Wnt Signaling in Form Deprivation Myopia of the Mice Retina
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{"title"=>"Wnt signaling in form deprivation myopia of the mice retina", "type"=>"journal", "authors"=>[{"first_name"=>"Mingming", "last_name"=>"Ma", "scopus_author_id"=>"36616482300"}, {"first_name"=>"Zhengwei", "last_name"=>"Zhang", "scopus_author_id"=>"55721756600"}, {"first_name"=>"Ergang", "last_name"=>"Du", "scopus_author_id"=>"55841351400"}, {"first_name"=>"Wenjing", "last_name"=>"Zheng", "scopus_author_id"=>"52365510000"}, {"first_name"=>"Qing", "last_name"=>"Gu", "scopus_author_id"=>"27167667200"}, {"first_name"=>"Xun", "last_name"=>"Xu", "scopus_author_id"=>"8615095400"}, {"first_name"=>"Bilian", "last_name"=>"Ke", "scopus_author_id"=>"56256766900"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84899727212", "sgr"=>"84899727212", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0091086", "pmid"=>"24755605", "pui"=>"373006309"}, "id"=>"7d024978-1249-3e33-b495-fcb8364c1709", "abstract"=>"BACKGROUND: The canonical Wnt signaling pathway plays important roles in cellular proliferation and differentiation, axonal outgrowth, cellular maintenance in retinas. Here we test the hypothesis that elements of the Wnt signaling pathway are involved in the regulation of eye growth and prevention of myopia, in the mouse form-deprivation myopia model.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: (1) One hundred twenty-five C57BL/6 mice were randomly distributed into form-deprivation myopia and control groups. Form-deprivation myopia (FDM) was induced by suturing the right eyelid, while the control group received no treatment. After 1, 2, and 4 weeks of treatment, eyes were assessed in vivo by cycloplegic retinoscopic refraction and axial length measurement by photography or A-scan ultrasonography. Levels of retinal Wnt2b, Fzd5 and β-catenin mRNA and protein were evaluated using RT-PCR and western blotting, respectively. (2) Another 96 mice were divided into three groups: control, drugs-only, and drugs+FDM (by diffuser). Experimentally treated eyes in the last two groups received intravitreal injections of vehicle or the proteins, DKK-1 (Wnt-pathway antagonist) or Norrin (Wnt-pathway agonist), once every three days, for 4 injections total. Axial length and retinoscopic refraction were measured on the 14th day of form deprivation. Following form-deprivation for 1, 2, and 4 weeks, FDM eyes had a relatively myopic refractive error, compared with contralateral eyes. There were no significant differences in refractive error between right and left eye in control group. The amounts of Wnt2b, Fzd5 and β-catenin mRNA and protein were significantly greater in form-deprived myopia eyes than in control eyes.DKK-1 (antagonist) reduced the myopic shift in refractive error and increase in axial elongation, whereas Norrin had the opposite effect in FDM eyes.\\n\\nCONCLUSIONS/SIGNIFICANCE: Our studies provide the first evidence that the Wnt2b signaling pathway may play a role in the development and progression of form-deprivation myopia, in a mammalian model.", "link"=>"http://www.mendeley.com/research/wnt-signaling-form-deprivation-myopia-mice-retina", "reader_count"=>8, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1551784"], "description"=>"<p>Intravitreal drug administration began on the second day of occlusion and was repeated every three days for a total of four times (2nd, 5th, 8th and 11th days of FD). A total of 3 µl of DKK-1 (10 ng/µl) or Norrin (5 ng/µl) was injected into the vitreous chamber each time. Refraction and axial length were measured 3 days after the last injection. There were no differences, neither between no-manipulation (“no-manip” in the figure) and sham-injection (“sham-inj” in the figure), nor between these and injection with vehicle in the drugs-only group. DKK-1 significantly reduced the time-dependent increases in axial length, and significantly increased refractions (made them more positive or hyperopic), while Norrin had the opposite effect. Six mice were used in each group. Data are presented as mean±SEM.(* <i>P</i><0.05 and ** <i>P</i><0.01).</p>", "links"=>[], "tags"=>["ophthalmology", "Geriatric ophthalmology", "Retinal disorders"], "article_id"=>1071981, "categories"=>["Biological Sciences"], "users"=>["Mingming Ma", "Zhengwei Zhang", "Ergang Du", "Wenjing Zheng", "Qing Gu", "Xun Xu", "Bilian Ke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091086.g005", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_pathway_is_involved_in_the_development_of_FDM_/1071981", "title"=>"pathway is involved in the development of FDM.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-22 09:29:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1551780"], "description"=>"<p>(A) Wnt2b protein content in the FDM group was significantly greater than that in the control group, at 1, 2 and 4 weeks. (B) Fzd5 protein content in the FDM group was significantly greater than that in the control group, at 2 and 4 weeks. (C) Nuclear <i>β</i>-catenin protein content was significantly higher in the FDM group than in the control group at 1, 2 and 4 weeks. Significant differences between FDM eyes and contralateral eyes also were found at 4 weeks, and content was significantly higher in the contralateral eye group than in the control group at 1 and 4 weeks. Retinas from both eyes of fourteen FDM mice and 9 control mice were used for each treatment duration. Data are presented as mean±SEM. (* <i>P</i><0.05 and ** <i>P</i><0.01).</p>", "links"=>[], "tags"=>["ophthalmology", "Geriatric ophthalmology", "Retinal disorders", "deprivation", "retinal", "fzd5"], "article_id"=>1071976, "categories"=>["Biological Sciences"], "users"=>["Mingming Ma", "Zhengwei Zhang", "Ergang Du", "Wenjing Zheng", "Qing Gu", "Xun Xu", "Bilian Ke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091086.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Form_deprivation_increased_the_retinal_content_of_Wnt2b_Fzd5_and_946_catenin_proteins_/1071976", "title"=>"Form deprivation increased the retinal content of Wnt2b, Fzd5 and β-catenin proteins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-22 09:29:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1551778"], "description"=>"<p>Wnt2b mRNA was greater in the FDM than in the control group, after 1, 2 and 4 weeks of treatment; Fzd5 mRNA also was significantly greater in FDM than control, but only after 2 and 4 weeks of treatment, and <i>β</i>-catenin mRNA was greater in the FDM group than controls, but only after 1 and 4 weeks. Differences were also significant between FDM eyes and contralateral eyes at 1 and 4 weeks, and between contralateral and control eyes at 4 weeks. The expression level at week 0 was defined as 1, and the values were normalized to those of <i>β</i>-catenin mRNA levels. Retinas from both eyes of ten FDM mice and 6 control mice were used for each treatment duration. Data are presented as mean±SEM.(*<i>P</i><0.05).</p>", "links"=>[], "tags"=>["ophthalmology", "Geriatric ophthalmology", "Retinal disorders", "fzd5", "mrna", "retinas"], "article_id"=>1071974, "categories"=>["Biological Sciences"], "users"=>["Mingming Ma", "Zhengwei Zhang", "Ergang Du", "Wenjing Zheng", "Qing Gu", "Xun Xu", "Bilian Ke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091086.g003", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_Wnt2b_FZD5_and_946_catenin_mRNA_in_mouse_retinas_as_a_function_of_treatment_duration_/1071974", "title"=>"Expression of Wnt2b, FZD5 and <i>β</i>-catenin mRNA in mouse retinas as a function of treatment duration.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-22 09:29:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1551774"], "description"=>"<p>The expression level of the 3-week mice was defined as 1, and the values were normalized to those of <i>β</i>-catenin mRNA levels. Retinas from both eyes of 9 mice were used at each age. Data are presented as mean±SEM. (*<i>P</i><0.05 and **<i>P</i><0.01).</p>", "links"=>[], "tags"=>["ophthalmology", "Geriatric ophthalmology", "Retinal disorders", "trends", "retinal", "fzd5", "mrna", "weeks"], "article_id"=>1071971, "categories"=>["Biological Sciences"], "users"=>["Mingming Ma", "Zhengwei Zhang", "Ergang Du", "Wenjing Zheng", "Qing Gu", "Xun Xu", "Bilian Ke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091086.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Natural_trends_of_retinal_Wnt2b_Fzd5_and_946_catenin_mRNA_expression_within_7_weeks_after_birth_in_normal_mice_/1071971", "title"=>"Natural trends of retinal Wnt2b, Fzd5 and <i>β</i>-catenin mRNA expression within 7 weeks after birth in normal mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-22 09:29:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1551789"], "description"=>"<p>Data are presented as mean±SD.</p>", "links"=>[], "tags"=>["ophthalmology", "Geriatric ophthalmology", "Retinal disorders", "dkk-1", "norrin", "refraction", "axial"], "article_id"=>1071985, "categories"=>["Biological Sciences"], "users"=>["Mingming Ma", "Zhengwei Zhang", "Ergang Du", "Wenjing Zheng", "Qing Gu", "Xun Xu", "Bilian Ke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091086.t003", "stats"=>{"downloads"=>5, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_DKK_1_or_Norrin_on_the_Refraction_and_Axial_Length_/1071985", "title"=>"Effect of DKK-1 or Norrin on the Refraction and Axial Length.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-22 09:29:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1551787"], "description"=>"<p>FDM: form-deprivation myopia.</p><p>Data are presented as mean±SD.</p><p>Axial length was measured by A-scan.</p>", "links"=>[], "tags"=>["ophthalmology", "Geriatric ophthalmology", "Retinal disorders", "axial", "lengths", "fdm"], "article_id"=>1071983, "categories"=>["Biological Sciences"], "users"=>["Mingming Ma", "Zhengwei Zhang", "Ergang Du", "Wenjing Zheng", "Qing Gu", "Xun Xu", "Bilian Ke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091086.t002", "stats"=>{"downloads"=>3, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Refractions_and_Axial_Lengths_of_FDM_and_Control_Eyes_/1071983", "title"=>"Refractions and Axial Lengths of FDM and Control Eyes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-22 09:29:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1551786"], "description"=>"<p>*Sham-injection: needle penetration and withdrawal, without injection.</p>", "links"=>[], "tags"=>["ophthalmology", "Geriatric ophthalmology", "Retinal disorders", "exclusion", "mice", "injected", "dkk-1"], "article_id"=>1071982, "categories"=>["Biological Sciences"], "users"=>["Mingming Ma", "Zhengwei Zhang", "Ergang Du", "Wenjing Zheng", "Qing Gu", "Xun Xu", "Bilian Ke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091086.t001", "stats"=>{"downloads"=>4, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Grouping_and_Exclusion_of_Mice_Injected_With_DKK_1_or_Norrin_/1071982", "title"=>"Grouping and Exclusion of Mice Injected With DKK-1 or Norrin.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-22 09:29:46"}
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PMC Usage Stats | Further Information

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Relative Metric

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