4_CD25_hi_Tregs_sorted_from_Aged_UBC_patients_/927834", "title"=>"Upregulated <i>SENEX</i> mRNA expression in CD4+CD25<sup>hi</sup> Tregs sorted from Aged UBC patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:11:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378247"], "description"=>"<p>Tregs were sorted by FACS, mRNA levels were detected by real-time quantitative PCR. In Aged UBC Patiens, apoptosis regulatory genes Caspase-3, P53, P16 and P21 mRNA expression (2<sup>−△△CT</sup> = 1183.42±321.17, 15.66±4.83, 23.06±4.59 and 2415.85±863.72, respectively) decreased in Tregs of Aged UBC patients (<i>p</i><0.05 for each Mann-Whitney U Test). Data were expressed as the mean ± SD. ▴ vs. Teffs sorted from Aged UBC patients, P<0.05.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "immunology", "Immune cells", "t cells", "Molecular cell biology", "Clinical immunology", "Immune system", "cytokines", "immunomodulation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "tregs", "aged", "ubc"], "article_id"=>927836, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tianping Chen", "Huiping Wang", "ZhiQiang Zhang", "Qing Li", "Kaili Yan", "Qianshan Tao", "Qianling Ye", "Shudao Xiong", "YiPing Wang", "Zhimin Zhai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087774.g004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Downregulated_gene_expression_of_P53_P16_P21_and_Caspase_3_in_CD4_CD25_hi_Tregs_of_aged_UBC_patients_/927836", "title"=>"Downregulated gene expression of <i>P53</i>, <i>P16</i>, <i>P21</i> and <i>Caspase-3</i> in CD4+CD25<sup>hi</sup> Tregs of aged UBC patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:11:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378248"], "description"=>"<p>Expressed as the mean ± SD, data were analyzed with the parametric Student’s T test. ▴ vs. Aged Healthy Controls and Young Healthy Controls, P<0.05; △vs. Young Healthy Controls, P<0.05.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "immunology", "Immune cells", "t cells", "Molecular cell biology", "Clinical immunology", "Immune system", "cytokines", "immunomodulation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "il-17", "serum", "il-2", "aged", "ubc"], "article_id"=>927837, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tianping Chen", "Huiping Wang", "ZhiQiang Zhang", "Qing Li", "Kaili Yan", "Qianshan Tao", "Qianling Ye", "Shudao Xiong", "YiPing Wang", "Zhimin Zhai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087774.g005", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_levels_of_TGF_946_1_IL_10_IL_17_and_TNF_945_serum_concentration_and_decreased_levels_of_IL_2_serum_concentration_in_aged_UBC_patients_/927837", "title"=>"Increased levels of TGF-β1, IL-10, IL-17 and TNF-α serum concentration and decreased levels of IL-2 serum concentration in aged UBC patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:11:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378249"], "description"=>"<p>Using Pearson’s coefficient test, <i>SENEX</i> expression was negatively correlated with (<b>A</b>) P53 mRNA expression (Pearson correlation coefficient = -0.405, p = 0.012) and (<b>B</b>) IL-2 concentration (Pearson correlation coefficient = -0.362, p = 0.026) in Aged UBC Patients. (<b>C</b>) Positive correlation between <i>SENEX</i> expression and TGF-β1 concentration (Pearson correlation coefficient = 0.507, p = 0.001) was figured out by Pearson’s coefficient test.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "immunology", "Immune cells", "t cells", "Molecular cell biology", "Clinical immunology", "Immune system", "cytokines", "immunomodulation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Bladder cancer", "urology", "Bladder cancer and urothelial neoplasias of the urinary tract", "mrna", "correlated", "il-2", "aged", "ubc"], "article_id"=>927838, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tianping Chen", "Huiping Wang", "ZhiQiang Zhang", "Qing Li", "Kaili Yan", "Qianshan Tao", "Qianling Ye", "Shudao Xiong", "YiPing Wang", "Zhimin Zhai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087774.g006", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SENEX_mRNA_expression_was_correlated_with_P53_TGF_1_and_IL_2_expression_in_Aged_UBC_Patients_/927838", "title"=>"<i>SENEX</i> mRNA expression was correlated with P53,TGF-β1 and IL-2 expression in Aged UBC Patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:11:59"}

PMC Usage Stats | Further Information

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Relative Metric

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