Same Day Identification and Full Panel Antimicrobial Susceptibility Testing of Bacteria from Positive Blood Culture Bottles Made Possible by a Combined Lysis-Filtration Method with MALDI-TOF VITEK Mass Spectrometry and the VITEK2 System
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{"title"=>"Same day identification and full panel antimicrobial susceptibility testing of bacteria from positive blood culture bottles made possible by a combined lysis-filtration method with MALDI-TOF VITEK mass spectrometry and the VITEK2 system", "type"=>"journal", "authors"=>[{"first_name"=>"Alexandra", "last_name"=>"Machen", "scopus_author_id"=>"55957449100"}, {"first_name"=>"Tim", "last_name"=>"Drake", "scopus_author_id"=>"55600292000"}, {"first_name"=>"Yun F.", "last_name"=>"Wang", "scopus_author_id"=>"37074963200"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84895884401", "doi"=>"10.1371/journal.pone.0087870", "pui"=>"372565646", "pmid"=>"24551067", "scopus"=>"2-s2.0-84895884401", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"db4b5140-2f8f-3355-858a-b61f6c0305ab", "abstract"=>"Rapid identification and antimicrobial susceptibility testing of microorganisms causing bloodstream infections or sepsis have the potential to improve patient care. This proof-of-principle study evaluates the Lysis-Filtration Method for identification as well as antimicrobial susceptibility testing of bacteria directly from positive blood culture bottles in a clinical setting. A total of 100 non-duplicated positive blood cultures were tested and 1012 microorganism-antimicrobial combinations were assessed. An aliquot of non-charcoal blood culture broth was incubated with lysis buffer briefly before being filtered and washed. Microorganisms recovered from the filter membrane were first identified by using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight VITEK(R) Mass Spectrometry (VITEK MS). After quick identification from VITEK MS, filtered microorganisms were inoculated to VITEK(R)2 system for full panel antimicrobial susceptibility testing analysis. Of 100 bottles tested, the VITEK MS resulted in 94.0% correct organism identification to the species level. Compared to the conventional antimicrobial susceptibility testing methods, direct antimicrobial susceptibility testing from VITEK(R)2 resulted in 93.5% (946/1012) category agreement of antimicrobials tested, with 3.6% (36/1012) minor error, 1.7% (7/1012) major error, and 1.3% (13/1012) very major error of antimicrobials. The average time to identification and antimicrobial susceptibility testing was 11.4 hours by using the Lysis-Filtration method for both VITEK MS and VITEK(R)2 compared to 56.3 hours by using conventional methods (p<0.00001). Thus, the same-day results of microorganism identification and antimicrobial susceptibility testing directly from positive blood culture can be achieved and can be used for appropriate antibiotic therapy and antibiotic stewardship.", "link"=>"http://www.mendeley.com/research/same-day-identification-full-panel-antimicrobial-susceptibility-testing-bacteria-positive-blood-cult", "reader_count"=>48, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Student > Doctoral Student"=>3, "Researcher"=>5, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>5, "Student > Master"=>7, "Other"=>3, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Student > Doctoral Student"=>3, "Researcher"=>5, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>5, "Student > Master"=>7, "Other"=>3, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>5}, "reader_count_by_subject_area"=>{"Engineering"=>3, "Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>22, "Agricultural and Biological Sciences"=>9, "Design"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>22}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Saudi Arabia"=>1, "Colombia"=>1, "France"=>2}, "group_count"=>4}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1387397"], "description"=>"a<p>Time was measured from when a blood culture bottle turned positive to ID and AST was reported.</p>", "links"=>[], "tags"=>["microbiology", "Emerging infectious diseases", "Microbial control", "proteomics", "Spectrometric identification of proteins", "Critical care and emergency medicine", "sepsis", "Diagnostic medicine", "pathology", "Clinical pathology", "Clinical microbiology", "Infectious diseases", "Bacterial diseases", "id", "ast", "lysis-filtration", "methods"], "article_id"=>935758, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Alexandra Machen", "Tim Drake", "Yun F. (Wayne) Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087870.t003", "stats"=>{"downloads"=>3, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_time_to_ID_and_AST_between_Lysis_Filtration_method_and_conventional_methods_hours_a_/935758", "title"=>"Comparison of time to ID and AST between Lysis-Filtration method and conventional methods (hours)<sup>a</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-14 02:55:41"}
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  • {"files"=>["https://ndownloader.figshare.com/files/1387395"], "description"=>"a<p>One isolate was identified by VITEK MS to the family level.</p>b<p>Two isolates were identified to the genus level.</p>c<p>Identified by VITEK MS as <i>E. coli.</i></p>d<p>No ID by VITEK MS for one isolate.</p>", "links"=>[], "tags"=>["microbiology", "Emerging infectious diseases", "Microbial control", "proteomics", "Spectrometric identification of proteins", "Critical care and emergency medicine", "sepsis", "Diagnostic medicine", "pathology", "Clinical pathology", "Clinical microbiology", "Infectious diseases", "Bacterial diseases", "bottles", "lysis-filtration", "maldi-tof", "saramis"], "article_id"=>935756, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Alexandra Machen", "Tim Drake", "Yun F. (Wayne) Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087870.t001", "stats"=>{"downloads"=>1, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Susceptibility_testing_of_bacteria_from_positive_blood_culture_bottles_by_using_a_Lysis_Filtration_Method_MALDI_TOF_Mass_Spectrum_Analysis_with_SARAMIS_Database_and_the_VITEK_174_2_System_/935756", "title"=>"Susceptibility testing of bacteria from positive blood culture bottles by using a Lysis-Filtration Method, MALDI-TOF Mass Spectrum Analysis with SARAMIS Database, and the VITEK®2 System.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-14 02:55:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1387393"], "description"=>"<p>Process flow diagram for identification and antimicrobial susceptibility testing of bacteria directly from positive blood culture bottles using the Lysis-Filtration Method with MALDI-TOF VITEK Mass Spectrometry and the VITEK®2 System.</p>", "links"=>[], "tags"=>["microbiology", "Emerging infectious diseases", "Microbial control", "proteomics", "Spectrometric identification of proteins", "Critical care and emergency medicine", "sepsis", "Diagnostic medicine", "pathology", "Clinical pathology", "Clinical microbiology", "Infectious diseases", "Bacterial diseases", "diagram", "antimicrobial", "susceptibility", "bottles", "lysis-filtration", "maldi-tof", "vitek", "spectrometry"], "article_id"=>935754, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Alexandra Machen", "Tim Drake", "Yun F. (Wayne) Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087870.g001", "stats"=>{"downloads"=>56, "page_views"=>674, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Process_flow_diagram_for_identification_and_antimicrobial_susceptibility_testing_of_bacteria_directly_from_positive_blood_culture_bottles_using_the_Lysis_Filtration_Method_with_MALDI_TOF_VITEK_Mass_Spectrometry_and_the_VITEK_174_2_System_/935754", "title"=>"Process flow diagram for identification and antimicrobial susceptibility testing of bacteria directly from positive blood culture bottles using the Lysis-Filtration Method with MALDI-TOF VITEK Mass Spectrometry and the VITEK®2 System.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-14 02:55:41"}

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