The Status of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibody Are Not Associated with the Effect of Anti-TNFα Agent Treatment in Patients with Rheumatoid Arthritis: A Meta-Analysis
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"The status of rheumatoid factor and anti-cyclic citrullinated peptide antibody are not associated with the effect of anti-TNF a agent treatment in patients with rheumatoid arthritis: A meta-analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Qianwen", "last_name"=>"Lv", "scopus_author_id"=>"56106409500"}, {"first_name"=>"Yufeng", "last_name"=>"Yin", "scopus_author_id"=>"56104871500"}, {"first_name"=>"Xin", "last_name"=>"Li", "scopus_author_id"=>"56105839600"}, {"first_name"=>"Guangliang", "last_name"=>"Shan", "scopus_author_id"=>"7005942365"}, {"first_name"=>"Xiangni", "last_name"=>"Wu", "scopus_author_id"=>"56106457300"}, {"first_name"=>"Di", "last_name"=>"Liang", "scopus_author_id"=>"56105858800"}, {"first_name"=>"Yongzhe", "last_name"=>"Li", "scopus_author_id"=>"16417293500"}, {"first_name"=>"Xuan", "last_name"=>"Zhang", "scopus_author_id"=>"36543238700"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84897831924", "sgr"=>"84897831924", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0089442", "pmid"=>"24586782", "isbn"=>"1932-6203", "pui"=>"372609708"}, "id"=>"aa34be3d-6fd4-39fc-a611-3fb0461ed2cf", "abstract"=>"OBJECTIVES: This meta-analysis was conducted to investigate whether the status of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody are associated with the clinical response to anti-tumor necrosis factor (TNF) alpha treatment in rheumatoid arthritis (RA).\\n\\nMETHODS: A systemic literature review was performed using the MEDLINE, SCOPUS, Cochrane Library, ISI Web of Knowledge, and Clinical Trials Register databases, and Hayden's criteria of quality assessment for prognostic studies were used to evaluate all of the studies. The correlation between the RF and anti-CCP antibody status with the treatment effect of anti-TNFα agents was analyzed separately using the Mantel Haenszel method. A fixed-effects model was used when there was no significant heterogeneity; otherwise, a random-effects model was applied. Publication bias was assessed using Egger's linear regression and a funnel plot.\\n\\nRESULTS: A total of 14 studies involving 5561 RA patients meeting the inclusion criteria were included. The overall analysis showed that the pooled relative risk for the predictive effects of the RF and anti-CCP antibody status on patient response to anti-TNFα agents was 0.98 (95% CI: 0.91-1.05, p=0.54) and 0.88 (95% CI: 0.76-1.03, p=0.11), respectively, with I(2) values of 43% (p=0.05) and 67% (p<0.01), respectively. Subgroup analyses of different anti-TNFα treatments (infliximab vs. etanercept vs. adalimumab vs. golimumab), response criteria (DAS28 vs. ACR20 vs. EULAR response), follow-up period (≥ 6 vs. <6 months), and ethnic group did not reveal a significant association for the status of RF and anti-CCP.\\n\\nCONCLUSIONS: Neither the RF nor anti-CCP antibody status in RA patients is associated with a clinical response to anti-TNFα treatment.", "link"=>"http://www.mendeley.com/research/status-rheumatoid-factor-anticyclic-citrullinated-peptide-antibody-not-associated-effect-antitnf-age", "reader_count"=>32, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>2, "Other"=>3, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>2, "Other"=>3, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>26, "Arts and Humanities"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>26}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Japan"=>1, "Italy"=>1}, "group_count"=>2}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84897831924"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84897831924?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897831924&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84897831924&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84897831924", "dc:identifier"=>"SCOPUS_ID:84897831924", "eid"=>"2-s2.0-84897831924", "dc:title"=>"The status of rheumatoid factor and anti-cyclic citrullinated peptide antibody are not associated with the effect of anti-TNF a agent treatment in patients with rheumatoid arthritis: A meta-analysis", "dc:creator"=>"Lv Q.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-02-27", "prism:coverDisplayDate"=>"27 February 2014", "prism:doi"=>"10.1371/journal.pone.0089442", "citedby-count"=>"33", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Chinese Academy of Medical Sciences", "affiliation-city"=>"Beijing", "affiliation-country"=>"China"}], "pubmed-id"=>"24586782", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e89442", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0089442", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"11", "html_views"=>"139"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"68", "xml_views"=>"3", "html_views"=>"224"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"34", "xml_views"=>"4", "html_views"=>"148"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"103"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"53"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"58"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"55"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"76"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"26", "xml_views"=>"2", "html_views"=>"39"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"53"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"4", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"3"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1401021"], "description"=>"<p>Flowchart of the study selection.</p>", "links"=>[], "tags"=>[], "article_id"=>946644, "categories"=>["Biological Sciences"], "users"=>["Qianwen Lv", "Yufeng Yin", "Xin Li", "Guangliang Shan", "Xiangni Wu", "Di Liang", "Yongzhe Li", "Xuan Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089442.g001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flowchart_of_the_study_selection_/946644", "title"=>"Flowchart of the study selection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-27 03:07:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1401022"], "description"=>"<p>The overall analysis of RF status showed a pooled RR of 0.98 (95% CI: 0.91–1.05, p = 0.54) and an I<sup>2</sup> of 43%. Subgroup analyses on different response criteria revealed no significant differences.</p>", "links"=>[], "tags"=>["graphs", "meta-analysis", "rf"], "article_id"=>946645, "categories"=>["Biological Sciences"], "users"=>["Qianwen Lv", "Yufeng Yin", "Xin Li", "Guangliang Shan", "Xiangni Wu", "Di Liang", "Yongzhe Li", "Xuan Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089442.g002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_graphs_of_the_meta_analysis_of_RF_status_and_response_to_anti_TNF_945_agents_/946645", "title"=>"Forest graphs of the meta-analysis of RF status and response to anti-TNFα agents.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-27 03:07:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1401023"], "description"=>"<p>The overall analysis of anti-CCP antibody status showed a pooled RR of 0.88 (95% CI: 0.76–1.03, p = 0.11) and an I<sup>2</sup> of 67%. Subgroup analyses on different response criteria revealed no significant differences.</p>", "links"=>[], "tags"=>["graphs", "meta-analysis", "anti-ccp", "antibody"], "article_id"=>946646, "categories"=>["Biological Sciences"], "users"=>["Qianwen Lv", "Yufeng Yin", "Xin Li", "Guangliang Shan", "Xiangni Wu", "Di Liang", "Yongzhe Li", "Xuan Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089442.g003", "stats"=>{"downloads"=>3, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_graphs_of_the_meta_analysis_of_anti_CCP_antibody_status_and_response_to_anti_TNF_945_agents_/946646", "title"=>"Forest graphs of the meta-analysis of anti-CCP antibody status and response to anti-TNFα agents.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-27 03:07:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1401024"], "description"=>"<p>Egger's linear regression test was performed to quantify publication bias. The p values of the RF status analysis were 0.777. The funnel plot showed no significant evidence of asymmetry.</p>", "links"=>[], "tags"=>["rf"], "article_id"=>946647, "categories"=>["Biological Sciences"], "users"=>["Qianwen Lv", "Yufeng Yin", "Xin Li", "Guangliang Shan", "Xiangni Wu", "Di Liang", "Yongzhe Li", "Xuan Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089442.g004", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overall_analysis_of_publication_bias_on_the_effect_of_RF_status_on_the_response_to_anti_TNF_945_treatment_/946647", "title"=>"Overall analysis of publication bias on the effect of RF status on the response to anti-TNFα treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-27 03:07:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1401025"], "description"=>"<p>Egger's linear regression test was performed to quantify publication bias. The p values of the anti-CCP antibody status analysis were 0.422. The funnel plot showed no significant evidence of asymmetry.</p>", "links"=>[], "tags"=>["anti-ccp", "antibody"], "article_id"=>946648, "categories"=>["Biological Sciences"], "users"=>["Qianwen Lv", "Yufeng Yin", "Xin Li", "Guangliang Shan", "Xiangni Wu", "Di Liang", "Yongzhe Li", "Xuan Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089442.g005", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overall_analysis_of_publication_bias_on_the_effect_of_anti_CCP_antibody_status_on_the_response_to_anti_TNF_945_treatment_/946648", "title"=>"Overall analysis of publication bias on the effect of anti-CCP antibody status on the response to anti-TNFα treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-27 03:07:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1401026"], "description"=>"<p>F, fixed-effects model; R, random-effects model; NA, not applicable.</p><p>*The number of studies and number of patients receiving individual anti-TNFα agent in this table are those that we could identified after literature review and contacting the authors.</p>", "links"=>[], "tags"=>["meta-analysis", "anti-ccp", "ra", "follow-up"], "article_id"=>946649, "categories"=>["Biological Sciences"], "users"=>["Qianwen Lv", "Yufeng Yin", "Xin Li", "Guangliang Shan", "Xiangni Wu", "Di Liang", "Yongzhe Li", "Xuan Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089442.t004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subgroup_meta_analysis_of_anti_CCP_and_RA_patient_response_according_to_different_anti_TNF_945_agents_follow_up_periods_response_criteria_and_ethnic_groups_/946649", "title"=>"Subgroup meta-analysis of anti-CCP and RA patient response according to different anti-TNFα agents, follow-up periods, response criteria, and ethnic groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-27 03:07:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1401027"], "description"=>"<p>R, random-effects model; NA, not applicable.</p><p>*The number of studies and number of patients receiving individual anti-TNFα agent in this table are those that we could identified after literature review and contacting the authors.</p>", "links"=>[], "tags"=>["meta-analysis", "rf", "ra", "follow-up"], "article_id"=>946650, "categories"=>["Biological Sciences"], "users"=>["Qianwen Lv", "Yufeng Yin", "Xin Li", "Guangliang Shan", "Xiangni Wu", "Di Liang", "Yongzhe Li", "Xuan Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089442.t003", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subgroup_meta_analysis_of_RF_and_RA_patient_response_according_to_different_anti_TNF_945_agents_follow_up_periods_response_criteria_and_ethnic_groups_/946650", "title"=>"Subgroup meta-analysis of RF and RA patient response according to different anti-TNFα agents, follow-up periods, response criteria, and ethnic groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-27 03:07:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1401028"], "description"=>"<p>Unsure: not enough information to evaluate.</p><p>Low, low risk of bias; moderate, moderate risk of bias; high, high risk of bias.</p><p>*One of the domains was assessed as “unsure” due to unavailable information even after the authors were contacted.</p>", "links"=>[], "tags"=>["accordance"], "article_id"=>946651, "categories"=>["Biological Sciences"], "users"=>["Qianwen Lv", "Yufeng Yin", "Xin Li", "Guangliang Shan", "Xiangni Wu", "Di Liang", "Yongzhe Li", "Xuan Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089442.t002", "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_results_of_an_assessment_for_bias_in_accordance_with_Hayden_s_criteria_/946651", "title"=>"The results of an assessment for bias in accordance with Hayden's criteria.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-27 03:07:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1401029"], "description"=>"<p>*Pro, prospective clinical trial; Retro, retrospective study; N/A, not available; INF, infliximab; ADA, adalimumab; ETA, etanercept; MTX, methotrexate; LEF, leflunomide; NSAIDs, non-steroidal anti-inflammatory drugs; DMARDs, disease-modifying anti-rheumatic drugs; CSs, corticosteroids.</p>#<p>Different prior biologic agents used may introduce potential heterogeneity, though the available data were insufficient for a sub-analysis.</p><p>Disease of duration, age, No. of swollen joints, No. of tender joints, DAS28 are presented as the mean (SD).</p>", "links"=>[], "tags"=>["extracted", "included"], "article_id"=>946652, "categories"=>["Biological Sciences"], "users"=>["Qianwen Lv", "Yufeng Yin", "Xin Li", "Guangliang Shan", "Xiangni Wu", "Di Liang", "Yongzhe Li", "Xuan Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089442.t001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Data_extracted_from_the_included_studies_/946652", "title"=>"Data extracted from the included studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-27 03:07:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1401030", "https://ndownloader.figshare.com/files/1401031"], "description"=>"<div><p>Objectives</p><p>This meta-analysis was conducted to investigate whether the status of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody are associated with the clinical response to anti-tumor necrosis factor (TNF) alpha treatment in rheumatoid arthritis (RA).</p><p>Methods</p><p>A systemic literature review was performed using the MEDLINE, SCOPUS, Cochrane Library, ISI Web of Knowledge, and Clinical Trials Register databases, and Hayden's criteria of quality assessment for prognostic studies were used to evaluate all of the studies. The correlation between the RF and anti-CCP antibody status with the treatment effect of anti-TNFα agents was analyzed separately using the Mantel Haenszel method. A fixed-effects model was used when there was no significant heterogeneity; otherwise, a random-effects model was applied. Publication bias was assessed using Egger's linear regression and a funnel plot.</p><p>Results</p><p>A total of 14 studies involving 5561 RA patients meeting the inclusion criteria were included. The overall analysis showed that the pooled relative risk for the predictive effects of the RF and anti-CCP antibody status on patient response to anti-TNFα agents was 0.98 (95% CI: 0.91–1.05, p = 0.54) and 0.88 (95% CI: 0.76–1.03, p = 0.11), respectively, with I<sup>2</sup> values of 43% (p = 0.05) and 67% (p<0.01), respectively. Subgroup analyses of different anti-TNFα treatments (infliximab vs. etanercept vs. adalimumab vs. golimumab), response criteria (DAS28 vs. ACR20 vs. EULAR response), follow-up period (≥6 vs. <6 months), and ethnic group did not reveal a significant association for the status of RF and anti-CCP.</p><p>Conclusions</p><p>Neither the RF nor anti-CCP antibody status in RA patients is associated with a clinical response to anti-TNFα treatment.</p></div>", "links"=>[], "tags"=>["rheumatoid", "anti-cyclic", "citrullinated", "peptide", "antibody", "patients"], "article_id"=>946653, "categories"=>["Biological Sciences"], "users"=>["Qianwen Lv", "Yufeng Yin", "Xin Li", "Guangliang Shan", "Xiangni Wu", "Di Liang", "Yongzhe Li", "Xuan Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0089442.s001", "https://dx.doi.org/10.1371/journal.pone.0089442.s002"], "stats"=>{"downloads"=>17, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Status_of_Rheumatoid_Factor_and_Anti_Cyclic_Citrullinated_Peptide_Antibody_Are_Not_Associated_with_the_Effect_of_Anti_TNF_945_Agent_Treatment_in_Patients_with_Rheumatoid_Arthritis_A_Meta_Analysis_/946653", "title"=>"The Status of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibody Are Not Associated with the Effect of Anti-TNFα Agent Treatment in Patients with Rheumatoid Arthritis: A Meta-Analysis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-02-27 03:07:01"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"98", "full-text"=>"108", "pdf"=>"71", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"39", "full-text"=>"44", "pdf"=>"48", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"57", "full-text"=>"57", "pdf"=>"41", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"50", "full-text"=>"54", "pdf"=>"39", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"39", "full-text"=>"42", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"28", "full-text"=>"30", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"55", "full-text"=>"55", "pdf"=>"36", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"33", "full-text"=>"33", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"31", "full-text"=>"41", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"37", "full-text"=>"39", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"21", "full-text"=>"35", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"27", "full-text"=>"27", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"41", "full-text"=>"48", "pdf"=>"47", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"40", "full-text"=>"46", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"35", "full-text"=>"32", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"29", "full-text"=>"36", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"39", "full-text"=>"43", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"39", "full-text"=>"42", "pdf"=>"36", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"31", "full-text"=>"31", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"36", "full-text"=>"39", "pdf"=>"29", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"30", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"25", "full-text"=>"26", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"28", "full-text"=>"29", "pdf"=>"31", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"36", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"25", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"22", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"33", "full-text"=>"30", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"31", "full-text"=>"36", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"23", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Computer and information sciences/Systems science", "average_usage"=>[289, 462]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Clinical medicine", "average_usage"=>[282]}, {"subject_area"=>"/Medicine and health sciences/Epidemiology", "average_usage"=>[333]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[289]}, {"subject_area"=>"/Medicine and health sciences/Pharmacology", "average_usage"=>[286]}, {"subject_area"=>"/Medicine and health sciences/Rheumatology", "average_usage"=>[300, 469]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[286]}]}
Loading … Spinner
There are currently no alerts