Neonatal Encephalopathic Cerebral Injury in South India Assessed by Perinatal Magnetic Resonance Biomarkers and Early Childhood Neurodevelopmental Outcome
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome", "type"=>"journal", "authors"=>[{"first_name"=>"Peter J.", "last_name"=>"Lally", "scopus_author_id"=>"56058701300"}, {"first_name"=>"David L.", "last_name"=>"Price", "scopus_author_id"=>"57199436764"}, {"first_name"=>"Shreela S.", "last_name"=>"Pauliah", "scopus_author_id"=>"55825339300"}, {"first_name"=>"Alan", "last_name"=>"Bainbridge", "scopus_author_id"=>"8576309800"}, {"first_name"=>"Justin", "last_name"=>"Kurien", "scopus_author_id"=>"56058028700"}, {"first_name"=>"Neeraja", "last_name"=>"Sivasamy", "scopus_author_id"=>"56058574300"}, {"first_name"=>"Frances M.", "last_name"=>"Cowan", "scopus_author_id"=>"56432392100"}, {"first_name"=>"Guhan", "last_name"=>"Balraj", "scopus_author_id"=>"55617545800"}, {"first_name"=>"Manjula", "last_name"=>"Ayer", "scopus_author_id"=>"56058399400"}, {"first_name"=>"Kariyapilly", "last_name"=>"Satheesan", "scopus_author_id"=>"55913447200"}, {"first_name"=>"Sreejith", "last_name"=>"Ceebi", "scopus_author_id"=>"56058583500"}, {"first_name"=>"Angie", "last_name"=>"Wade", "scopus_author_id"=>"7202754332"}, {"first_name"=>"Ravi", "last_name"=>"Swamy", "scopus_author_id"=>"7005987636"}, {"first_name"=>"Shaji", "last_name"=>"Padinjattel", "scopus_author_id"=>"56058520900"}, {"first_name"=>"Betty", "last_name"=>"Hutchon", "scopus_author_id"=>"54389343200"}, {"first_name"=>"Madhava", "last_name"=>"Vijayakumar", "scopus_author_id"=>"7005357785"}, {"first_name"=>"Mohandas", "last_name"=>"Nair", "scopus_author_id"=>"56058418700"}, {"first_name"=>"Krishnakumar", "last_name"=>"Padinharath", "scopus_author_id"=>"56058054600"}, {"first_name"=>"Hui", "last_name"=>"Zhang", "scopus_author_id"=>"36088339000"}, {"first_name"=>"Ernest B.", "last_name"=>"Cady", "scopus_author_id"=>"7005849630"}, {"first_name"=>"Seetha", "last_name"=>"Shankaran", "scopus_author_id"=>"7006858337"}, {"first_name"=>"Sudhin", "last_name"=>"Thayyil", "scopus_author_id"=>"24484901000"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84895519922", "pui"=>"372535239", "doi"=>"10.1371/journal.pone.0087874", "isbn"=>"1932-6203", "sgr"=>"84895519922", "pmid"=>"24505327"}, "id"=>"cb899a30-4c65-33c2-832e-d0ca112bd129", "abstract"=>"UNLABELLED: Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and middle-income countries. Such injury accounts for an estimated 1 million neonatal deaths per year. We used magnetic resonance (MR) biomarkers to characterise perinatal brain injury, and examined early childhood outcomes in South India.\n\nMETHODS: We recruited consecutive term or near term infants with evidence of perinatal asphyxia and a Thompson encephalopathy score ≥6 within 6 h of birth, over 6 months. We performed conventional MR imaging, diffusion tensor MR imaging and thalamic proton MR spectroscopy within 3 weeks of birth. We computed group-wise differences in white matter fractional anisotropy (FA) using tract based spatial statistics. We allocated Sarnat encephalopathy stage aged 3 days, and evaluated neurodevelopmental outcomes aged 3½ years using Bayley III.\n\nRESULTS: Of the 54 neonates recruited, Sarnat staging was mild in 30 (56%); moderate in 15 (28%) and severe in 6 (11%), with no encephalopathy in 3 (6%). Six infants died. Of the 48 survivors, 44 had images available for analysis. In these infants, imaging indicated perinatal rather than established antenatal origins to injury. Abnormalities were frequently observed in white matter (n = 40, 91%) and cortex (n = 31, 70%) while only 12 (27%) had abnormal basal ganglia/thalami. Reduced white matter FA was associated with Sarnat stage, deep grey nuclear injury, and MR spectroscopy N-acetylaspartate/choline, but not early Thompson scores. Outcome data were obtained in 44 infants (81%) with 38 (79%) survivors examined aged 3½ years; of these, 16 (42%) had adverse neurodevelopmental outcomes.\n\nCONCLUSIONS: No infants had evidence for established brain lesions, suggesting potentially treatable perinatal origins. White matter injury was more common than deep brain nuclei injury. Our results support the need for rigorous evaluation of the efficacy of rescue hypothermic neuroprotection in low- and middle-income countries.", "link"=>"http://www.mendeley.com/research/neonatal-encephalopathic-cerebral-injury-south-india-assessed-perinatal-magnetic-resonance-biomarker", "reader_count"=>37, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Student > Master"=>9, "Other"=>2, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Student > Master"=>9, "Other"=>2, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>26, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>1, "Psychology"=>3, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>26}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Egypt"=>1}, "group_count"=>2}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84895519922"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84895519922?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84895519922&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84895519922&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84895519922", "dc:identifier"=>"SCOPUS_ID:84895519922", "eid"=>"2-s2.0-84895519922", "dc:title"=>"Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome", "dc:creator"=>"Lally P.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-02-05", "prism:coverDisplayDate"=>"5 February 2014", "prism:doi"=>"10.1371/journal.pone.0087874", "citedby-count"=>"20", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Imperial College London", "affiliation-city"=>"London", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"24505327", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e87874", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0087874", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"28", "xml_views"=>"4", "html_views"=>"214"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"3", "html_views"=>"101"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"3", "html_views"=>"91"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"82"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"50"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"78"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"70"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"11", "html_views"=>"26"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"66"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"51"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"11"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"24"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1377172"], "description"=>"<p>Values are frequency (% of n);</p><p>*Normal outcome defined as Bayley III cognitive score ≥85 and motor composite score ≥82; with normal head growth; normal neurological examination; normal vision and hearing; and no ongoing seizures at 3½ years.</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "neurology", "cerebral palsy", "Cognitive neurology", "Developmental and pediatric neurology", "neuroimaging", "pediatrics", "Neonatology", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "outcomes", "infants", "sarnat", "neonatal", "encephalopathy"], "article_id"=>926939, "categories"=>["Physics", "Medicine"], "users"=>["Peter J. Lally", "David L. Price", "Shreela S. Pauliah", "Alan Bainbridge", "Justin Kurien", "Neeraja Sivasamy", "Frances M. Cowan", "Guhan Balraj", "Manjula Ayer", "Kariyapilly Satheesan", "Sreejith Ceebi", "Angie Wade", "Ravi Swamy", "Shaji Padinjattel", "Betty Hutchon", "Madhava Vijayakumar", "Mohandas Nair", "Krishnakumar Padinharath", "Hui Zhang", "Ernest B. Cady", "Seetha Shankaran", "Sudhin Thayyil"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087874.t003", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Early_childhood_outcomes_of_infants_according_to_Sarnat_neonatal_encephalopathy_staging_/926939", "title"=>"Early childhood outcomes of infants according to Sarnat neonatal encephalopathy staging.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-05 03:16:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377171"], "description"=>"<p>BG = basal ganglia; T = thalami; BGT = composite basal ganglia and thalami, WM = white matter; GMFCS = Gross Motor Function Classification System; CP = cerebral palsy at follow-up; AE = anti-epileptics at follow-up; M = composite motor score; C = composite cognitive score; L = composite language score; HC = head circumference; na = not available/applicable. MRI scoring system described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087874#pone-0087874-t003\" target=\"_blank\">Table 3</a>, under ‘Visual Interpretation’.</p><p>*Underwent therapeutic hypothermia.</p>†<p>Requiring visual aids.</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "neurology", "cerebral palsy", "Cognitive neurology", "Developmental and pediatric neurology", "neuroimaging", "pediatrics", "Neonatology", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "children", "adverse"], "article_id"=>926938, "categories"=>["Physics", "Medicine"], "users"=>["Peter J. Lally", "David L. Price", "Shreela S. Pauliah", "Alan Bainbridge", "Justin Kurien", "Neeraja Sivasamy", "Frances M. Cowan", "Guhan Balraj", "Manjula Ayer", "Kariyapilly Satheesan", "Sreejith Ceebi", "Angie Wade", "Ravi Swamy", "Shaji Padinjattel", "Betty Hutchon", "Madhava Vijayakumar", "Mohandas Nair", "Krishnakumar Padinharath", "Hui Zhang", "Ernest B. Cady", "Seetha Shankaran", "Sudhin Thayyil"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087874.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_children_with_adverse_early_childhood_outcomes_/926938", "title"=>"Characteristics of children with adverse early childhood outcomes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-05 03:16:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377166"], "description"=>"<p>In each case FA is compared between the infants classified abnormal (by the criterion given), and the other infants in the cohort. Red-yellow pixels denote regions of white matter where FA values are different between groups with p<0.05–p<0.01, green pixels denote regions where p≥0.05.</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "neurology", "cerebral palsy", "Cognitive neurology", "Developmental and pediatric neurology", "neuroimaging", "pediatrics", "Neonatology", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "whole-brain", "fa", "mr", "imaging"], "article_id"=>926933, "categories"=>["Physics", "Medicine"], "users"=>["Peter J. Lally", "David L. Price", "Shreela S. Pauliah", "Alan Bainbridge", "Justin Kurien", "Neeraja Sivasamy", "Frances M. Cowan", "Guhan Balraj", "Manjula Ayer", "Kariyapilly Satheesan", "Sreejith Ceebi", "Angie Wade", "Ravi Swamy", "Shaji Padinjattel", "Betty Hutchon", "Madhava Vijayakumar", "Mohandas Nair", "Krishnakumar Padinharath", "Hui Zhang", "Ernest B. Cady", "Seetha Shankaran", "Sudhin Thayyil"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087874.g002", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_TBSS_analysis_of_whole_brain_white_matter_FA_according_to_conventional_MR_imaging_abnormalities_/926933", "title"=>"TBSS analysis of whole-brain white matter FA according to conventional MR imaging abnormalities.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:16:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377165"], "description"=>"<p>Study flow chart.</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "neurology", "cerebral palsy", "Cognitive neurology", "Developmental and pediatric neurology", "neuroimaging", "pediatrics", "Neonatology", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics"], "article_id"=>926932, "categories"=>["Physics", "Medicine"], "users"=>["Peter J. Lally", "David L. Price", "Shreela S. Pauliah", "Alan Bainbridge", "Justin Kurien", "Neeraja Sivasamy", "Frances M. Cowan", "Guhan Balraj", "Manjula Ayer", "Kariyapilly Satheesan", "Sreejith Ceebi", "Angie Wade", "Ravi Swamy", "Shaji Padinjattel", "Betty Hutchon", "Madhava Vijayakumar", "Mohandas Nair", "Krishnakumar Padinharath", "Hui Zhang", "Ernest B. Cady", "Seetha Shankaran", "Sudhin Thayyil"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087874.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_flow_chart_/926932", "title"=>"Study flow chart.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:16:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377175", "https://ndownloader.figshare.com/files/1377176", "https://ndownloader.figshare.com/files/1377177", "https://ndownloader.figshare.com/files/1377178", "https://ndownloader.figshare.com/files/1377179", "https://ndownloader.figshare.com/files/1377180", "https://ndownloader.figshare.com/files/1377181", "https://ndownloader.figshare.com/files/1377182", "https://ndownloader.figshare.com/files/1377183", "https://ndownloader.figshare.com/files/1377184", "https://ndownloader.figshare.com/files/1377185"], "description"=>"<div><p></p><p>Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and middle-income countries. Such injury accounts for an estimated 1 million neonatal deaths per year. We used magnetic resonance (MR) biomarkers to characterise perinatal brain injury, and examined early childhood outcomes in South India.</p><p>Methods</p><p>We recruited consecutive term or near term infants with evidence of perinatal asphyxia and a Thompson encephalopathy score ≥6 within 6 h of birth, over 6 months. We performed conventional MR imaging, diffusion tensor MR imaging and thalamic proton MR spectroscopy within 3 weeks of birth. We computed group-wise differences in white matter fractional anisotropy (FA) using tract based spatial statistics. We allocated Sarnat encephalopathy stage aged 3 days, and evaluated neurodevelopmental outcomes aged 3½ years using Bayley III.</p><p>Results</p><p>Of the 54 neonates recruited, Sarnat staging was mild in 30 (56%); moderate in 15 (28%) and severe in 6 (11%), with no encephalopathy in 3 (6%). Six infants died. Of the 48 survivors, 44 had images available for analysis. In these infants, imaging indicated perinatal rather than established antenatal origins to injury. Abnormalities were frequently observed in white matter (n = 40, 91%) and cortex (n = 31, 70%) while only 12 (27%) had abnormal basal ganglia/thalami. Reduced white matter FA was associated with Sarnat stage, deep grey nuclear injury, and MR spectroscopy N-acetylaspartate/choline, but not early Thompson scores. Outcome data were obtained in 44 infants (81%) with 38 (79%) survivors examined aged 3½ years; of these, 16 (42%) had adverse neurodevelopmental outcomes.</p><p>Conclusions</p><p>No infants had evidence for established brain lesions, suggesting potentially treatable perinatal origins. White matter injury was more common than deep brain nuclei injury. Our results support the need for rigorous evaluation of the efficacy of rescue hypothermic neuroprotection in low- and middle-income countries.</p></div>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "neurology", "cerebral palsy", "Cognitive neurology", "Developmental and pediatric neurology", "neuroimaging", "pediatrics", "Neonatology", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "encephalopathic", "cerebral", "india", "perinatal", "resonance", "biomarkers", "neurodevelopmental"], "article_id"=>926941, "categories"=>["Physics", "Medicine"], "users"=>["Peter J. Lally", "David L. Price", "Shreela S. Pauliah", "Alan Bainbridge", "Justin Kurien", "Neeraja Sivasamy", "Frances M. Cowan", "Guhan Balraj", "Manjula Ayer", "Kariyapilly Satheesan", "Sreejith Ceebi", "Angie Wade", "Ravi Swamy", "Shaji Padinjattel", "Betty Hutchon", "Madhava Vijayakumar", "Mohandas Nair", "Krishnakumar Padinharath", "Hui Zhang", "Ernest B. Cady", "Seetha Shankaran", "Sudhin Thayyil"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0087874.s001", "https://dx.doi.org/10.1371/journal.pone.0087874.s002", "https://dx.doi.org/10.1371/journal.pone.0087874.s003", "https://dx.doi.org/10.1371/journal.pone.0087874.s004", "https://dx.doi.org/10.1371/journal.pone.0087874.s005", "https://dx.doi.org/10.1371/journal.pone.0087874.s006", "https://dx.doi.org/10.1371/journal.pone.0087874.s007", "https://dx.doi.org/10.1371/journal.pone.0087874.s008", "https://dx.doi.org/10.1371/journal.pone.0087874.s009", "https://dx.doi.org/10.1371/journal.pone.0087874.s010", "https://dx.doi.org/10.1371/journal.pone.0087874.s011"], "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Neonatal_Encephalopathic_Cerebral_Injury_in_South_India_Assessed_by_Perinatal_Magnetic_Resonance_Biomarkers_and_Early_Childhood_Neurodevelopmental_Outcome_/926941", "title"=>"Neonatal Encephalopathic Cerebral Injury in South India Assessed by Perinatal Magnetic Resonance Biomarkers and Early Childhood Neurodevelopmental Outcome", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-02-05 03:16:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377170"], "description"=>"<p>Values are frequency (% of n).</p>†<p>Three infants had no encephalopathy on day 3 Sarnat stage.</p>‡<p>13 had moderate encephalopathy.</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "neurology", "cerebral palsy", "Cognitive neurology", "Developmental and pediatric neurology", "neuroimaging", "pediatrics", "Neonatology", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "mr"], "article_id"=>926937, "categories"=>["Physics", "Medicine"], "users"=>["Peter J. Lally", "David L. Price", "Shreela S. Pauliah", "Alan Bainbridge", "Justin Kurien", "Neeraja Sivasamy", "Frances M. Cowan", "Guhan Balraj", "Manjula Ayer", "Kariyapilly Satheesan", "Sreejith Ceebi", "Angie Wade", "Ravi Swamy", "Shaji Padinjattel", "Betty Hutchon", "Madhava Vijayakumar", "Mohandas Nair", "Krishnakumar Padinharath", "Hui Zhang", "Ernest B. Cady", "Seetha Shankaran", "Sudhin Thayyil"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087874.t001", "stats"=>{"downloads"=>1, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Brain_injury_on_conventional_MR_imaging_/926937", "title"=>"Brain injury on conventional MR imaging.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-05 03:16:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377169"], "description"=>"<p>p value maps are displayed as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087874#pone-0087874-g002\" target=\"_blank\">Figure 2</a>, only using those with 3½ year outcome data for group-wise comparisons. Low Bayley III = infants with scores below predefined cut-offs for Bayley III (<82 for composite motor score, <85 for composite cognitive score); Slow head growth = isolated slow head growth (fall in head circumference centile from birth to follow-up of >2 standard deviations), with otherwise normal neurological examination and Bayley III scores.</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "neurology", "cerebral palsy", "Cognitive neurology", "Developmental and pediatric neurology", "neuroimaging", "pediatrics", "Neonatology", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "fa", "aged"], "article_id"=>926936, "categories"=>["Physics", "Medicine"], "users"=>["Peter J. Lally", "David L. Price", "Shreela S. Pauliah", "Alan Bainbridge", "Justin Kurien", "Neeraja Sivasamy", "Frances M. Cowan", "Guhan Balraj", "Manjula Ayer", "Kariyapilly Satheesan", "Sreejith Ceebi", "Angie Wade", "Ravi Swamy", "Shaji Padinjattel", "Betty Hutchon", "Madhava Vijayakumar", "Mohandas Nair", "Krishnakumar Padinharath", "Hui Zhang", "Ernest B. Cady", "Seetha Shankaran", "Sudhin Thayyil"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087874.g004", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Whole_brain_white_matter_FA_according_to_outcome_assessment_aged_3_189_years_/926936", "title"=>"Whole-brain white matter FA according to outcome assessment aged 3½ years.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:16:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1377167"], "description"=>"<p>p value maps are displayed as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087874#pone-0087874-g002\" target=\"_blank\">Figure 2</a>. Neuro = neurological; Ther. hypotherm. = therapeutic hypothermia.</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "neurology", "cerebral palsy", "Cognitive neurology", "Developmental and pediatric neurology", "neuroimaging", "pediatrics", "Neonatology", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "Medical physics", "fa", "perinatal"], "article_id"=>926934, "categories"=>["Physics", "Medicine"], "users"=>["Peter J. Lally", "David L. Price", "Shreela S. Pauliah", "Alan Bainbridge", "Justin Kurien", "Neeraja Sivasamy", "Frances M. Cowan", "Guhan Balraj", "Manjula Ayer", "Kariyapilly Satheesan", "Sreejith Ceebi", "Angie Wade", "Ravi Swamy", "Shaji Padinjattel", "Betty Hutchon", "Madhava Vijayakumar", "Mohandas Nair", "Krishnakumar Padinharath", "Hui Zhang", "Ernest B. Cady", "Seetha Shankaran", "Sudhin Thayyil"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0087874.g003", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Whole_brain_white_matter_FA_according_to_perinatal_clinical_assessment_/926934", "title"=>"Whole-brain white matter FA according to perinatal clinical assessment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 03:16:55"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"49", "full-text"=>"52", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"30", "full-text"=>"25", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"63", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"24", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"32", "full-text"=>"35", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"32", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"22", "full-text"=>"55", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"29", "full-text"=>"53", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"38", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"47", "full-text"=>"86", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"41", "full-text"=>"67", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"28", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"24", "full-text"=>"31", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"29", "full-text"=>"26", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"28", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"10", "cited-by"=>"1", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"2", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Neuroscience", "average_usage"=>[289]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[266]}, {"subject_area"=>"/Medicine and health sciences/Critical care and emergency medicine", "average_usage"=>[245]}, {"subject_area"=>"/Medicine and health sciences/Neurology", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Radiology and imaging", "average_usage"=>[246]}]}
Loading … Spinner
There are currently no alerts