Antitumor Efficacy of α-Solanine against Pancreatic Cancer In Vitro and In Vivo
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Mendeley | Further Information

{"title"=>"Antitumor efficacy of ??-solanine against pancreatic cancer in vitro and in vivo.", "type"=>"journal", "authors"=>[{"first_name"=>"Chongqing", "last_name"=>"Lv"}, {"first_name"=>"Hongru", "last_name"=>"Kong"}, {"first_name"=>"Guohua", "last_name"=>"Dong"}, {"first_name"=>"Lewei", "last_name"=>"Liu"}, {"first_name"=>"Kun", "last_name"=>"Tong"}, {"first_name"=>"Hongwei", "last_name"=>"Sun"}, {"first_name"=>"Bicheng", "last_name"=>"Chen"}, {"first_name"=>"Chunwu", "last_name"=>"Zhang"}, {"first_name"=>"Mengtao", "last_name"=>"Zhou"}], "year"=>2014, "source"=>"PloS one", "identifiers"=>{"issn"=>"19326203", "pui"=>"373985744", "doi"=>"10.1371/journal.pone.0087868", "sgr"=>"84908550691", "pmid"=>"24505326"}, "id"=>"6c997ddd-d520-3620-b43a-7363a6d23532", "abstract"=>"α-solanine, a steroidal glycoalkaloid in potato, was found to have proliferation-inhibiting and apoptosis-promoting effect on multiple cancer cells, such as clone, liver, melanoma cancer cells. However, the antitumor efficacy of α-solanine on pancreatic cancer has not been fully evaluated. In this study, we inquired into the anti-carcinogenic effect of α-solanine against human pancreatic cancer cells. In the present study, we investigated the anti-carcinogenic effect of α-solanine against human pancreatic cancer cells. In vitro, α-solanine inhibited proliferation of PANC-1, sw1990, MIA PaCa-2 cells in a dose-dependent manner, as well as cell migration and invasion with atoxic doses. The expression of MMP-2/9, extracellular inducer of matrix metalloproteinase (EMMPRIN), CD44, eNOS and E-cadherin were suppressed by α-solanine in PANC-1 cells. Moreover, significantly decreased vascular endothelial growth factor (VEGF) expression and tube formation of endothelial cells were discerned following α-solanine treatment. Suppressed phosphorylation of Akt, mTOR, and Stat3, and strengthen phosphorylation of β-catenin was found, along with markedly decreased tran-nuclear of NF-κB, β-catenin and TCF-1. Following the administration of α-solanine (6 µg/g for 2 weeks) in xenograft model, tumor volume and weight were decreased by 61% and 43% (p<0.05) respectively, showing decreased MMP-2/9, PCNA and VEGF expression. In conclusion, α-solanine showed beneficial effects on pancreatic cancer in vitro and in vivo, which may via suppressing the pathway proliferation, angiogenesis and metastasis.", "link"=>"http://www.mendeley.com/research/antitumor-efficacy-solanine-against-pancreatic-cancer-vitro-vivo", "reader_count"=>12, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>2, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1377105"], "description"=>"<p>(A) Cells of each cancer cell line were treated with various concentrations of α-solanine for 24 h and 48 h. (B) Photos of anchorage-independent cell growth of PANC-1(100×magnification). (C) The colony number were quantified and data were calculated from three independent experiments. Each bar represents the means ± S.E.M. (n = 3). **p<0.01, compared with the control.</p>", "links"=>[], "tags"=>["Drugs and devices", "Drug research and development", "drug discovery", "oncology", "Basic cancer research", "metastasis", "Cancer treatment", "Antiangiogenesis therapy", "Cancers and neoplasms", "Gastrointestinal tumors", "Pancreatic cancer", "toxicology", "Toxic agents", "viability", "assay"], "article_id"=>926887, "categories"=>["Medicine"], "users"=>["Chongqing Lv", "Hongru Kong", "Guohua Dong", "Lewei Liu", "Kun Tong", "Hongwei Sun", "Bicheng Chen", "Chunwu Zhang", "Mengtao Zhou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087868.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cell_Viability_Assay_and_Colony_Assay_/926887", "title"=>"Cell Viability Assay and Colony Assay.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:13:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377111"], "description"=>"<p>Cells were treated with various concentrations of α-solanine for 24 h. (A) Cells were photographed(100×magnification). (B) The wound area were quantified in four fields in each treatment, and data were calculated from three independent experiments.(C) Cells were photographed(100×maginfication). (D) The invaded cells were quantified by counting fo DAPI-stained cells. Each bar represents the means ± S.E.M. (n = 3).*p<0.05, **p<0.01, compared with the control.</p>", "links"=>[], "tags"=>["Drugs and devices", "Drug research and development", "drug discovery", "oncology", "Basic cancer research", "metastasis", "Cancer treatment", "Antiangiogenesis therapy", "Cancers and neoplasms", "Gastrointestinal tumors", "Pancreatic cancer", "toxicology", "Toxic agents"], "article_id"=>926893, "categories"=>["Medicine"], "users"=>["Chongqing Lv", "Hongru Kong", "Guohua Dong", "Lewei Liu", "Kun Tong", "Hongwei Sun", "Bicheng Chen", "Chunwu Zhang", "Mengtao Zhou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087868.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cell_Migration_and_Invasion_Assays_/926893", "title"=>"Cell Migration and Invasion Assays.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:13:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377112"], "description"=>"<p>(A) Representative micrographs (100×) of tube after treatment of conditioned medium for 6 h. HUVECS were plated onto the Matrigel –precoated wells and cultured in conditioned medium from PANC-1 cells treated with for 24 h. (B) The tube lengths were measured by Image-ProPlus 6.0. (C) The mRNA expression of VEGF was presented as means ± S.E.M. of three independent experiments.(D) Western blot analysis of the expression of VEGF. GAPDH was used as a loading control. (E) Quantification of the western blot result was performed by calculating the ratio of the value to the control group. *p<0.05, **p<0.01, compared with the control.</p>", "links"=>[], "tags"=>["Drugs and devices", "Drug research and development", "drug discovery", "oncology", "Basic cancer research", "metastasis", "Cancer treatment", "Antiangiogenesis therapy", "Cancers and neoplasms", "Gastrointestinal tumors", "Pancreatic cancer", "toxicology", "Toxic agents", "vitro", "angiogenesis"], "article_id"=>926894, "categories"=>["Medicine"], "users"=>["Chongqing Lv", "Hongru Kong", "Guohua Dong", "Lewei Liu", "Kun Tong", "Hongwei Sun", "Bicheng Chen", "Chunwu Zhang", "Mengtao Zhou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087868.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_Vitro_Angiogenesis_Assay_/926894", "title"=>"In Vitro Angiogenesis Assay.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:13:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377113"], "description"=>"<p>(A) The mRNA expression of MMP-2/9, EMMPRIN, CD44, ENOS and Ecadherin was presented as means ± S.E.M. of three independent experiments.(B) The expressions of MMP-2 and MMP-9 protein were analyzed by Western blot.(C) The expressions of Ecadherin protein was performed by Western blot.(D) Quantification of the western blot results were performed by calculating the ratio of the value to the control group.(E) The activity of MMP-2 and MMP-9 were analyzed by Gelatin Zymography. (F) Quantification of the Gelatin Zymography results were performed by calculating the ratio of the value to the control group. *p<0.05, **p<0.01, compared with the control. GAPDH was used as a loading control.</p>", "links"=>[], "tags"=>["Drugs and devices", "Drug research and development", "drug discovery", "oncology", "Basic cancer research", "metastasis", "Cancer treatment", "Antiangiogenesis therapy", "Cancers and neoplasms", "Gastrointestinal tumors", "Pancreatic cancer", "toxicology", "Toxic agents"], "article_id"=>926895, "categories"=>["Medicine"], "users"=>["Chongqing Lv", "Hongru Kong", "Guohua Dong", "Lewei Liu", "Kun Tong", "Hongwei Sun", "Bicheng Chen", "Chunwu Zhang", "Mengtao Zhou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087868.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_945_Solanine_on_expression_of_metastasis_associated_molecule_/926895", "title"=>"Effect of α-Solanine on expression of metastasis associated molecule.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:13:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377114"], "description"=>"<p>PANC-1 cells were treated with various doses of α-solanine for 24 h, or 9 µg/µl of α-solanine for 6,12,18,24 h. The phosphorylation level of β-catenin(A,B), Stat3(C,D) were determined by Western blot. GAPDH was used as a loading control.(E,F,G,H) Quantification of the western blot results were performed by calculating the ratio of the value to the control group. *p<0.05, **p<0.01, compared with the control.</p>", "links"=>[], "tags"=>["Drugs and devices", "Drug research and development", "drug discovery", "oncology", "Basic cancer research", "metastasis", "Cancer treatment", "Antiangiogenesis therapy", "Cancers and neoplasms", "Gastrointestinal tumors", "Pancreatic cancer", "toxicology", "Toxic agents", "phosphorylation"], "article_id"=>926896, "categories"=>["Medicine"], "users"=>["Chongqing Lv", "Hongru Kong", "Guohua Dong", "Lewei Liu", "Kun Tong", "Hongwei Sun", "Bicheng Chen", "Chunwu Zhang", "Mengtao Zhou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087868.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_945_solanine_on_phosphorylation_of_946_catenin_and_Stat3_/926896", "title"=>"Effect of α-solanine on phosphorylation of β-catenin and Stat3.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:13:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377115"], "description"=>"<p>PANC-1 cells were treated with various doses of α-solanine for 24 h, or 9 µg/µl of α-solanine for 6,12,18,24 h. (A,C) The phosphorylation level of Akt and mTOR were determined by Western blot. GAPDH was used as a loading control. (B,D) Quantification of the western blot results were performed by calculating the ratio of the value to the control group. *p<0.05, **p<0.01, compared with the control.</p>", "links"=>[], "tags"=>["Drugs and devices", "Drug research and development", "drug discovery", "oncology", "Basic cancer research", "metastasis", "Cancer treatment", "Antiangiogenesis therapy", "Cancers and neoplasms", "Gastrointestinal tumors", "Pancreatic cancer", "toxicology", "Toxic agents", "phosphorylation", "akt"], "article_id"=>926897, "categories"=>["Medicine"], "users"=>["Chongqing Lv", "Hongru Kong", "Guohua Dong", "Lewei Liu", "Kun Tong", "Hongwei Sun", "Bicheng Chen", "Chunwu Zhang", "Mengtao Zhou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087868.g006", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_945_solanine_on_phosphorylation_of_Akt_and_mTOR_/926897", "title"=>"Effect of α-solanine on phosphorylation of Akt and mTOR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:13:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377116"], "description"=>"<p>PANC-1 cells were treated with various doses of α-solanine for 24 h. (A,C) The level of NF-κB/p65, β-catenin and TCF-1 in nucleus were determined by Western blot. Laminb1 was used as a nuclear protein loading control. (B,D) Quantification of the densitometric results were performed by calculating the ratio of the value to the control group. *p<0.05, **p<0.01, compared with the control.</p>", "links"=>[], "tags"=>["Drugs and devices", "Drug research and development", "drug discovery", "oncology", "Basic cancer research", "metastasis", "Cancer treatment", "Antiangiogenesis therapy", "Cancers and neoplasms", "Gastrointestinal tumors", "Pancreatic cancer", "toxicology", "Toxic agents", "tcf-1", "nucleus", "panc-1"], "article_id"=>926898, "categories"=>["Medicine"], "users"=>["Chongqing Lv", "Hongru Kong", "Guohua Dong", "Lewei Liu", "Kun Tong", "Hongwei Sun", "Bicheng Chen", "Chunwu Zhang", "Mengtao Zhou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087868.g007", "stats"=>{"downloads"=>0, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_945_solanine_on_the_expression_of_NF_954_B_p65_946_catenin_and_TCF_1_in_nucleus_of_PANC_1_cells_/926898", "title"=>"Effect of α-solanine on the expression of NF-κB/p65, β-catenin and TCF-1 in nucleus of PANC-1 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:13:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377132"], "description"=>"<p>PANC-1 cells were subcutaneously injected into the flanks of nude mice. When the tumors were measurable, mice were given DMSO or α-solanine for 2 weeks. (A) Tumor volume/mouse as a function of time.(B) The mouse of each group was monitored for body weight once a day. Mean body weight/mouse as a function of time.(C) Tumor volume/mouse and (D) tumor weight/mouse at the end of the study were analyzed. *p<0.05, compared with the control.</p>", "links"=>[], "tags"=>["Drugs and devices", "Drug research and development", "drug discovery", "oncology", "Basic cancer research", "metastasis", "Cancer treatment", "Antiangiogenesis therapy", "Cancers and neoplasms", "Gastrointestinal tumors", "Pancreatic cancer", "toxicology", "Toxic agents", "panc-1", "xenograft", "athymic", "nude"], "article_id"=>926900, "categories"=>["Medicine"], "users"=>["Chongqing Lv", "Hongru Kong", "Guohua Dong", "Lewei Liu", "Kun Tong", "Hongwei Sun", "Bicheng Chen", "Chunwu Zhang", "Mengtao Zhou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087868.g008", "stats"=>{"downloads"=>0, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_945_solanine_on_the_PANC_1_tumor_xenograft_growth_and_body_weight_of_athymic_nude_mice_/926900", "title"=>"Effect of α-solanine on the PANC-1 tumor xenograft growth and body weight of athymic nude mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:13:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377137"], "description"=>"<p>When tumor xenografts were seperated, parts of tumor were used for Western blot and Immunohistochemistry. (A) The expressions of MMP-2 and MMP-9 protein were analyzede by Western blot. (B,C) Tumor tissus were innunohistochemically analyzed for PCNA-positive cells and VEGF staining density. Representative photographs of IHC staining of PCNA and VEGF are shown at 400×magnifications. Scale bar: 50 µm. The data are presented as the mean ± SE. *p<0.05, **p<0.01, compared with the control.</p>", "links"=>[], "tags"=>["Drugs and devices", "Drug research and development", "drug discovery", "oncology", "Basic cancer research", "metastasis", "Cancer treatment", "Antiangiogenesis therapy", "Cancers and neoplasms", "Gastrointestinal tumors", "Pancreatic cancer", "toxicology", "Toxic agents", "pcna", "vegf", "panc-1"], "article_id"=>926904, "categories"=>["Medicine"], "users"=>["Chongqing Lv", "Hongru Kong", "Guohua Dong", "Lewei Liu", "Kun Tong", "Hongwei Sun", "Bicheng Chen", "Chunwu Zhang", "Mengtao Zhou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087868.g009", "stats"=>{"downloads"=>0, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_945_solanine_on_the_expression_of_MMP_2_MMP_9_PCNA_and_VEGF_in_PANC_1_tumor_xenograft_/926904", "title"=>"Effect of α-solanine on the expression of MMP-2, MMP-9, PCNA and VEGF in PANC-1 tumor xenograft.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:13:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377139"], "description"=>"<p>Prime pairs used in Realtime PCR.</p>", "links"=>[], "tags"=>["Drugs and devices", "Drug research and development", "drug discovery", "oncology", "Basic cancer research", "metastasis", "Cancer treatment", "Antiangiogenesis therapy", "Cancers and neoplasms", "Gastrointestinal tumors", "Pancreatic cancer", "toxicology", "Toxic agents", "pairs", "realtime"], "article_id"=>926906, "categories"=>["Medicine"], "users"=>["Chongqing Lv", "Hongru Kong", "Guohua Dong", "Lewei Liu", "Kun Tong", "Hongwei Sun", "Bicheng Chen", "Chunwu Zhang", "Mengtao Zhou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087868.t001", "stats"=>{"downloads"=>5, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prime_pairs_used_in_Realtime_PCR_/926906", "title"=>"Prime pairs used in Realtime PCR.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-05 03:13:21"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
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  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
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  • {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
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  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
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Relative Metric

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