Effects of β-Lactam Antibiotics and Fluoroquinolones on Human Gut Microbiota in Relation to Clostridium difficile Associated Diarrhea
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{"title"=>"Effects of b-lactam antibiotics and fluoroquinolones on human gut microbiota in relation to clostridium difficile associated diarrhea", "type"=>"journal", "authors"=>[{"first_name"=>"Henrik", "last_name"=>"Knecht", "scopus_author_id"=>"55134545500"}, {"first_name"=>"Sven C.", "last_name"=>"Neulinger", "scopus_author_id"=>"13807899800"}, {"first_name"=>"Femke Anouska", "last_name"=>"Heinsen", "scopus_author_id"=>"55135855700"}, {"first_name"=>"Carolin", "last_name"=>"Knecht", "scopus_author_id"=>"55924243600"}, {"first_name"=>"Anke", "last_name"=>"Schilhabel", "scopus_author_id"=>"24449459300"}, {"first_name"=>"Ruth A.", "last_name"=>"Schmitz", "scopus_author_id"=>"55273641200"}, {"first_name"=>"Alexandra", "last_name"=>"Zimmermann", "scopus_author_id"=>"56074678700"}, {"first_name"=>"Vitor Martins", "last_name"=>"Dos Santos", "scopus_author_id"=>"6506726905"}, {"first_name"=>"Manuel", "last_name"=>"Ferrer", "scopus_author_id"=>"7202504171"}, {"first_name"=>"Philip C.", "last_name"=>"Rosenstiel", "scopus_author_id"=>"6603628533"}, {"first_name"=>"Stefan", "last_name"=>"Schreiber", "scopus_author_id"=>"7402870125"}, {"first_name"=>"Anette K.", "last_name"=>"Friedrichs", "scopus_author_id"=>"55314419400"}, {"first_name"=>"Stephan J.", "last_name"=>"Ott", "scopus_author_id"=>"55437184900"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"372643369", "sgr"=>"84896520726", "issn"=>"19326203", "pmid"=>"24586762", "scopus"=>"2-s2.0-84896520726", "doi"=>"10.1371/journal.pone.0089417", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)"}, "id"=>"d3294f2b-b0e0-3dd9-9988-38234b57b04a", "abstract"=>"Clostridium difficile infections are an emerging health problem in the modern hospital environment. Severe alterations of the gut microbiome with loss of resistance to colonization against C. difficile are thought to be the major trigger, but there is no clear concept of how C. difficile infection evolves and which microbiological factors are involved. We sequenced 16S rRNA amplicons generated from DNA and RNA/cDNA of fecal samples from three groups of individuals by FLX technology: (i) healthy controls (no antibiotic therapy); (ii) individuals receiving antibiotic therapy (Ampicillin/Sulbactam, cephalosporins, and fluoroquinolones with subsequent development of C. difficile infection or (iii) individuals receiving antibiotic therapy without C. difficile infection. We compared the effects of the three different antibiotic classes on the intestinal microbiome and the effects of alterations of the gut microbiome on C. difficile infection at the DNA (total microbiota) and rRNA (potentially active) levels. A comparison of antibiotic classes showed significant differences at DNA level, but not at RNA level. Among individuals that developed or did not develop a C. difficile infection under antibiotics we found no significant differences. We identified single species that were up- or down regulated in individuals receiving antibiotics who developed the infection compared to non-infected individuals. We found no significant differences in the global composition of the transcriptionally active gut microbiome associated with C. difficile infections. We suggest that up- and down regulation of specific bacterial species may be involved in colonization resistance against C. difficile providing a potential therapeutic approach through specific manipulation of the intestinal microbiome.", "link"=>"http://www.mendeley.com/research/effects-blactam-antibiotics-fluoroquinolones-human-gut-microbiota-relation-clostridium-difficile-ass", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>1, "Student > Master"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>1, "Student > Master"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>3, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1403455", "https://ndownloader.figshare.com/files/1403456", "https://ndownloader.figshare.com/files/1403457", "https://ndownloader.figshare.com/files/1403458", "https://ndownloader.figshare.com/files/1403459"], "description"=>"<div><p><i>Clostridium difficile</i> infections are an emerging health problem in the modern hospital environment. Severe alterations of the gut microbiome with loss of resistance to colonization against <i>C. difficile</i> are thought to be the major trigger, but there is no clear concept of how <i>C. difficile</i> infection evolves and which microbiological factors are involved. We sequenced 16S rRNA amplicons generated from DNA and RNA/cDNA of fecal samples from three groups of individuals by FLX technology: (i) healthy controls (no antibiotic therapy); (ii) individuals receiving antibiotic therapy (Ampicillin/Sulbactam, cephalosporins, and fluoroquinolones with subsequent development of <i>C. difficile</i> infection or (iii) individuals receiving antibiotic therapy without <i>C. difficile</i> infection. We compared the effects of the three different antibiotic classes on the intestinal microbiome and the effects of alterations of the gut microbiome on <i>C. difficile</i> infection at the DNA (total microbiota) and rRNA (potentially active) levels. A comparison of antibiotic classes showed significant differences at DNA level, but not at RNA level. Among individuals that developed or did not develop a <i>C. difficile</i> infection under antibiotics we found no significant differences. We identified single species that were up- or down regulated in individuals receiving antibiotics who developed the infection compared to non-infected individuals. We found no significant differences in the global composition of the transcriptionally active gut microbiome associated with <i>C. difficile</i> infections. We suggest that up- and down regulation of specific bacterial species may be involved in colonization resistance against <i>C. difficile</i> providing a potential therapeutic approach through specific manipulation of the intestinal microbiome.</p></div>", "links"=>[], "tags"=>["Computational biology", "Sequence analysis", "ecology", "microbial ecology", "Gastroenterology and hepatology", "Bacterial and foodborne illness", "colon", "Gastrointestinal infections", "Infectious diseases", "Bacterial diseases", "Clostridium difficile", "antibiotics", "fluoroquinolones", "microbiota", "diarrhea"], "article_id"=>948583, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Henrik Knecht", "Sven C. Neulinger", "Femke Anouska Heinsen", "Carolin Knecht", "Anke Schilhabel", "Ruth A. Schmitz", "Alexandra Zimmermann", "Vitor Martins dos Santos", "Manuel Ferrer", "Philip C. Rosenstiel", "Stefan Schreiber", "Anette K. Friedrichs", "Stephan J. Ott"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0089417.s001", "https://dx.doi.org/10.1371/journal.pone.0089417.s002", "https://dx.doi.org/10.1371/journal.pone.0089417.s003", "https://dx.doi.org/10.1371/journal.pone.0089417.s004", "https://dx.doi.org/10.1371/journal.pone.0089417.s005"], "stats"=>{"downloads"=>9, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Effects_of_Lactam_Antibiotics_and_Fluoroquinolones_on_Human_Gut_Microbiota_in_Relation_to_Clostridium_difficile_Associated_Diarrhea/948583", "title"=>"Effects of β-Lactam Antibiotics and Fluoroquinolones on Human Gut Microbiota in Relation to <i>Clostridium difficile</i> Associated Diarrhea", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-02-28 03:39:38"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"5"}
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  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[306, 482]}, {"subject_area"=>"/Biology and life sciences/Microbiology", "average_usage"=>[317]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[292, 461]}, {"subject_area"=>"/Ecology and environmental sciences/Ecology", "average_usage"=>[313]}]}
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