Curcumin Alleviates Neuropathic Pain by Inhibiting p300/CBP Histone Acetyltransferase Activity-Regulated Expression of BDNF and Cox-2 in a Rat Model
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and Cox-2 in a rat model", "type"=>"journal", "authors"=>[{"first_name"=>"Xiaoyan", "last_name"=>"Zhu", "scopus_author_id"=>"57109489200"}, {"first_name"=>"Qian", "last_name"=>"Li", "scopus_author_id"=>"57191695401"}, {"first_name"=>"Ruimin", "last_name"=>"Chang", "scopus_author_id"=>"48461141800"}, {"first_name"=>"Dong", "last_name"=>"Yang", "scopus_author_id"=>"57198914806"}, {"first_name"=>"Zongbing", "last_name"=>"Song", "scopus_author_id"=>"55581945400"}, {"first_name"=>"Qulian", "last_name"=>"Guo", "scopus_author_id"=>"55500468400"}, {"first_name"=>"Changsheng", "last_name"=>"Huang", "scopus_author_id"=>"18437249000"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"372731129", "doi"=>"10.1371/journal.pone.0091303", "sgr"=>"84897381657", "scopus"=>"2-s2.0-84897381657", "isbn"=>"1932-6203", "pmid"=>"24603592"}, "id"=>"60a99012-700a-365f-a19a-85632c3200f4", "abstract"=>"The management of neuropathic pain is still a major challenge because of its unresponsiveness to most common treatments. Curcumin has been reported to play an active role in the treatment of various neurological disorders, such as neuropathic pain. Curcumin has long been recognized as a p300/CREB-binding protein (CBP) inhibitor of histone acetyltransferase (HAT) activity. However, this mechanism has never been investigated for the treatment of neuropathic pain with curcumin. The aim of the present study was to investigate the anti-nociceptive role of curcumin in the chronic constriction injury (CCI) rat model of neuropathic pain. Furthermore, with this model we investigated the effect of curcumin on P300/CBP HAT activity-regulated release of the pro-nociceptive molecules, brain-derived neurotrophic factor (BDNF) and cyclooxygenase-2 (Cox-2). Treatment with 40 and 60 mg/kg body weight curcumin for 7 consecutive days significantly attenuated CCI-induced thermal hyperalgesia and mechanical allodynia, whereas 20 mg/kg curcumin showed no significant analgesic effect. Chromatin immunoprecipitation analysis revealed that curcumin dose-dependently reduced the recruitment of p300/CBP and acetyl-Histone H3/acetyl-Histone H4 to the promoter of BDNF and Cox-2 genes. A similar dose-dependent decrease of BDNF and Cox-2 in the spinal cord was also observed after curcumin treatment. These results indicated that curcumin exerted a therapeutic role in neuropathic pain by down-regulating p300/CBP HAT activity-mediated gene expression of BDNF and Cox-2.", "link"=>"http://www.mendeley.com/research/curcumin-alleviates-neuropathic-pain-inhibiting-p300cbp-histone-acetyltransferase-activityregulated", "reader_count"=>39, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>5, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>5, "Student > Master"=>7, "Student > Bachelor"=>7, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>5, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>5, "Student > Master"=>7, "Student > Bachelor"=>7, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>12, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>9, "Physics and Astronomy"=>1, "Chemistry"=>1, "Psychology"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>12}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>9}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84897381657"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84897381657?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897381657&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84897381657&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84897381657", "dc:identifier"=>"SCOPUS_ID:84897381657", "eid"=>"2-s2.0-84897381657", "dc:title"=>"Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and Cox-2 in a rat model", "dc:creator"=>"Zhu X.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-03-06", "prism:coverDisplayDate"=>"6 March 2014", "prism:doi"=>"10.1371/journal.pone.0091303", "citedby-count"=>"75", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Xiangya Hospital of Central-South University", "affiliation-city"=>"Changsha", "affiliation-country"=>"China"}], "pubmed-id"=>"24603592", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e91303", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0091303", "share_count"=>14, "like_count"=>28, "comment_count"=>26, "click_count"=>0, "total_count"=>68}

Counter

  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"85", "xml_views"=>"8", "html_views"=>"732"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"44", "xml_views"=>"3", "html_views"=>"205"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"39", "xml_views"=>"2", "html_views"=>"256"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"195"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"287"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"151"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"187"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"164"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"154"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"251"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"166"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"120"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"136"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"98"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"134"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"200"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"136"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"122"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"127"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"107"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"116"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"130"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"134"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"116"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"150"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"157"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"119"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"113"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"127"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"285"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"318"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"376"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"438"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"347"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"350"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"232"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"367"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"535"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"180"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"161"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"157"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"156"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"146"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"228"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"108"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"3", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"29"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"42", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"18"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1410825"], "description"=>"<p>The chromatin immunoprecipitation assay was performed with antibodies against p300, CBP, H3K9ac, H4K5ac or non-immune rabbit IgG, after 7 days of treatment with DMSO or curcumin at 20, 40, and 60 mg/kg body weight. Binding of p300/CBP and H3K9ac/H4K5ac to the BDNF promoter (A). Binding of p300/CBP and H3K9ac/H4K5ac to the Cox-2 promoter (B). *p<0.05, CCI versus sham; **p<0.01, CCI versus sham; <sup>#</sup>p<0.05 curcumin versus vehicle; <sup>##</sup>p<0.01 curcumin versus vehicle (n = 10 per group). cur20: curcumin 20 mg/kg; cur40: curcumin 40 mg/kg; cur60: curcumin 60 mg/kg.</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "rat", "Molecular cell biology", "Signal transduction", "Signaling in cellular processes", "Creb signaling", "neuroscience", "Cognitive neuroscience", "pain", "Molecular neuroscience", "anesthesiology", "Pain management", "neurology", "promoter", "bdnf", "cox-2"], "article_id"=>954494, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xiaoyan Zhu", "Qian Li", "Ruimin Chang", "Dong Yang", "Zongbing Song", "Qulian Guo", "Changsheng Huang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091303.g004", "stats"=>{"downloads"=>3, "page_views"=>60, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Binding_of_p300_CBP_and_H3K9ac_H4K5ac_to_the_promoter_of_BDNF_and_Cox_2_gene_/954494", "title"=>"Binding of p300/CBP and H3K9ac/H4K5ac to the promoter of BDNF and Cox-2 gene.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 04:22:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410830"], "description"=>"<p>Western immunoblotting analysis was performed 7/kg body curcumin. β-actin was used as an internal control. Representative images of BDNF expression (A). Relative amount of BDNF protein (B). Representative images of Cox-2 expression (C). Relative amount of Cox-2 protein (D). *p<0.05, CCI versus sham; **p<0.01, CCI versus sham; <sup>#</sup>p<0.05 curcumin versus vehicle (n = 10 per group). Sham: vehicle-treated sham rats; vehicle: vehicle-treated CCI rats; cur20: curcumin 20 mg/kg-treated CCI rats; cur40: curcumin 40 mg/kg-treated CCI rats; cur60: curcumin 60 mg/kg-treated CCI rats.</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "rat", "Molecular cell biology", "Signal transduction", "Signaling in cellular processes", "Creb signaling", "neuroscience", "Cognitive neuroscience", "pain", "Molecular neuroscience", "anesthesiology", "Pain management", "neurology", "bdnf", "cox-2"], "article_id"=>954499, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xiaoyan Zhu", "Qian Li", "Ruimin Chang", "Dong Yang", "Zongbing Song", "Qulian Guo", "Changsheng Huang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091303.g006", "stats"=>{"downloads"=>0, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protein_expression_of_BDNF_and_Cox_2_protein_/954499", "title"=>"Protein expression of BDNF and Cox-2 protein.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 04:22:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410820"], "description"=>"<p>Cox-2 is localized in the cytoplasm and cell membranes surrounding immunoreactive P300 or CBP nuclei. Arrows indicate the co-localization of Cox-2 and p300 or CBP. Scale bar = 45 µm.</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "rat", "Molecular cell biology", "Signal transduction", "Signaling in cellular processes", "Creb signaling", "neuroscience", "Cognitive neuroscience", "pain", "Molecular neuroscience", "anesthesiology", "Pain management", "neurology", "immunofluorescence", "staining", "cyclooxygenase-2", "ipsilateral", "spinal", "dorsal", "vehicle-treated", "cci"], "article_id"=>954489, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xiaoyan Zhu", "Qian Li", "Ruimin Chang", "Dong Yang", "Zongbing Song", "Qulian Guo", "Changsheng Huang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091303.g003", "stats"=>{"downloads"=>4, "page_views"=>163, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Double_immunofluorescence_staining_of_p300_CBP_and_cyclooxygenase_2_Cox_2_in_the_ipsilateral_spinal_dorsal_horn_laminae_I_8211_IV_of_vehicle_treated_CCI_rats_/954489", "title"=>"Double immunofluorescence staining of p300/CBP and cyclooxygenase-2 (Cox-2) in the ipsilateral spinal dorsal horn (laminae I–IV) of vehicle-treated CCI rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 04:22:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410815"], "description"=>"<p>Immunoreactivity of BDNF is localized in the cytoplasm and cell membranes surrounding immunoreactive p300 or CBP nuclei. Arrows indicate the co-localization of BDNF and p300 or CBP. Scale bar = 45 µm.</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "rat", "Molecular cell biology", "Signal transduction", "Signaling in cellular processes", "Creb signaling", "neuroscience", "Cognitive neuroscience", "pain", "Molecular neuroscience", "anesthesiology", "Pain management", "neurology", "immunofluorescence", "staining", "binding", "derived", "neurotrophic", "ipsilateral", "spinal", "dorsal", "vehicle-treated", "cci"], "article_id"=>954487, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xiaoyan Zhu", "Qian Li", "Ruimin Chang", "Dong Yang", "Zongbing Song", "Qulian Guo", "Changsheng Huang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091303.g002", "stats"=>{"downloads"=>6, "page_views"=>64, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Double_immunofluorescence_staining_of_p300_CREB_binding_protein_CBP_and_brain_derived_neurotrophic_factor_BDNF_in_the_ipsilateral_spinal_dorsal_horn_laminae_I_8211_IV_of_vehicle_treated_CCI_rats_/954487", "title"=>"Double immunofluorescence staining of p300/CREB binding protein (CBP) and brain derived neurotrophic factor (BDNF) in the ipsilateral spinal dorsal horn (laminae I–IV) of vehicle-treated CCI rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 04:22:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410814"], "description"=>"<p>Treatment with vehicle or curcumin started 7*p<0.05, CCI versus sham; <sup>#</sup>p<0.05 curcumin versus vehicle (n = 10 per group). cur20: curcumin 20 mg/kg; cur40: curcumin 40 mg/kg; cur60: curcumin 60 mg/kg.</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "rat", "Molecular cell biology", "Signal transduction", "Signaling in cellular processes", "Creb signaling", "neuroscience", "Cognitive neuroscience", "pain", "Molecular neuroscience", "anesthesiology", "Pain management", "neurology", "thermal", "latency", "ipsilateral", "hindpaw"], "article_id"=>954486, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xiaoyan Zhu", "Qian Li", "Ruimin Chang", "Dong Yang", "Zongbing Song", "Qulian Guo", "Changsheng Huang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091303.g001", "stats"=>{"downloads"=>1, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Time_course_changes_of_thermal_withdrawal_latency_A_and_mechanical_withdrawal_threshold_B_in_the_ipsilateral_hindpaw_of_rats_/954486", "title"=>"Time-course changes of thermal withdrawal latency (A) and mechanical withdrawal threshold (B) in the ipsilateral hindpaw of rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 04:22:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410826"], "description"=>"<p>Quantitative real time polymerase chain reaction was performed 7/kg body weight curcumin. Relative amount of BDNF gene (A). Relative amount of Cox-2 gene (B). Data were normalized to the β-actin gene. **p<0.01, CCI versus sham; <sup>#</sup>p<0.05 curcumin versus vehicle; <sup>##</sup>p<0.01 curcumin versus vehicle (n = 10 per group). sham: vehicle-treated sham rats; vehicle: vehicle-treated CCI rats; cur20: curcumin 20 mg/kg-treated CCI rats; cur40: curcumin 40 mg/kg-treated CCI rats; cur60: curcumin 60 mg/kg-treated CCI rats.</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "rat", "Molecular cell biology", "Signal transduction", "Signaling in cellular processes", "Creb signaling", "neuroscience", "Cognitive neuroscience", "pain", "Molecular neuroscience", "anesthesiology", "Pain management", "neurology", "bdnf"], "article_id"=>954495, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Xiaoyan Zhu", "Qian Li", "Ruimin Chang", "Dong Yang", "Zongbing Song", "Qulian Guo", "Changsheng Huang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091303.g005", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_mRNA_expression_of_BDNF_and_Cox_2_/954495", "title"=>"mRNA expression of BDNF and Cox-2.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 04:22:49"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"87", "full-text"=>"90", "pdf"=>"57", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"23", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"56", "full-text"=>"61", "pdf"=>"39", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"38", "full-text"=>"43", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"64", "full-text"=>"66", "pdf"=>"31", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"28", "full-text"=>"29", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"38", "full-text"=>"39", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"34", "full-text"=>"33", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"30", "full-text"=>"32", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"44", "full-text"=>"50", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"46", "full-text"=>"44", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"29", "full-text"=>"24", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"26", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"36", "full-text"=>"40", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"31", "full-text"=>"36", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"39", "full-text"=>"36", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"46", "full-text"=>"44", "pdf"=>"19", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"33", "full-text"=>"33", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"42", "full-text"=>"39", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"34", "full-text"=>"34", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"34", "full-text"=>"32", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"32", "full-text"=>"27", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"31", "full-text"=>"27", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"34", "full-text"=>"36", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"32", "full-text"=>"36", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"23", "full-text"=>"27", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"27", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"30", "full-text"=>"58", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"34", "full-text"=>"39", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"42", "full-text"=>"44", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"31", "full-text"=>"50", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"42", "full-text"=>"50", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"67", "full-text"=>"75", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"87", "full-text"=>"97", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"181", "full-text"=>"213", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"174", "full-text"=>"199", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"117", "full-text"=>"131", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"119", "full-text"=>"125", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"134", "full-text"=>"168", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"131", "full-text"=>"149", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"251", "full-text"=>"279", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"170", "full-text"=>"186", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"192", "full-text"=>"218", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"222", "full-text"=>"268", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"163", "full-text"=>"191", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"186", "full-text"=>"213", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"253", "full-text"=>"292", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"248", "full-text"=>"274", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"275", "full-text"=>"301", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"266", "full-text"=>"305", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"297", "full-text"=>"345", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"230", "full-text"=>"260", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"328", "full-text"=>"369", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"292", "full-text"=>"316", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"306", "full-text"=>"344", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"325", "full-text"=>"366", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"277", "full-text"=>"332", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"298", "full-text"=>"330", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"306", "full-text"=>"370", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"8"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[267]}, {"subject_area"=>"/Biology and life sciences/Neuroscience", "average_usage"=>[289]}, {"subject_area"=>"/Medicine and health sciences/Pain management", "average_usage"=>[277, 451]}]}
Loading … Spinner
There are currently no alerts