CD4 Counts and Viral Loads of Newly Diagnosed HIV-Infected Individuals: Implications for Treatment as Prevention
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{"title"=>"CD4 Counts and viral loads of newly diagnosed HIV-infected individuals: Implications for treatment as prevention", "type"=>"journal", "authors"=>[{"first_name"=>"Sarishen", "last_name"=>"Govender", "scopus_author_id"=>"56088146000"}, {"first_name"=>"Kennedy", "last_name"=>"Otwombe", "scopus_author_id"=>"8923896500"}, {"first_name"=>"Thandekile", "last_name"=>"Essien", "scopus_author_id"=>"54392210000"}, {"first_name"=>"Ravindre", "last_name"=>"Panchia", "scopus_author_id"=>"6505631165"}, {"first_name"=>"Guy", "last_name"=>"De Bruyn", "scopus_author_id"=>"56032009200"}, {"first_name"=>"Lerato", "last_name"=>"Mohapi", "scopus_author_id"=>"24734526800"}, {"first_name"=>"Glenda", "last_name"=>"Gray", "scopus_author_id"=>"7401812026"}, {"first_name"=>"Neil", "last_name"=>"Martinson", "scopus_author_id"=>"13907655800"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"372716724", "sgr"=>"84897032505", "pmid"=>"24595317", "scopus"=>"2-s2.0-84897032505", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0090754", "issn"=>"19326203"}, "id"=>"9ee787bd-cdc9-3aec-876a-199f4e8752f5", "abstract"=>"OBJECTIVE: To report the viral load and CD4 count in HIV-infected, antiretroviral naïve, first -time HIV-testers, not immediately eligible for treatment initiation by current South Africa treatment guidelines.\\n\\nDESIGN: This was a cross-sectional study in a high-volume, free-of-charge HIV testing centre in Soweto, South Africa.\\n\\nMETHODS: We enrolled first time HIV testers and collected demographic and risk-behaviour data and measured CD4 count and viral load.\\n\\nRESULTS: Between March and October 2011, a total of 4793 adults attended VCT and 1062 (22%) tested positive. Of the 1062, 799 (75%) were ART naïve and 348/799 (44%) were first-time HIV testers. Of this group of 348, 225 (65%) were female. Overall their median age, CD4 count and viral load was 34 years (IQR: 28-41), 364 (IQR: 238-542) cells/mm3 and 13,000 (IQR: 2050-98171) copies/ml, respectively. Female first time HIV testers had higher CD4 counts (419 IQR: 262-582 vs. 303 IQR: 199-418 cells/mm3) and lower viral loads (9,100 vs. 34,000 copies/ml) compared to males. Of 183 participants with CD4 count >350 cells/mm3, 62 (34%) had viral loads > 10,000 copies/ml.\\n\\nCONCLUSIONS: A large proportion of HIV infected adults not qualifying for immediate ART at the CD4 count threshold of 350 cells/mm3 have high viral loads. HIV-infected men at their first HIV diagnosis are more likely to have lower CD4 counts and higher viral loads than women.", "link"=>"http://www.mendeley.com/research/cd4-counts-viral-loads-newly-diagnosed-hivinfected-individuals-implications-treatment-prevention-3", "reader_count"=>35, "reader_count_by_academic_status"=>{"Researcher"=>11, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>8, "Student > Bachelor"=>5, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>11, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>8, "Student > Bachelor"=>5, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Mathematics"=>1, "Medicine and Dentistry"=>18, "Agricultural and Biological Sciences"=>5, "Social Sciences"=>4, "Computer Science"=>3, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>18}, "Social Sciences"=>{"Social Sciences"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Computer Science"=>{"Computer Science"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Mathematics"=>{"Mathematics"=>1}}, "reader_count_by_country"=>{"Kenya"=>1, "Switzerland"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

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