Effects of THAP11 on Erythroid Differentiation and Megakaryocytic Differentiation of K562 Cells
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{"title"=>"Effects of THAP11 on erythroid differentiation and megakaryocytic differentiation of K562 cells", "type"=>"journal", "authors"=>[{"first_name"=>"Xiang Zhen", "last_name"=>"Kong", "scopus_author_id"=>"55207672600"}, {"first_name"=>"Rong Hua", "last_name"=>"Yin", "scopus_author_id"=>"55206218300"}, {"first_name"=>"Hong Mei", "last_name"=>"Ning", "scopus_author_id"=>"8615883700"}, {"first_name"=>"Wei Wei", "last_name"=>"Zheng", "scopus_author_id"=>"57197956466"}, {"first_name"=>"Xiao Ming", "last_name"=>"Dong", "scopus_author_id"=>"55976173000"}, {"first_name"=>"Yang", "last_name"=>"Yang", "scopus_author_id"=>"55206710700"}, {"first_name"=>"Fei Fei", "last_name"=>"Xu", "scopus_author_id"=>"55440849400"}, {"first_name"=>"Jian Jie", "last_name"=>"Li", "scopus_author_id"=>"55023376800"}, {"first_name"=>"Yi Qun", "last_name"=>"Zhan", "scopus_author_id"=>"35486150500"}, {"first_name"=>"Miao", "last_name"=>"Yu", "scopus_author_id"=>"55371204200"}, {"first_name"=>"Chang Hui", "last_name"=>"Ge", "scopus_author_id"=>"14319104000"}, {"first_name"=>"Jian Hong", "last_name"=>"Zhang", "scopus_author_id"=>"56114802100"}, {"first_name"=>"Hui", "last_name"=>"Chen", "scopus_author_id"=>"57072179700"}, {"first_name"=>"Chang Yan", "last_name"=>"Li", "scopus_author_id"=>"8637667900"}, {"first_name"=>"Xiao Ming", "last_name"=>"Yang", "scopus_author_id"=>"35279010900"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "pmid"=>"24637716", "doi"=>"10.1371/journal.pone.0091557", "pui"=>"372838510", "issn"=>"19326203", "sgr"=>"84898612122", "scopus"=>"2-s2.0-84898612122"}, "id"=>"0bad9ed6-5fb1-3a87-bfc4-5033bf3757db", "abstract"=>"Hematopoiesis is a complex process regulated by sets of transcription factors in a stage-specific and context-dependent manner. THAP11 is a transcription factor involved in cell growth, ES cell pluripotency, and embryogenesis. Here we showed that THAP11 was down-regulated during erythroid differentiation but up-regulated during megakaryocytic differentiation of cord blood CD34+ cells. Overexpression of THAP11 in K562 cells inhibited the erythroid differentiation induced by hemin with decreased numbers of benzidine-positive cells and decreased mRNA levels of α-globin (HBA) and glycophorin A (GPA), and knockdown of THAP11 enhanced the erythroid differentiation. Conversely, THAP11 overexpression accelerated the megakaryocytic differentiation induced by phorbol myristate acetate (PMA) with increased percentage of CD41+ cells, increased numbers of 4N cells, and elevated CD61 mRNA levels, and THAP11 knockdown attenuated the megakaryocytic differentiation. The expression levels of transcription factors such as c-Myc, c-Myb, GATA-2, and Fli1 were changed by THAP11 overexpression. In this way, our results suggested that THAP11 reversibly regulated erythroid and megakaryocytic differentiation.", "link"=>"http://www.mendeley.com/research/effects-thap11-erythroid-differentiation-megakaryocytic-differentiation-k562-cells", "reader_count"=>13, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>6, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>6, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>1, "Immunology and Microbiology"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1423034", "https://ndownloader.figshare.com/files/1423035", "https://ndownloader.figshare.com/files/1423036", "https://ndownloader.figshare.com/files/1423037", "https://ndownloader.figshare.com/files/1423038", "https://ndownloader.figshare.com/files/1423039", "https://ndownloader.figshare.com/files/1423040", "https://ndownloader.figshare.com/files/1423041", "https://ndownloader.figshare.com/files/1423042", "https://ndownloader.figshare.com/files/1423043"], "description"=>"<div><p>Hematopoiesis is a complex process regulated by sets of transcription factors in a stage-specific and context-dependent manner. THAP11 is a transcription factor involved in cell growth, ES cell pluripotency, and embryogenesis. Here we showed that THAP11 was down-regulated during erythroid differentiation but up-regulated during megakaryocytic differentiation of cord blood CD34<sup>+</sup> cells. Overexpression of THAP11 in K562 cells inhibited the erythroid differentiation induced by hemin with decreased numbers of benzidine-positive cells and decreased mRNA levels of α-globin (HBA) and glycophorin A (GPA), and knockdown of THAP11 enhanced the erythroid differentiation. Conversely, THAP11 overexpression accelerated the megakaryocytic differentiation induced by phorbol myristate acetate (PMA) with increased percentage of CD41<sup>+</sup> cells, increased numbers of 4N cells, and elevated CD61 mRNA levels, and THAP11 knockdown attenuated the megakaryocytic differentiation. The expression levels of transcription factors such as c-Myc, c-Myb, GATA-2, and Fli1 were changed by THAP11 overexpression. In this way, our results suggested that THAP11 reversibly regulated erythroid and megakaryocytic differentiation.</p></div>", "links"=>[], "tags"=>["cell biology", "Cellular types", "Animal cells", "stem cells", "Hematopoietic progenitor cells", "Hematopoietic stem cells", "Molecular cell biology", "developmental biology", "Cell differentiation", "Cell fate determination", "genetics", "gene expression", "DNA transcription", "hematology", "hematopoiesis", "thap11", "erythroid", "differentiation", "megakaryocytic", "k562"], "article_id"=>964135, "categories"=>["Biological Sciences"], "users"=>["Xiang-zhen Kong", "Rong-Hua Yin", "Hong-Mei Ning", "Wei-Wei Zheng", "Xiao-Ming Dong", "Yang Yang", "Fei-Fei Xu", "Jian-Jie Li", "Yi-Qun Zhan", "Miao Yu", "Chang-Hui Ge", "Jian-Hong Zhang", "Hui Chen", "Chang-Yan Li", "Xiao-Ming Yang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0091557.s001", "https://dx.doi.org/10.1371/journal.pone.0091557.s002", "https://dx.doi.org/10.1371/journal.pone.0091557.s003", "https://dx.doi.org/10.1371/journal.pone.0091557.s004", "https://dx.doi.org/10.1371/journal.pone.0091557.s005", "https://dx.doi.org/10.1371/journal.pone.0091557.s006", "https://dx.doi.org/10.1371/journal.pone.0091557.s007", "https://dx.doi.org/10.1371/journal.pone.0091557.s008", "https://dx.doi.org/10.1371/journal.pone.0091557.s009", "https://dx.doi.org/10.1371/journal.pone.0091557.s010"], "stats"=>{"downloads"=>40, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_THAP11_on_Erythroid_Differentiation_and_Megakaryocytic_Differentiation_of_K562_Cells_/964135", "title"=>"Effects of THAP11 on Erythroid Differentiation and Megakaryocytic Differentiation of K562 Cells", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-03-17 03:14:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1423030"], "description"=>"<p>THAP11 lentivirus infected K562 cells (THAP11-LV) and control cells were treated with 10 nM PMA for the indicated lengths of time. CD41<sup>+</sup> cells (A) and percentage of 4N cells (B) were analyzed using FACS. The CD61 mRNA level was measured by real-time PCR analysis (C). (D) THAP11 siRNA lentivirus infected-K562 cells or control K562 cells were treated with 10 nM PMA for 3 days. Then CD41<sup>+</sup> cells and the percentage of 4N cells (E) were analyzed using FACS. (F) The CD61 mRNA level was measured using real-time PCR analysis.</p>", "links"=>[], "tags"=>["cell biology", "Cellular types", "Animal cells", "stem cells", "Hematopoietic progenitor cells", "Hematopoietic stem cells", "Molecular cell biology", "developmental biology", "Cell differentiation", "Cell fate determination", "genetics", "gene expression", "DNA transcription", "hematology", "hematopoiesis", "accelerates", "megakaryocytic", "differentiation", "k562", "cells", "induced"], "article_id"=>964131, "categories"=>["Biological Sciences"], "users"=>["Xiang-zhen Kong", "Rong-Hua Yin", "Hong-Mei Ning", "Wei-Wei Zheng", "Xiao-Ming Dong", "Yang Yang", "Fei-Fei Xu", "Jian-Jie Li", "Yi-Qun Zhan", "Miao Yu", "Chang-Hui Ge", "Jian-Hong Zhang", "Hui Chen", "Chang-Yan Li", "Xiao-Ming Yang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091557.g004", "stats"=>{"downloads"=>4, "page_views"=>84, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_THAP11_accelerates_megakaryocytic_differentiation_of_K562_cells_induced_by_PMA_/964131", "title"=>"THAP11 accelerates megakaryocytic differentiation of K562 cells induced by PMA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-17 03:14:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1423029"], "description"=>"<p>(A) K562 cells were infected with control lentivirus or THAP11 RNAi lentivirus (siTHAP11-1 and siTHAP11-2) and then the GFP positive cells were sorted. The THAP11 expression level was detected by real-time PCR (upper panel) and Western blot analysis (lower panel). Then the cells were treated with 40 µM hemin for the indicated lengths of time. (B) Benzidine-positive cells were counted. (C) HBA and (D) GPA mRNA levels were measured using real-time PCR analysis.</p>", "links"=>[], "tags"=>["cell biology", "Cellular types", "Animal cells", "stem cells", "Hematopoietic progenitor cells", "Hematopoietic stem cells", "Molecular cell biology", "developmental biology", "Cell differentiation", "Cell fate determination", "genetics", "gene expression", "DNA transcription", "hematology", "hematopoiesis", "knockdown", "hemin", "induced", "erythroid", "differentiation", "k562"], "article_id"=>964130, "categories"=>["Biological Sciences"], "users"=>["Xiang-zhen Kong", "Rong-Hua Yin", "Hong-Mei Ning", "Wei-Wei Zheng", "Xiao-Ming Dong", "Yang Yang", "Fei-Fei Xu", "Jian-Jie Li", "Yi-Qun Zhan", "Miao Yu", "Chang-Hui Ge", "Jian-Hong Zhang", "Hui Chen", "Chang-Yan Li", "Xiao-Ming Yang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091557.g003", "stats"=>{"downloads"=>4, "page_views"=>115, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_THAP11_knockdown_enhances_hemin_induced_erythroid_differentiation_of_K562_cells_/964130", "title"=>"THAP11 knockdown enhances hemin induced erythroid differentiation of K562 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-17 03:14:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1423024"], "description"=>"<p>(A) CD34<sup>+</sup> cells were cultured in the presence of EPO for the indicated lengths of time and the expression level of THAP11 was detected using real-time PCR and Western blot analysis. (B) For the Western blot analysis, 80 µg protein was loaded. (C) CD34<sup>+</sup> cells were cultured in the presence of TPO for the indicated lengths of time and the expression level of THAP11 was detected using real-time PCR and Western blot analysis. (D) For the Western blot analysis, 10 µg protein were loaded. Real-time PCR results were expressed as fold induction compared to cells at day 0 and normalized to GAPDH mRNA. Each bar represents the mean ± SD for three independent experiments. The statistical difference between the samples is given using * <i>P</i>≤0.05 or ** <i>P</i>≤0.001.</p>", "links"=>[], "tags"=>["cell biology", "Cellular types", "Animal cells", "stem cells", "Hematopoietic progenitor cells", "Hematopoietic stem cells", "Molecular cell biology", "developmental biology", "Cell differentiation", "Cell fate determination", "genetics", "gene expression", "DNA transcription", "hematology", "hematopoiesis", "differentiation"], "article_id"=>964125, "categories"=>["Biological Sciences"], "users"=>["Xiang-zhen Kong", "Rong-Hua Yin", "Hong-Mei Ning", "Wei-Wei Zheng", "Xiao-Ming Dong", "Yang Yang", "Fei-Fei Xu", "Jian-Jie Li", "Yi-Qun Zhan", "Miao Yu", "Chang-Hui Ge", "Jian-Hong Zhang", "Hui Chen", "Chang-Yan Li", "Xiao-Ming Yang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091557.g001", "stats"=>{"downloads"=>2, "page_views"=>48, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_THAP11_expression_profile_during_differentiation_of_cord_blood_CD34_cells_/964125", "title"=>"THAP11 expression profile during differentiation of cord blood CD34<sup>+</sup> cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-17 03:14:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1423031"], "description"=>"<p>K562 cells infected with THAP11-lentiviruses (THAP11-LV) and control cells were treated with 10 nM PMA for 72 hours. Then total RNA was extracted for real-time PCR analysis. Real-time PCR results were expressed as fold induction relative to cells at day 0 and normalized to GAPDH mRNA. Each bar represented the mean ± SD for three independent experiments. The statistical difference between the samples was demonstrated as * <i>P</i>≤0.05 or ** <i>P</i>≤0.001.</p>", "links"=>[], "tags"=>["cell biology", "Cellular types", "Animal cells", "stem cells", "Hematopoietic progenitor cells", "Hematopoietic stem cells", "Molecular cell biology", "developmental biology", "Cell differentiation", "Cell fate determination", "genetics", "gene expression", "DNA transcription", "hematology", "hematopoiesis", "hematopoietic", "transcription", "thap11-overexpressing", "k562"], "article_id"=>964132, "categories"=>["Biological Sciences"], "users"=>["Xiang-zhen Kong", "Rong-Hua Yin", "Hong-Mei Ning", "Wei-Wei Zheng", "Xiao-Ming Dong", "Yang Yang", "Fei-Fei Xu", "Jian-Jie Li", "Yi-Qun Zhan", "Miao Yu", "Chang-Hui Ge", "Jian-Hong Zhang", "Hui Chen", "Chang-Yan Li", "Xiao-Ming Yang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091557.g005", "stats"=>{"downloads"=>3, "page_views"=>37, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Alteration_of_expression_levels_of_several_hematopoietic_transcription_factors_in_THAP11_overexpressing_K562_cells_/964132", "title"=>"Alteration of expression levels of several hematopoietic transcription factors in THAP11-overexpressing K562 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-17 03:14:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1423026"], "description"=>"<p>(A) THAP11 lentivirus infected K562 cells (THAP11-LV) and control cells were treated with 40 µM hemin for the indicated lengths of time and the benzidine-positive cells were counted. The pictures of cells treated with hemin for 5 days were shown in (B). (C) HBA mRNA level and (D) GPA mRNA level were detected using real-time PCR analysis. Real-time PCR results were expressed as fold induction relative to control cells at day 0 and normalized to GAPDH mRNA.</p>", "links"=>[], "tags"=>["cell biology", "Cellular types", "Animal cells", "stem cells", "Hematopoietic progenitor cells", "Hematopoietic stem cells", "Molecular cell biology", "developmental biology", "Cell differentiation", "Cell fate determination", "genetics", "gene expression", "DNA transcription", "hematology", "hematopoiesis", "overexpression", "leads", "inhibition", "hemin", "induced", "erythroid", "differentiation", "k562"], "article_id"=>964127, "categories"=>["Biological Sciences"], "users"=>["Xiang-zhen Kong", "Rong-Hua Yin", "Hong-Mei Ning", "Wei-Wei Zheng", "Xiao-Ming Dong", "Yang Yang", "Fei-Fei Xu", "Jian-Jie Li", "Yi-Qun Zhan", "Miao Yu", "Chang-Hui Ge", "Jian-Hong Zhang", "Hui Chen", "Chang-Yan Li", "Xiao-Ming Yang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091557.g002", "stats"=>{"downloads"=>3, "page_views"=>113, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_THAP11_overexpression_leads_to_inhibition_of_hemin_induced_erythroid_differentiation_of_K562_cells_/964127", "title"=>"THAP11 overexpression leads to inhibition of hemin induced erythroid differentiation of K562 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-17 03:14:16"}

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Relative Metric

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