Adaptive Expression of MicroRNA-125a in Adipose Tissue in Response to Obesity in Mice and Men
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{"title"=>"Adaptive expression of microRNA-125a in adipose tissue in response to obesity in mice and men", "type"=>"journal", "authors"=>[{"first_name"=>"Malika R.", "last_name"=>"Diawara", "scopus_author_id"=>"56150734700"}, {"first_name"=>"Christophe", "last_name"=>"Hue", "scopus_author_id"=>"6602144109"}, {"first_name"=>"Steven P.", "last_name"=>"Wilder", "scopus_author_id"=>"7003532386"}, {"first_name"=>"Nicolas", "last_name"=>"Venteclef", "scopus_author_id"=>"8290359300"}, {"first_name"=>"Judith", "last_name"=>"Aron-Wisnewsky", "scopus_author_id"=>"35331621400"}, {"first_name"=>"James", "last_name"=>"Scott", "scopus_author_id"=>"55568516857"}, {"first_name"=>"Karine", "last_name"=>"Clément", "scopus_author_id"=>"7005043037"}, {"first_name"=>"Dominique", "last_name"=>"Gauguier", "scopus_author_id"=>"7004461140"}, {"first_name"=>"Sophie", "last_name"=>"Calderari", "scopus_author_id"=>"12765618600"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84899839946", "pui"=>"373031057", "doi"=>"10.1371/journal.pone.0091375", "pmid"=>"24675842", "scopus"=>"2-s2.0-84899839946", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)"}, "id"=>"3f116795-4806-32df-bd3d-8e6214307afc", "abstract"=>"MicroRNAs are emerging as new mediators in the regulation of adipose tissue biology and the development of obesity. An important role of microRNA-125a has been suggested in the pathogenesis of insulin resistance (IR). Here, we characterized the function of microRNA-125a in adipose tissue in a context of experimentally-induced IR and obesity in mice and in obese patients. We showed time dependent overexpression of the microRNA in adipose tissue of BALB/c and C57BL/6J mice in response to high fat diet (HFD) feeding. MicroRNA-125a expression was downregulated in vitro in insulin resistant 3T3-L1 adipocytes and ex vivo in adipose tissue of obese patients. In vitro modulation of microRNA-125a expression in 3T3-L1 adipocytes did not affect glucose uptake. Gene set enrichment analysis (GSEA) identified significantly altered expression patterns of predicted microRNA-125a gene targets in transcriptomic datasets of adipose tissue from HFD-fed mice and obese patients. Among genes that contributed to global enrichment of altered expression of microRNA-125a targets, Thyrotroph embryonic factor (Tef), Mannan-binding lectin serine peptidase 1, Reticulon 2 and Ubiquitin-conjugating enzyme E2L3 were significantly differentially expressed in adipose tissue in these groups. We showed that Tef expression is reduced in adipose tissue of obese patients following gastric bypass surgery. Our findings indicate that microRNA-125a expression in adipose tissue adapts to IR and may play a role in the development of obesity in mice and obese subjects through uncoupled regulation of the expression of microRNA-125a and its targets.", "link"=>"http://www.mendeley.com/research/adaptive-expression-microrna125a-adipose-tissue-response-obesity-mice-men", "reader_count"=>31, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>3, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Student > Master"=>10, "Student > Bachelor"=>2, "Lecturer"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>3, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Student > Master"=>10, "Student > Bachelor"=>2, "Lecturer"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>3, "Agricultural and Biological Sciences"=>14, "Medicine and Dentistry"=>4, "Chemistry"=>1, "Social Sciences"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"United States"=>1, "Slovenia"=>1}, "group_count"=>4}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1438815"], "description"=>"<p>Gene set enrichment profiles of miR-125a gene targets (A) were determined for BALB/c mice after 1 week of HFD feeding (left) and C57BL/6J mice after 15 weeks of HFD feeding (right). Heatmap of miR-125a leading edge subsets are shown for fat fed C57BL/6J (top) and BALB/c (bottom) mice (B), alongwith enriched target genes significantly differentially expressed in these mice (C). Expression of <i>Tef</i>, <i>Masp1</i>, <i>Rtn2</i>, <i>Ube2l3</i> and <i>Adam9</i> was quantified by qRT-PCR in IR-3T3-L1 (▪) and control (□) adipocytes (D). Expression level was normalized with mouse <i>β-Actin</i>. Data are the mean ± SEM of 4 cultured cell replicates. *p<0.05 significant differences between IR-3T3-L1 adipocytes and control-3T3-L1 adipocytes.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Computational biology", "genome analysis", "Transcriptome analysis", "genetics", "gene expression", "Gene regulation", "genomics", "Molecular genetics", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "Network Analysis", "Metabolic networks", "Regulatory networks", "Endocrinology", "Diabetic endocrinology", "Model organisms", "Animal models", "Mouse models", "patterns", "mir-125a", "sets", "fed", "mice", "insulin", "resistant"], "article_id"=>977248, "categories"=>["Biological Sciences"], "users"=>["Malika R. Diawara", "Christophe Hue", "Steven P. Wilder", "Nicolas Venteclef", "Judith Aron-Wisnewsky", "James Scott", "Karine Clement", "Dominique Gauguier", "Sophie Calderari"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091375.g004", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_patterns_of_miR_125a_target_gene_sets_in_fat_fed_mice_and_in_insulin_resistant_adipocytes_/977248", "title"=>"Expression patterns of miR-125a target gene sets in fat fed mice and in insulin resistant adipocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-27 03:48:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1438828"], "description"=>"<div><p>MicroRNAs are emerging as new mediators in the regulation of adipose tissue biology and the development of obesity. An important role of microRNA-125a has been suggested in the pathogenesis of insulin resistance (IR). Here, we characterized the function of microRNA-125a in adipose tissue in a context of experimentally-induced IR and obesity in mice and in obese patients. We showed time dependent overexpression of the microRNA in adipose tissue of BALB/c and C57BL/6J mice in response to high fat diet (HFD) feeding. MicroRNA-125a expression was downregulated <i>in vitro</i> in insulin resistant 3T3-L1 adipocytes and <i>ex vivo</i> in adipose tissue of obese patients. <i>In vitro</i> modulation of microRNA-125a expression in 3T3-L1 adipocytes did not affect glucose uptake. Gene set enrichment analysis (GSEA) identified significantly altered expression patterns of predicted microRNA-125a gene targets in transcriptomic datasets of adipose tissue from HFD-fed mice and obese patients. Among genes that contributed to global enrichment of altered expression of microRNA-125a targets, Thyrotroph embryonic factor (<i>Tef</i>), Mannan-binding lectin serine peptidase 1, Reticulon 2 and Ubiquitin-conjugating enzyme E2L3 were significantly differentially expressed in adipose tissue in these groups. We showed that <i>Tef</i> expression is reduced in adipose tissue of obese patients following gastric bypass surgery. Our findings indicate that microRNA-125a expression in adipose tissue adapts to IR and may play a role in the development of obesity in mice and obese subjects through uncoupled regulation of the expression of microRNA-125a and its targets.</p></div>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Computational biology", "genome analysis", "Transcriptome analysis", "genetics", "gene expression", "Gene regulation", "genomics", "Molecular genetics", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "Network Analysis", "Metabolic networks", "Regulatory networks", "Endocrinology", "Diabetic endocrinology", "Model organisms", "Animal models", "Mouse models", "microrna-125a", "adipose", "mice"], "article_id"=>977261, "categories"=>["Biological Sciences"], "users"=>["Malika R. Diawara", "Christophe Hue", "Steven P. Wilder", "Nicolas Venteclef", "Judith Aron-Wisnewsky", "James Scott", "Karine Clement", "Dominique Gauguier", "Sophie Calderari"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091375", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adaptive_Expression_of_MicroRNA_125a_in_Adipose_Tissue_in_Response_to_Obesity_in_Mice_and_Men_/977261", "title"=>"Adaptive Expression of MicroRNA-125a in Adipose Tissue in Response to Obesity in Mice and Men", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-27 03:48:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1438827"], "description"=>"<p>Patient physiological parameters (F, Female; M, Male; BMI, Body mass index; TGL, Triglyceride; γGT, γ-glutamyltransferase; IL6, Interleukin 6; ApoB, Apolipoprotein B;QUICKI, Quantitative insulin sensitivity index).</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Computational biology", "genome analysis", "Transcriptome analysis", "genetics", "gene expression", "Gene regulation", "genomics", "Molecular genetics", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "Network Analysis", "Metabolic networks", "Regulatory networks", "Endocrinology", "Diabetic endocrinology", "Model organisms", "Animal models", "Mouse models", "physiological", "interleukin", "apolipoprotein", "quantitative", "insulin"], "article_id"=>977260, "categories"=>["Biological Sciences"], "users"=>["Malika R. Diawara", "Christophe Hue", "Steven P. Wilder", "Nicolas Venteclef", "Judith Aron-Wisnewsky", "James Scott", "Karine Clement", "Dominique Gauguier", "Sophie Calderari"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091375.t001", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_physiological_parameters_F_Female_M_Male_BMI_Body_mass_index_TGL_Triglyceride_947_GT_947_glutamyltransferase_IL6_Interleukin_6_ApoB_Apolipoprotein_B_QUICKI_Quantitative_insulin_sensitivity_index_/977260", "title"=>"Patient physiological parameters (F, Female; M, Male; BMI, Body mass index; TGL, Triglyceride; γGT, γ-glutamyltransferase; IL6, Interleukin 6; ApoB, Apolipoprotein B;QUICKI, Quantitative insulin sensitivity index).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-27 03:48:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1438824"], "description"=>"<p>Heatmaps of miR-125a leading edge subsets are shown for obese patients before (top) or after gastric bypass (bottom) when compared to lean subjects (A). Patterns of expression for <i>Tef</i>, <i>Masp1</i>, <i>Rtn2</i>, <i>Ube2l3</i> and <i>Adam9</i> in these groups are illustrated. Cells are hatched when differences are not statistically significant (B).</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Computational biology", "genome analysis", "Transcriptome analysis", "genetics", "gene expression", "Gene regulation", "genomics", "Molecular genetics", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "Network Analysis", "Metabolic networks", "Regulatory networks", "Endocrinology", "Diabetic endocrinology", "Model organisms", "Animal models", "Mouse models", "mir-125a", "adipose", "obese", "patients", "gastric"], "article_id"=>977257, "categories"=>["Biological Sciences"], "users"=>["Malika R. Diawara", "Christophe Hue", "Steven P. Wilder", "Nicolas Venteclef", "Judith Aron-Wisnewsky", "James Scott", "Karine Clement", "Dominique Gauguier", "Sophie Calderari"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091375.g006", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_profile_of_miR_125a_target_gene_in_adipose_tissue_of_obese_patients_before_and_after_gastric_bypass_/977257", "title"=>"Expression profile of miR-125a target gene in adipose tissue of obese patients before and after gastric bypass.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-27 03:48:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1438826"], "description"=>"<p>*p<0.05, **p<0.01, ***p<0.001 significant differences between mice fed with HFD and CHD.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Computational biology", "genome analysis", "Transcriptome analysis", "genetics", "gene expression", "Gene regulation", "genomics", "Molecular genetics", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "Network Analysis", "Metabolic networks", "Regulatory networks", "Endocrinology", "Diabetic endocrinology", "Model organisms", "Animal models", "Mouse models", "characterization", "15", "weeks", "hfd", "feeding", "mice", "high-fat"], "article_id"=>977259, "categories"=>["Biological Sciences"], "users"=>["Malika R. Diawara", "Christophe Hue", "Steven P. Wilder", "Nicolas Venteclef", "Judith Aron-Wisnewsky", "James Scott", "Karine Clement", "Dominique Gauguier", "Sophie Calderari"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091375.t002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phenotype_characterization_of_the_effects_of_1_and_15_weeks_of_HFD_feeding_in_C57BL_6J_and_BALB_c_mice_CHD_Carbohydrate_diet_HFD_High_fat_diet_/977259", "title"=>"Phenotype characterization of the effects of 1 and 15 weeks of HFD feeding in C57BL/6J and BALB/c mice (CHD, Carbohydrate diet; HFD, High-fat diet).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-27 03:48:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1438811"], "description"=>"<p>MiR-125a expression was quantified by qRT-PCR in subcutaneous (A) and visceral adipose tissue (B) in obese patients (Ob) with or without diabetes (Diab) and controls. MiR-125a expression level in obese patients was correlated with total triglycerides level, circulating leptin, γ-glutamyltransferase (γ-GT) and adiponectin levels, fat mass and fat free mass percentages (C) in males (▪) and females (•). Expression data were normalized with miR-16, an endogenous miR whom expression level do not vary across group of study. Data are the mean ± SEM of 6 non obese subjects for subcutaneous adipose tissue, 7 non obese subjects for visceral adipose tissue, 9 obese non diabetic and 7 obese diabetic patients. Parametric Pearson correlation tests were performed. *p<0.05, **p<0.01, ***p<0.001 significant differences between obese patients and controls.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Computational biology", "genome analysis", "Transcriptome analysis", "genetics", "gene expression", "Gene regulation", "genomics", "Molecular genetics", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "Network Analysis", "Metabolic networks", "Regulatory networks", "Endocrinology", "Diabetic endocrinology", "Model organisms", "Animal models", "Mouse models", "adipose", "obese", "patients", "correlations", "physiological"], "article_id"=>977244, "categories"=>["Biological Sciences"], "users"=>["Malika R. Diawara", "Christophe Hue", "Steven P. Wilder", "Nicolas Venteclef", "Judith Aron-Wisnewsky", "James Scott", "Karine Clement", "Dominique Gauguier", "Sophie Calderari"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091375.g003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MiR_125a_expression_in_adipose_tissue_of_obese_patients_and_correlations_with_physiological_parameters_/977244", "title"=>"MiR-125a expression in adipose tissue of obese patients and correlations with physiological parameters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-27 03:48:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1438808"], "description"=>"<p>The effects of miR-125a expression downregulation (A) and upregulation (C) on glucose transport (B–D) were measured <i>in vitro</i> in 3T3-L1 differentiated adipocytes. Expression of miR-125a was normalized with U6. Data are expressed as mean ± SEM for 3 replicated experiments. $$$p<0.001 significant differences between miR-125a inhibitor/mimic, and control (not transfected cells) and cells transfected with C. elegans (Cel)-miR-67. £££p<0.001, ££p<0.01 significant differences in glucose transport stimulated by insulin in 3T3-L1 adipocytes.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Computational biology", "genome analysis", "Transcriptome analysis", "genetics", "gene expression", "Gene regulation", "genomics", "Molecular genetics", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "Network Analysis", "Metabolic networks", "Regulatory networks", "Endocrinology", "Diabetic endocrinology", "Model organisms", "Animal models", "Mouse models", "modulation", "3t3-l1", "differentiated", "adipocytes", "adipocyte", "glucose"], "article_id"=>977241, "categories"=>["Biological Sciences"], "users"=>["Malika R. Diawara", "Christophe Hue", "Steven P. Wilder", "Nicolas Venteclef", "Judith Aron-Wisnewsky", "James Scott", "Karine Clement", "Dominique Gauguier", "Sophie Calderari"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091375.g002", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MiR_125a_modulation_of_expression_in_3T3_L1_differentiated_adipocytes_do_not_affect_adipocyte_glucose_uptake_/977241", "title"=>"MiR-125a modulation of expression in 3T3-L1 differentiated adipocytes do not affect adipocyte glucose uptake.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-27 03:48:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1438825"], "description"=>"<p>Correlations between <i>Tef</i> expression level (2-ΔCT unit) and fasting insulinemia (A) and QUICKI (B) were calculated in male (▪) and female (•) obese patients.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Computational biology", "genome analysis", "Transcriptome analysis", "genetics", "gene expression", "Gene regulation", "genomics", "Molecular genetics", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "Network Analysis", "Metabolic networks", "Regulatory networks", "Endocrinology", "Diabetic endocrinology", "Model organisms", "Animal models", "Mouse models", "subcutaneous", "adipose", "fasting", "insulinemia", "quantitative", "insulin", "obese"], "article_id"=>977258, "categories"=>["Biological Sciences"], "users"=>["Malika R. Diawara", "Christophe Hue", "Steven P. Wilder", "Nicolas Venteclef", "Judith Aron-Wisnewsky", "James Scott", "Karine Clement", "Dominique Gauguier", "Sophie Calderari"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091375.g007", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tef_expression_level_in_subcutaneous_adipose_tissue_is_associated_with_fasting_insulinemia_and_Quantitative_insulin_sensitivity_index_QUICKI_in_obese_patients_/977258", "title"=>"<i>Tef</i> expression level in subcutaneous adipose tissue is associated with fasting insulinemia and Quantitative insulin sensitivity index (QUICKI) in obese patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-27 03:48:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1438807"], "description"=>"<p>MiR-125a expression levels were quantified by q (quantitative) RT-PCR in adipose tissue of mice fed HFD for 1 week (A) or 15 weeks (B). The effect of <i>in vitro</i> insulin resistance (C) on miR-125a expression (D) was tested by qRT-PCR in 3T3-L1 adipocytes. Expression of miR-125a was normalized with small nucleolar (sno) RNA202 in adipose tissue and U6 in cultured cells. Data are expressed as mean ± SEM for 4–5 mice per group and for 3 replicated experiments in cultured cells. *p<0.05 significant differential expression of miR-125a between HFD-fed and control mice of the same strain. <sup>£££</sup>p<0.001 significant differences in glucose transport stimulated by insulin in 3T3-L1 adipocytes. ∧∧p<0.01 significant differences in miR-125a expression between IR-3T3-L1 adipocytes and control-3T3-L1 adipocytes.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Computational biology", "genome analysis", "Transcriptome analysis", "genetics", "gene expression", "Gene regulation", "genomics", "Molecular genetics", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "Network Analysis", "Metabolic networks", "Regulatory networks", "Endocrinology", "Diabetic endocrinology", "Model organisms", "Animal models", "Mouse models", "relationships", "insulin", "mir-125a"], "article_id"=>977240, "categories"=>["Biological Sciences"], "users"=>["Malika R. Diawara", "Christophe Hue", "Steven P. Wilder", "Nicolas Venteclef", "Judith Aron-Wisnewsky", "James Scott", "Karine Clement", "Dominique Gauguier", "Sophie Calderari"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091375.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Biological_relationships_between_insulin_resistance_and_miR_125a_expression_/977240", "title"=>"Biological relationships between insulin resistance and miR-125a expression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-27 03:48:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1438819"], "description"=>"<p>Expression of <i>Tef</i>, <i>Masp1</i>, <i>Rtn2</i>, <i>Ube2l3</i> and <i>Adam9</i> was quantified by qRT-PCR in subcutaneous (A) and visceral (B) adipose tissue of obese patients (Ob) with diabetes (Diab) or without (NonDiab) and non obese subjects (Controls). Expression levels were normalized with human <i>β-Actin</i>. <sup>$</sup>p<0.05, <sup>$$</sup>p<0.01, <sup>$$$</sup>p<0.001 significantly different to non obese subjects.</p>", "links"=>[], "tags"=>["Biochemistry", "Nucleic acids", "rna", "Computational biology", "genome analysis", "Transcriptome analysis", "genetics", "gene expression", "Gene regulation", "genomics", "Molecular genetics", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "Network Analysis", "Metabolic networks", "Regulatory networks", "Endocrinology", "Diabetic endocrinology", "Model organisms", "Animal models", "Mouse models", "adipose", "obese"], "article_id"=>977252, "categories"=>["Biological Sciences"], "users"=>["Malika R. Diawara", "Christophe Hue", "Steven P. Wilder", "Nicolas Venteclef", "Judith Aron-Wisnewsky", "James Scott", "Karine Clement", "Dominique Gauguier", "Sophie Calderari"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091375.g005", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MiR_125a_target_gene_expression_regulation_in_adipose_tissue_of_obese_patients_/977252", "title"=>"MiR-125a target gene expression regulation in adipose tissue of obese patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-27 03:48:19"}

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