Administration of Reconstituted Polyphenol Oil Bodies Efficiently Suppresses Dendritic Cell Inflammatory Pathways and Acute Intestinal Inflammation
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Administration of reconstituted polyphenol oil bodies efficiently suppresses dendritic cell inflammatory pathways and acute intestinal inflammation", "type"=>"journal", "authors"=>[{"first_name"=>"Elisabetta", "last_name"=>"Cavalcanti", "scopus_author_id"=>"23984027500"}, {"first_name"=>"Elisa", "last_name"=>"Vadrucci", "scopus_author_id"=>"47561969100"}, {"first_name"=>"Francesca Romana", "last_name"=>"Delvecchio", "scopus_author_id"=>"56063086500"}, {"first_name"=>"Francesco", "last_name"=>"Addabbo", "scopus_author_id"=>"18233504300"}, {"first_name"=>"Simona", "last_name"=>"Bettini", "scopus_author_id"=>"35104420900"}, {"first_name"=>"Rachel", "last_name"=>"Liou", "scopus_author_id"=>"55441339900"}, {"first_name"=>"Vladia", "last_name"=>"Monsurrò", "scopus_author_id"=>"6603376401"}, {"first_name"=>"Alex Yee Chen", "last_name"=>"Huang", "scopus_author_id"=>"7402307277"}, {"first_name"=>"Theresa Torres", "last_name"=>"Pizarro", "scopus_author_id"=>"6701374821"}, {"first_name"=>"Angelo", "last_name"=>"Santino", "scopus_author_id"=>"6603105586"}, {"first_name"=>"Marcello", "last_name"=>"Chieppa", "scopus_author_id"=>"9639838400"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24558444", "doi"=>"10.1371/journal.pone.0088898", "sgr"=>"84895895474", "scopus"=>"2-s2.0-84895895474", "issn"=>"19326203", "pui"=>"372565713"}, "id"=>"1405f813-5fec-3969-8cea-b1a4494fa817", "abstract"=>"Polyphenols are natural compounds capable of interfering with the inflammatory pathways of several in vitro model systems. In this study, we developed a stable and effective strategy to administer polyphenols to treat in vivo models of acute intestinal inflammation. The in vitro suppressive properties of several polyphenols were first tested and compared for dendritic cells (DCs) production of inflammatory cytokines. A combination of the polyphenols, quercetin and piperine, were then encapsulated into reconstituted oil bodies (OBs) in order to increase their stability. Our results showed that administration of low dose reconstituted polyphenol OBs inhibited LPS-mediated inflammatory cytokine secretion, including IL-6, IL-23, and IL-12, while increasing IL-10 and IL-1Rα production. Mice treated with the polyphenol-containing reconstituted OBs (ROBs) were partially protected from dextran sodium sulfate (DSS)-induced colitis and associated weight loss, while mortality and inflammatory scores revealed an overall anti-inflammatory effect that was likely mediated by impaired DC immune responses. Our study indicates that the administration of reconstituted quercetin and piperine-containing OBs may represent an effective and potent anti-inflammatory strategy to treat acute intestinal inflammation.", "link"=>"http://www.mendeley.com/research/administration-reconstituted-polyphenol-oil-bodies-efficiently-suppresses-dendritic-cell-inflammator", "reader_count"=>22, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>4, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>5, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>4, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>5, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84895895474"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84895895474?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84895895474&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84895895474&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84895895474", "dc:identifier"=>"SCOPUS_ID:84895895474", "eid"=>"2-s2.0-84895895474", "dc:title"=>"Administration of reconstituted polyphenol oil bodies efficiently suppresses dendritic cell inflammatory pathways and acute intestinal inflammation", "dc:creator"=>"Cavalcanti E.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-02-18", "prism:coverDisplayDate"=>"18 February 2014", "prism:doi"=>"10.1371/journal.pone.0088898", "citedby-count"=>"30", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"IRCCS Saverio de Bellis", "affiliation-city"=>"Castellana Grotte", "affiliation-country"=>"Italy"}], "pubmed-id"=>"24558444", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e88898", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0088898", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"43", "xml_views"=>"10", "html_views"=>"258"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"34", "xml_views"=>"2", "html_views"=>"162"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"31", "xml_views"=>"2", "html_views"=>"134"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"100"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"42"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"66"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"86"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"55"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"71"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"5"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"1"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"1"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1390124"], "description"=>"<p>BMDCs were exposed to different ROBs-QP concentrations on day 5 and 7. LPS [1 µg/ml] was administered on day 8, and 24 h later SNs were collected. Cytokine protein levels were measured by ELISA. Data are shown as mean ± S.D. of five independent experiments. Statistically significant differences were considered when **P<0.01; ***P<0.001 between control (LPS, no polyphenols) and LPS-ROBS-QP-treated cells.</p>", "links"=>[], "tags"=>["immunology", "Immune system", "cytokines", "Immune response", "immunomodulation", "Model organisms", "Animal models", "mouse", "Drugs and devices", "Pharmacodynamics", "Gastroenterology and hepatology", "Inflammatory bowel disease", "cytokine", "lps-treated"], "article_id"=>937845, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Elisabetta Cavalcanti", "Elisa Vadrucci", "Francesca Romana Delvecchio", "Francesco Addabbo", "Simona Bettini", "Rachel Liou", "Vladia Monsurro", "Alex Yee-Chen Huang", "Theresa Torres Pizarro", "Angelo Santino", "Marcello Chieppa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088898.g005", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ROBs_QP_administration_promotes_a_unique_cytokine_profile_in_LPS_treated_DCs_/937845", "title"=>"ROBs-QP administration promotes a unique cytokine profile in LPS-treated DCs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-18 03:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1390117"], "description"=>"<p>A) model structure of a natural oil body: external PL monolayer, embedded proteins (<i>i.e</i>. oleosin) and TAGs; Piperine and quercetin were encapsulated in the core. B and D) CLSM micrograph of empty ROBs and quercetin encapsulated ROBs imaged by transmitted light. C and E) LSM micrograph of empty ROBs and ROBs quercetin imaged by fluorescence light using an excitation wavelength of 488 nm and emission recorded with a 505–530 nm filter set. F) Degradation profiles of free (squares) and NE (circles) quercetin incubated in 0.1 M phosphate buffer pH 7 at 37°C in the dark for different times; HPLC chromatograms of free quercetin (12.5 µM) incubated with 0.1 M phosphate buffer pH 7 in the dark at 37°C after 0 h (G), 4 h (H) and 48 h (I) compared to HPLC chromatograms of quercetin encapsulated ROBs (12.5 µM) treated in the same experimental conditions at 48 h (2 days, L), 144 h (6 days, M) and 432 h (18 days, N).</p>", "links"=>[], "tags"=>["immunology", "Immune system", "cytokines", "Immune response", "immunomodulation", "Model organisms", "Animal models", "mouse", "Drugs and devices", "Pharmacodynamics", "Gastroenterology and hepatology", "Inflammatory bowel disease", "polyphenol-embedded"], "article_id"=>937841, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Elisabetta Cavalcanti", "Elisa Vadrucci", "Francesca Romana Delvecchio", "Francesco Addabbo", "Simona Bettini", "Rachel Liou", "Vladia Monsurro", "Alex Yee-Chen Huang", "Theresa Torres Pizarro", "Angelo Santino", "Marcello Chieppa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088898.g002", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterization_of_polyphenol_embedded_ROBs_/937841", "title"=>"Characterization of polyphenol-embedded ROBs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-18 03:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1390116"], "description"=>"<p>25 µM of each polyphenol was administered on day 5 and 7; LPS [1 µg/ml] was administered on day 8. SNs were collected 24 h later, and TNFα and IL-6 protein levels were assessed by ELISA. Both cytokine concentrations were significantly inhibited when cells were exposed to Quercetin (Querc) and Piperine (Pip) when compared to control (RPMI+LPS). Data are shown as mean ± S.D. of five independent experiments. Differences where considered between control (RPMI-LPS) and LPS-Quer- or LPS-Pip-treated cells **P<0.01, ***P<0.001. Capsaicin (Caps), Resveratrol (Resv), Rosmarinic Acid (RA), Epigallocatechin (Epig) and Curcumin (Curc).</p>", "links"=>[], "tags"=>["immunology", "Immune system", "cytokines", "Immune response", "immunomodulation", "Model organisms", "Animal models", "mouse", "Drugs and devices", "Pharmacodynamics", "Gastroenterology and hepatology", "Inflammatory bowel disease", "bmdcs", "interferes", "lps-mediated", "il-6"], "article_id"=>937840, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Elisabetta Cavalcanti", "Elisa Vadrucci", "Francesca Romana Delvecchio", "Francesco Addabbo", "Simona Bettini", "Rachel Liou", "Vladia Monsurro", "Alex Yee-Chen Huang", "Theresa Torres Pizarro", "Angelo Santino", "Marcello Chieppa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088898.g001", "stats"=>{"downloads"=>5, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Polyphenol_administration_to_BMDCs_interferes_with_LPS_mediated_TNF_945_and_IL_6_production_/937840", "title"=>"Polyphenol administration to BMDCs interferes with LPS-mediated TNFα and IL-6 production.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-18 03:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1390128"], "description"=>"<p>(A) Histology from ROBs-QP treated mice indicates signs of inflammation and infiltrating granulocytes in the colon of vehicle- and ROBs-QP-treated mice. (B) Western blot staining of colon lysates obtained from mice treated as previously described. Reduced expression of COX2 can be observed with or without epithelial cells from colon lysates of ROBs-QP-treated colons. The constitutive isoform COX1 showed no detectable differences.</p>", "links"=>[], "tags"=>["immunology", "Immune system", "cytokines", "Immune response", "immunomodulation", "Model organisms", "Animal models", "mouse", "Drugs and devices", "Pharmacodynamics", "Gastroenterology and hepatology", "Inflammatory bowel disease", "reduced", "cox2", "colon", "lysates", "epithelial", "cells"], "article_id"=>937848, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Elisabetta Cavalcanti", "Elisa Vadrucci", "Francesca Romana Delvecchio", "Francesco Addabbo", "Simona Bettini", "Rachel Liou", "Vladia Monsurro", "Alex Yee-Chen Huang", "Theresa Torres Pizarro", "Angelo Santino", "Marcello Chieppa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088898.g007", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ROBs_QP_in_vivo_administration_reduced_expression_of_COX2_in_colon_lysates_even_in_absence_of_the_epithelial_cells_layer_/937848", "title"=>"ROBs-QP <i>in vivo</i> administration reduced expression of COX2 in colon lysates even in absence of the epithelial cells layer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-18 03:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1390126"], "description"=>"<p>Sex- and weight-matched mice were divided in 2 groups (10 mice each). Mice received 2% DSS in drinking water from day 0, and either ROBs-QP or vehicle starting from day 3. Body weight and presence of diarrhea and rectal bleeding were monitored daily. (A) Average body weight is shown as mean ± SEM. Arrow indicates the beginning of ROBs-QP administration; *P<0.05, **P<0.01. (B) Survival rate is shown as percentage of initial number of either untreated or ROBs-QP-treated mice; N = 10/group, P≤0.01 vs. all treated groups. (C) Disease Activity Index (DAI) was calculated daily. The values represent the mean of 6 mice (3 females and 3 males) ± SEM; *P<0.05, **P<0.01. (D) Macroscopic changes at day 9 of representative colons isolated from mice treated with 2% DSS. (E) At day 9, mice were sacrificed and MLNs explanted, and percentages of CD4<sup>+</sup>Foxp3<sup>+</sup> cells were assessed by FACS; figure shows a representative dot plot. (F) Fur and perianal beading of representative untreated vs. ROBs-QP-treated mice 9 days after the beginning of 2% DSS administration.</p>", "links"=>[], "tags"=>["immunology", "Immune system", "cytokines", "Immune response", "immunomodulation", "Model organisms", "Animal models", "mouse", "Drugs and devices", "Pharmacodynamics", "Gastroenterology and hepatology", "Inflammatory bowel disease", "robs", "ameliorates", "dss-mediated", "acute"], "article_id"=>937846, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Elisabetta Cavalcanti", "Elisa Vadrucci", "Francesca Romana Delvecchio", "Francesco Addabbo", "Simona Bettini", "Rachel Liou", "Vladia Monsurro", "Alex Yee-Chen Huang", "Theresa Torres Pizarro", "Angelo Santino", "Marcello Chieppa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088898.g006", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Intraperitoneal_administration_of_ROBs_ameliorates_2_DSS_mediated_acute_colitis_/937846", "title"=>"Intraperitoneal administration of ROBs ameliorates 2% DSS-mediated acute colitis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-18 03:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1390119"], "description"=>"<p>DCs were cultured in the presence of either ROBs-P, ROBs-Q or ROBs-QP as mentioned previously; empty ROBs were used as control. LPS (A) or PG (B) was administered at indicated time points. DC lysates were subjected to immunoblotting with antibodies to detect total and phosphorylated forms of p38 MAPK and COX-2. Representative immunoblots from at least three independent experiments are shown for each condition. Each bar represents the mean ± SEM of densitometric analyses for phosphorylated proteins normalized to their respective total forms; *P<0.05, **P<0.01 vs. basal conditions.</p>", "links"=>[], "tags"=>["immunology", "Immune system", "cytokines", "Immune response", "immunomodulation", "Model organisms", "Animal models", "mouse", "Drugs and devices", "Pharmacodynamics", "Gastroenterology and hepatology", "Inflammatory bowel disease", "activation", "pro-inflammatory", "mapk", "p38", "inducible", "cox-2", "robs-qp", "treated"], "article_id"=>937843, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Elisabetta Cavalcanti", "Elisa Vadrucci", "Francesca Romana Delvecchio", "Francesco Addabbo", "Simona Bettini", "Rachel Liou", "Vladia Monsurro", "Alex Yee-Chen Huang", "Theresa Torres Pizarro", "Angelo Santino", "Marcello Chieppa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088898.g004", "stats"=>{"downloads"=>0, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Modulated_activation_of_pro_inflammatory_MAPK_p38_signaling_and_inducible_COX_2_on_ROBs_QP_treated_DCs_/937843", "title"=>"Modulated activation of pro-inflammatory MAPK p38 signaling and inducible COX-2 on ROBs-QP treated DCs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-18 03:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1390118"], "description"=>"<p>ROB-embedded piperine (ROBs-P), quercetin (ROBs-Q) or a mix of the two (ROBs-QP) were administered on day 5 and 7 [25 µM] to DC cultures. LPS [1 µg/ml] was administered on day 8. SNs were collected 24 h later and TNFα and IL-6 content evaluated by ELISA. Data are shown as mean ± S.D. of five independent experiments; **P<0.01, ***P<0.001.</p>", "links"=>[], "tags"=>["immunology", "Immune system", "cytokines", "Immune response", "immunomodulation", "Model organisms", "Animal models", "mouse", "Drugs and devices", "Pharmacodynamics", "Gastroenterology and hepatology", "Inflammatory bowel disease", "polyphenol", "interferes", "lps-mediated"], "article_id"=>937842, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Elisabetta Cavalcanti", "Elisa Vadrucci", "Francesca Romana Delvecchio", "Francesco Addabbo", "Simona Bettini", "Rachel Liou", "Vladia Monsurro", "Alex Yee-Chen Huang", "Theresa Torres Pizarro", "Angelo Santino", "Marcello Chieppa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0088898.g003", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ROB_embedded_polyphenol_mix_interferes_with_production_of_LPS_mediated_cytokines_from_DCs_/937842", "title"=>"ROB-embedded polyphenol mix interferes with production of LPS-mediated cytokines from DCs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-18 03:43:35"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"69", "full-text"=>"65", "pdf"=>"59", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"26", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"31", "full-text"=>"38", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"46", "full-text"=>"49", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"7", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"25", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"11", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"8", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"27", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[267]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[286]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[285]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[280]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[289]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[278]}]}
Loading … Spinner
There are currently no alerts