Dynamic Association of Mortality Hazard with Body Shape
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{"title"=>"Dynamic association of mortality hazard with body shape", "type"=>"journal", "authors"=>[{"first_name"=>"Nir Y.", "last_name"=>"Krakauer", "scopus_author_id"=>"6506316395"}, {"first_name"=>"Jesse C.", "last_name"=>"Krakauer", "scopus_author_id"=>"7003596904"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24586394", "doi"=>"10.1371/journal.pone.0088793", "sgr"=>"84896796217", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-84896796217", "issn"=>"19326203", "pui"=>"372579898"}, "id"=>"c0e06c4a-7880-304f-8306-5d505d2623a6", "abstract"=>"BACKGROUND A Body Shape Index (ABSI) had been derived from a study of the United States National Health and Nutrition Examination Survey (NHANES) 1999-2004 mortality data to quantify the risk associated with abdominal obesity (as indicated by a wide waist relative to height and body mass index). A national survey with longer follow-up, the British Health and Lifestyle Survey (HALS), provides another opportunity to assess the predictive power for mortality of ABSI. HALS also includes repeat observations, allowing estimation of the implications of changes in ABSI. METHODS AND FINDINGS We evaluate ABSI z score relative to population normals as a predictor of all-cause mortality over 24 years of follow-up to HALS. We found that ABSI is a strong indicator of mortality hazard in this population, with death rates increasing by a factor of 1.13 (95% confidence interval, 1.09-1.16) per standard deviation increase in ABSI and a hazard ratio of 1.61 (1.40-1.86) for those with ABSI in the top 20% of the population compared to those with ABSI in the bottom 20%. Using the NHANES normals to compute ABSI z scores gave similar results to using z scores derived specifically from the HALS sample. ABSI outperformed as a predictor of mortality hazard other measures of abdominal obesity such as waist circumference, waist to height ratio, and waist to hip ratio. Moreover, it was a consistent predictor of mortality hazard over at least 20 years of follow-up. Change in ABSI between two HALS examinations 7 years apart also predicted mortality hazard: individuals with a given initial ABSI who had rising ABSI were at greater risk than those with falling ABSI. CONCLUSIONS ABSI is a readily computed dynamic indicator of health whose correlation with lifestyle and with other risk factors and health outcomes warrants further investigation.", "link"=>"http://www.mendeley.com/research/dynamic-association-mortality-hazard-body-shape", "reader_count"=>32, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>4, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>1, "Librarian"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>4, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>1, "Librarian"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>9, "Neuroscience"=>1, "Sports and Recreations"=>3, "Chemistry"=>1, "Social Sciences"=>2, "Computer Science"=>1, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>3}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>1, "Germany"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1394137"], "description"=>"<p>Comparison of mean values in HALS1 and in NHANES 1999–2004 nonpregnant adults. ABSI z scores are based on the NHANES 1999–2004 population normals.</p>", "links"=>[], "tags"=>["algorithms", "Applied mathematics", "epidemiology", "Lifecourse epidemiology", "Global health", "Non-clinical medicine", "Health care policy", "Health risk analysis", "Socioeconomic aspects of health", "nutrition", "obesity", "Public health", "Behavioral and social aspects of health", "Health screening", "nhanes", "means"], "article_id"=>940955, "categories"=>["Mathematics", "Medicine"], "users"=>["Nir Y. Krakauer", "Jesse C. Krakauer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088793.t001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HALS_and_NHANES_means_of_body_measures_/940955", "title"=>"HALS and NHANES means of body measures.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-20 04:33:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394136"], "description"=>"<p>Results of Cox proportional hazard modeling for mortality risk with ABSI1 or ABSI2 (ABSI from HALS1 or HALS2 measurements, respectively) or ΔABSI (ABSI2 minus ABSI1), or combinations thereof, taken as linear predictors. Ranges in parentheses are 95% confidence intervals. Only the subsample with measurements in both HALS1 and HALS2 is used (; 1094 deaths).</p><p>SD = standard deviation.</p>", "links"=>[], "tags"=>["algorithms", "Applied mathematics", "epidemiology", "Lifecourse epidemiology", "Global health", "Non-clinical medicine", "Health care policy", "Health risk analysis", "Socioeconomic aspects of health", "nutrition", "obesity", "Public health", "Behavioral and social aspects of health", "Health screening", "absi", "hals1"], "article_id"=>940954, "categories"=>["Mathematics", "Medicine"], "users"=>["Nir Y. Krakauer", "Jesse C. Krakauer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088793.t006", "stats"=>{"downloads"=>5, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mortality_hazard_association_with_ABSI_from_HALS1_and_HALS2_/940954", "title"=>"Mortality hazard association with ABSI from HALS1 and HALS2.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-20 04:33:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394131"], "description"=>"<p>For each sample, the 1st through the 99th percentiles are plotted.</p>", "links"=>[], "tags"=>["algorithms", "Applied mathematics", "epidemiology", "Lifecourse epidemiology", "Global health", "Non-clinical medicine", "Health care policy", "Health risk analysis", "Socioeconomic aspects of health", "nutrition", "obesity", "Public health", "Behavioral and social aspects of health", "Health screening", "absi", "nhanes", "compared", "hals1", "seen"], "article_id"=>940949, "categories"=>["Mathematics", "Medicine"], "users"=>["Nir Y. Krakauer", "Jesse C. Krakauer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088793.g001", "stats"=>{"downloads"=>2, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cumulative_distribution_function_for_ABSI_z_score_calculated_using_NHANES_normals_in_the_NHANES_1999_8211_2004_compared_to_the_HALS1_samples_showing_the_mostly_lower_values_of_ABSI_seen_in_HALS_/940949", "title"=>"Cumulative distribution function for ABSI z score (calculated using NHANES normals) in the NHANES 1999–2004 compared to the HALS1 samples, showing the mostly lower values of ABSI seen in HALS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-20 04:33:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394139"], "description"=>"<p>Results of Cox proportional hazard modeling for mortality risk with ABSI, BMI, WC, or WHtR z scores at HALS1 taken as linear predictors. Ranges in parentheses are 95% confidence intervals.</p><p>SD = standard deviation; Δ<i><sub>i</sub></i>  = Akaike information criterion score difference relative to the best performing model shown (see Methods for details); <i>R</i><sup>2</sup> = coefficient of determination; ABSI(N) and ABSI(H) refer to ABSI z scores calculated using NHANES or HALS normals, respectively.</p>", "links"=>[], "tags"=>["algorithms", "Applied mathematics", "epidemiology", "Lifecourse epidemiology", "Global health", "Non-clinical medicine", "Health care policy", "Health risk analysis", "Socioeconomic aspects of health", "nutrition", "obesity", "Public health", "Behavioral and social aspects of health", "Health screening", "hals1"], "article_id"=>940957, "categories"=>["Mathematics", "Medicine"], "users"=>["Nir Y. Krakauer", "Jesse C. Krakauer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088793.t002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mortality_hazard_association_with_HALS1_body_size_and_shape_/940957", "title"=>"Mortality hazard association with HALS1 body size and shape.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-20 04:33:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394138"], "description"=>"<p>Cox proportional hazard modeling for mortality risk with ABSI, BMI, WC, or WHtR z score quintiles at HALS1 taken as the predictors. Hazard ratios are relative to the middle quintile in each case. Ranges in parentheses are 95% confidence intervals.</p><p>ABSI(N) and ABSI(H) refer to ABSI z scores calculated using NHANES or HALS normals, respectively.</p><p>The between-quintile cut points are for ABSI (N); for ABSI (H); for BMI; for WC; and for WHtR.</p>", "links"=>[], "tags"=>["algorithms", "Applied mathematics", "epidemiology", "Lifecourse epidemiology", "Global health", "Non-clinical medicine", "Health care policy", "Health risk analysis", "Socioeconomic aspects of health", "nutrition", "obesity", "Public health", "Behavioral and social aspects of health", "Health screening"], "article_id"=>940956, "categories"=>["Mathematics", "Medicine"], "users"=>["Nir Y. Krakauer", "Jesse C. Krakauer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088793.t003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mortality_by_quintile_/940956", "title"=>"Mortality by quintile.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-20 04:33:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394135"], "description"=>"<p>Results of Cox proportional hazard modeling for mortality risk at different lead times with ABSI (N) at HALS1 taken as a linear predictor. Ranges in parentheses are 95% confidence intervals.</p><p>SD = standard deviation.</p>", "links"=>[], "tags"=>["algorithms", "Applied mathematics", "epidemiology", "Lifecourse epidemiology", "Global health", "Non-clinical medicine", "Health care policy", "Health risk analysis", "Socioeconomic aspects of health", "nutrition", "obesity", "Public health", "Behavioral and social aspects of health", "Health screening", "hals1", "absi"], "article_id"=>940953, "categories"=>["Mathematics", "Medicine"], "users"=>["Nir Y. Krakauer", "Jesse C. Krakauer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088793.t007", "stats"=>{"downloads"=>1, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mortality_hazard_association_with_HALS1_ABSI_z_score_/940953", "title"=>"Mortality hazard association with HALS1 ABSI z score.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-20 04:33:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394133"], "description"=>"<p>Mean and standard deviation (SD) of changes in z scores between HALS1 and HALS2. All z scores are based on HALS1 population normals.</p>", "links"=>[], "tags"=>["algorithms", "Applied mathematics", "epidemiology", "Lifecourse epidemiology", "Global health", "Non-clinical medicine", "Health care policy", "Health risk analysis", "Socioeconomic aspects of health", "nutrition", "obesity", "Public health", "Behavioral and social aspects of health", "Health screening", "hals1"], "article_id"=>940951, "categories"=>["Mathematics", "Medicine"], "users"=>["Nir Y. Krakauer", "Jesse C. Krakauer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088793.t005", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Anthropometry_changes_between_HALS1_and_HALS2_/940951", "title"=>"Anthropometry changes between HALS1 and HALS2.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-20 04:33:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394134"], "description"=>"<p>Results of Cox proportional hazard modeling for mortality risk with ABSI or WHR z scores, or both, taken as linear predictors. Ranges in parentheses are 95% confidence intervals. Only the subsample with hip measurements in HALS1 is used (; 1408 deaths).</p><p>SD = standard deviation; Δ<i><sub>i</sub></i>  = Akaike information criterion score difference relative to the best performing model shown (see Methods); <i>R</i><sup>2</sup> = coefficient of determination.</p>", "links"=>[], "tags"=>["algorithms", "Applied mathematics", "epidemiology", "Lifecourse epidemiology", "Global health", "Non-clinical medicine", "Health care policy", "Health risk analysis", "Socioeconomic aspects of health", "nutrition", "obesity", "Public health", "Behavioral and social aspects of health", "Health screening", "absi"], "article_id"=>940952, "categories"=>["Mathematics", "Medicine"], "users"=>["Nir Y. Krakauer", "Jesse C. Krakauer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088793.t004", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HALS1_mortality_hazard_association_with_ABSI_versus_waist_to_hip_ratio_/940952", "title"=>"HALS1 mortality hazard association with ABSI versus waist to hip ratio.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-20 04:33:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1394132"], "description"=>"<p>Estimates are from proportional hazard modeling where log mortality hazard is a smoothing-spline function in ABSI z score (calculated using NHANES normals). Curves are positioned so that an ABSI z score of 0 has a relative death rate of 1. Dashed curves show 95% confidence intervals. The ranges shown cover the 1st through 99th percentiles of ABSI in each sample. The vertical axis is logarithmic.</p>", "links"=>[], "tags"=>["algorithms", "Applied mathematics", "epidemiology", "Lifecourse epidemiology", "Global health", "Non-clinical medicine", "Health care policy", "Health risk analysis", "Socioeconomic aspects of health", "nutrition", "obesity", "Public health", "Behavioral and social aspects of health", "Health screening", "absi", "nhanes", "compared"], "article_id"=>940950, "categories"=>["Mathematics", "Medicine"], "users"=>["Nir Y. Krakauer", "Jesse C. Krakauer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088793.g002", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mortality_hazard_by_ABSI_for_NHANES_1999_8211_2004_compared_to_HALS1_/940950", "title"=>"Mortality hazard by ABSI for NHANES 1999–2004 compared to HALS1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-20 04:33:11"}

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Relative Metric

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