Widespread Nanoparticle-Assay Interference: Implications for Nanotoxicity Testing
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Widespread nanoparticle-assay interference: Implications for nanotoxicity testing", "type"=>"journal", "authors"=>[{"first_name"=>"Kimberly J.", "last_name"=>"Ong", "scopus_author_id"=>"55360202700"}, {"first_name"=>"Tyson J.", "last_name"=>"MacCormack", "scopus_author_id"=>"6603484087"}, {"first_name"=>"Rhett J.", "last_name"=>"Clark", "scopus_author_id"=>"36700994500"}, {"first_name"=>"James D.", "last_name"=>"Ede", "scopus_author_id"=>"35366314600"}, {"first_name"=>"Van A.", "last_name"=>"Ortega", "scopus_author_id"=>"56036322900"}, {"first_name"=>"Lindsey C.", "last_name"=>"Felix", "scopus_author_id"=>"55336234800"}, {"first_name"=>"Michael K M", "last_name"=>"Dang", "scopus_author_id"=>"36991947100"}, {"first_name"=>"Guibin", "last_name"=>"Ma", "scopus_author_id"=>"55587292600"}, {"first_name"=>"Hicham", "last_name"=>"Fenniri", "scopus_author_id"=>"6603806323"}, {"first_name"=>"Jonathan G C", "last_name"=>"Veinot", "scopus_author_id"=>"55389969200"}, {"first_name"=>"Greg G.", "last_name"=>"Goss", "scopus_author_id"=>"7007032058"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84897490257", "sgr"=>"84897490257", "pui"=>"372764235", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"24618833", "doi"=>"10.1371/journal.pone.0090650"}, "id"=>"61a7d1c2-d5b8-3e46-be8a-093e4fbdd0ea", "abstract"=>"The evaluation of engineered nanomaterial safety has been hindered by conflicting reports demonstrating differential degrees of toxicity with the same nanoparticles. The unique properties of these materials increase the likelihood that they will interfere with analytical techniques, which may contribute to this phenomenon. We tested the potential for: 1) nanoparticle intrinsic fluorescence/absorbance, 2) interactions between nanoparticles and assay components, and 3) the effects of adding both nanoparticles and analytes to an assay, to interfere with the accurate assessment of toxicity. Silicon, cadmium selenide, titanium dioxide, and helical rosette nanotubes each affected at least one of the six assays tested, resulting in either substantial over- or under-estimations of toxicity. Simulation of realistic assay conditions revealed that interference could not be predicted solely by interactions between nanoparticles and assay components. Moreover, the nature and degree of interference cannot be predicted solely based on our current understanding of nanomaterial behaviour. A literature survey indicated that ca. 95% of papers from 2010 using biochemical techniques to assess nanotoxicity did not account for potential interference of nanoparticles, and this number had not substantially improved in 2012. We provide guidance on avoiding and/or controlling for such interference to improve the accuracy of nanotoxicity assessments.", "link"=>"http://www.mendeley.com/research/widespread-nanoparticleassay-interference-implications-nanotoxicity-testing", "reader_count"=>129, "reader_count_by_academic_status"=>{"Unspecified"=>7, "Professor > Associate Professor"=>4, "Student > Doctoral Student"=>7, "Researcher"=>24, "Student > Ph. D. Student"=>34, "Student > Postgraduate"=>6, "Other"=>3, "Student > Master"=>19, "Student > Bachelor"=>18, "Lecturer"=>2, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>7, "Professor > Associate Professor"=>4, "Student > Doctoral Student"=>7, "Researcher"=>24, "Student > Ph. D. Student"=>34, "Student > Postgraduate"=>6, "Other"=>3, "Student > Master"=>19, "Student > Bachelor"=>18, "Lecturer"=>2, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>13, "Agricultural and Biological Sciences"=>39, "Chemistry"=>22, "Engineering"=>5, "Environmental Science"=>6, "Biochemistry, Genetics and Molecular Biology"=>18, "Nursing and Health Professions"=>1, "Materials Science"=>3, "Medicine and Dentistry"=>6, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>10, "Physics and Astronomy"=>3, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Physics and Astronomy"=>{"Physics and Astronomy"=>3}, "Unspecified"=>{"Unspecified"=>13}, "Environmental Science"=>{"Environmental Science"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>10}, "Engineering"=>{"Engineering"=>5}, "Chemistry"=>{"Chemistry"=>22}, "Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>39}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>18}}, "reader_count_by_country"=>{"Canada"=>1, "Sweden"=>1, "Austria"=>1, "United States"=>1, "Norway"=>1, "Brazil"=>1, "United Kingdom"=>1, "Mexico"=>1, "India"=>1}, "group_count"=>3}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84897490257"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84897490257?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897490257&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84897490257&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84897490257", "dc:identifier"=>"SCOPUS_ID:84897490257", "eid"=>"2-s2.0-84897490257", "dc:title"=>"Widespread nanoparticle-assay interference: Implications for nanotoxicity testing", "dc:creator"=>"Ong K.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-03-11", "prism:coverDisplayDate"=>"11 March 2014", "prism:doi"=>"10.1371/journal.pone.0090650", "citedby-count"=>"101", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Alberta", "affiliation-city"=>"Edmonton", "affiliation-country"=>"Canada"}], "pubmed-id"=>"24618833", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e90650", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0090650", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"68", "xml_views"=>"8", "html_views"=>"219"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"50", "xml_views"=>"4", "html_views"=>"179"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"51", "xml_views"=>"2", "html_views"=>"174"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"125"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"43", "xml_views"=>"0", "html_views"=>"150"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"34", "xml_views"=>"2", "html_views"=>"146"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"130"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"154"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"48", "xml_views"=>"3", "html_views"=>"138"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"115"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"86"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"100"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"111"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"107"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"29", "xml_views"=>"2", "html_views"=>"127"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"34", "xml_views"=>"1", "html_views"=>"149"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"48", "xml_views"=>"1", "html_views"=>"125"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"92"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"82"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"3", "html_views"=>"101"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"110"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"95"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"3", "html_views"=>"74"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"3", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"36"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"4", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"25"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1415372"], "description"=>"<p>(A) Absorbance of nanoparticles; (B) Fluorescence (RFU) of nanoparticles (excitation, 531 nm).</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Small molecules", "biotechnology", "Bionanotechnology", "toxicology", "Toxic agents", "Mechanical engineering", "Nanoengineering", "Material by attribute", "Nanomaterials", "nanotechnology", "optical"], "article_id"=>958196, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Kimberly J. Ong", "Tyson J. MacCormack", "Rhett J. Clark", "James D. Ede", "Van A. Ortega", "Lindsey C. Felix", "Michael K. M. Dang", "Guibin Ma", "Hicham Fenniri", "Jonathan G. C. Veinot", "Greg G. Goss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090650.g002", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spectroscopic_measurement_of_optical_characteristics_of_nanoparticles_/958196", "title"=>"Spectroscopic measurement of optical characteristics of nanoparticles.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-11 03:18:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1415377"], "description"=>"a<p>Hydrodynamic diameter as measured by DLS and reported as mean±standard error.</p>b<p>Zeta potential as measured by Zetasizer and reported as mean±standard error.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Small molecules", "biotechnology", "Bionanotechnology", "toxicology", "Toxic agents", "Mechanical engineering", "Nanoengineering", "Material by attribute", "Nanomaterials", "nanotechnology", "characterization"], "article_id"=>958201, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Kimberly J. Ong", "Tyson J. MacCormack", "Rhett J. Clark", "James D. Ede", "Van A. Ortega", "Lindsey C. Felix", "Michael K. M. Dang", "Guibin Ma", "Hicham Fenniri", "Jonathan G. C. Veinot", "Greg G. Goss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090650.t001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Physicochemical_characterization_of_nanoparticles_/958201", "title"=>"Physicochemical characterization of nanoparticles.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-11 03:18:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1415375"], "description"=>"<p>(A) BCA protein assay with 250 µg/mL BSA addition; (B) Bradford protein assay with 40 µg/mL BSA addition; (C) LDH assay with 12.5×10<sup>6</sup> lysed cells; (D) Catalase assay with 250 U/mL catalase addition (excitation 531 nm, emission 595 nm); (E) Catalase assay with 250 U/mL catalase addition (absorbance 560 nm). * indicates significantly different than control (p<0.05, ANOVA followed by Dunnett's post-hoc comparison).</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Small molecules", "biotechnology", "Bionanotechnology", "toxicology", "Toxic agents", "Mechanical engineering", "Nanoengineering", "Material by attribute", "Nanomaterials", "nanotechnology", "nanoparticle", "interference", "assays"], "article_id"=>958199, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Kimberly J. Ong", "Tyson J. MacCormack", "Rhett J. Clark", "James D. Ede", "Van A. Ortega", "Lindsey C. Felix", "Michael K. M. Dang", "Guibin Ma", "Hicham Fenniri", "Jonathan G. C. Veinot", "Greg G. Goss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090650.g004", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Assessment_of_nanoparticle_interference_with_the_assays_components_with_addition_of_analyte_/958199", "title"=>"Assessment of nanoparticle interference with the assays components, with addition of analyte.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-11 03:18:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1415376"], "description"=>"<p>(A) Percentage of published papers that use a toxicity assay based on measurement of colorimetric or fluorescent change in either 2010 or 2012; (B) Breakdown of controls performed in papers using one of these assays. (note: Percentages do not add up to 100% due to overlap in papers performing more than one control).</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Small molecules", "biotechnology", "Bionanotechnology", "toxicology", "Toxic agents", "Mechanical engineering", "Nanoengineering", "Material by attribute", "Nanomaterials", "nanotechnology", "papers", "nanoparticle", "interference", "spectroscopic-based"], "article_id"=>958200, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Kimberly J. Ong", "Tyson J. MacCormack", "Rhett J. Clark", "James D. Ede", "Van A. Ortega", "Lindsey C. Felix", "Michael K. M. Dang", "Guibin Ma", "Hicham Fenniri", "Jonathan G. C. Veinot", "Greg G. Goss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090650.g005", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Literature_survey_to_determine_the_percentage_of_papers_testing_for_nanoparticle_interference_in_spectroscopic_based_assays_/958200", "title"=>"Literature survey to determine the percentage of papers testing for nanoparticle interference in spectroscopic-based assays.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-11 03:18:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1415374"], "description"=>"<p>(A) BCA (bicinchoninic) protein assay; (B) Bradford protein assay, (C) MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay; (D) Alamar blue assay (excitation 531 nm, emission 595 nm); (E) Amplex red catalase assay (excitation 531 nm, emission 595 nm); (F) Amplex red catalase assay (emission 560 nm). * indicates significantly different than control (p<0.05, ANOVA followed by Dunnett's post-hoc comparison).</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Small molecules", "biotechnology", "Bionanotechnology", "toxicology", "Toxic agents", "Mechanical engineering", "Nanoengineering", "Material by attribute", "Nanomaterials", "nanotechnology", "nanoparticle", "interference", "assay"], "article_id"=>958198, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Kimberly J. Ong", "Tyson J. MacCormack", "Rhett J. Clark", "James D. Ede", "Van A. Ortega", "Lindsey C. Felix", "Michael K. M. Dang", "Guibin Ma", "Hicham Fenniri", "Jonathan G. C. Veinot", "Greg G. Goss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090650.g003", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Assessment_of_nanoparticle_interference_with_the_assay_components_without_analyte_/958198", "title"=>"Assessment of nanoparticle interference with the assay components, without analyte.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-11 03:18:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1415371"], "description"=>"<p>(A) High-resolution TEM of silicon nanoparticles functionalized with undecylenic acid, arrow points to Si crystalline structure; (B) Cadmium selenide nanoparticles functionalized with undecylenic acid; (C) Titanium dioxide nanoparticles functionalized with polyacrylic acid; (D) Zinc oxide nanoparticles functionalized with polyacrylic acid; (E) Helical rosette nanotubes functionalized with lysine.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Small molecules", "biotechnology", "Bionanotechnology", "toxicology", "Toxic agents", "Mechanical engineering", "Nanoengineering", "Material by attribute", "Nanomaterials", "nanotechnology", "electron", "micrographs", "nanoparticles", "nanoparticle", "cores"], "article_id"=>958195, "categories"=>["Biological Sciences", "Medicine", "Engineering"], "users"=>["Kimberly J. Ong", "Tyson J. MacCormack", "Rhett J. Clark", "James D. Ede", "Van A. Ortega", "Lindsey C. Felix", "Michael K. M. Dang", "Guibin Ma", "Hicham Fenniri", "Jonathan G. C. Veinot", "Greg G. Goss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0090650.g001", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Transmission_Electron_Micrographs_TEM_of_nanoparticles_show_that_nanoparticle_cores_range_from_3_8211_9_nm_/958195", "title"=>"Transmission Electron Micrographs (TEM) of nanoparticles show that nanoparticle cores range from 3–9 nm.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-11 03:18:38"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"31", "full-text"=>"35", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"31", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"46", "full-text"=>"46", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"41", "full-text"=>"44", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"51", "full-text"=>"58", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"49", "full-text"=>"55", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"33", "full-text"=>"43", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"47", "full-text"=>"48", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"36", "full-text"=>"38", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"56", "full-text"=>"67", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"58", "full-text"=>"59", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"64", "full-text"=>"79", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"34", "full-text"=>"38", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"43", "full-text"=>"45", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"47", "full-text"=>"78", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"43", "full-text"=>"46", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"59", "full-text"=>"86", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"52", "full-text"=>"58", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"41", "full-text"=>"47", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"51", "full-text"=>"64", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"61", "full-text"=>"63", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"61", "full-text"=>"67", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"31", "full-text"=>"31", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"25", "full-text"=>"34", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"41", "full-text"=>"55", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"32", "full-text"=>"33", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"37", "full-text"=>"51", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"34", "full-text"=>"37", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"44", "full-text"=>"51", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"43", "full-text"=>"50", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"34", "full-text"=>"37", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"41", "full-text"=>"50", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"53", "full-text"=>"59", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"33", "full-text"=>"72", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"28", "full-text"=>"29", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"47", "full-text"=>"50", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"34", "full-text"=>"40", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"49", "full-text"=>"61", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"38", "full-text"=>"36", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"36", "full-text"=>"41", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"31", "full-text"=>"32", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"25", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"32", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"32", "full-text"=>"34", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"24", "full-text"=>"31", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"31", "full-text"=>"36", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"49", "full-text"=>"69", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"31", "full-text"=>"43", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"41", "full-text"=>"55", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Toxicology", "average_usage"=>[266, 408]}, {"subject_area"=>"/Engineering and technology", "average_usage"=>[282]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[287]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[271]}]}
Loading … Spinner
There are currently no alerts