Gestational Chronodisruption Impairs Hippocampal Expression of NMDA Receptor Subunits Grin1b/Grin3a and Spatial Memory in the Adult Offspring
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{"title"=>"Gestational chronodisruption impairs hippocampal expression of NMDA receptor subunits Grin1b/Grin3a and spatial memory in the adult offspring", "type"=>"journal", "authors"=>[{"first_name"=>"Nelson", "last_name"=>"Vilches", "scopus_author_id"=>"46961429800"}, {"first_name"=>"Carlos", "last_name"=>"Spichiger", "scopus_author_id"=>"8557546900"}, {"first_name"=>"Natalia", "last_name"=>"Mendez", "scopus_author_id"=>"23478337400"}, {"first_name"=>"Lorena", "last_name"=>"Abarzua-Catalan", "scopus_author_id"=>"23977660900"}, {"first_name"=>"Hugo A.", "last_name"=>"Galdames", "scopus_author_id"=>"55337361400"}, {"first_name"=>"David G.", "last_name"=>"Hazlerigg", "scopus_author_id"=>"6701834786"}, {"first_name"=>"Hans G.", "last_name"=>"Richter", "scopus_author_id"=>"7401793305"}, {"first_name"=>"Claudia", "last_name"=>"Torres-Farfan", "scopus_author_id"=>"6507977747"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84899746414", "sgr"=>"84899746414", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0091313", "pmid"=>"24663672", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"373006640"}, "id"=>"74211d3e-8836-3323-bb60-d76f4cb7ec98", "abstract"=>"Epidemiological and experimental evidence correlates adverse intrauterine conditions with the onset of disease later in life. For a fetus to achieve a successful transition to extrauterine life, a myriad of temporally integrated humoral/biophysical signals must be accurately provided by the mother. We and others have shown the existence of daily rhythms in the fetus, with peripheral clocks being entrained by maternal cues, such as transplacental melatonin signaling. Among developing tissues, the fetal hippocampus is a key structure for learning and memory processing that may be anticipated as a sensitive target of gestational chronodisruption. Here, we used pregnant rats exposed to constant light treated with or without melatonin as a model of gestational chronodisruption, to investigate effects on the putative fetal hippocampus clock, as well as on adult offspring's rhythms, endocrine and spatial memory outcomes. The hippocampus of fetuses gestated under light:dark photoperiod (12:12 LD) displayed daily oscillatory expression of the clock genes Bmal1 and Per2, clock-controlled genes Mtnr1b, Slc2a4, Nr3c1 and NMDA receptor subunits 1B-3A-3B. In contrast, in the hippocampus of fetuses gestated under constant light (LL), these oscillations were suppressed. In the adult LL offspring (reared in LD during postpartum), we observed complete lack of day/night differences in plasma melatonin and decreased day/night differences in plasma corticosterone. In the adult LL offspring, overall hippocampal day/night difference of gene expression was decreased, which was accompanied by a significant deficit of spatial memory. Notably, maternal melatonin replacement to dams subjected to gestational chronodisruption prevented the effects observed in both, LL fetuses and adult LL offspring. Collectively, the present data point to adverse effects of gestational chronodisruption on long-term cognitive function; raising challenging questions about the consequences of shift work during pregnancy. The present study also supports that developmental plasticity in response to photoperiodic cues may be modulated by maternal melatonin.", "link"=>"http://www.mendeley.com/research/gestational-chronodisruption-impairs-hippocampal-expression-nmda-receptor-subunits-grin1bgrin3a-spat", "reader_count"=>29, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>5, "Student > Bachelor"=>4, "Professor"=>6}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>5, "Student > Bachelor"=>4, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>6, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>12, "Neuroscience"=>4, "Psychology"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>4}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>12}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Chile"=>1, "Switzerland"=>1, "Spain"=>2}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1433131"], "description"=>"<p>Mean ± SEM of 2<sup>−ΔΔCt</sup>. *: Different from other time points (P<0.05; ANOVA). Black bars indicate lights-off hours. In each graph the value at 0400 h is repeated in the next 24 h.</p>", "links"=>[], "tags"=>["anatomy", "Endocrine system", "Biochemistry", "Neurochemistry", "Neuroendocrinology", "Chronobiology", "developmental biology", "neuroscience", "Cognitive neuroscience", "working memory", "cognitive science", "cognition", "Animal cognition", "memory", "Cognitive psychology", "Developmental neuroscience", "physiology", "Endocrine physiology", "Physiological processes", "psychology", "Endocrinology", "Mental health and psychiatry", "oscillatory", "nmda", "receptor", "subunit", "1b", "3a-3b", "fetal", "hippocampus", "18", "days", "gestational", "dams", "maintained", "ld"], "article_id"=>972599, "categories"=>["Biological Sciences"], "users"=>["Nelson Vilches", "Carlos Spichiger", "Natalia Mendez", "Lorena Abarzua-Catalan", "Hugo A. Galdames", "David G. Hazlerigg", "Hans G. Richter", "Claudia Torres-Farfan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0091313.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Daily_oscillatory_expression_of_Per2_and_Bmal1_a_Mtnr1a_and_Mtnr1b_b_Nr3c1_and_Slc2a4_c_NMDA_receptor_subunit_1B_Grin1b_d_and_3A_3B_Grin3a_and_Grin3b_e_in_the_fetal_rat_hippocampus_at_18_days_of_gestational_age_from_pregnant_dams_maintained_in_12_12_LD_p/972599", "title"=>"Daily oscillatory expression of <i>Per2</i> and <i>Bmal1</i> (a); <i>Mtnr1a</i> and <i>Mtnr1b</i> (b); <i>Nr3c1</i> and <i>Slc2a4</i> (c); NMDA receptor subunit 1B [<i>Grin1b</i>] (d); and 3A-3B [<i>Grin3a</i> and <i>Grin3b</i>] (e), in the fetal rat hippocampus at 18 days of gestational age from pregnant dams maintained in 12:12 LD photoperiod.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-24 03:43:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1433132"], "description"=>"<p>Mean ± SEM of 2<sup>−ΔΔCt</sup> *: Different from other time points (P<0.05; ANOVA). Note that LL was different to LL + Mel (P<0.05; Two way ANOVA). Grey bars indicate the clock time of melatonin replacement or placebo. In each graph the value at 0400 h is repeated in the next 24 h.</p>", "links"=>[], "tags"=>["anatomy", "Endocrine system", "Biochemistry", "Neurochemistry", "Neuroendocrinology", "Chronobiology", "developmental biology", "neuroscience", "Cognitive neuroscience", "working memory", "cognitive science", "cognition", "Animal cognition", "memory", "Cognitive psychology", "Developmental neuroscience", "physiology", "Endocrine physiology", "Physiological processes", "psychology", "Endocrinology", "Mental health and psychiatry", "gestational", "chronodisruption", "maternal", "melatonin", "oscillatory", "transcription", "nmda", "receptors", "subunits", "fetal", "hippocampus", "18", "dams", "ll", "mel"], "article_id"=>972600, "categories"=>["Biological Sciences"], "users"=>["Nelson Vilches", "Carlos Spichiger", "Natalia Mendez", "Lorena Abarzua-Catalan", "Hugo A. Galdames", "David G. Hazlerigg", "Hans G. Richter", "Claudia Torres-Farfan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0091313.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_gestational_chronodisruption_and_maternal_melatonin_replacement_on_daily_oscillatory_transcription_of_Per2_a_Bmal1_b_Mtnr1b_c_Slc2a4_d_Nr3c1_e_and_NMDA_receptors_Grin_subunits_f_h_in_the_fetal_rat_hippocampus_at_day_18_of_gestation_from_pregnan/972600", "title"=>"Effect of gestational chronodisruption and maternal melatonin replacement on daily oscillatory transcription of <i>Per2</i> (a), <i>Bmal1</i> (b), <i>Mtnr1b</i> (c), <i>Slc2a4</i> (d), <i>Nr3c1</i> (e) and NMDA receptors (<i>Grin</i>) subunits (f-h) in the fetal rat hippocampus at day 18 of gestation, from pregnant dams under LL (<i>Red symbols</i>) and LL + Mel (<i>Blue symbols</i>).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-24 03:43:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1433135"], "description"=>"<p>Mean ± SEM for plasma hormones, latency time and of 2<sup>−ΔΔCt</sup>. 90 days old offspring gestated under LD (<i>Green symbols</i>), LL (<i>Red symbols</i>) and LL + Mel (<i>Blue symbols</i>). #: Different to LD and LL+Mel (P<0.05; Two way ANOVA). *: Different to 11-h (P<0.05; Two way ANOVA).</p>", "links"=>[], "tags"=>["anatomy", "Endocrine system", "Biochemistry", "Neurochemistry", "Neuroendocrinology", "Chronobiology", "developmental biology", "neuroscience", "Cognitive neuroscience", "working memory", "cognitive science", "cognition", "Animal cognition", "memory", "Cognitive psychology", "Developmental neuroscience", "physiology", "Endocrine physiology", "Physiological processes", "psychology", "Endocrinology", "Mental health and psychiatry", "maternal", "melatonin", "plasma", "corticosterone", "spatial", "differences", "genes", "controlled", "nmda", "receptor", "subunits"], "article_id"=>972603, "categories"=>["Biological Sciences"], "users"=>["Nelson Vilches", "Carlos Spichiger", "Natalia Mendez", "Lorena Abarzua-Catalan", "Hugo A. Galdames", "David G. Hazlerigg", "Hans G. Richter", "Claudia Torres-Farfan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0091313.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Long_term_postnatal_day_90_effects_of_maternal_exposure_to_constant_light_and_maternal_melatonin_replacement_on_plasma_melatonin_a_and_corticosterone_b_spatial_memory_c_and_on_day_night_differences_in_expression_of_clock_genes_d_e_clock_controlled_genes_/972603", "title"=>"Long-term (postnatal day 90) effects of maternal exposure to constant light and maternal melatonin replacement on plasma melatonin (a) and corticosterone (b), spatial memory (c) and on day/night differences in expression of clock genes (d-e), clock controlled genes (f-h) and NMDA receptor subunits (i-k).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-24 03:43:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1433136"], "description"=>"<p>Effects of gestational condition (LD, LL and LL+Mel) on body weight (g) at birth, 30 and 90 days of age (Mean ± SEM).</p>", "links"=>[], "tags"=>["anatomy", "Endocrine system", "Biochemistry", "Neurochemistry", "Neuroendocrinology", "Chronobiology", "developmental biology", "neuroscience", "Cognitive neuroscience", "working memory", "cognitive science", "cognition", "Animal cognition", "memory", "Cognitive psychology", "Developmental neuroscience", "physiology", "Endocrine physiology", "Physiological processes", "psychology", "Endocrinology", "Mental health and psychiatry", "gestational", "ll", "30", "90", "days"], "article_id"=>972604, "categories"=>["Biological Sciences"], "users"=>["Nelson Vilches", "Carlos Spichiger", "Natalia Mendez", "Lorena Abarzua-Catalan", "Hugo A. Galdames", "David G. Hazlerigg", "Hans G. Richter", "Claudia Torres-Farfan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0091313.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_gestational_condition_LD_LL_and_LL_Mel_on_body_weight_g_at_birth_30_and_90_days_of_age_Mean_177_SEM_/972604", "title"=>"Effects of gestational condition (LD, LL and LL+Mel) on body weight (g) at birth, 30 and 90 days of age (Mean ± SEM).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-24 03:43:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1433137"], "description"=>"<p>N.D.: Not detectable. *: Different to LD (student t test).</p>", "links"=>[], "tags"=>["anatomy", "Endocrine system", "Biochemistry", "Neurochemistry", "Neuroendocrinology", "Chronobiology", "developmental biology", "neuroscience", "Cognitive neuroscience", "working memory", "cognitive science", "cognition", "Animal cognition", "memory", "Cognitive psychology", "Developmental neuroscience", "physiology", "Endocrine physiology", "Physiological processes", "psychology", "Endocrinology", "Mental health and psychiatry", "melatonin", "supplementation", "dams", "kept", "circadian", "clock-controlled", "genes", "fetal", "hippocampus"], "article_id"=>972605, "categories"=>["Biological Sciences"], "users"=>["Nelson Vilches", "Carlos Spichiger", "Natalia Mendez", "Lorena Abarzua-Catalan", "Hugo A. Galdames", "David G. Hazlerigg", "Hans G. Richter", "Claudia Torres-Farfan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0091313.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_of_melatonin_supplementation_to_pregnant_dams_kept_under_constant_light_on_the_circadian_rhythm_of_clock_and_clock_controlled_genes_in_the_fetal_hippocampus_Mean_177_SEM_/972605", "title"=>"of melatonin supplementation to pregnant dams kept under constant light on the circadian rhythm of clock and clock-controlled genes in the fetal hippocampus (Mean ± SEM).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-24 03:43:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1433138"], "description"=>"<p>E: Efficiency assay using fetal and adult hippocampus pooled RNA. a: <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091313#pone.0091313-TorresFarfan2\" target=\"_blank\">[24]</a>; b: <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091313#pone.0091313-Young1\" target=\"_blank\">[59]</a>; c:<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091313#pone.0091313-Floyd1\" target=\"_blank\">[60]</a>.</p>", "links"=>[], "tags"=>["anatomy", "Endocrine system", "Biochemistry", "Neurochemistry", "Neuroendocrinology", "Chronobiology", "developmental biology", "neuroscience", "Cognitive neuroscience", "working memory", "cognitive science", "cognition", "Animal cognition", "memory", "Cognitive psychology", "Developmental neuroscience", "physiology", "Endocrine physiology", "Physiological processes", "psychology", "Endocrinology", "Mental health and psychiatry", "primers", "genes"], "article_id"=>972606, "categories"=>["Biological Sciences"], "users"=>["Nelson Vilches", "Carlos Spichiger", "Natalia Mendez", "Lorena Abarzua-Catalan", "Hugo A. Galdames", "David G. Hazlerigg", "Hans G. Richter", "Claudia Torres-Farfan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0091313.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RT_qPCR_primers_for_genes_studied_/972606", "title"=>"RT-qPCR primers for genes studied<b>.</b>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-24 03:43:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1433139"], "description"=>"<div><p>Epidemiological and experimental evidence correlates adverse intrauterine conditions with the onset of disease later in life. For a fetus to achieve a successful transition to extrauterine life, a myriad of temporally integrated humoral/biophysical signals must be accurately provided by the mother. We and others have shown the existence of daily rhythms in the fetus, with peripheral clocks being entrained by maternal cues, such as transplacental melatonin signaling. Among developing tissues, the fetal hippocampus is a key structure for learning and memory processing that may be anticipated as a sensitive target of gestational chronodisruption. Here, we used pregnant rats exposed to constant light treated with or without melatonin as a model of gestational chronodisruption, to investigate effects on the putative fetal hippocampus clock, as well as on adult offspring’s rhythms, endocrine and spatial memory outcomes. The hippocampus of fetuses gestated under light:dark photoperiod (12:12 LD) displayed daily oscillatory expression of the clock genes <i>Bmal1</i> and <i>Per2</i>, clock-controlled genes <i>Mtnr1b</i>, <i>Slc2a4</i>, <i>Nr3c1</i> and <i>NMDA</i> receptor subunits 1B-3A-3B. In contrast, in the hippocampus of fetuses gestated under constant light (LL), these oscillations were suppressed. In the adult LL offspring (reared in LD during postpartum), we observed complete lack of day/night differences in plasma melatonin and decreased day/night differences in plasma corticosterone. In the adult LL offspring, overall hippocampal day/night difference of gene expression was decreased, which was accompanied by a significant deficit of spatial memory. Notably, maternal melatonin replacement to dams subjected to gestational chronodisruption prevented the effects observed in both, LL fetuses and adult LL offspring. Collectively, the present data point to adverse effects of gestational chronodisruption on long-term cognitive function; raising challenging questions about the consequences of shift work during pregnancy. The present study also supports that developmental plasticity in response to photoperiodic cues may be modulated by maternal melatonin.</p></div>", "links"=>[], "tags"=>["anatomy", "Endocrine system", "Biochemistry", "Neurochemistry", "Neuroendocrinology", "Chronobiology", "developmental biology", "neuroscience", "Cognitive neuroscience", "working memory", "cognitive science", "cognition", "Animal cognition", "memory", "Cognitive psychology", "Developmental neuroscience", "physiology", "Endocrine physiology", "Physiological processes", "psychology", "Endocrinology", "Mental health and psychiatry", "chronodisruption", "impairs", "hippocampal", "nmda", "receptor", "subunits", "spatial"], "article_id"=>972607, "categories"=>["Biological Sciences"], "users"=>["Nelson Vilches", "Carlos Spichiger", "Natalia Mendez", "Lorena Abarzua-Catalan", "Hugo A. Galdames", "David G. Hazlerigg", "Hans G. Richter", "Claudia Torres-Farfan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0091313"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gestational_Chronodisruption_Impairs_Hippocampal_Expression_of_NMDA_Receptor_Subunits_Grin1b_Grin3a_and_Spatial_Memory_in_the_Adult_Offspring_/972607", "title"=>"Gestational Chronodisruption Impairs Hippocampal Expression of NMDA Receptor Subunits Grin1b/Grin3a and Spatial Memory in the Adult Offspring", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-24 03:43:36"}

PMC Usage Stats | Further Information

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Relative Metric

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