A Functional Polymorphism in the Promoter Region of MicroRNA-146a Is Associated with the Risk of Alzheimer Disease and the Rate of Cognitive Decline in Patients
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{"title"=>"A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of alzheimer disease and the rate of cognitive decline in patients", "type"=>"journal", "authors"=>[{"first_name"=>"Lili", "last_name"=>"Cui", "scopus_author_id"=>"35361396700"}, {"first_name"=>"You", "last_name"=>"Li", "scopus_author_id"=>"56658785200"}, {"first_name"=>"Guoda", "last_name"=>"Ma", "scopus_author_id"=>"55641935000"}, {"first_name"=>"Yan", "last_name"=>"Wang", "scopus_author_id"=>"56107588900"}, {"first_name"=>"Yujie", "last_name"=>"Cai", "scopus_author_id"=>"56067138100"}, {"first_name"=>"Shengyuan", "last_name"=>"Liu", "scopus_author_id"=>"55598367800"}, {"first_name"=>"Yanyan", "last_name"=>"Chen", "scopus_author_id"=>"56067538400"}, {"first_name"=>"Jia", "last_name"=>"Li", "scopus_author_id"=>"57196156708"}, {"first_name"=>"Yuliu", "last_name"=>"Xie", "scopus_author_id"=>"56067199600"}, {"first_name"=>"Gen", "last_name"=>"Liu", "scopus_author_id"=>"56067102100"}, {"first_name"=>"Bin", "last_name"=>"Zhao", "scopus_author_id"=>"56495987400"}, {"first_name"=>"Keshen", "last_name"=>"Li", "scopus_author_id"=>"23482145100"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84897791983", "doi"=>"10.1371/journal.pone.0089019", "pui"=>"372599225", "issn"=>"19326203", "pmid"=>"24586483", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-84897791983"}, "id"=>"31cc4b8b-bca9-30cb-ad5a-c48a29cd2bac", "abstract"=>"miR146a is well known for its regulatory role in the immune response and inflammation. Recent studies have demonstrated the links between miR146a and Alzheimer disease (AD) and suggested that miR146a may be involved in neuroinflammation and the metabolism of amyloid-β (Aβ), which are critical events in AD pathology. Although genetic studies have focused on the association between the miR146a gene and susceptibility to several diseases, no association study of miR146a variability with AD has been conducted. In this report, we performed a case-control association study to analyze the genotype and allele distributions of the miR146a, rs2910464 and rs57095329 polymorphisms in a Chinese population consisting of 292 AD cases and 300 healthy controls. We found a significant difference in the genotypes and allele frequencies of rs57095329 between the AD cases and the controls (p = 0.0147 and p = 0.0184, respectively), where the AA genotype of rs57095329 was associated with an increased risk of AD as well the cognitive decline in AD patients. Additionally, the AA genotype of rs57095329 exhibited significantly higher miR146a expression than the GG+GA genotypes of rs2910164 in the peripheral blood cells (PBMCs) of healthy individuals and had a stronger effect on the production of IL-6 and IL-1β when the cells were stimulated with LPS. Our data provide preliminary evidence that the rs57095329 polymorphism in the miR146a promoter is involved in the genetic susceptibility to AD, and this risk AA genotype may increase the expression of miR146a and influence certain proinflammatory cytokines, thus playing a role in the pathogenesis of AD.", "link"=>"http://www.mendeley.com/research/functional-polymorphism-promoter-region-microrna146a-associated-risk-alzheimer-disease-rate-cognitiv", "reader_count"=>23, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>7, "Student > Master"=>5, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>7, "Student > Master"=>5, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>11, "Neuroscience"=>4, "Psychology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>4}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}}, "reader_count_by_country"=>{"Brazil"=>1, "United Kingdom"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1398430"], "description"=>"<p>The decreased MMSE scores derived from SNP rs2910164 for GG (n = 23) and GC+CC (n = 173) genotypes and SNP rs57095329 for AA (n = 125) and GG+ GA (n = 71) Genotypes. Values are presented as the means±SD (*p<0.05).</p>", "links"=>[], "tags"=>["Computational biology", "population genetics", "Genetic polymorphism", "Molecular genetics", "Evolutionary biology", "genetics", "Human genetics", "Genetic association studies", "Genetics of disease", "immunology", "Genetics of the immune system", "neuroscience", "Molecular neuroscience", "Clinical immunology", "immunity", "inflammation", "neurology", "dementia", "Alzheimer disease", "mir146a", "polymorphisms", "patients", "stratified", "mmse", "scores", "patiemts", "two-year"], "article_id"=>944503, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Lili Cui", "You Li", "Guoda Ma", "Yan Wang", "Yujie Cai", "Shengyuan Liu", "Yanyan Chen", "Jia Li", "Yuliu Xie", "Gen Liu", "Bin Zhao", "Keshen Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089019.g001", "stats"=>{"downloads"=>1, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genotype_distribution_of_the_miR146a_polymorphisms_in_AD_patients_stratified_according_to_the_decreased_MMSE_scores_of_cognitive_decline_in_AD_patiemts_n_8202_8202_196_with_two_year_periods_/944503", "title"=>"Genotype distribution of the miR146a polymorphisms in AD patients stratified according to the decreased MMSE scores of cognitive decline in AD patiemts (n = 196) with two-year periods.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-25 03:42:39"}
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PMC Usage Stats | Further Information

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Relative Metric

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