Androgen Receptor Status Is a Prognostic Marker in Non-Basal Triple Negative Breast Cancers and Determines Novel Therapeutic Options
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{"title"=>"Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options", "type"=>"journal", "authors"=>[{"first_name"=>"Pierluigi", "last_name"=>"Gasparini", "scopus_author_id"=>"25924283200"}, {"first_name"=>"Matteo", "last_name"=>"Fassan", "scopus_author_id"=>"20733941800"}, {"first_name"=>"Luciano", "last_name"=>"Cascione", "scopus_author_id"=>"54580781600"}, {"first_name"=>"Gulnur", "last_name"=>"Guler", "scopus_author_id"=>"7003406862"}, {"first_name"=>"Serdar", "last_name"=>"Balci", "scopus_author_id"=>"55040148100"}, {"first_name"=>"Cigdem", "last_name"=>"Irkkan", "scopus_author_id"=>"6508085884"}, {"first_name"=>"Carolyn", "last_name"=>"Paisie", "scopus_author_id"=>"15835745000"}, {"first_name"=>"Francesca", "last_name"=>"Lovat", "scopus_author_id"=>"55198487700"}, {"first_name"=>"Carl", "last_name"=>"Morrison", "scopus_author_id"=>"7201898006"}, {"first_name"=>"Jianying", "last_name"=>"Zhang", "scopus_author_id"=>"55547086200"}, {"first_name"=>"Aldo", "last_name"=>"Scarpa", "scopus_author_id"=>"7102664619"}, {"first_name"=>"Carlo M.", "last_name"=>"Croce", "scopus_author_id"=>"7202975031"}, {"first_name"=>"Charles L.", "last_name"=>"Shapiro", "scopus_author_id"=>"7102469628"}, {"first_name"=>"Kay", "last_name"=>"Huebner", "scopus_author_id"=>"7101976858"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84895525356", "sgr"=>"84895525356", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0088525", "pmid"=>"24505496", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "pui"=>"372535096"}, "id"=>"26d16c5f-fa5d-3e06-acf7-fa7f748f8c20", "abstract"=>"Triple negative breast cancers are a heterogeneous group of tumors characterized by poor patient survival and lack of targeted therapeutics. Androgen receptor has been associated with triple negative breast cancer pathogenesis, but its role in the different subtypes has not been clearly defined. We examined androgen receptor protein expression by immunohistochemical analysis in 678 breast cancers, including 396 triple negative cancers. Fifty matched lymph node metastases were also examined. Association of expression status with clinical (race, survival) and pathological (basal, non-basal subtype, stage, grade) features was also evaluated. In 160 triple negative breast cancers, mRNA microarray expression profiling was performed, and differences according to androgen receptor status were analyzed. In triple negative cancers the percentage of androgen receptor positive cases was lower (24.8% vs 81.6% of non-triple negative cases), especially in African American women (16.7% vs 25.5% of cancers of white women). No significant difference in androgen receptor expression was observed in primary tumors vs matched metastatic lesions. Positive androgen receptor immunoreactivity was inversely correlated with tumor grade (p<0.01) and associated with better overall patient survival (p = 0.032) in the non-basal triple negative cancer group. In the microarray study, expression of three genes (HER4, TNFSF10, CDK6) showed significant deregulation in association with androgen receptor status; eg CDK6, a novel therapeutic target in triple negative cancers, showed significantly higher expression level in androgen receptor negative cases (p<0.01). These findings confirm the prognostic impact of androgen receptor expression in non-basal triple negative breast cancers, and suggest targeting of new androgen receptor-related molecular pathways in patients with these cancers.", "link"=>"http://www.mendeley.com/research/androgen-receptor-status-prognostic-marker-nonbasal-triple-negative-breast-cancers-determines-novel-1", "reader_count"=>39, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>7, "Researcher"=>11, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>7, "Researcher"=>11, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>4, "Medicine and Dentistry"=>16, "Agricultural and Biological Sciences"=>12, "Pharmacology, Toxicology and Pharmaceutical Science"=>4}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>12}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>4}}, "reader_count_by_country"=>{"United States"=>1, "Mexico"=>1, "Italy"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1378102"], "description"=>"<p>Differentially expressed genes in TNBCs according to AR status.</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Nuclear receptor signaling", "Clinical immunology", "Diagnostic medicine", "pathology", "epidemiology", "Cancer epidemiology", "Obstetrics and gynecology", "breast cancer", "oncology", "Cancers and neoplasms", "Breast tumors", "Cancer detection and diagnosis", "Cancer risk factors", "genes", "tnbcs", "ar"], "article_id"=>927712, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pierluigi Gasparini", "Matteo Fassan", "Luciano Cascione", "Gulnur Guler", "Serdar Balci", "Cigdem Irkkan", "Carolyn Paisie", "Francesca Lovat", "Carl Morrison", "Jianying Zhang", "Aldo Scarpa", "Carlo M. Croce", "Charles L. Shapiro", "Kay Huebner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088525.t003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differentially_expressed_genes_in_TNBCs_according_to_AR_status_/927712", "title"=>"Differentially expressed genes in TNBCs according to AR status.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-05 04:02:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378097"], "description"=>"<p>AR expression distribution according to tumor stage and grade (<b>A</b>). AR was lower in high grade tumors in both the whole series and in the TNBC subgroup (<i>p</i><0.01 both), but was consistently distributed among the different tumor stages. Black  =  AR positive cases, gray  =  AR negative cases. (<b>B</b>) AR mRNA expression is down-regulated in TNBC primary tumors and lymph node metastases. (<b>C</b>) Representative images of AR immunostaining in two matched primary tumors and lymph node metastases. Case #172 showed a positive primary neoplasm and a negative metastatic lesion. Case #284 is AR negative in both neoplastic lesions. (Original magnification, 200×)</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Nuclear receptor signaling", "Clinical immunology", "Diagnostic medicine", "pathology", "epidemiology", "Cancer epidemiology", "Obstetrics and gynecology", "breast cancer", "oncology", "Cancers and neoplasms", "Breast tumors", "Cancer detection and diagnosis", "Cancer risk factors", "receptor"], "article_id"=>927707, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pierluigi Gasparini", "Matteo Fassan", "Luciano Cascione", "Gulnur Guler", "Serdar Balci", "Cigdem Irkkan", "Carolyn Paisie", "Francesca Lovat", "Carl Morrison", "Jianying Zhang", "Aldo Scarpa", "Carlo M. Croce", "Charles L. Shapiro", "Kay Huebner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088525.g004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Androgen_receptor_status_is_associated_with_tumor_grade_and_is_consistent_among_primary_and_secondary_lesions_/927707", "title"=>"Androgen receptor status is associated with tumor grade and is consistent among primary and secondary lesions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:02:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378091"], "description"=>"<p>* All the 54 lymph node metastases were analyzed by Nanostring mRNA array.</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Nuclear receptor signaling", "Clinical immunology", "Diagnostic medicine", "pathology", "epidemiology", "Cancer epidemiology", "Obstetrics and gynecology", "breast cancer", "oncology", "Cancers and neoplasms", "Breast tumors", "Cancer detection and diagnosis", "Cancer risk factors", "cohorts", "examined", "molecular"], "article_id"=>927701, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pierluigi Gasparini", "Matteo Fassan", "Luciano Cascione", "Gulnur Guler", "Serdar Balci", "Cigdem Irkkan", "Carolyn Paisie", "Francesca Lovat", "Carl Morrison", "Jianying Zhang", "Aldo Scarpa", "Carlo M. Croce", "Charles L. Shapiro", "Kay Huebner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088525.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overview_of_the_cohorts_examined_and_molecular_tests_applied_/927701", "title"=>"Overview of the cohorts examined and molecular tests applied.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:02:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378099"], "description"=>"<p>mRNA expression profiling of 160 TNBC cases was dichotomized according to their AR immunohistochemical status (AR negative <i>vs</i> AR positive). As expected, AR mRNA was significantly up-regulated in AR-positive cases (logFC 2.33; p<0.01; <b>A</b>). Among the deregulated mRNAs, CDK6 showed significantly higher expression in AR-negative cases (logFC -1.16; p<0.01; <b>B</b>).</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Nuclear receptor signaling", "Clinical immunology", "Diagnostic medicine", "pathology", "epidemiology", "Cancer epidemiology", "Obstetrics and gynecology", "breast cancer", "oncology", "Cancers and neoplasms", "Breast tumors", "Cancer detection and diagnosis", "Cancer risk factors", "receptor", "defines", "therapeutic"], "article_id"=>927709, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pierluigi Gasparini", "Matteo Fassan", "Luciano Cascione", "Gulnur Guler", "Serdar Balci", "Cigdem Irkkan", "Carolyn Paisie", "Francesca Lovat", "Carl Morrison", "Jianying Zhang", "Aldo Scarpa", "Carlo M. Croce", "Charles L. Shapiro", "Kay Huebner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088525.g006", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Androgen_receptor_expression_status_defines_novel_potential_therapeutic_targets_/927709", "title"=>"Androgen receptor expression status defines novel potential therapeutic targets.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:02:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378098"], "description"=>"<p>Correlation between AR expression status and overall survival in TNBCs (<i>n</i> = 153; <i>p</i> = 0.032) (<b>A</b>), Core Basal TNBCs (<i>n</i> = 84; <i>p</i> = ns) (<b>B</b>), and 5NP TNBCs (<i>n</i> = 69; <i>p</i> = 0.026) (<b>C</b>) patients.</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Nuclear receptor signaling", "Clinical immunology", "Diagnostic medicine", "pathology", "epidemiology", "Cancer epidemiology", "Obstetrics and gynecology", "breast cancer", "oncology", "Cancers and neoplasms", "Breast tumors", "Cancer detection and diagnosis", "Cancer risk factors", "receptor", "correlates", "prognosis", "5np"], "article_id"=>927708, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pierluigi Gasparini", "Matteo Fassan", "Luciano Cascione", "Gulnur Guler", "Serdar Balci", "Cigdem Irkkan", "Carolyn Paisie", "Francesca Lovat", "Carl Morrison", "Jianying Zhang", "Aldo Scarpa", "Carlo M. Croce", "Charles L. Shapiro", "Kay Huebner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088525.g005", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Androgen_receptor_status_correlates_with_better_prognosis_in_5NP_TNBCs_/927708", "title"=>"Androgen receptor status correlates with better prognosis in 5NP TNBCs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:02:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378095"], "description"=>"<p>AR expression distribution in the considered cancers. (<b>A</b>) Nuclear AR staining was significantly lower in TNBC specimens than in HER2-positive and ER/PR-positive tissues (p < 0.001). The trend toward expression differences among different ethnicities was not significant. Among TNBCs, 5NP cancers showed a higher frequency of AR expression (<i>p</i> = ns). Numbers represent TMA cores available for the analysis. Black  =  AR positive cases, gray  =  AR negative cases. (<b>B</b>) Representative images of AR immunostaining in the three cancer subtypes (HER2-positive, ER/PR-positive, and TNBC). (Original magnification, 200×)</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Nuclear receptor signaling", "Clinical immunology", "Diagnostic medicine", "pathology", "epidemiology", "Cancer epidemiology", "Obstetrics and gynecology", "breast cancer", "oncology", "Cancers and neoplasms", "Breast tumors", "Cancer detection and diagnosis", "Cancer risk factors", "receptor", "tnbc"], "article_id"=>927705, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pierluigi Gasparini", "Matteo Fassan", "Luciano Cascione", "Gulnur Guler", "Serdar Balci", "Cigdem Irkkan", "Carolyn Paisie", "Francesca Lovat", "Carl Morrison", "Jianying Zhang", "Aldo Scarpa", "Carlo M. Croce", "Charles L. Shapiro", "Kay Huebner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088525.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Androgen_receptor_expression_is_low_in_TNBC_cases_/927705", "title"=>"Androgen receptor expression is low in TNBC cases.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:02:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378092"], "description"=>"<p>Expression microarray results of the TCGA consortium data set was analyzed, and statistical significance was calculated using the Oncomine website (<a href=\"http://www.oncomine.org\" target=\"_blank\">www.oncomine.org</a>). Box plots show differences in mRNA expression between the different classes according to TNBC (<b>A</b>), HER2 (<b>B</b>), ER (<b>C</b>), and PR (<b>D</b>) status. Data are presented as box plot distribution (Line within the boxes =  median value).</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Nuclear receptor signaling", "Clinical immunology", "Diagnostic medicine", "pathology", "epidemiology", "Cancer epidemiology", "Obstetrics and gynecology", "breast cancer", "oncology", "Cancers and neoplasms", "Breast tumors", "Cancer detection and diagnosis", "Cancer risk factors", "receptor", "mrna", "down-regulated", "tnbc"], "article_id"=>927702, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pierluigi Gasparini", "Matteo Fassan", "Luciano Cascione", "Gulnur Guler", "Serdar Balci", "Cigdem Irkkan", "Carolyn Paisie", "Francesca Lovat", "Carl Morrison", "Jianying Zhang", "Aldo Scarpa", "Carlo M. Croce", "Charles L. Shapiro", "Kay Huebner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088525.g002", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Androgen_receptor_mRNA_expression_is_down_regulated_in_TNBC_cases_/927702", "title"=>"Androgen receptor mRNA expression is down-regulated in TNBC cases.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-05 04:02:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378103"], "description"=>"<p>Clinico-pathological features of the considered series.</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Nuclear receptor signaling", "Clinical immunology", "Diagnostic medicine", "pathology", "epidemiology", "Cancer epidemiology", "Obstetrics and gynecology", "breast cancer", "oncology", "Cancers and neoplasms", "Breast tumors", "Cancer detection and diagnosis", "Cancer risk factors", "considered"], "article_id"=>927713, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pierluigi Gasparini", "Matteo Fassan", "Luciano Cascione", "Gulnur Guler", "Serdar Balci", "Cigdem Irkkan", "Carolyn Paisie", "Francesca Lovat", "Carl Morrison", "Jianying Zhang", "Aldo Scarpa", "Carlo M. Croce", "Charles L. Shapiro", "Kay Huebner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088525.t001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinico_pathological_features_of_the_considered_series_/927713", "title"=>"Clinico-pathological features of the considered series.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-05 04:02:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1378101"], "description"=>"<p>Immunohistochemical profiles of the considered series.</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Nuclear receptor signaling", "Clinical immunology", "Diagnostic medicine", "pathology", "epidemiology", "Cancer epidemiology", "Obstetrics and gynecology", "breast cancer", "oncology", "Cancers and neoplasms", "Breast tumors", "Cancer detection and diagnosis", "Cancer risk factors", "profiles", "considered"], "article_id"=>927711, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pierluigi Gasparini", "Matteo Fassan", "Luciano Cascione", "Gulnur Guler", "Serdar Balci", "Cigdem Irkkan", "Carolyn Paisie", "Francesca Lovat", "Carl Morrison", "Jianying Zhang", "Aldo Scarpa", "Carlo M. Croce", "Charles L. Shapiro", "Kay Huebner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088525.t002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemical_profiles_of_the_considered_series_/927711", "title"=>"Immunohistochemical profiles of the considered series.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-05 04:02:09"}

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Relative Metric

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