Genetic Factors Regulating Lung Vasculature and Immune Cell Functions Associate with Resistance to Pneumococcal Infection
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection", "type"=>"journal", "authors"=>[{"first_name"=>"Magda S.", "last_name"=>"Jonczyk", "scopus_author_id"=>"56633484800"}, {"first_name"=>"Michelle", "last_name"=>"Simon", "scopus_author_id"=>"55356989200"}, {"first_name"=>"Saumya", "last_name"=>"Kumar", "scopus_author_id"=>"56088126300"}, {"first_name"=>"Vitor E.", "last_name"=>"Fernandes", "scopus_author_id"=>"36155199000"}, {"first_name"=>"Nicolas", "last_name"=>"Sylvius", "scopus_author_id"=>"8559416700"}, {"first_name"=>"Ann Marie", "last_name"=>"Mallon", "scopus_author_id"=>"6603661835"}, {"first_name"=>"Paul", "last_name"=>"Denny", "scopus_author_id"=>"7004644890"}, {"first_name"=>"Peter W.", "last_name"=>"Andrew", "scopus_author_id"=>"7102018329"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84897090368", "doi"=>"10.1371/journal.pone.0089831", "issn"=>"19326203", "pui"=>"372716779", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"24594938", "scopus"=>"2-s2.0-84897090368"}, "id"=>"6c0fad5a-1e0e-3a9b-8eff-f1eb28bc63b7", "abstract"=>"Streptococcus pneumoniae is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors. To elucidate these factors could help to develop new medical treatments and tools to identify those most at risk. In recent years genome wide association studies (GWAS) in mice and humans have proved successful in identification of causal genes involved in many complex diseases for example diabetes, systemic lupus or cholesterol metabolism. In this study a GWAS approach was used to map genetic loci associated with susceptibility to pneumococcal infection in 26 inbred mouse strains. As a result four candidate QTLs were identified on chromosomes 7, 13, 18 and 19. Interestingly, the QTL on chromosome 7 was located within S. pneumoniae resistance QTL (Spir1) identified previously in a linkage study of BALB/cOlaHsd and CBA/CaOlaHsd F2 intercrosses. We showed that only a limited number of genes encoded within the QTLs carried phenotype-associated polymorphisms (22 genes out of several hundred located within the QTLs). These candidate genes are known to regulate TGFβ signalling, smooth muscle and immune cells functions. Interestingly, our pulmonary histopathology and gene expression data demonstrated, lung vasculature plays an important role in resistance to pneumococcal infection. Therefore we concluded that the cumulative effect of these candidate genes on vasculature and immune cells functions as contributory factors in the observed differences in susceptibility to pneumococcal infection. We also propose that TGFβ-mediated regulation of fibroblast differentiation plays an important role in development of invasive pneumococcal disease. Gene expression data submitted to the NCBI Gene Expression Omnibus Accession No: GSE49533 SNP data submitted to NCBI dbSNP Short Genetic Variation http://www.ncbi.nlm.nih.gov/projects/SNP/snp_viewTable.cgi?handle=MUSPNEUMONIA.", "link"=>"http://www.mendeley.com/research/genetic-factors-regulating-lung-vasculature-immune-cell-functions-associate-resistance-pneumococcal", "reader_count"=>11, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>2, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>2, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>5, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84897090368"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84897090368?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897090368&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84897090368&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84897090368", "dc:identifier"=>"SCOPUS_ID:84897090368", "eid"=>"2-s2.0-84897090368", "dc:title"=>"Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection", "dc:creator"=>"Jonczyk M.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-03-03", "prism:coverDisplayDate"=>"3 March 2014", "prism:doi"=>"10.1371/journal.pone.0089831", "citedby-count"=>"11", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Leicester", "affiliation-city"=>"Leicester", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"24594938", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e89831", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0089831", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"50", "xml_views"=>"10", "html_views"=>"278"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"3", "html_views"=>"99"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"101"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"34"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"27"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"11"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"4", "html_views"=>"24"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"2", "html_views"=>"5"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"1"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"3"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"1"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"1"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1406196"], "description"=>"<p>Fold change is represented as compared to control animals (PBS-treated). Only the ten most up-regulated and ten most down-regulated genes are presented.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "6-infection"], "article_id"=>950848, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Change_in_gene_expression_6_infection_of_BALB_cOlaHsd_resistant_and_CBA_CaOlaHsd_susceptible_with_S_pneumoniae_D39_/950848", "title"=>"Change in gene expression 6-infection of BALB/cOlaHsd (resistant) and CBA/CaOlaHsd (susceptible) with <i>S. pneumoniae</i>, D39.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406225", "https://ndownloader.figshare.com/files/1406226", "https://ndownloader.figshare.com/files/1406227"], "description"=>"<div><p><i>Streptococcus pneumoniae</i> is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors. To elucidate these factors could help to develop new medical treatments and tools to identify those most at risk. In recent years genome wide association studies (GWAS) in mice and humans have proved successful in identification of causal genes involved in many complex diseases for example diabetes, systemic lupus or cholesterol metabolism. In this study a GWAS approach was used to map genetic loci associated with susceptibility to pneumococcal infection in 26 inbred mouse strains. As a result four candidate QTLs were identified on chromosomes 7, 13, 18 and 19. Interestingly, the QTL on chromosome 7 was located within <i>S. pneumoniae</i> resistance QTL (<i>Spir1</i>) identified previously in a linkage study of BALB/cOlaHsd and CBA/CaOlaHsd F2 intercrosses. We showed that only a limited number of genes encoded within the QTLs carried phenotype-associated polymorphisms (22 genes out of several hundred located within the QTLs). These candidate genes are known to regulate TGFβ signalling, smooth muscle and immune cells functions. Interestingly, our pulmonary histopathology and gene expression data demonstrated, lung vasculature plays an important role in resistance to pneumococcal infection. Therefore we concluded that the cumulative effect of these candidate genes on vasculature and immune cells functions as contributory factors in the observed differences in susceptibility to pneumococcal infection. We also propose that TGFβ-mediated regulation of fibroblast differentiation plays an important role in development of invasive pneumococcal disease. Gene expression data submitted to the NCBI Gene Expression Omnibus Accession No: GSE49533</p><p>SNP data submitted to NCBI dbSNP Short Genetic Variation <a href=\"http://www.ncbi.nlm.nih.gov/projects/SNP/snp_viewTable.cgi?handle=MUSPNEUMONIA\" target=\"_blank\">http://www.ncbi.nlm.nih.gov/projects/SNP/snp_viewTable.cgi?handle=MUSPNEUMONIA</a>.</p></div>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "regulating", "vasculature", "functions", "pneumococcal"], "article_id"=>950875, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0089831.s001", "https://dx.doi.org/10.1371/journal.pone.0089831.s002", "https://dx.doi.org/10.1371/journal.pone.0089831.s003"], "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genetic_Factors_Regulating_Lung_Vasculature_and_Immune_Cell_Functions_Associate_with_Resistance_to_Pneumococcal_Infection_/950875", "title"=>"Genetic Factors Regulating Lung Vasculature and Immune Cell Functions Associate with Resistance to Pneumococcal Infection", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406223"], "description"=>"<p>Names of pathways (KEGG) and their significance (PValue) are provided.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "regulated", "pathways", "differentiating", "pbs-treated"], "article_id"=>950874, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.t008", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Significantly_regulated_pathways_KEGG_during_infection_and_differentiating_PBS_treated_BALB_c_and_CBA_Ca_mice_/950874", "title"=>"Significantly regulated pathways (KEGG) during infection and differentiating PBS-treated BALB/c and CBA/Ca mice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406217"], "description"=>"<p>Expression is represented as fold change (infected animals versus PBS-treated). Only the five most up-regulated and the five most down-regulated uDEGs are presented for each strain.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "genes", "intranasal-infection"], "article_id"=>950868, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.t006", "stats"=>{"downloads"=>1, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differentially_expressed_genes_unique_uDEGs_in_either_BALB_cOlaHsd_resistant_or_CBA_CaOlaHsd_susceptible_after_intranasal_infection_with_S_pneumoniae_D39_/950868", "title"=>"Differentially expressed genes unique (uDEGs) in either BALB/cOlaHsd (resistant) or CBA/CaOlaHsd (susceptible) after intranasal-infection with <i>S. pneumoniae</i>, D39.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406214"], "description"=>"<p>Pulmonary gene expression 6 h post-infection is represented as fold change between infected and non-infected animals (BALB/c infection: BALB/c-infected <i>versus</i> PBS-treated, CBA/Ca infection: CBA/Ca infected <i>versus</i> PBS-treated), between PBS-treated control animals (BALB/CBA: BALB/c <i>versus</i> CBA/Ca PBS-treated) and between infected BALB/c and infected CBA/Ca (BALB/CBA infection). Chrom. - chromosome.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "genes", "susceptibility", "qtl", "mice", "intranasally", "infected", "d39"], "article_id"=>950865, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.t005", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differentially_expressed_genes_DEGs_within_candidate_susceptibility_QTL_between_mice_intranasally_infected_with_S_pneumoniae_D39_and_control_animals_/950865", "title"=>"Differentially expressed genes (DEGs) within candidate susceptibility QTL between mice intranasally infected with <i>S. pneumoniae</i>, D39 and control animals.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406198"], "description"=>"<p>Results are presented for 6-infection for BALB/cOlaHsd (black bars) and CBA/CaOlaHsd (open bars), from two independent experiments, with a total of 5 animals per group. ** p<0.001.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "affected", "perivascular", "areas"], "article_id"=>950850, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percentage_of_lung_s_blood_vessel_affected_by_inflammation_within_perivascular_areas_after_infection_with_S_pneumoniae_D39_/950850", "title"=>"Percentage of lung's blood vessel affected by inflammation within perivascular areas after infection with <i>S. pneumoniae</i> D39.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406213"], "description"=>"<p>Hematoxylin-and-eosin-stained paraffin wax lung sections from BALB/cOlaHsd (A, A1–C,C1) and CBA/CaOlaHsd (D,D1–F,F1). Panels A,A1 and D,D1 represent lungs of PBS-treated animals, panels B,B1–C,C1 and E,E1–F,F1 are lung sections at 24 h-post infection. Panels A–F represent magnification 40× and panels A1–F1 magnification 200×. Bar indicates 500 µm for 40× magnification and 100 µm for 200× magnification. Black arrows indicate perivascular areas. Yellow arrow in panel F1 indicates perivascular adipose tissue.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "lungs", "mice"], "article_id"=>950864, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.g005", "stats"=>{"downloads"=>0, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inflammation_pattern_in_lungs_of_BALB_cOlaHsd_and_CBA_CaOlaHsd_mice_after_infection_with_S_pneumoniae_D39_/950864", "title"=>"Inflammation pattern in lungs of BALB/cOlaHsd and CBA/CaOlaHsd mice after infection with <i>S. pneumoniae</i>, D39.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406222"], "description"=>"<p>Only clusters with enrichment score above 5 are shown. Information provided: the overall enrichment score for the cluster based on EASE score of each member (Enrichment score), name of annotation (Description) and its GO code (ID) if applicable, p-value for the term (PValue).</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "annotation", "clustering", "differentially", "genes", "pneumococcal"], "article_id"=>950873, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.t009", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Functional_annotation_clustering_of_differentially_expressed_genes_during_pneumococcal_infection_of_BALB_cOlaHsd_and_CBA_CaOlaHsd_/950873", "title"=>"Functional annotation clustering of differentially expressed genes during pneumococcal infection of BALB/cOlaHsd and CBA/CaOlaHsd.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406220"], "description"=>"<p>The number of phenotype-associated polymorphisms within the coding region of the QTLs and their consequences. The presented number of SNPs includes the SNPs identified in the EMMA mapping and in the analyses of the full-length sequences within the disease QTLs. No of SNPs– number of phenotype-associated SNPs identified within the gene; Chrom – chromosome, non-synon – SNP causing amino acid change, synon – SNP causing silent mutation, intron – SNP within intron, splicing – SNP within splicing site of the gene. EMMA – indicates whether the genome-wide significant SNPs (p-value< 5×10<sup>−8</sup>) were identified within the gene during the EMMA mapping: Y-yes, N-no.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "polymorphisms"], "article_id"=>950871, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.t003", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phenotype_specific_genetic_polymorphisms_within_S_pneumoniae_resistance_QTLs_/950871", "title"=>"Phenotype-specific genetic polymorphisms within <i>S. pneumoniae</i> resistance QTLs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406221"], "description"=>"<p><i>S. pneumoniae</i> resistance QTLs identified by genome wide mapping from EMMA and HAM mapping using survival data (h).</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "qtls", "genome", "emma", "ham"], "article_id"=>950872, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.t002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_S_pneumoniae_resistance_QTLs_identified_by_genome_wide_mapping_from_EMMA_and_HAM_mapping_using_survival_data_h_/950872", "title"=>"<i>S. pneumoniae</i> resistance QTLs identified by genome wide mapping from EMMA and HAM mapping using survival data (h).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406219"], "description"=>"<p>SE – standard error.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "tested", "inbred", "strains", "phenotype", "intranasal"], "article_id"=>950870, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.t001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Survival_of_tested_inbred_mouse_strains_and_disease_phenotype_after_intranasal_infection_with_S_pneumoniae_D39_/950870", "title"=>"Survival of tested inbred mouse strains and disease phenotype after intranasal infection with <i>S. pneumoniae</i>, D39.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406216"], "description"=>"<p>Differentially expressed genes during intranasal-infection with <i>S. pneumoniae</i>, D39 in both BALB/cOlaHsd and CBA/CaOlaHsd and showing at least two-fold change difference between the two strains during the infection.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "genes", "intranasal-infection", "d39", "two-fold", "strains"], "article_id"=>950867, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.t007", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differentially_expressed_genes_during_intranasal_infection_with_S_pneumoniae_D39_in_both_BALB_cOlaHsd_and_CBA_CaOlaHsd_and_showing_at_least_two_fold_change_difference_between_the_two_strains_during_the_infection_/950867", "title"=>"Differentially expressed genes during intranasal-infection with <i>S. pneumoniae</i>, D39 in both BALB/cOlaHsd and CBA/CaOlaHsd and showing at least two-fold change difference between the two strains during the infection.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406197"], "description"=>"<p>The included genes show fold change in expression ≥1.5 and change is significant at p≤0.05. The total number of BALB/cOlaHsd (resistant) and CBA/CaOlaHsd (susceptible) DEGs is indicated below the strain number and amount of commonly and uniquely regulated genes is indicated within the Venn diagram.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "differentially", "regulated", "genes"], "article_id"=>950849, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_differentially_regulated_genes_DEGs_during_infection_with_S_pneumoniae_D39_/950849", "title"=>"Number of differentially regulated genes (DEGs) during infection with <i>S. pneumoniae</i>, D39.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406215"], "description"=>"<p>change: R>S – amino acid or nucleotide change, resistant (R) <i>versus</i> susceptible (S) variant.</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "polymorphisms", "qtls", "amino", "alteration", "splicing"], "article_id"=>950866, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.t004", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phenotype_specific_genetic_polymorphisms_within_S_pneumoniae_resistance_QTLs_leading_to_amino_acid_change_or_alteration_within_the_splicing_site_/950866", "title"=>"Phenotype-specific genetic polymorphisms within <i>S. pneumoniae</i> resistance QTLs leading to amino acid change or alteration within the splicing site.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-03 03:52:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406195"], "description"=>"<p>Strains are ordered by increasing mean survival time post-infection. A) Bacterial count in blood 24 h post-infection B) Bacterial count in blood at the time of death C) Bacterial count in lungs at the time of death. Results are for a group of 10 animals. Error bar shows standard error (SE).</p>", "links"=>[], "tags"=>["genetics", "population genetics", "Genetic polymorphism", "Genetics of disease", "Genome-wide association studies", "genomics", "Genome expression analysis", "histology", "immunology", "immunity", "Immunity to infections", "inflammation", "Innate immunity", "microbiology", "Bacterial pathogens", "streptococci", "Host-pathogen interaction", "Infectious diseases", "Bacterial diseases", "pneumococcus", "counts", "tissues", "tested", "inbred", "mice", "intranasal-infection"], "article_id"=>950847, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Magda S. Jonczyk", "Michelle Simon", "Saumya Kumar", "Vitor E. Fernandes", "Nicolas Sylvius", "Ann-Marie Mallon", "Paul Denny", "Peter W. Andrew"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0089831.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bacterial_counts_in_tissues_of_the_tested_inbred_mice_after_intranasal_infection_with_S_pneumoniae_D39_/950847", "title"=>"Bacterial counts in tissues of the tested inbred mice after intranasal-infection with <i>S. pneumoniae</i>, D39.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-03 03:52:14"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"58", "full-text"=>"49", "pdf"=>"33", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"27", "full-text"=>"15", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"29", "full-text"=>"21", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"18", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"28", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"34", "full-text"=>"28", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"29", "full-text"=>"26", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"32", "full-text"=>"36", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"27", "full-text"=>"36", "pdf"=>"0", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"26", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"3", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[306, 482]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[293]}, {"subject_area"=>"/Biology and life sciences/Microbiology", "average_usage"=>[317]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[266]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[289]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[287]}]}
Loading … Spinner

Net::HTTPUnauthorized

Source
CrossRef
Time
2020-05-27 02:16:31 UTC
Target URL
http://doi.crossref.org/servlet/getForwardLinks?usr=plos&pwd=plos1&doi=10.1371%2Fjournal.pone.0089831
Trace

/app/models/concerns/networkable.rb:21:in `get_result'
/app/models/source.rb:165:in `get_data'
/app/models/retrieval_status.rb:47:in `perform_get_data'
/app/jobs/source_job.rb:52:in `block (2 levels) in perform'
/app/jobs/source_job.rb:51:in `block in perform'
/app/jobs/source_job.rb:35:in `each'
/app/jobs/source_job.rb:35:in `perform'