Association of Lower Extremity Arterial Calcification with Amputation and Mortality in Patients with Symptomatic Peripheral Artery Disease
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{"title"=>"Association of Lower Extremity Arterial Calcification with Amputation and Mortality in Patients with Symptomatic Peripheral Artery Disease", "type"=>"journal", "authors"=>[{"first_name"=>"Chi-Lun", "last_name"=>"Huang"}, {"first_name"=>"I-Hui", "last_name"=>"Wu"}, {"first_name"=>"Yen-Wen", "last_name"=>"Wu"}, {"first_name"=>"Juey-Jen", "last_name"=>"Hwang"}, {"first_name"=>"Shoei-Shen", "last_name"=>"Wang"}, {"first_name"=>"Wen-Jone", "last_name"=>"Chen"}, {"first_name"=>"Wen-Jeng", "last_name"=>"Lee"}, {"first_name"=>"Wei-Shiung", "last_name"=>"Yang"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "pmid"=>"24587279", "doi"=>"10.1371/journal.pone.0090201"}, "id"=>"65a0a5aa-2d2d-392e-a90d-8a0a49d1fb3d", "abstract"=>"OBJECTIVE: The clinical implication of the coronary artery calcium score (CS) is well demonstrated. However, little is known about the association between lower extremity arterial calcification and clinical outcomes.\\n\\nMETHODS AND RESULTS: Eighty-two patients with symptomatic peripheral artery disease (age 61.0±12.4 years) were followed for 21±11 months. CSs, ranging from the common iliac artery bifurcation to the ankle area, were analyzed through noncontrast multidetector computed tomography images retrospectively. The primary endpoints of this study were amputation and mortality. Old age, diabetes, hyperlipidemia, and end-stage renal disease were associated with higher CSs. Patients with more advanced Fontaine stages also tended to have significantly higher CSs (p = 0.03). During the follow-up period (21±11 months), 29 (35%) patients underwent amputation, and 24 (29%) patients died. Among the patients who underwent amputation, there were no significant differences in CSs between the amputated legs and the non-amputated legs. In the Cox proportional hazard model with CS divided into quartiles, patients with CS in the highest quartile had a 2.88-fold (95% confidence interval [CI] 1.18-12.72, p = 0.03) and a 5.16-fold (95% CI 1.13-21.61, p = 0.04) higher risk for amputation and all-cause mortality, respectively, than those with CS in the lowest quartile. These predictive effects remained after conventional risk factor adjustment.\\n\\nCONCLUSION: Lower extremity arterial CSs are associated with disease severity and outcomes, including amputation and all-cause mortality, in patients with symptomatic peripheral artery disease. However, the independent predictive value needs further investigation in large scale, prospective studies.", "link"=>"http://www.mendeley.com/research/association-lower-extremity-arterial-calcification-amputation-mortality-patients-symptomatic-periphe", "reader_count"=>24, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>5, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>5, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>3, "Neuroscience"=>1, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Canada"=>1, "Germany"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1398746"], "description"=>"<p>Kaplan-Meier survival curves for amputation and all-cause mortality according to lower extremity arterial calcium scores with the median as cutoff value in patients with symptomatic peripheral artery disease.</p>", "links"=>[], "tags"=>["Chemical reactions", "calcification", "statistics", "Biostatistics", "Statistical methods", "Anatomy and physiology", "Neurological system", "Peripheral nervous system", "cardiovascular", "Cardiovascular imaging", "Coronary artery disease", "Peripheral vascular diseases", "radiology", "Diagnostic radiology", "Computed tomography", "curves", "amputation", "all-cause", "extremity", "arterial", "calcium", "scores", "median", "cutoff", "patients", "symptomatic", "peripheral", "artery"], "article_id"=>944771, "categories"=>["Mathematics", "Medicine", "Chemistry"], "users"=>["Chi-Lun Huang", "I-Hui Wu", "Yen-Wen Wu", "Juey-Jen Hwang", "Shoei-Shen Wang", "Wen-Jone Chen", "Wen-Jeng Lee", "Wei-Shiung Yang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090201.g002", "stats"=>{"downloads"=>2, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kaplan_Meier_survival_curves_for_amputation_and_all_cause_mortality_according_to_lower_extremity_arterial_calcium_scores_with_the_median_as_cutoff_value_in_patients_with_symptomatic_peripheral_artery_disease_/944771", "title"=>"Kaplan-Meier survival curves for amputation and all-cause mortality according to lower extremity arterial calcium scores with the median as cutoff value in patients with symptomatic peripheral artery disease.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-02-26 02:56:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1398747"], "description"=>"<p>Calcium score (CS) was logarithmically transformed before analysis.</p><p>AKCS: above-knee calcium score; BKCS: below-knee calcium score; IFCS: iliac-femoral calcium score; LDL-C: low-density lipoprotein cholesterol.</p>", "links"=>[], "tags"=>["Chemical reactions", "calcification", "statistics", "Biostatistics", "Statistical methods", "Anatomy and physiology", "Neurological system", "Peripheral nervous system", "cardiovascular", "Cardiovascular imaging", "Coronary artery disease", "Peripheral vascular diseases", "radiology", "Diagnostic radiology", "Computed tomography", "segmental", "calcium", "scores", "biochemical"], "article_id"=>944772, "categories"=>["Mathematics", "Medicine", "Chemistry"], "users"=>["Chi-Lun Huang", "I-Hui Wu", "Yen-Wen Wu", "Juey-Jen Hwang", "Shoei-Shen Wang", "Wen-Jone Chen", "Wen-Jeng Lee", "Wei-Shiung Yang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090201.t002", "stats"=>{"downloads"=>4, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_segmental_calcium_scores_CS_and_biochemical_parameters_/944772", "title"=>"Correlation between segmental calcium scores (CS) and biochemical parameters.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-26 02:56:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1398748"], "description"=>"<p>Adjusted for age, gender, diabetes, hypertension, smoking, total cholesterol and eGFR.</p><p>AKCS: above-knee calcium score; BKCS: below-knee calcium score; IFCS: iliac-femoral calcium score.</p>", "links"=>[], "tags"=>["Chemical reactions", "calcification", "statistics", "Biostatistics", "Statistical methods", "Anatomy and physiology", "Neurological system", "Peripheral nervous system", "cardiovascular", "Cardiovascular imaging", "Coronary artery disease", "Peripheral vascular diseases", "radiology", "Diagnostic radiology", "Computed tomography", "cox", "proportional", "hazards", "calcium", "scores", "extremity", "amputation", "all-cause"], "article_id"=>944773, "categories"=>["Mathematics", "Medicine", "Chemistry"], "users"=>["Chi-Lun Huang", "I-Hui Wu", "Yen-Wen Wu", "Juey-Jen Hwang", "Shoei-Shen Wang", "Wen-Jone Chen", "Wen-Jeng Lee", "Wei-Shiung Yang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090201.t003", "stats"=>{"downloads"=>6, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multivariate_Cox_proportional_hazards_analyses_of_calcium_scores_for_lower_extremity_amputation_and_all_cause_mortality_/944773", "title"=>"Multivariate Cox proportional hazards analyses of calcium scores for lower extremity amputation and all-cause mortality.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-26 02:56:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1398749"], "description"=>"<p>* Presented as median (25<sup>th</sup>, 75<sup>th</sup> percentile) and analyzed by Wilcoxon rank-sum test.</p><p>ACEi/ARB: angiotensin converting enzyme inhibitor/angiotensin II receptor blocker; BMI: body-mass index; CAD: coronary artery disease; CVA: cerebral vascular accident; ESRD: end-stage renal disease; LDL-C: low-density lipoprotein cholesterol.</p>", "links"=>[], "tags"=>["Chemical reactions", "calcification", "statistics", "Biostatistics", "Statistical methods", "Anatomy and physiology", "Neurological system", "Peripheral nervous system", "cardiovascular", "Cardiovascular imaging", "Coronary artery disease", "Peripheral vascular diseases", "radiology", "Diagnostic radiology", "Computed tomography"], "article_id"=>944774, "categories"=>["Mathematics", "Medicine", "Chemistry"], "users"=>["Chi-Lun Huang", "I-Hui Wu", "Yen-Wen Wu", "Juey-Jen Hwang", "Shoei-Shen Wang", "Wen-Jone Chen", "Wen-Jeng Lee", "Wei-Shiung Yang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090201.t001", "stats"=>{"downloads"=>5, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_study_population_/944774", "title"=>"Baseline characteristics of study population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-02-26 02:56:02"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[267]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[278]}, {"subject_area"=>"/Medicine and health sciences/Vascular medicine", "average_usage"=>[248]}]}
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