T Follicular Helper Cells and Regulatory B Cells Dynamics in Systemic Lupus Erythematosus
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{"title"=>"T follicular helper cells and regulatory B cells dynamics in systemic lupus erythematosus", "type"=>"journal", "authors"=>[{"first_name"=>"Xue", "last_name"=>"Yang", "scopus_author_id"=>"39863819100"}, {"first_name"=>"Ji", "last_name"=>"Yang", "scopus_author_id"=>"50562309700"}, {"first_name"=>"Yiwei", "last_name"=>"Chu", "scopus_author_id"=>"7403050757"}, {"first_name"=>"Yu", "last_name"=>"Xue", "scopus_author_id"=>"55440816900"}, {"first_name"=>"Dandan", "last_name"=>"Xuan", "scopus_author_id"=>"55856873400"}, {"first_name"=>"Shucong", "last_name"=>"Zheng", "scopus_author_id"=>"56411101700"}, {"first_name"=>"Hejian", "last_name"=>"Zou", "scopus_author_id"=>"22939805000"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84895800711", "sgr"=>"84895800711", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0088441", "pmid"=>"24551101", "isbn"=>"10.1371/journal.pone.0088441", "pui"=>"372557769"}, "id"=>"317ec437-6af4-3200-8b60-6f9bb3c75619", "abstract"=>"T follicular helper (Tfh) cells aid effector B cells, and augment autoimmunity, whereas the role of Tfh cells on regulatory B (Breg) cells in systemic lupus erythematosus (SLE) is not known. The aim of this study is to investigate the percentage of Breg cells in SLE, and the role of Tfh cells on Breg cells. First, we demonstrated the presence of Breg cells in SLE peripheral blood mononuclear cells and in involved skins. Both the percentage of circulating Breg cells and the ability to produce interleukin-10 (IL-10) were elevated in SLE patients. The percentage of Breg cells increased during SLE flares and decreased following disease remission. Second, Tfh cell expansion was not only related to autoantibody production but also correlated with the increased percentage of Breg cells. Third, in vitro studies revealed that Tfh cell-derived IL-21 could promote IL-10 production and Breg cell differentiation. In conclusions, these data imply that SLE flares may be linked to the expansion of Tfh cells and that Breg cells are increased in a regulatory feedback manner. Thus, SLE development may be associated with the complex regulation of Tfh cells and diverse B cell subsets.", "link"=>"http://www.mendeley.com/research/t-follicular-helper-cells-regulatory-b-cells-dynamics-systemic-lupus-erythematosus-2", "reader_count"=>42, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>12, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>3, "Other"=>3, "Student > Master"=>4, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>12, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>3, "Other"=>3, "Student > Master"=>4, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>17, "Neuroscience"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>6}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>17}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Japan"=>1, "Chile"=>2}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1387372", "https://ndownloader.figshare.com/files/1387373", "https://ndownloader.figshare.com/files/1387374", "https://ndownloader.figshare.com/files/1387375", "https://ndownloader.figshare.com/files/1387376"], "description"=>"<div><p>T follicular helper (Tfh) cells aid effector B cells, and augment autoimmunity, whereas the role of Tfh cells on regulatory B (Breg) cells in systemic lupus erythematosus (SLE) is not known. The aim of this study is to investigate the percentage of Breg cells in SLE, and the role of Tfh cells on Breg cells. First, we demonstrated the presence of Breg cells in SLE peripheral blood mononuclear cells and in involved skins. Both the percentage of circulating Breg cells and the ability to produce interleukin-10 (IL-10) were elevated in SLE patients. The percentage of Breg cells increased during SLE flares and decreased following disease remission. Second, Tfh cell expansion was not only related to autoantibody production but also correlated with the increased percentage of Breg cells. Third, in vitro studies revealed that Tfh cell-derived IL-21 could promote IL-10 production and Breg cell differentiation. In conclusions, these data imply that SLE flares may be linked to the expansion of Tfh cells and that Breg cells are increased in a regulatory feedback manner. Thus, SLE development may be associated with the complex regulation of Tfh cells and diverse B cell subsets.</p></div>", "links"=>[], "tags"=>["immunology", "autoimmunity", "Clinical immunology", "Autoimmune diseases", "lupus erythematosus", "Immune cells", "b cells", "t cells", "dermatology", "Connective tissue diseases", "rheumatology", "Systemic lupus erythematosus", "follicular", "helper", "cells", "systemic", "lupus"], "article_id"=>935742, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xue Yang", "Ji Yang", "Yiwei Chu", "Yu Xue", "Dandan Xuan", "Shucong Zheng", "Hejian Zou"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0088441.s001", "https://dx.doi.org/10.1371/journal.pone.0088441.s002", "https://dx.doi.org/10.1371/journal.pone.0088441.s003", "https://dx.doi.org/10.1371/journal.pone.0088441.s004", "https://dx.doi.org/10.1371/journal.pone.0088441.s005"], "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T_Follicular_Helper_Cells_and_Regulatory_B_Cells_Dynamics_in_Systemic_Lupus_Erythematosus_/935742", "title"=>"T Follicular Helper Cells and Regulatory B Cells Dynamics in Systemic Lupus Erythematosus", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-02-14 02:54:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1387368"], "description"=>"<p>HCQ = hydroxychloroquine; Pred = prednisone; CTX = cyclophosphamide.</p>", "links"=>[], "tags"=>["immunology", "autoimmunity", "Clinical immunology", "Autoimmune diseases", "lupus erythematosus", "Immune cells", "b cells", "t cells", "dermatology", "Connective tissue diseases", "rheumatology", "Systemic lupus erythematosus"], "article_id"=>935738, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xue Yang", "Ji Yang", "Yiwei Chu", "Yu Xue", "Dandan Xuan", "Shucong Zheng", "Hejian Zou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088441.t001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_characteristics_/935738", "title"=>"Patient characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-14 02:54:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1387363"], "description"=>"<p>(A) Real-time RT-PCR analysis of IL-10 mRNA expression in PBMCs from patients with active SLE (n = 16), patients with inactive SLE (n = 14), and control subject (n = 15). (B) Serum levels of IL-10 were detected in patients with active SLE (n = 16), patients with inactive SLE (n = 14), and control subject (n = 15) by ELISA. (C) PBMCs were isolated and stimulated with LPS for 24 hours and PIB for the final 5 hours. CD19<sup>+</sup>IL-10<sup>+</sup> cells were detected by flow cytometry analysis in a CD19 gate (left). Results of flow cytometric analysis of CD19<sup>+</sup>IL-10<sup>+</sup> cells (right, n = 6 for each group). (D) Sorted CD19<sup>+</sup>CD5<sup>+</sup>CD1d<sup>high</sup> B cells from SLE patients and healthy controls were stimulated with LPS for 24 hours and PIB for the last 5 hours. IL-10 mRNA expression was detected by real-time RT-PCR. Results shown are representative of at least three independent experiments. (E) Sorted CD19<sup>+</sup>CD5<sup>+</sup>CD1d<sup>high</sup> B cells from SLE patients and healthy controls were stimulated with LPS for 24 hours and PI for the last 5 hours. IL-10 in supernatants was detected by ELISA. Results shown are representative of at least three independent experiments.</p>", "links"=>[], "tags"=>["immunology", "autoimmunity", "Clinical immunology", "Autoimmune diseases", "lupus erythematosus", "Immune cells", "b cells", "t cells", "dermatology", "Connective tissue diseases", "rheumatology", "Systemic lupus erythematosus", "breg", "cells", "sle"], "article_id"=>935733, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xue Yang", "Ji Yang", "Yiwei Chu", "Yu Xue", "Dandan Xuan", "Shucong Zheng", "Hejian Zou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088441.g003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_IL_10_production_in_Breg_cells_of_SLE_patients_/935733", "title"=>"IL-10 production in Breg cells of SLE patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-14 02:54:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1387358"], "description"=>"<p>(A) Human PBMCs were labeled with lymphocyte-specific antibodies (CD19, CD5, and CD1d). The percentage of CD5<sup>+</sup>CD1d<sup>high</sup> cells among a CD19 gate was determined by flow cytometry. (B) Results of flow cytometric analysis of Breg cells in patients with active SLE (n = 16), patients with inactive SLE (n = 14), and control subject (n = 15). (C) A positive correlation between the proportion of CD5<sup>+</sup>CD1d<sup>high</sup> cells among CD19<sup>+</sup> B cells and the clinical severity of the flare as scored using the SLEDAI (n = 30) was observed.</p>", "links"=>[], "tags"=>["immunology", "autoimmunity", "Clinical immunology", "Autoimmune diseases", "lupus erythematosus", "Immune cells", "b cells", "t cells", "dermatology", "Connective tissue diseases", "rheumatology", "Systemic lupus erythematosus", "circulating", "breg", "cells", "sle"], "article_id"=>935728, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xue Yang", "Ji Yang", "Yiwei Chu", "Yu Xue", "Dandan Xuan", "Shucong Zheng", "Hejian Zou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088441.g001", "stats"=>{"downloads"=>2, "page_views"=>81, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expansion_of_circulating_Breg_cells_in_SLE_patients_/935728", "title"=>"Expansion of circulating Breg cells in SLE patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-14 02:54:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1387365"], "description"=>"<p>(A) Human PBMCs were labeled with lymphocyte-specific antibodies (CD4, CXCR5 and PD-1). The percentage of CXCR5<sup>+</sup>PD-1<sup>+</sup> cells among CD4<sup>+</sup> T cells was analyzed by flow cytometry (left). Results of flow cytometric analysis of Tfh cells (right) in patients with active SLE (n = 16), patients with inactive SLE (n = 14), and control subject (n = 15). (B) A positive correlation between the proportion of CXCR5<sup>+</sup>PD-1<sup>+</sup> cells among CD4<sup>+</sup> T cells and the clinical severity of the flare as scored using the SLEDAI (n = 30) was noted. (C) A positive correlation between the proportion of CD4<sup>+</sup>CXCR5<sup>+</sup>PD-1<sup>+</sup> T cells and CD19<sup>+</sup>CD5<sup>+</sup>CD1d<sup>high</sup> B cells in PBMCs from SLE patients (n = 30) was observed. (D) Serum IL-21 levels were detected in patients with active SLE (n = 16), patients with inactive SLE (n = 14), and control subject (n = 15) by ELISA. (E) A positive correlation between serum IL-10 levels and IL-21 levels in SLE patients (n = 30) was observed.</p>", "links"=>[], "tags"=>["immunology", "autoimmunity", "Clinical immunology", "Autoimmune diseases", "lupus erythematosus", "Immune cells", "b cells", "t cells", "dermatology", "Connective tissue diseases", "rheumatology", "Systemic lupus erythematosus", "cells", "breg", "sle"], "article_id"=>935735, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xue Yang", "Ji Yang", "Yiwei Chu", "Yu Xue", "Dandan Xuan", "Shucong Zheng", "Hejian Zou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088441.g004", "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tfh_cells_are_associated_with_expansion_of_Breg_cells_in_SLE_patients_/935735", "title"=>"Tfh cells are associated with expansion of Breg cells in SLE patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-14 02:54:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1387366"], "description"=>"<p>(A) Sorted B cells (CD43 depletion) from healthy controls were cultured in the presence of LPS and the indicated concentrations of IL-21 for 48 hours followed by stimulation with PI for the final 5 hours (Control: LPS+PIB). IL-10 in supernatants was detected by ELISA. Results shown are representative of at least three independent experiments. (B) Sorted B cells (CD43 depletion) from healthy controls were cultured in the presence of LPS with or without 40 ng/ml IL-21 for 48 hours followed by stimulation with PIB for the last 5 hours (Control: LPS+PIB). IL-10<sup>+</sup> cells were analyzed in a CD19 gate by flow cytometry. Results shown are representative of at least three independent experiments. (C) Sorted CD4<sup>+</sup>CXCR5<sup>+</sup>PD-1<sup>+</sup> T cells were cultured with anti-CD3 and anti-CD28 for 48 hours, IL-21 was detected in the supernatants by ELISA. Results shown are representative of at least three independent experiments (C: healthy controls; S: SLE patients). (D) Sorted B cells (CD43 depletion) were stimulated for 48 hours with LPS plus supernatants from cultures of Tfh cells of SLE patients with or without neutralization of IL-21. The cells were also stimulated with PI for the last 5 hours. Levels of IL-10 in the supernatants were determined by ELISA (Control: LPS+PI; Tfh (S): LPS+supernatants from Tfh cells of SLE patients+PI; Tfh (C): LPS+supernatants from Tfh cells of healthy controls+PI). Results shown are representative of at least three independent experiments. (E) Sorted B cells (CD43 depletion) were cultured for 48 hours in the presence of LPS plus supernatants from Tfh cells of SLE patients. These cells were cultured with or without neutralization of IL-21 and were stimulated with PIB for the last 5 hours (Control: LPS+PIB; Tfh (S): LPS+supernatants from Tfh cells of SLE patients+PIB). IL-10<sup>+</sup> cells were analyzed by flow cytometry with a CD19 gate. Results shown are representative of at least three independent experiments.</p>", "links"=>[], "tags"=>["immunology", "autoimmunity", "Clinical immunology", "Autoimmune diseases", "lupus erythematosus", "Immune cells", "b cells", "t cells", "dermatology", "Connective tissue diseases", "rheumatology", "Systemic lupus erythematosus", "cell-derived", "il-21", "il-10", "differentiation", "breg"], "article_id"=>935736, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xue Yang", "Ji Yang", "Yiwei Chu", "Yu Xue", "Dandan Xuan", "Shucong Zheng", "Hejian Zou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088441.g005", "stats"=>{"downloads"=>4, "page_views"=>163, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tfh_cell_derived_IL_21_promotes_IL_10_production_during_the_differentiation_of_Breg_cells_/935736", "title"=>"Tfh cell-derived IL-21 promotes IL-10 production during the differentiation of Breg cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-14 02:54:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1387361"], "description"=>"<p>(A) Consecutive levels obtained by serially section showed typical pathological changes of lupus (upper panel), lymphocytes infiltration confirmed by CD20 (middle panel) and IL-10 (lower panel) immunohistochemical staining (× 100 magnification). Further magnification of the black-bordered box shows typical IL-10<sup>+</sup> lymphocytes (×400 magnification). (B) The counts of IL-10<sup>+</sup> lymphocytes in skins were showed in right (SLE patients n = 10, healthy controls n = 4).</p>", "links"=>[], "tags"=>["immunology", "autoimmunity", "Clinical immunology", "Autoimmune diseases", "lupus erythematosus", "Immune cells", "b cells", "t cells", "dermatology", "Connective tissue diseases", "rheumatology", "Systemic lupus erythematosus", "cells", "sle"], "article_id"=>935731, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xue Yang", "Ji Yang", "Yiwei Chu", "Yu Xue", "Dandan Xuan", "Shucong Zheng", "Hejian Zou"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088441.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Infiltration_of_IL_10_B_cells_in_involved_skin_of_SLE_patients_/935731", "title"=>"Infiltration of IL-10<sup>+</sup> B cells in involved skin of SLE patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-14 02:54:41"}

PMC Usage Stats | Further Information

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Relative Metric

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