Identification of Borrelia Species after Creation of an In-House MALDI-TOF MS Database
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{"title"=>"Identification of Borrelia species after creation of an in-house MALDI-TOF MS database", "type"=>"journal", "authors"=>[{"first_name"=>"Adriana", "last_name"=>"Calderaro", "scopus_author_id"=>"7004897431"}, {"first_name"=>"Chiara", "last_name"=>"Gorrini", "scopus_author_id"=>"22234491800"}, {"first_name"=>"Giovanna", "last_name"=>"Piccolo", "scopus_author_id"=>"7006696102"}, {"first_name"=>"Sara", "last_name"=>"Montecchini", "scopus_author_id"=>"26639567200"}, {"first_name"=>"Mirko", "last_name"=>"Buttrini", "scopus_author_id"=>"39560921500"}, {"first_name"=>"Sabina", "last_name"=>"Rossi", "scopus_author_id"=>"35760574900"}, {"first_name"=>"Maddalena", "last_name"=>"Piergianni", "scopus_author_id"=>"55964675100"}, {"first_name"=>"Maria Cristina", "last_name"=>"Arcangeletti", "scopus_author_id"=>"6601990799"}, {"first_name"=>"Flora", "last_name"=>"De Conto", "scopus_author_id"=>"6603373980"}, {"first_name"=>"Carlo", "last_name"=>"Chezzi", "scopus_author_id"=>"7006491533"}, {"first_name"=>"Maria Cristina", "last_name"=>"Medici", "scopus_author_id"=>"35494757000"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84895740554", "pmid"=>"24533160", "sgr"=>"84895740554", "doi"=>"10.1371/journal.pone.0088895", "issn"=>"19326203", "pui"=>"372545360"}, "id"=>"dff0114c-dfb2-3657-888e-b80060c128a2", "abstract"=>"Lyme borreliosis (LB) is a multisystemic disease caused by Borrelia burgdorferi sensu lato ( sl ) complex transmitted to humans by Ixodes ticks. B . burgdorferi sl complex, currently comprising at least 19 genospecies, includes the main pathogenic species responsible for human disease in Europe: B . burgdorferi sensu stricto ( ss ), B . afzelii , and B . garinii . In this study, for the first time, MALDI-TOF MS was applied to Borrelia spp., supplementing the existing database, limited to the species B . burgdorferi ss , B . spielmanii and B . garinii , with the species B . afzelii , in order to enable the identification of all the species potentially implicated in LB in Europe. Moreover, we supplemented the database also with B . hermsii , which is the primary cause of tick-borne relapsing fever in western North America, B . japonica , circulating in Asia, and another reference strain of B . burgdorferi ss (B31 strain). The dendrogram obtained by analyzing the protein profiles of the different Borrelia species reflected Borrelia taxonomy, showing that all the species included in the Borrelia sl complex clustered in a unique branch, while Borrelia hermsii clustered separately. In conclusion, in this study MALDI-TOF MS proved a useful tool suitable for identification of Borrelia spp. both for diagnostic purpose and epidemiological surveillance.", "link"=>"http://www.mendeley.com/research/identification-borrelia-species-after-creation-inhouse-malditof-ms-database", "reader_count"=>23, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>5, "Other"=>4, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>5, "Other"=>4, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>6, "Design"=>1, "Philosophy"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1, "Russia"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1382626"], "description"=>"<div><p>Lyme borreliosis (LB) is a multisystemic disease caused by <i>Borrelia burgdorferi sensu lato</i> (<i>sl</i>) complex transmitted to humans by <i>Ixodes</i> ticks. <i>B</i>. <i>burgdorferi sl</i> complex, currently comprising at least 19 genospecies, includes the main pathogenic species responsible for human disease in Europe: <i>B</i>. <i>burgdorferi sensu stricto</i> (<i>ss</i>), <i>B</i>. <i>afzelii</i>, and <i>B</i>. <i>garinii</i>. In this study, for the first time, MALDI-TOF MS was applied to <i>Borrelia</i> spp., supplementing the existing database, limited to the species <i>B</i>. <i>burgdorferi ss</i>, <i>B</i><b>.</b><i>spielmanii</i> and <i>B</i>. <i>garinii</i>, with the species <i>B</i>. <i>afzelii</i>, in order to enable the identification of all the species potentially implicated in LB in Europe. Moreover, we supplemented the database also with <i>B</i>. <i>hermsii</i>, which is the primary cause of tick-borne relapsing fever in western North America, <i>B</i>. <i>japonica</i>, circulating in Asia, and another reference strain of <i>B</i>. <i>burgdorferi ss</i> (B31 strain). The dendrogram obtained by analyzing the protein profiles of the different <i>Borrelia</i> species reflected <i>Borrelia</i> taxonomy, showing that all the species included in the <i>Borrelia sl</i> complex clustered in a unique branch, while <i>Borrelia hermsii</i> clustered separately. In conclusion, in this study MALDI-TOF MS proved a useful tool suitable for identification of <i>Borrelia</i> spp. both for diagnostic purpose and epidemiological surveillance.</p></div>", "links"=>[], "tags"=>["Computational biology", "Sequence analysis", "proteomics", "sequencing", "dermatology", "Diagnostic medicine", "Clinical laboratory sciences", "epidemiology", "Infectious diseases", "Bacterial diseases", "Lyme disease", "Infectious disease control", "Infectious diseases of the nervous system", "Skin infections", "Vectors and hosts", "Zoonoses", "in-house", "maldi-tof", "ms"], "article_id"=>931552, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Adriana Calderaro", "Chiara Gorrini", "Giovanna Piccolo", "Sara Montecchini", "Mirko Buttrini", "Sabina Rossi", "Maddalena Piergianni", "Maria Cristina Arcangeletti", "Flora De Conto", "Carlo Chezzi", "Maria Cristina Medici"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088895", "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Identification_of_Borrelia_Species_after_Creation_of_an_In_House_MALDI_TOF_MS_Database/931552", "title"=>"Identification of <i>Borrelia</i> Species after Creation of an In-House MALDI-TOF MS Database", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-12 03:30:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1382623"], "description"=>"<p>(a): spectra obtained by MALDI-TOF MS analysis of the reference strains of four <i>Borrelia</i> spp. (<i>B</i>. <i>hermsii</i> HS1 in green, <i>B</i>. <i>japonica</i> F63B in yellow, <i>B</i>. <i>afzelii</i> 103469 in red, <i>B</i>. <i>burgdorferi ss</i> B31 in blue) and field isolates of both human (<i>B</i>. <i>burgdorferi ss</i> UCSC and <i>B</i>. <i>garinii</i> G1) and tick origin (<i>B. burgdorferi</i> ZS7 and <i>B. lusitaniae</i> MT 0407-M8), all in black. (b): three-dimensional plot of the spectra of the reference strains obtained by Principal Component Analysis (PCA) (dots of the same colour represent replicates of the same strain: <i>B</i>. <i>hermsii</i> HS1 in green, <i>B</i>. <i>japonica</i> F63B in yellow, <i>B</i>. <i>afzelii</i> 103469 in red, <i>B</i>. <i>burgdorferi ss</i> B31 in blue). (c): m/z window bins with the details of 2 among the 10 discriminating peaks within the 4 analyzed <i>Borrelia</i> reference strains (<i>B</i>. <i>hermsii</i> HS1 in green, <i>B</i>. <i>japonica</i> F63B in yellow, <i>B</i>. <i>afzelii</i> 103469 in red, <i>B</i>. <i>burgdorferi ss</i> B31 in blue).</p>", "links"=>[], "tags"=>["Computational biology", "Sequence analysis", "proteomics", "sequencing", "dermatology", "Diagnostic medicine", "Clinical laboratory sciences", "epidemiology", "Infectious diseases", "Bacterial diseases", "Lyme disease", "Infectious disease control", "Infectious diseases of the nervous system", "Skin infections", "Vectors and hosts", "Zoonoses", "ms", "strains", "isolates", "tick"], "article_id"=>931549, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Adriana Calderaro", "Chiara Gorrini", "Giovanna Piccolo", "Sara Montecchini", "Mirko Buttrini", "Sabina Rossi", "Maddalena Piergianni", "Maria Cristina Arcangeletti", "Flora De Conto", "Carlo Chezzi", "Maria Cristina Medici"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088895.g001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MALDI_TOF_MS_analysis_of_the_reference_strains_of_four_Borrelia_spp_and_field_isolates_of_both_human_and_tick_origin_/931549", "title"=>"MALDI-TOF MS analysis of the reference strains of four <i>Borrelia</i> spp. and field isolates of both human and tick origin.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-12 03:30:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1382624"], "description"=>"<p>“Main Spectra Profiles”- based dendrogram of the <i>Borrelia</i> spp. used in this study to supplement the database.</p>", "links"=>[], "tags"=>["Computational biology", "Sequence analysis", "proteomics", "sequencing", "dermatology", "Diagnostic medicine", "Clinical laboratory sciences", "epidemiology", "Infectious diseases", "Bacterial diseases", "Lyme disease", "Infectious disease control", "Infectious diseases of the nervous system", "Skin infections", "Vectors and hosts", "Zoonoses", "spectra", "dendrogram", "supplement"], "article_id"=>931550, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Adriana Calderaro", "Chiara Gorrini", "Giovanna Piccolo", "Sara Montecchini", "Mirko Buttrini", "Sabina Rossi", "Maddalena Piergianni", "Maria Cristina Arcangeletti", "Flora De Conto", "Carlo Chezzi", "Maria Cristina Medici"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088895.g002", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Main_Spectra_Profiles_based_dendrogram_of_the_Borrelia_spp_used_in_this_study_to_supplement_the_database_/931550", "title"=>"“Main Spectra Profiles”- based dendrogram of the <i>Borrelia</i> spp. used in this study to supplement the database.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-12 03:30:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1382625"], "description"=>"<p>Patterns of 10 differentiating peaks based on the statistical analysis by the ClinProTools software of the 4 <i>Borrelia</i> species analyzed.</p>", "links"=>[], "tags"=>["Computational biology", "Sequence analysis", "proteomics", "sequencing", "dermatology", "Diagnostic medicine", "Clinical laboratory sciences", "epidemiology", "Infectious diseases", "Bacterial diseases", "Lyme disease", "Infectious disease control", "Infectious diseases of the nervous system", "Skin infections", "Vectors and hosts", "Zoonoses", "10", "differentiating", "peaks", "clinprotools"], "article_id"=>931551, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Adriana Calderaro", "Chiara Gorrini", "Giovanna Piccolo", "Sara Montecchini", "Mirko Buttrini", "Sabina Rossi", "Maddalena Piergianni", "Maria Cristina Arcangeletti", "Flora De Conto", "Carlo Chezzi", "Maria Cristina Medici"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088895.t001", "stats"=>{"downloads"=>3, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patterns_of_10_differentiating_peaks_based_on_the_statistical_analysis_by_the_ClinProTools_software_of_the_4_Borrelia_species_analyzed_/931551", "title"=>"Patterns of 10 differentiating peaks based on the statistical analysis by the ClinProTools software of the 4 <i>Borrelia</i> species analyzed.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-12 03:30:35"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"43", "full-text"=>"34", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"23", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"12", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"26", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"7", "cited-by"=>"1", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Evolutionary biology", "average_usage"=>[333]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Diagnostic medicine", "average_usage"=>[257]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[287]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[271]}, {"subject_area"=>"/Physical sciences/Chemistry", "average_usage"=>[262]}]}
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