The Severe Adverse Reaction to Vitamin K1 Injection Is Anaphylactoid Reaction but Not Anaphylaxis
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Mendeley | Further Information

{"title"=>"The severe adverse reaction to vitamin K1 injection is anaphylactoid reaction but not anaphylaxis", "type"=>"journal", "authors"=>[{"first_name"=>"Yan Ni", "last_name"=>"Mi"}, {"first_name"=>"Na Na", "last_name"=>"Ping"}, {"first_name"=>"Xue", "last_name"=>"Xiao"}, {"first_name"=>"Yan Bing", "last_name"=>"Zhu"}, {"first_name"=>"Jing", "last_name"=>"Liu"}, {"first_name"=>"Yong Xiao", "last_name"=>"Cao"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24594861", "isbn"=>"1671-4083", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0090199"}, "id"=>"36eeb0ac-1f61-3058-86cf-80743e2d0571", "abstract"=>"The severe adverse reaction to vitamin K1 injection is always remarkable and is thought to result from anaphylaxis. Paradoxically, however, some patients administered vitamin K1 injection for the first time have adverse reactions. Using beagle dogs, the present study tested the hypothesis that the response to vitamin K1 is an anaphylactoid reaction. The results showed that serious anaphylaxis-like symptoms appeared in beagle dogs after the administration of vitamin K1 injection for the first time. The plasma histamine concentration increased, and blood pressure decreased sharply. After sensitization, dogs were challenged with vitamin K1 injection and displayed the same degree of symptoms as prior to sensitization. However, when the vitamin K1 injection-sensitized dogs were challenged with a vitamin K1-fat emulsion without solubilizers such asTween-80, the abnormal reactions did not occur. Furthermore, there was no significant change in the plasma immunoglobulin E concentration after vitamin K1 challenge. Following treatment with vitamin K1 injection, the release of histamine and β-hexosaminidase by rat basophilic leukemia-2H3 cells as well as the rate of apoptosis increased. The Tween-80 group displayed results similar to those observed following vitamin K1 injection in vivo. However, the dogs in the vitamin K1-fat emulsion group did not display any abnormal behavior or significant change in plasma histamine. Additionally, degranulation and apoptosis did not occur in rat basophilic leukemia-2H3 cells. Our results indicate that the adverse reaction induced by vitamin K1 injection is an anaphylactoid reaction, not anaphylaxis. Vitamin K1 injection induces the release of inflammatory factors via a non-IgE-mediated immune pathway, for which the trigger may be the solubilizer.", "link"=>"http://www.mendeley.com/research/severe-adverse-reaction-vitamin-k1-injection-anaphylactoid-reaction-not-anaphylaxis", "reader_count"=>10, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>3, "Chemistry"=>1, "Social Sciences"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1406664"], "description"=>"<p>The change in blood pressure is presented as the decrease in blood pressure from before to after drug administration. The values are shown as the mean ± SE, n = 6. <sup>*</sup><i>P</i><0.05, <sup>**</sup><i>P</i><0.01 vs. control. VK<sub>1</sub>-FE: vitamin K<sub>1</sub>-fat emulsion.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "injection", "systolic", "diastolic", "beagle"], "article_id"=>951234, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_vitamin_K_1_VK_1_injection_on_systolic_blood_pressure_A_and_diastolic_blood_pressure_B_in_Beagle_dogs_/951234", "title"=>"Effect of vitamin K<sub>1</sub> (VK<sub>1</sub>) injection on systolic blood pressure (A) and diastolic blood pressure (B) in Beagle dogs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-04 02:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406665"], "description"=>"<p>RBL-2H3 cells were treated with the different drugs for 30 min. The supernatants were collected, and the absorbance was measured at 405 nm. The supernatant from cells stimulated with Triton was considered to represent the total β-hexosaminidase release. The β-hexosaminidase release rates are shown as the mean ± SE, n = 6. <sup>*</sup><i>P</i><0.05, <sup>**</sup><i>P</i><0.01 vs. control (conl). VK<sub>1</sub>-FE: vitamin K<sub>1</sub>-fat emulsion.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "injection", "rbl-2h3"], "article_id"=>951235, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.g002", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_vitamin_K_1_VK_1_injection_on_946_hexosaminidase_release_in_RBL_2H3_cells_/951235", "title"=>"Effect of vitamin K<sub>1</sub> (VK<sub>1</sub>) injection on β-hexosaminidase release in RBL-2H3 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-04 02:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406666"], "description"=>"<p>RBL-2H3 cells were treated with the different drugs for 30 min. The supernatants were collected and measured by spectrofluorometry. PBS was used as a blank, and the supernatant from cells stimulated with Triton was considered to represent the total histamine release. The histamine release rates are shown as the mean ± SE, n = 6. <sup>*</sup><i>P</i><0.05, <sup>**</sup><i>P</i><0.01 vs. control (conl). VK<sub>1</sub>-FE: vitamin K<sub>1</sub>-fat emulsion.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "injection", "histamine", "rbl-2h3"], "article_id"=>951236, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.g003", "stats"=>{"downloads"=>15, "page_views"=>44, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_vitamin_K_1_VK_1_injection_on_histamine_release_in_RBL_2H3_cells_/951236", "title"=>"Effect of vitamin K<sub>1</sub> (VK<sub>1</sub>) injection on histamine release in RBL-2H3 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-04 02:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406668"], "description"=>"<p>AnnexinV-FITC-stained cells appear green at the early stage of apoptosis. PI caused the cells to appear red during the middle to late stages of apoptosis. The magnification is 400×. The merged green and red images represent total apoptosis. VK<sub>1</sub>-FE: vitamin K<sub>1</sub>-fat emulsion.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "apoptosis", "rbl-2h3", "cells", "fluorescence"], "article_id"=>951238, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.g004", "stats"=>{"downloads"=>1, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_vitamin_K_1_VK_1_on_apoptosis_of_RBL_2H3_cells_by_fluorescence_staining_/951238", "title"=>"Effect of vitamin K<sub>1</sub> (VK<sub>1</sub>) on apoptosis of RBL-2H3 cells by fluorescence staining.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-04 02:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406669"], "description"=>"<p>Apoptotic cells were identified by Annexin V-FITC and PI staining. The concentrations of Tween-80 are 1000, 100, and 10 µg/mL, from top to bottom. The values are shown as the mean ± SE, n = 6. <sup>*</sup><i>P</i><0.05, <sup>**</sup><i>P</i><0.01 vs. control (conl). VK<sub>1</sub>-FE: vitamin K<sub>1</sub>-fat emulsion.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "injection", "apoptosis", "rbl-2h3", "cells"], "article_id"=>951239, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.g005", "stats"=>{"downloads"=>1, "page_views"=>74, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_vitamin_K_1_VK_1_injection_on_the_apoptosis_of_RBL_2H3_cells_by_flow_cytometry_/951239", "title"=>"Effect of vitamin K<sub>1</sub> (VK<sub>1</sub>) injection on the apoptosis of RBL-2H3 cells by flow cytometry.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-04 02:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406670"], "description"=>"<p>Dogs sensitized with 0.25 mg/kg vitamin K<sub>1</sub> (VK<sub>1</sub>) injection were challenged with 0.5 mg/kg vitamin K1-fat emulsion (VK<sub>1</sub>-FE), and dogs sensitized with 0.25 mg/kg VK<sub>1</sub>-FE were challenged with 0.25 mg/kg VK<sub>1</sub> injection. Symptoms were observed and recorded for 30 min. The sum of the scores was determined for each symptom. The values are shown as the mean ± SE, n = 6.</p><p>**<i>P</i><0.01 vs. control.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "scores", "symptoms", "presented", "dogs", "cross-challenge"], "article_id"=>951240, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.t006", "stats"=>{"downloads"=>4, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Grades_and_scores_for_the_symptoms_presented_by_the_dogs_in_a_cross_challenge_experiment_/951240", "title"=>"Grades and scores for the symptoms presented by the dogs in a cross-challenge experiment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-04 02:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406671"], "description"=>"<p>Blood samples were collected into a tube containing heparin at 10 min after drug administration. The plasma IgE concentrations were determined by ELISA. The values are shown as the mean ± SE, n = 6.</p><p>*<i>P</i><0.05 vs. control.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "plasma", "ige", "concentrations", "injection", "emulsion"], "article_id"=>951241, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.t007", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_change_in_plasma_IgE_concentrations_after_the_challenge_with_vitamin_K_1_VK_1_injection_and_vitamin_K_1_fat_emulsion_VK_1_FE_/951241", "title"=>"The change in plasma IgE concentrations after the challenge with vitamin K<sub>1</sub> (VK<sub>1</sub>) injection and vitamin K<sub>1</sub>-fat emulsion (VK<sub>1</sub>-FE).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-04 02:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406672"], "description"=>"<p>The dogs were intravenously stimulated with double doses of drug via a micro-injection pump at 0.4 ml/min, and symptoms were then observed and recorded for 30 min. The sum of the scores was determined for each symptom. The values are shown as the mean ± SE, n = 6.</p><p>**<i>P</i><0.01 vs. control.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "grades", "scores", "symptoms", "dogs", "injection", "emulsion"], "article_id"=>951242, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.t004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_grades_and_scores_of_symptoms_in_dogs_after_the_challenge_with_vitamin_K_1_VK_1_injection_and_vitamin_K_1_fat_emulsion_VK_1_FE_/951242", "title"=>"The grades and scores of symptoms in dogs after the challenge with vitamin K<sub>1</sub> (VK<sub>1</sub>) injection and vitamin K<sub>1</sub>-fat emulsion (VK<sub>1</sub>-FE).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-04 02:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406673"], "description"=>"<p>The dogs were sensitized by intravenous drugs every other day for a total of three administrations via a micro-injection pump at 0.4 ml/min; symptoms were then observed and recorded for 30 min. The sum of the scores was determined for each symptom. The values are shown as the mean ± SE, n = 6.</p><p>**<i>P</i><0.01 vs. control.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "scores", "symptoms", "dogs", "sensitizations", "injection", "emulsion"], "article_id"=>951243, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.t005", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_scores_of_the_symptoms_shown_by_the_dogs_after_three_sensitizations_with_vitamin_K_1_VK_1_injection_and_vitamin_K_1_fat_emulsion_VK_1_FE_/951243", "title"=>"The scores of the symptoms shown by the dogs after three sensitizations with vitamin K<sub>1</sub> (VK<sub>1</sub>) injection and vitamin K<sub>1</sub>-fat emulsion (VK<sub>1</sub>-FE).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-04 02:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406674"], "description"=>"<p>Drugs were intravenously administered to the dogs via a micro-injection pump at 0.4 ml/min. Symptoms were observed and recorded for 30 min. The sums of the scores were determined for each symptom. The values are shown as the mean ± SE, n = 6.</p><p>**<i>P</i><0.01 vs. control.</p><p>VK<sub>1</sub>: vitamin K<sub>1</sub>; VK<sub>1</sub>-FE: vitamin K<sub>1</sub>-fat emulsion.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "scores", "anaphylactoid", "reactions", "dogs", "intravenous"], "article_id"=>951244, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.t002", "stats"=>{"downloads"=>5, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Grades_and_scores_for_anaphylactoid_reactions_in_dogs_after_the_first_intravenous_administration_/951244", "title"=>"Grades and scores for anaphylactoid reactions in dogs after the first intravenous administration.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-04 02:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406675"], "description"=>"<p>Blood samples were taken before and 10 min after drug administration. The plasma histamine concentrations were quantified by ELISA. The values are shown as the mean ± SE, n = 6.</p><p>*<i>P</i><0.05 vs. control.</p><p>VK<sub>1</sub>: vitamin K<sub>1</sub>; VK<sub>1</sub>-FE: vitamin K<sub>1</sub>-fat emulsion.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "plasma", "histamine", "concentrations", "intravenous"], "article_id"=>951245, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.t003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_change_in_plasma_histamine_concentrations_after_the_first_intravenous_administration_/951245", "title"=>"The change in plasma histamine concentrations after the first intravenous administration.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-04 02:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1406676"], "description"=>"<p>Each symptom in the dogs received a score corresponding to that symptom.</p>", "links"=>[], "tags"=>["immunology", "Allergy and hypersensitivity", "Immune response", "Model organisms", "Animal models", "Zoology", "Animal behavior", "Clinical immunology", "Drugs and devices", "Adverse reactions", "nutrition", "vitamins", "anaphylactoid", "reactions", "anaphylaxis"], "article_id"=>951246, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Yan-Ni Mi", "Na-Na Ping", "Xue Xiao", "Yan-Bing Zhu", "Jing Liu", "Yong-Xiao Cao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090199.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_An_assessment_norm_for_the_anaphylactoid_reactions_and_anaphylaxis_in_dogs_/951246", "title"=>"An assessment norm for the anaphylactoid reactions and anaphylaxis in dogs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-04 02:55:27"}

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Relative Metric

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