Acupuncture Modulates Resting State Hippocampal Functional Connectivity in Alzheimer Disease
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{"title"=>"Acupuncture modulates resting state hippocampal functional connectivity in Alzheimer disease", "type"=>"journal", "authors"=>[{"first_name"=>"Zhiqun", "last_name"=>"Wang", "scopus_author_id"=>"55938817500"}, {"first_name"=>"Peipeng", "last_name"=>"Liang", "scopus_author_id"=>"23467234500"}, {"first_name"=>"Zhilian", "last_name"=>"Zhao", "scopus_author_id"=>"36967660500"}, {"first_name"=>"Ying", "last_name"=>"Han", "scopus_author_id"=>"55369279900"}, {"first_name"=>"Haiqing", "last_name"=>"Song", "scopus_author_id"=>"36187456200"}, {"first_name"=>"Jianyang", "last_name"=>"Xu", "scopus_author_id"=>"8502625300"}, {"first_name"=>"Jie", "last_name"=>"Lu", "scopus_author_id"=>"25623527600"}, {"first_name"=>"Kuncheng", "last_name"=>"Li", "scopus_author_id"=>"36066893600"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24603951", "doi"=>"10.1371/journal.pone.0091160", "sgr"=>"84897391831", "isbn"=>"1011070522100", "scopus"=>"2-s2.0-84897391831", "issn"=>"19326203", "pui"=>"372731126"}, "id"=>"1784fe96-86dd-3469-97ed-2da4cec0580e", "abstract"=>"Our objective is to clarify the effects of acupuncture on hippocampal connectivity in patients with Alzheimer disease (AD) using functional magnetic resonance imaging (fMRI). Twenty-eight right-handed subjects (14 AD patients and 14 healthy elders) participated in this study. Clinical and neuropsychological examinations were performed on all subjects. MRI was performed using a SIEMENS verio 3-Tesla scanner. The fMRI study used a single block experimental design. We first acquired baseline resting state data during the initial 3 minutes and then performed acupuncture stimulation on the Tai chong and He gu acupoints for 3 minutes. Last, we acquired fMRI data for another 10 minutes after the needle was withdrawn. The preprocessing and data analysis were performed using statistical parametric mapping (SPM5) software. Two-sample t-tests were performed using data from the two groups in different states. We found that during the resting state, several frontal and temporal regions showed decreased hippocampal connectivity in AD patients relative to control subjects. During the resting state following acupuncture, AD patients showed increased connectivity in most of these hippocampus related regions compared to the first resting state. In conclusion, we investigated the effect of acupuncture on AD patients by combing fMRI and traditional acupuncture. Our fMRI study confirmed that acupuncture at Tai chong and He gu can enhance the hippocampal connectivity in AD patients.", "link"=>"http://www.mendeley.com/research/acupuncture-modulates-resting-state-hippocampal-functional-connectivity-alzheimer-disease", "reader_count"=>39, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Researcher"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>3, "Student > Bachelor"=>5, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Researcher"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>3, "Student > Bachelor"=>5, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Agricultural and Biological Sciences"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Computer Science"=>1, "Economics, Econometrics and Finance"=>1, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>13, "Neuroscience"=>6, "Sports and Recreations"=>1, "Psychology"=>6, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Social Sciences"=>{"Social Sciences"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>6}, "Unspecified"=>{"Unspecified"=>2}, "Engineering"=>{"Engineering"=>2}, "Neuroscience"=>{"Neuroscience"=>6}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>2, "Italy"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1410099"], "description"=>"<p>The acupuncture induced increased functional connectivity for the AD patients (t = 1.61, p = 0.056). There was no significant difference for healthy controls (t = 0.403,p = 0.345).</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "connectivity", "hippocampus", "itg", "pre", "acupuncture", "patients"], "article_id"=>953997, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.g005", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_connectivity_of_right_hippocampus_and_right_ITG_between_pre_and_post_acupuncture_among_AD_patients_and_controls_/953997", "title"=>"Comparison of connectivity of right hippocampus and right ITG between pre and post acupuncture among AD patients and controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410113"], "description"=>"<p>MMSE, Mini-Mental State Examination; Plus-minus values are means ± S.D. AVLT, Auditory verbal learning test; immediate, immediate recall of learning verbal; delayed; delayed recall of learning verbal; recognition, recognition of learning verbal; CDR, clinical dementia rate. *The <i>P</i> values were obtained by one-way analysis of variance tests.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "patients"], "article_id"=>954011, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.t001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_AD_patients_and_Normal_controls_/954011", "title"=>"Characteristics of the AD patients and Normal controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410095"], "description"=>"<p>Left in picture is left in the brain. The color scale represents t values. Warm color represents decreased connectivity.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "regions", "connectivity", "hippocampus", "comparing"], "article_id"=>953993, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.g002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Brain_regions_showing_decreased_connectivity_to_left_hippocampus_in_AD_group_comparing_to_control_group_/953993", "title"=>"Brain regions showing decreased connectivity to left hippocampus in AD group comparing to control group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410112"], "description"=>"<p><i>P</i><0.01, uncorrected, extent threshold = 10. BA Broadman area. MNI, Montreal Neurological Institute; x, y, z, coordinates of primary peak locations in the MNI space. T value represents differences of hippocampal connectivity in AD and normal controls. MPFC, medial prefrontal cortex; MTG, middle temporal gyrus; ITG, inferior temporal gyrus; STG, superior temporal gyrus.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "hippocampal", "connectivity", "subjects", "resting"], "article_id"=>954010, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.t002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regions_showing_decreased_and_increased_hippocampal_connectivity_in_AD_subjects_during_resting_state_/954010", "title"=>"Regions showing decreased and increased hippocampal connectivity in AD subjects during resting state.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410093"], "description"=>"<p>The left acupoint represent Taichong, which is located in the dorsal foot, the first and second metatarsal cavity before integration. The right acupoint represent Hegu, which is located in the dorsal hand, between the first and second metacarpal and the midpoint of the second metacarpal radial side.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "acupoints"], "article_id"=>953991, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Location_of_acupoints_used_in_the_experiment_/953991", "title"=>"Location of acupoints used in the experiment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410107"], "description"=>"<p>The thalamus showed increased connectivity while the MPFC showed decreased connectivity to left hippocampus in controls after acupuncture. Left in picture is left in the brain. The color scale represents t values.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "regions", "altered", "connectivity", "hippocampus", "acupuncture", "comparing"], "article_id"=>954005, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.g008", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Brain_regions_showing_altered_connectivity_to_left_hippocampus_in_control_group_after_acupuncture_comparing_to_before_acupuncture_/954005", "title"=>"Brain regions showing altered connectivity to left hippocampus in control group after acupuncture comparing to before acupuncture.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410101"], "description"=>"<p>The right MFG showed increased connectivity to left hippocampus in AD patients after acupuncture. Left in picture is left in the brain. The color scale represents t values.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "regions", "altered", "connectivity", "hippocampus", "acupuncture", "comparing"], "article_id"=>953999, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.g007", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Brain_regions_showing_altered_connectivity_to_left_or_right_hippocampus_in_AD_group_after_acupuncture_comparing_to_before_acupuncture_/953999", "title"=>"Brain regions showing altered connectivity to left or right hippocampus in AD group after acupuncture comparing to before acupuncture.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410115"], "description"=>"<div><p>Our objective is to clarify the effects of acupuncture on hippocampal connectivity in patients with Alzheimer disease (AD) using functional magnetic resonance imaging (fMRI). Twenty-eight right-handed subjects (14 AD patients and 14 healthy elders) participated in this study. Clinical and neuropsychological examinations were performed on all subjects. MRI was performed using a SIEMENS verio 3-Tesla scanner. The fMRI study used a single block experimental design. We first acquired baseline resting state data during the initial 3 minutes and then performed acupuncture stimulation on the Tai chong and He gu acupoints for 3 minutes. Last, we acquired fMRI data for another 10 minutes after the needle was withdrawn. The preprocessing and data analysis were performed using statistical parametric mapping (SPM5) software. Two-sample t-tests were performed using data from the two groups in different states. We found that during the resting state, several frontal and temporal regions showed decreased hippocampal connectivity in AD patients relative to control subjects. During the resting state following acupuncture, AD patients showed increased connectivity in most of these hippocampus related regions compared to the first resting state. In conclusion, we investigated the effect of acupuncture on AD patients by combing fMRI and traditional acupuncture. Our fMRI study confirmed that acupuncture at Tai chong and He gu can enhance the hippocampal connectivity in AD patients.</p></div>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "modulates", "resting", "hippocampal", "connectivity", "alzheimer"], "article_id"=>954013, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Acupuncture_Modulates_Resting_State_Hippocampal_Functional_Connectivity_in_Alzheimer_Disease_/954013", "title"=>"Acupuncture Modulates Resting State Hippocampal Functional Connectivity in Alzheimer Disease", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410100"], "description"=>"<p>The acupuncture induced increased functional connectivity for the AD patients (t = 1.458, p = 0.08). There was no significant difference for healthy controls (t = 0.675, p = 0.254).</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "connectivity", "hippocampus", "stg", "pre", "acupuncture", "patients"], "article_id"=>953998, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.g006", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_connectivity_of_right_hippocampus_and_right_STG_between_pre_and_post_acupuncture_among_AD_patients_and_controls_/953998", "title"=>"Comparison of connectivity of right hippocampus and right STG between pre and post acupuncture among AD patients and controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410097"], "description"=>"<p>There is a significant decreased connectivity following acupuncture for healthy controls (t = 1.942, p = 0.033). However, the AD patients showed negative connectivity after acupuncture, the different is not significant for the AD patients (t = 0.774, p = 0.225),</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "connectivity", "hippocampus-right", "mpfc", "pre", "acupuncture", "patients"], "article_id"=>953995, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.g004", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_connectivity_of_left_hippocampus_right_MPFC_between_pre_and_post_acupuncture_among_AD_patients_and_controls_/953995", "title"=>"Comparison of connectivity of left hippocampus-right MPFC between pre and post acupuncture among AD patients and controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410114"], "description"=>"<p><i>P</i><0.01 uncorrected, extent threshold = 20. BA, Broadman area. MNI, Montreal Neurological Institute; x, y, z, coordinates of primary peak locations in the MNI space. T value represents differences of hippocampal connectivity in normal controls between post-acupuncture and pre-acupuncture. MPFC, medial prefrontal cortex; MFG, middle frontal gyrus.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "hippocampal", "connectivity", "controls", "acupuncture", "comparing"], "article_id"=>954012, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.t004", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regions_showing_decreased_and_increased_hippocampal_connectivity_in_normal_controls_after_acupuncture_comparing_to_before_acupuncture_/954012", "title"=>"Regions showing decreased and increased hippocampal connectivity in normal controls after acupuncture comparing to before acupuncture.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410111"], "description"=>"<p><i>P</i><0.01 uncorrected, extent threshold = 20. BA, Broadman area. MNI, Montreal Neurological Institute; x, y, z, coordinates of primary peak locations in the MNI space. T value represents differences of hippocampal connectivity in AD and normal controls. MFG, middle frontal gyrus.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "hippocampal", "connectivity", "subjects", "acupuncture", "comparing"], "article_id"=>954009, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.t003", "stats"=>{"downloads"=>3, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regions_showing_decreased_and_increased_hippocampal_connectivity_in_AD_subjects_after_acupuncture_comparing_to_before_acupuncture_/954009", "title"=>"Regions showing decreased and increased hippocampal connectivity in AD subjects after acupuncture comparing to before acupuncture.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410096"], "description"=>"<p>Left in picture is left in the brain. The color scale represents t values. Warm color represents decreased connectivity.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "regions", "connectivity", "hippocampus", "comparing"], "article_id"=>953994, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.g003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Brain_regions_showing_decreased_connectivity_to_right_hippocampus_in_AD_group_comparing_to_control_group_/953994", "title"=>"Brain regions showing decreased connectivity to right hippocampus in AD group comparing to control group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410110"], "description"=>"<p>The left thalamus, MFG and insula showed increased connectivity to right hippocampus in controls after acupuncture. Left in picture is left in the brain. The color scale represents t values.</p>", "links"=>[], "tags"=>["neuroscience", "neuroimaging", "fmri", "Complementary and alternative medicine", "Diagnostic medicine", "pathology", "anatomical pathology", "neuropathology", "neurology", "dementia", "Alzheimer disease", "Neurodegenerative diseases", "regions", "altered", "connectivity", "hippocampus", "acupuncture", "comparing"], "article_id"=>954008, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Zhiqun Wang", "Peipeng Liang", "Zhilian Zhao", "Ying Han", "Haiqing Song", "Jianyang Xu", "Jie Lu", "Kuncheng Li"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091160.g009", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Brain_regions_showing_altered_connectivity_to_right_hippocampus_in_control_group_after_acupuncture_comparing_to_before_acupuncture_/954008", "title"=>"Brain regions showing altered connectivity to right hippocampus in control group after acupuncture comparing to before acupuncture.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:42:58"}

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Relative Metric

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