Increased Mortality in Groups of Cattle Administered the β-Adrenergic Agonists Ractopamine Hydrochloride and Zilpaterol Hydrochloride
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{"title"=>"Increased mortality in groups of cattle administered the β-adrenergic agonists ractopamine hydrochloride and zilpaterol hydrochloride", "type"=>"journal", "authors"=>[{"first_name"=>"Guy H.", "last_name"=>"Loneragan", "scopus_author_id"=>"6603755266"}, {"first_name"=>"Daniel U.", "last_name"=>"Thomson", "scopus_author_id"=>"7202586676"}, {"first_name"=>"H. Morgan", "last_name"=>"Scott", "scopus_author_id"=>"7402297769"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24621596", "sgr"=>"84898017008", "doi"=>"10.1371/journal.pone.0091177", "scopus"=>"2-s2.0-84898017008", "pui"=>"372799594", "issn"=>"19326203"}, "id"=>"21cac45a-4828-3d6f-b67c-76607ae3c1a1", "abstract"=>"<p>The United States Food and Drug Administration (FDA) approved two β-adrenergic agonists (βAA) for in-feed administration to cattle fed in confinement for human consumption. Anecdotal reports have generated concern that administration of βAA might be associated with an increased incidence of cattle deaths. Our objectives, therefore, were to a) quantify the association between βAA administration and mortality in feedlot cattle, and b) explore those variables that may confound or modify this association. Three datasets were acquired for analysis: one included information from randomized and controlled clinical trials of the βAA ractopamine hydrochloride, while the other two were observational data on zilpaterol hydrochloride administration to large numbers of cattle housed, fed, and cared for using routine commercial production practices in the U.S. Various population and time at-risk models were developed to explore potential βAA relationships with mortality, as well as the extent of confounding and effect modification. Measures of effect were relatively consistent across datasets and models in that the cumulative risk and incidence rate of death was 75 to 90% greater in animals administered the βAA compared to contemporaneous controls. During the exposure period, 40 to 50% of deaths among groups administered the βAA were attributed to administration of the drug. None of the available covariates meaningfully confounded the relationship between βAA and increased mortality. Only month of slaughter, presumably a proxy for climate, consistently modified the effect in that the biological association was generally greatest during the warmer months of the year. While death is a rare event in feedlot cattle, the data reported herein provide compelling evidence that mortality is nevertheless increased in response to administration of FDA-approved βAA and represents a heretofore unquantified adverse drug event.</p>", "link"=>"http://www.mendeley.com/research/increased-mortality-groups-cattle-administered-%CE%B2adrenergic-agonists-ractopamine-hydrochloride-zilpat", "reader_count"=>24, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Researcher"=>4, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Other"=>3, "Student > Master"=>2, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Researcher"=>4, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Other"=>3, "Student > Master"=>2, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Environmental Science"=>2, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>5, "Veterinary Science and Veterinary Medicine"=>3, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>3}}, "reader_count_by_country"=>{"United States"=>2, "Finland"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1417129"], "description"=>"<p>Kaplan-Meier non-parametric (actual) and Cox proportional hazards (predicted) survivor functions (S(t)) for cattle administered a diet containing ractopamine hydrochloride (RH) compared to a diet without RH in Company C.</p>", "links"=>[], "tags"=>["Animal management", "Animal welfare", "Population biology", "Population metrics", "Death rate", "Clinical research design", "clinical trials", "Observational studies", "Drugs and devices", "Adverse reactions", "Drug research and development", "Endocrinology", "adrenal cortex", "Veterinary epidemiology", "Veterinary medicine", "Livestock care", "administered"], "article_id"=>959628, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Guy H. Loneragan", "Daniel U. Thomson", "H. Morgan Scott"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091177.g002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Survival_analysis_for_cattle_administered_a_946_adrenergic_agonist_/959628", "title"=>"Survival analysis for cattle administered a β-adrenergic agonist.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-12 03:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1417138"], "description"=>"<p>Cumulative risk of treatment for disease among the exposed cohort (i.e., groups of cattle administered zilpaterol hydrochloride [ZH]) and the unexposed cohort.</p>", "links"=>[], "tags"=>["Animal management", "Animal welfare", "Population biology", "Population metrics", "Death rate", "Clinical research design", "clinical trials", "Observational studies", "Drugs and devices", "Adverse reactions", "Drug research and development", "Endocrinology", "adrenal cortex", "Veterinary epidemiology", "Veterinary medicine", "Livestock care", "exposed", "cohort", "groups", "administered", "zilpaterol", "hydrochloride", "unexposed"], "article_id"=>959637, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Guy H. Loneragan", "Daniel U. Thomson", "H. Morgan Scott"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091177.t003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cumulative_risk_of_treatment_for_disease_among_the_exposed_cohort_i_e_groups_of_cattle_administered_zilpaterol_hydrochloride_ZH_and_the_unexposed_cohort_/959637", "title"=>"Cumulative risk of treatment for disease among the exposed cohort (i.e., groups of cattle administered zilpaterol hydrochloride [ZH]) and the unexposed cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-12 03:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1417137"], "description"=>"<p>Prevalence of carcasses classified as <i>dry, dark, and firm</i> among the exposed cohort (i.e., groups of cattle administered zilpaterol hydrochloride [ZH]) and the unexposed cohort.</p>", "links"=>[], "tags"=>["Animal management", "Animal welfare", "Population biology", "Population metrics", "Death rate", "Clinical research design", "clinical trials", "Observational studies", "Drugs and devices", "Adverse reactions", "Drug research and development", "Endocrinology", "adrenal cortex", "Veterinary epidemiology", "Veterinary medicine", "Livestock care", "carcasses", "classified", "exposed", "cohort", "groups", "administered", "zilpaterol", "hydrochloride", "unexposed"], "article_id"=>959636, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Guy H. Loneragan", "Daniel U. Thomson", "H. Morgan Scott"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091177.t004", "stats"=>{"downloads"=>3, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prevalence_of_carcasses_classified_as_dry_dark_and_firm_among_the_exposed_cohort_i_e_groups_of_cattle_administered_zilpaterol_hydrochloride_ZH_and_the_unexposed_cohort_/959636", "title"=>"Prevalence of carcasses classified as <i>dry, dark, and firm</i> among the exposed cohort (i.e., groups of cattle administered zilpaterol hydrochloride [ZH]) and the unexposed cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-12 03:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1417127"], "description"=>"<p>Model-adjusted estimates of incidence of death per 10,000 animal-days for cattle administered either ractopamine hydrochloride (RH – graph A) or zilpaterol hydrochloride (ZH – graph B) compared to a diet without a beta agonist. No deaths were reported for Company A (graph A) and rates for Feedlot I (graph B) were non-estimable. <i>P</i> values are those associated with interaction term for exposure by company (graph A) or feedlot (graph B). Bars represent upper 95% confidence limit.</p>", "links"=>[], "tags"=>["Animal management", "Animal welfare", "Population biology", "Population metrics", "Death rate", "Clinical research design", "clinical trials", "Observational studies", "Drugs and devices", "Adverse reactions", "Drug research and development", "Endocrinology", "adrenal cortex", "Veterinary epidemiology", "Veterinary medicine", "Livestock care", "agonist"], "article_id"=>959626, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Guy H. Loneragan", "Daniel U. Thomson", "H. Morgan Scott"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091177.g001", "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_946_adrenergic_agonist_administration_and_mortality_/959626", "title"=>"Association between β-adrenergic agonist administration and mortality.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-12 03:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1417140"], "description"=>"<p>* Not calculated as both cohorts had the same exposure period of 24 days.</p>", "links"=>[], "tags"=>["Animal management", "Animal welfare", "Population biology", "Population metrics", "Death rate", "Clinical research design", "clinical trials", "Observational studies", "Drugs and devices", "Adverse reactions", "Drug research and development", "Endocrinology", "adrenal cortex", "Veterinary epidemiology", "Veterinary medicine", "Livestock care", "crude", "model-adjusted", "dataset", "exposed", "cohort", "groups", "administered", "ractopamine", "hydrochloride", "zilpaterol", "unexposed"], "article_id"=>959639, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Guy H. Loneragan", "Daniel U. Thomson", "H. Morgan Scott"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091177.t001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_statistics_for_death_loss_counts_and_crude_and_model_adjusted_estimates_by_dataset_for_all_cattle_the_exposed_cohort_i_e_groups_of_cattle_administered_either_ractopamine_hydrochloride_RH_or_zilpaterol_hydrochloride_ZH_and_the_unexposed_cohort_/959639", "title"=>"Summary statistics for death loss (counts, and crude and model-adjusted estimates) by dataset for all cattle, the exposed cohort (i.e., groups of cattle administered either ractopamine hydrochloride [RH] or zilpaterol hydrochloride [ZH]), and the unexposed cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-12 03:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1417139"], "description"=>"<p>Administration of ZH was associated with mortality (<i>P</i><0.01) in all multivariable models.</p><p>*<i>P</i> value indicated was that observed at the time of removal from the multivariable model if >0.10, or if retained, i.e., ≤0.10, its value in the final multivariable model.</p><p>** Interaction term of the covariate with administration of ZH, i.e., evaluation of potential modification of the association between death loss and administration.</p>", "links"=>[], "tags"=>["Animal management", "Animal welfare", "Population biology", "Population metrics", "Death rate", "Clinical research design", "clinical trials", "Observational studies", "Drugs and devices", "Adverse reactions", "Drug research and development", "Endocrinology", "adrenal cortex", "Veterinary epidemiology", "Veterinary medicine", "Livestock care", "evaluated", "groups", "administered", "zilpaterol", "hydrochloride", "multi-feedlot", "zh", "dataset", "univariate", "multivariable"], "article_id"=>959638, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Guy H. Loneragan", "Daniel U. Thomson", "H. Morgan Scott"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091177.t002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Covariates_evaluated_for_an_association_with_mortality_in_groups_of_cattle_either_administered_zilpaterol_hydrochloride_ZH_or_not_in_the_multi_feedlot_ZH_dataset_in_univariate_and_multivariable_models_/959638", "title"=>"Covariates evaluated for an association with mortality in groups of cattle either administered zilpaterol hydrochloride (ZH) or not in the multi-feedlot ZH dataset in univariate and multivariable models.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-12 03:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1417136"], "description"=>"<p>Model-adjusted estimates of the percentage of cattle that died among groups of animals administered zilpaterol hydrochloride (ZH) compared to a diet without ZH by month in which they were shipped to slaughter. Graph A represents 722,704 animals housed in 9 feedlots and graph B represents 149,636 animals housed in a single feedlot.</p>", "links"=>[], "tags"=>["Animal management", "Animal welfare", "Population biology", "Population metrics", "Death rate", "Clinical research design", "clinical trials", "Observational studies", "Drugs and devices", "Adverse reactions", "Drug research and development", "Endocrinology", "adrenal cortex", "Veterinary epidemiology", "Veterinary medicine", "Livestock care", "modification", "agonist"], "article_id"=>959635, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Guy H. Loneragan", "Daniel U. Thomson", "H. Morgan Scott"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091177.g004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Seasonal_modification_of_the_association_between_946_adrenergic_agonist_administration_and_mortality_/959635", "title"=>"Seasonal modification of the association between β-adrenergic agonist administration and mortality.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-12 03:31:14"}
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Relative Metric

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Loading … Spinner

Net::HTTPTooManyRequests

Source
Scopus
Time
2019-07-21 10:12:00 UTC
Target URL
https://api.elsevier.com/content/search/index:SCOPUS?query=DOI(10.1371%2Fjournal.pone.0091177)
Trace

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